Ruta Independencia

Oaxaca

A cactus garden with tall cacti and a reflective pond.
A desert garden with cacti, a purple flowering tree, and mountains in the background.
A historic cathedral with two prominent towers and a large dome.
A traditional festival with participants in colorful attire, carrying baskets and decorated floats.
A colorful elephant sculpture with a large mouth and teeth, hanging from a building.

Stay near popular Ruta Independencia attractions

A historic stone building with a bell tower and palm trees.

Church of Santo Domingo de Guzmán

9.6/10 (3,897 reviews)
<p>Experience the vibrant cultural atmosphere of the Church of Santo Domingo de Guzmán, a stunning example of colonial architecture and a hub for local traditions.</p>
See properties

Things to do

Tour in Oaxaca Monte Alban Mezcal Alebrijes and Barro Negro

Monte Alban, Ancestral Mezcal, Alebrijes and Black Mud Tour

CA $48
per adult
Monte Alban, Ancestral Mezcal, Alebrijes and Black Mud Tour
Boil Water Full Day Guided Tour from Oaxaca

Tour Ruta Hierve el Agua, Tule, Mitla, Teotitlan and Mezcal

CA $38
per adult
100% of travellers recommend
Tour Ruta Hierve el Agua, Tule, Mitla, Teotitlan and Mezcal
Oaxaca de Juarez: Monte Alban Half-Day Tour

Oaxaca de Juarez: Monte Alban Half-Day Tour

CA $49
per adult
96% of travellers recommend
Oaxaca de Juarez: Monte Alban Half-Day Tour
Oaxaca: Hierve El Agua, El Tule, Mitla and Mezcal Tasting

Oaxaca: Hierve El Agua, El Tule, Mitla and Mezcal Tasting

CA $49
per adult
Oaxaca: Hierve El Agua, El Tule, Mitla and Mezcal Tasting
Monte Alban Full Day Guided Tour from Oaxaca

Tour to Monte Alban, Black Mud, Waist Loom and Alebrijes

CA $29
per adult
Tour to Monte Alban, Black Mud, Waist Loom and Alebrijes
Oaxaca: Walking Traditional Food Tour with Ancestral Drinks

Oaxaca: Walking Traditional Food Tour with Ancestral Drinks

CA $36
per adult
Oaxaca: Walking Traditional Food Tour with Ancestral Drinks
See all activities in Oaxaca

Ruta Independencia Hotel Deals

Quinta Real Oaxaca

Quinta Real Oaxaca

4.5 out of 5
Calle 5 De Mayo 300 Oaxaca OAX
The price is CA $385 per night from Sep 6 to Sep 7
CA $385
CA $458 total
Sep 6 - Sep 7
includes taxes & fees
Book a stay at this luxury hotel in Oaxaca. Enjoy free WiFi, 24-hour room service, and a fitness center. Our guests praise the helpful staff and the property ...
9.6/10 Exceptional! (1,003 reviews)
"Property and grounds were very beautiful! Staff was super helpful. Room was a little bit plain—needs a little more decor to offset the small size and white walls but the grounds and staff made up for it and our stay was otherwise superb!"

Reviewed on Aug 4, 2026

Quinta Real Oaxaca
Grand Fiesta Americana Oaxaca

Grand Fiesta Americana Oaxaca

5 out of 5
Jose Maria Pino Suarez 702 Oaxaca OAX
The price is CA $394 per night from Sep 1 to Sep 2
CA $394
CA $469 total
Sep 1 - Sep 2
includes taxes & fees
Book a stay at this luxury hotel in Oaxaca. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff in our reviews. Popular ...
9.6/10 Exceptional! (803 reviews)
"Great Stay! Comfy hotel with excellent service. Recommend!!"

