Title: La Mesa Vacation Rentals : Short-Term Rentals for 2025 | Expedia.ca [La Mesa Travel Guide](https://expedia.ca/La-Mesa.dx919364220840247296)[Hotels in La Mesa](https://expedia.ca/La-Mesa-Hotels.d919364220840247296.Travel-Guide-Hotels)[La Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-La-Mesa.d919364220840247296.Car-Rental-Guide)[La Mesa Vacation Packages](https://expedia.ca/La-Mesa.d919364220840247296.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # La Mesa Vacation Rentals - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Nov 12 - Nov 13](https://www.expedia.ca/Hotel-Search?regionId=919364220840247296&startDate=2025-11-12&endDate=2025-11-13&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 13 - Nov 14](https://www.expedia.ca/Hotel-Search?regionId=919364220840247296&startDate=2025-11-13&endDate=2025-11-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=919364220840247296&startDate=2025-11-14&endDate=2025-11-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 21 - Nov 23](https://www.expedia.ca/Hotel-Search?regionId=919364220840247296&startDate=2025-11-21&endDate=2025-11-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Vacation Rentals in La Mesa ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FLa-Mesa-Vacation-Rentals.d919364220840247296.Travel-Guide-VacationRentals)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FLa-Mesa-Vacation-Rentals.d919364220840247296.Travel-Guide-VacationRentals) ## Top La Mesa Hotel Reviews ## Find out more about La Mesa **Everything you need to know about** **La Mesa** **vacation rentals** Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the La Mesa vacation rental for you. At Expedia, you can take your pick from [private vacation homes](https://www.expedia.ca/aa/PrivateVacationHomes), [apartments](https://www.expedia.ca/aa/Apartments), cottages, [cabins](https://www.expedia.ca/aa/Cabins), villas... The list goes on, and on… and on! There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect La Mesa vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.  **La Mesa vacation rentals: An excellent choice for every season** Whenever you want to travel, a warm welcome awaits you in La Mesa. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in .  Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A La Mesa vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of La Mesa vacation rentals we have selected for you start as low as per night. Entering your travel dates in the search wizard you might find even better deals! **How to find incredible deals on La Mesa rentals** At Expedia, we put the best La Mesa vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.  To find some top La Mesa rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream La Mesa vacation. If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around La Mesa. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.  ## Explore a world of travel with Expedia - Trending destinations on Expedia.ca ### Trending destinations on Expedia.ca - [Canmore Vacation Rentals](https://www.expedia.ca/Canmore-Vacation-Rentals.d10131.Travel-Guide-VacationRentals) - [Maui Vacation Rentals](https://www.expedia.ca/Maui-Vacation-Rentals.d180073.Travel-Guide-VacationRentals) - [Kelowna Vacation Rentals](https://www.expedia.ca/Kelowna-Vacation-Rentals.d3997.Travel-Guide-VacationRentals) - [Whistler Vacation Rentals](https://www.expedia.ca/Whistler-Vacation-Rentals.d4115.Travel-Guide-VacationRentals) - [Florida Vacation Rentals](https://www.expedia.ca/Destinations-In-Florida.d211.Vacation-Rental-Destinations) - [Victoria Vacation Rentals](https://www.expedia.ca/Victoria-Vacation-Rentals.d4138.Travel-Guide-VacationRentals) - [Vancouver Vacation Rentals](https://www.expedia.ca/Vancouver-Vacation-Rentals.d178315.Travel-Guide-VacationRentals) - [Palm Springs Vacation Rentals](https://www.expedia.ca/Palm-Springs-Vacation-Rentals.d180676.Travel-Guide-VacationRentals) - [Tofino Vacation Rentals](https://www.expedia.ca/Tofino-Vacation-Rentals.d6094955.Travel-Guide-VacationRentals) - [Calgary Vacation Rentals](https://www.expedia.ca/Calgary-Vacation-Rentals.d178245.Travel-Guide-VacationRentals) - [Costa Rica Vacation Rentals](https://www.expedia.ca/Destinations-In-Costa-Rica.d42.Vacation-Rental-Destinations) - [Vancouver Island Vacation Rentals](https://www.expedia.ca/Vancouver-Island-Vacation-Rentals.d6058387.Travel-Guide-VacationRentals) - [Puerto Vallarta Vacation Rentals](https://www.expedia.ca/Puerto-Vallarta-Vacation-Rentals.d180016.Travel-Guide-VacationRentals) - [Hawaii Vacation Rentals](https://www.expedia.ca/Destinations-In-Hawaii.d213.Vacation-Rental-Destinations) - [Toronto Vacation Rentals](https://www.expedia.ca/Toronto-Vacation-Rentals.d178314.Travel-Guide-VacationRentals) - [Banff Vacation Rentals](https://www.expedia.ca/Banff-Vacation-Rentals.d10550.Travel-Guide-VacationRentals) - [Penticton Vacation Rentals](https://www.expedia.ca/Penticton-Vacation-Rentals.d4135.Travel-Guide-VacationRentals) - [Osoyoos Vacation Rentals](https://www.expedia.ca/Osoyoos-Vacation-Rentals.d181782.Travel-Guide-VacationRentals) - [Mont Tremblant Vacation