Name: 21C Museum Hotel St Louis
Price range: CA $231
Rating: 9

Your Madison Vacation

When a break in the city is calling, answer it with a vacation package to Madison. The neighborhood of Downtown St. Louis, which is good for festivals, bars and pubs and dining, makes a fantastic base for your adventures. If your trip to Madison includes some sightseeing, visit well-known attractions like Busch Stadium, Gateway Arch and Dome at America’s Center. A few clicks is all it takes to build your ideal Madison vacation on Expedia.

Top Madison Vacation Deals

Price found within the past 48 hours. Click for updated prices.

The Wildwood Hotel

CA $774

per person

Jun 23 - Jun 25

found 16 hours ago

Roundtrip flight included

Toronto (YYZ) to St. Louis (STL)

9.2/10 Wonderful! (1,639 reviews)

The entire stay was incredible

Reviewed on May 7, 2026

The Royal Sonesta Chase Park Plaza St. Louis

Central West End

CA $1,001

per person

Jun 21 - Jun 24

found 1 day ago

Roundtrip non-stop flight included

Vancouver (YVR) to St. Louis (STL)

9/10 Wonderful! (1,011 reviews)

This was a weekend staycation for my wife and I and as usual we were not disappointed. Very helpful staff and excellent accommodations.

Reviewed on May 4, 2026

Tru By Hilton St. Louis Downtown

Downtown West

CA $1,006

per person

Jun 21 - Jun 24

found 1 day ago

Roundtrip non-stop flight included

Vancouver (YVR) to St. Louis (STL)

7.6/10 Good! (723 reviews)

Everything was clean and staff was very friendly. Breakfast was meh, but sufficient to start the day.

Reviewed on May 8, 2026

Hilton St. Louis at the Ballpark

Downtown St. Louis

CA $1,270

per person

Jun 21 - Jun 24

found 1 day ago

Roundtrip non-stop flight included

Vancouver (YVR) to St. Louis (STL)

7.6/10 Good! (1,125 reviews)

The staff was incredible. They helped get our bags in and out of the room

Reviewed on May 5, 2026

The Cheshire

CA $938

per person

Jun 21 - Jun 24

found 1 day ago

Roundtrip non-stop flight included

Vancouver (YVR) to St. Louis (STL)

8.8/10 Excellent! (1,006 reviews)

It has a very quaintly English theme. Very unique and fun.

Reviewed on May 8, 2026

Ready to book your vacation to Madison?

Choose your dates

Madison Hotel Deals

Hyatt Regency St. Louis at The Arch

315 Chestnut St St. Louis MO

Fully refundableReserve now, pay when you stay

CA $173

CA $204 total

May 25 - May 26

includes taxes & fees

8.6/10 Excellent! (4,061 reviews)

Very clean

Reviewed on May 8, 2026

Clayton Plaza Hotel & Extended Stay

7750 Carondelet Avenue St. Louis MO

Fully refundableReserve now, pay when you stay

CA $136

CA $159 total

May 17 - May 18

includes taxes & fees

8.8/10 Excellent! (3,198 reviews)

Wonderful hot breakfast! Very clean room. Friendly, attentive staff! Great price for what you get. Would stay there again.

Reviewed on May 8, 2026

21C Museum Hotel St Louis

1528 Locust street St. Louis MO

Fully refundableReserve now, pay when you stay

CA $231

CA $277 total

May 10 - May 11

includes taxes & fees

9/10 Wonderful! (1,823 reviews)

Really cool hotel with great onsite bar/restaurant, gym, pool and art gallery.

Reviewed on May 6, 2026

See all 1,825 properties in Madison

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.