Title: Book the Best Muscatine LUXURY Hotels - Upscale Hotels in Muscatine, IA | Expedia.ca [Muscatine Travel Guide](https://expedia.ca/Muscatine.dx8837)[Hotels in Muscatine](https://expedia.ca/Muscatine-Hotels.d8837.Travel-Guide-Hotels)[Vacation Rentals in Muscatine](https://expedia.ca/Muscatine-Vacation-Rentals.d8837.Travel-Guide-VacationRentals)[Muscatine Car Rentals](https://expedia.ca/Car-Rentals-In-Muscatine.d8837.Car-Rental-Guide)[Muscatine Vacation Packages](https://expedia.ca/Muscatine.d8837.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/ecc93cd42b9ebb9e37741b6092febdab.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Bill Eaker # Find luxury hotels in Muscatine, IA - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Muscatine Luxury Hotels Tonight [Nov 1 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=8837&startDate=2025-11-01&endDate=2025-11-02&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [Nov 2 - Nov 3](https://www.expedia.ca/Hotel-Search?regionId=8837&startDate=2025-11-02&endDate=2025-11-03&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=8837&startDate=2025-11-07&endDate=2025-11-09&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) In two weeks [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=8837&startDate=2025-11-14&endDate=2025-11-16&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top Muscatine Luxury Hotels ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/130000/123000/122937/30eeb5c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/130000/123000/122937/12f80ea0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/130000/123000/122937/197dd8c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, deep soaking tub, rainfall showerhead](https://images.trvl-media.com/lodging/1000000/130000/123000/122937/1cc95300.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Muscatine Muscatine 6.2/10 (275) "It was really nice and clean hotel. I enjoyed myself with my lady. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marvin CA $89 CA $100 total includes taxes & fees Nov 12 - Nov 13 [](https://www.expedia.ca/Muscatine-Hotels-Super-8-By-Wyndham-Muscatine.h122937.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-15&endDate=2025-11-16®ionId=8837&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Top Muscatine Hotel Reviews ![Wyndham Moline on John Deere Commons](//images.trvl-media.com/lodging/1000000/50000/43400/43329/bc3dbe4c_y.jpg) ### Wyndham Moline on John Deere Commons 10/10 Excellent "The room was clean and comfortable, the pool area was clean and well appointed" [](https://expedia.ca/Moline-Hotels-Radisson-On-John-Deere-Commons-Moline.h43329.Hotel-Information) ![DoubleTree by Hilton Davenport](//images.trvl-media.com/lodging/1000000/30000/28200/28199/w3839h2586x0y0-7ce07d45_y.jpg) ### DoubleTree by Hilton Davenport 10/10 Excellent "Friendly staff" [](https://expedia.ca/Davenport-Hotels-DoubleTree-By-Hilton-Davenport.h28199.Hotel-Information) ![Isle Casino Hotel - Bettendorf](//images.trvl-media.com/lodging/2000000/1780000/1771100/1771006/dcb75544_y.jpg) ### Isle Casino Hotel - Bettendorf 10/10 Excellent "The casino was absolutely amazing and the parking was absolutely perfect for us" [](https://expedia.ca/Bettendorf-Hotels-Isle-Casino-Hotel-Bettendorf.h1771006.Hotel-Information) ![La Quinta Inn by Wyndham Davenport & Conference Center](//images.trvl-media.com/lodging/1000000/10000/6100/6063/8e5f2e52_y.jpg) ### La Quinta Inn by Wyndham Davenport & Conference Center 10/10 Excellent "Excellent place near our friend " [](https://expedia.ca/Davenport-Hotels-La-Quinta-Inn-By-Wyndham-Davenport-Conference-Center.h6063.Hotel-Information) ![Super 8 by Wyndham Muscatine](//images.trvl-media.com/lodging/1000000/130000/123000/122937/30eeb5c3_y.jpg) ### Super 8 by Wyndham Muscatine 10/10 Excellent "Yes" [](https://expedia.ca/Muscatine-Hotels-Super-8-By-Wyndham-Muscatine.h122937.Hotel-Information) ## Frequently asked questions ### Are you searching for a great accommodation for your luxury holiday in Muscatine? > Use Expedia to help you arrange a flight to Quad City Intl. Airport (MLI) airport, and then choose from a variety of places to stay that will deliver the luxury you want. Amenities are important when you plan a trip, so we make it easy to get what you'd like to make your stay relaxing and comfortable. If you want an upscale hotel with fine dining, a spa, or several swimming pools, Expedia can help you find the best luxury hotel experience that Muscatine has to offer. Muscatine has some interesting things to see and do including Mississippi River and Riverside Park, so you might want to take in the local sights during your visit. ### When can I expect good weather in Muscatine? > Planning for the weather is an important factor for making your trip to Muscatine a success, especially when you're splurging. The hottest months are usually July and August with an average temp of 72°F, while the coldest months are January and February with an average of 30°F. The snowiest months in Muscatine are January, November, February, and December, with each month seeing an average of 7 inches of snowfall. ### What's there to see and do in Muscatine? > Enjoy Muscatine with a stop at Mississippi River, Riverside Park, and Cedar River. 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