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A cityscape with a prominent tower, modern buildings, and a park with trees.

Search Guest Houses in Knoxville from CA $99

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    Check prices for these dates, December 15–16, 2026

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    Our top choices for Knoxville guest houses

    1. Knoxville Retreat | Near Zoo, Gardens & Downtown

    A small, single-story building with a dark exterior, a garage door, and a small window.

    2. Quirky Guest Cottage

    A spacious kitchen with white cabinets, a wooden dining table, and a staircase with wooden railings.

    3. New In-Law Apt: Hot Tub, Fireplace, & Workspace!

    A two-story yellow house with a garage, surrounded by greenery and a clear sky.

    4. La Casita, King Suite, 3 minutes to parkway

    An outdoor patio with a round table and two chairs, a potted plant, and a decorative metal piece on the wall.

    Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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    Knoxville and related destinations

    Nestled along the Tennessee River, this vibrant city blends Appalachian charm with a thriving arts scene at the historic Market Square. Outdoor enthusiasts can hike nearby Smoky Mountain trails, then return for live music and Southern comfort food at locally-owned downtown restaurants.

    See all hotels in Knoxville

    A cityscape with a prominent tower, modern buildings, and a park with trees.

    Top reviews in Knoxville

    The Oliver Hotel

    A historic building with a restaurant named "Olivier Royale" featuring outdoor seating and brick architecture.

    Drury Inn & Suites Knoxville West

    A spacious lobby with a sectional sofa, a wooden coffee table, and a marble floor.

    Hampton Inn & Suites Knoxville Papermill Drive

    A Hampton Inn & Suites hotel with a modern design, featuring a large entrance and a covered outdoor area.

    Crowne Plaza Knoxville Downtown University by IHG

    A multi-story hotel with a modern design, featuring a prominent sign at the top.

    THE TENNESSEAN Hotel

    A golf cart parked in front of The Tennessean Personal Luxury Hotel & Residences.

    Courtyard by Marriott Knoxville Downtown

    A modern hotel with a courtyard, large windows, and a mix of architectural styles.

    Hampton Inn & Suites-Knoxville/North I-75

    A snack display with various packaged treats and a sign indicating the section.

    Embassy Suites by Hilton Knoxville Downtown

    A rooftop pool area with seating and a bar, overlooking a cityscape during sunset.

    Fairfield Inn & Suites by Marriott Knoxville Northwest

    A modern living room with a stone fireplace, comfortable seating, and a large flat-screen TV.

    Comfort Suites Knoxville West - Farragut

    An indoor swimming pool with clear glass walls, a tiled floor, and a seating area with chairs and tables.

    Holiday Inn Express & Suites Knoxville-Clinton by IHG

    A reception area with a modern desk, a large abstract painting, and a seating area with two chairs.

    La Quinta Inn & Suites by Wyndham Knoxville West

    A hotel reception area with a cityscape mural, wooden panel dividers, and a Lenovo desk.

    TownePlace Suites by Marriott Knoxville Oak Ridge

    A hotel patio with outdoor seating, a fire pit, and a barbecue grill.

    Hampton Inn Knoxville-West At Cedar Bluff

    A modern reception desk with a "WELCOME THE VOLUNTEER STATE" sign, a wooden accent panel, and a marble countertop.

    Cumberland House Knoxville, Tapestry Collection by Hilton

    A reception area with a wooden reception desk, a large illuminated sign reading "CUMBERLAND HOUSE", and shelves displaying various items.

    La Quinta Inn & Suites by Wyndham Knoxville Papermill

    A reception area with a cityscape mural, two reception desks, and a modern design.

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