Rentals](https://www.expedia.ca/Mont-Tremblant-Vacation-Rentals.d55374.Travel-Guide-VacationRentals) - [Big White Ski Resort Vacation Rentals](https://www.expedia.ca/Big-White-Ski-Resort-Vacation-Rentals.d6058319.Travel-Guide-VacationRentals) - [Ontario Vacation Rentals](https://www.expedia.ca/Destinations-In-Ontario.d11178.Vacation-Rental-Destinations) - [British Columbia Vacation Rentals](https://www.expedia.ca/Destinations-In-British-Columbia.d11117.Vacation-Rental-Destinations) - [Prince Edward Island Vacation Rentals](https://www.expedia.ca/Destinations-In-Prince-Edward-Island.d6058122.Vacation-Rental-Destinations) - [Québec Vacation Rentals](https://www.expedia.ca/Quebec-Vacation-Rentals.d180017.Travel-Guide-VacationRentals) ## Frequently asked questions ### Can I find vacation rentals in La Mesa? > Yes, we have vacation rentals close to top attractions in La Mesa, or you can choose a more remote option if you want a relaxing place to stay. ### What are some of the best vacation rentals in La Mesa? > [Residential Cabo - 2 Bedroom Regular Apartment #002](https://www.expedia.ca/Changuinola-Hotels-Residential-Cabo-2-Bedroom-Regular-Apartment-002.h73478896.Hotel-Information): This vacation home rental outside of La Mesa offers a balcony, a terrace, and air-conditioning to help you feel perfectly comfortable in your new surroundings. ### What’s there to see and do in La Mesa? > While exploring the area, visit family-friendly sights like Talamanca Family Art, or get outside and enjoy nature at Punta Uva Beach. Sixaola Bridge and Playa Chiquita are a couple of places you'll find in the larger area. ### What’s a vacation rental in La Mesa like? > A vacation rental is a private property where you can stay for a couple of days or more in La Mesa. Vacation rentals feature extras like laundry facilities and kitchens so you'll have everything you need. If you're concerned about cleanliness, vacation rentals can offer a sense of safety away from public hotel elevators and busy lobbies while still allowing you the excitement and enjoyment of travel. You'll also get more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is a great choice for families. ### Expedia's Latest Trends Hotels - [Hotels with Free Airport Shuttle in Panama City](https://expedia.ca/Panama-City-Hotels-Hotels-With-Free-Airport-Shuttle.0-0-d2897-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels) - [Hotels in Almirante](https://expedia.ca/Almirante-Hotels.d6245958.Travel-Guide-Hotels) - [Hotels in Panama City](https://expedia.ca/Panama-City-Hotels.d2897.Travel-Guide-Hotels) - [All Inclusive Resorts and Hotels in Rio Hato](https://expedia.ca/Rio-Hato-Hotels-All-Inclusive-Hotel.0-0-d6246042-tAllInclusiveHotel.Travel-Guide-Filter-Hotels) - [Hotels in Bocas del Toro](https://expedia.ca/Bocas-Del-Toro-Hotels.d6023445.Travel-Guide-Hotels) Flights - [Flights to Colon](https://expedia.ca/Cheap-Flights-To-Colon.d601867.Travel-Guide-Flights) - [EVA Airways](https://expedia.ca/EVA-Airways-Flights.cBR.Travel-Guide-Airlines) - [Flights to Boca Chica](https://expedia.ca/Cheap-Flights-To-Boca-Chica.d6198033.Travel-Guide-Flights) - [Flights to Chepo](https://expedia.ca/Cheap-Flights-To-Chepo.d553248622834396118.Travel-Guide-Flights) - [Flights to Rio Hato](https://expedia.ca/Cheap-Flights-To-Rio-Hato.d6246042.Travel-Guide-Flights) - [Flights from Toronto (YYZ) to Cairo (CAI)](https://expedia.ca/lp/flights/yyz/cai/toronto-to-cairo) - [Flights to Panama City](https://expedia.ca/Cheap-Flights-To-Panama-City.d2897.Travel-Guide-Flights) - [Flights to Bocas del Toro](https://expedia.ca/Cheap-Flights-To-Bocas-Del-Toro.d6023445.Travel-Guide-Flights) Cars - [Car rentals in Panama City](https://expedia.ca/Car-Rentals-In-Panama-City.d2897.Car-Rental-Guide) - [Car rentals in Rio Hato](https://expedia.ca/Car-Rentals-In-Rio-Hato.d6246042.Car-Rental-Guide) - [Car rentals in David](https://expedia.ca/Car-Rentals-In-David.d500195.Car-Rental-Guide) Activities - [Things to do in Santa Clara](https://expedia.ca/Things-To-Do-In-Santa-Clara.d553248623287315690.Travel-Guide-Activities) - [Things to do in Panama City](https://expedia.ca/Things-To-Do-In-Panama-City.d2897.Travel-Guide-Activities) - [Things to do in Bocas del Toro](https://expedia.ca/Things-To-Do-In-Bocas-Del-Toro.d6023445.Travel-Guide-Activities) - [Things to do in Colon](https://expedia.ca/Things-To-Do-In-Colon.d601867.Travel-Guide-Activities) - [Things to do in Rio Hato](https://expedia.ca/Things-To-Do-In-Rio-Hato.d6246042.Travel-Guide-Activities) Packages - [Bocas del Toro Vacations](https://expedia.ca/Bocas-Del-Toro.d6023445.Destination-Travel-Guides) - [Rio Hato Vacations](https://expedia.ca/Rio-Hato.d6246042.Destination-Travel-Guides) - [Nashville Vacations](https://expedia.ca/Nashville.d178291.Destination-Travel-Guides) - [Panama City Vacations](https://expedia.ca/Panama-City.d2897.Destination-Travel-Guides) - [all inclusive vacations](https://expedia.ca/lp/theme-vacations/all-inclusive-vacations) General - [Visit Boquete](https://expedia.ca/Boquete.dx500194) - [Visit El Valle de Anton](https://expedia.ca/El-Valle-De-Anton.dx6053180) - [Visit Panama City](https://expedia.ca/Panama-City.dx2897) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)