Reviewed on Aug 5, 2026

Grand Fiesta Americana Oaxaca
Holiday Inn Express Oaxaca-Centro Historico by IHG

Holiday Inn Express Oaxaca-Centro Historico by IHG

3 out of 5
Diaz Quintas 115, Col. Centro Oaxaca OAX
The price is CA $174 per night from Aug 16 to Aug 17
CA $174
CA $207 total
Aug 16 - Aug 17
includes taxes & fees
Book a stay at this business-friendly hotel in Oaxaca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Holiday Inn Express Oaxaca-Centro Historico by IHG
One Oaxaca Centro Hotel

One Oaxaca Centro Hotel

3 out of 5
Calzada de la Republica #205 Oaxaca OAX
The price is CA $99 per night from Aug 16 to Aug 17
CA $99
CA $117 total
Aug 16 - Aug 17
includes taxes & fees
Book a stay at this business-friendly hotel in Oaxaca. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...
One Oaxaca Centro Hotel
Hotel Oaxaca Real

Hotel Oaxaca Real

3.5 out of 5
Manuel Garcia Vigil No. 306 Oaxaca OAX
The price is CA $88 per night from Aug 16 to Aug 17
CA $88
CA $107 total
Aug 16 - Aug 17
includes taxes & fees
Book a stay at this business-friendly hotel in Oaxaca. Enjoy free WiFi, free parking, and a rooftop terrace. Our guests praise the helpful staff and the property ...
8.6/10 Excellent! (1,003 reviews)
"Nice property, conveniently located, close to restaurants, museums, bars and just in an overall great area to be with lots going on. Only complaint I have is that the room we were in had a window that opened up to the hotel parking garage… but since we spent very little time in the room it was not ..."

Reviewed on Aug 4, 2026

Hotel Oaxaca Real
Hotel Abu

Hotel Abu

4 out of 5
Murguia 104 Col. Centro Oaxaca OAX
The price is CA $132 per night from Sep 1 to Sep 2
CA $132
CA $159 total
Sep 1 - Sep 2
includes taxes & fees
Stay at this hotel in Oaxaca. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the helpful staff in our reviews. Popular attractions ...
8.6/10 Excellent! (570 reviews)
"Great location; right next to the Andador turístico, rooms are very clean, staff is amazing, very helpful, it has an elevator. Overall it is very affordable and has all the great things for you to have an amazing experience."

Reviewed on Aug 2, 2026

Hotel Abu
See all 970 properties in Ruta Independencia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Ruta Independencia

Find the best Ruta Independencia areas and neighborhoods for the activities you enjoy most. Learn more about Ruta Independencia
Learn more about Ruta Independencia
A cactus garden with tall cacti and a reflective pond.
Photo by Marina Alcantara
Open Photo by Marina Alcantara

Oaxaca Centro

Churches, museums, and art galleries highlight some of the noteworthy features of Oaxaca Centro. Make a stop by Oaxaca Textile Museum or Oaxaca Cathedral while you're exploring the neighborhood.
A narrow cobblestone street flanked by colorful buildings with balconies and hanging plants.

Jalatlaco

While Jalatlaco isn't home to many top sights, El Llano Park and Oaxaca Ethnobotanical Garden are some notable places to visit nearby.
A colorful sign with the letters "OAKLA" in a public square with a fountain and statues in the background.
Photo by Tahino2000
Open Photo by Tahino2000

Reforma

If you're spending some time in Reforma, Plaza Mazari and Plaza Parque are top sights worth seeing.
A person with arms raised, a colorful hot air balloon, and ancient ruins in the background.

Santa Lucía del Camino

When in Santa Lucía del Camino, you can plan a visit to Oaxaca Cultural and Convention Center and El Llano Park, some noteworthy sights in the nearby area.
An ancient archaeological site with ruins, including stepped pyramids and stone walls, set against a backdrop of mountains and clear skies.
Photo by Rodrigo López
Open Photo by Rodrigo López

Santa Cruz Xoxocotlán

Visitors to Santa Cruz Xoxocotlán like its archaeological sites and cafes, and Monte Albán is a sight worth a stop.

Ruta Independencia

Choose two or more items and save on your trip:

Explore a world of travel with Expedia