Title: Hotels by Best Western in Guadalupe from CA $144 | Expedia.ca [Guadalupe Travel Guide](https://expedia.ca/Guadalupe.dx6204275)[Hotels in Guadalupe](https://expedia.ca/Guadalupe-Hotels.d6204275.Travel-Guide-Hotels)[Vacation Rentals in Guadalupe](https://expedia.ca/Guadalupe-Vacation-Rentals.d6204275.Travel-Guide-VacationRentals)[Flights to Guadalupe](https://expedia.ca/Cheap-Flights-To-Guadalupe.d6204275.Travel-Guide-Flights)[Guadalupe Car Rentals](https://expedia.ca/Car-Rentals-In-Guadalupe.d6204275.Car-Rental-Guide)[Guadalupe Vacation Packages](https://expedia.ca/Guadalupe.d6204275.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/383c1430f76f79934a0d48f8d739c519.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by robb image # Find Hotels by Best Western in Guadalupe from CA $144 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 23 - Oct 24](https://www.expedia.ca/Hotel-Search?regionId=6204275&startDate=2025-10-23&endDate=2025-10-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 24 - Oct 25](https://www.expedia.ca/Hotel-Search?regionId=6204275&startDate=2025-10-24&endDate=2025-10-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6204275&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6204275&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Guadalupe Best Western Hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/23100/23008/e16ece78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/23100/23008/a9f9803a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/23100/23008/8d75e25e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/30000/23100/23008/b65e2fa7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Casa Grande Inn Pismo Beach 8.8/10 Excellent (1128) "Enjoyed our stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Laura CA $127 CA $144 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/San-Luis-Obispo-Hotels-Best-Western-Casa-Grande-Inn.h23008.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-06&endDate=2025-11-07®ionId=6204275&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FGuadalupe-Hotels-Best-Western.0-0-d6204275--bBestWestern.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FGuadalupe-Hotels-Best-Western.0-0-d6204275--bBestWestern.Travel-Guide-Filter-Hotels) ## Top Guadalupe Hotel Reviews ![Pismo Lighthouse Suites](//images.trvl-media.com/lodging/1000000/20000/11000/10966/791e4270_y.jpg) ### Pismo Lighthouse Suites 10/10 Excellent "YES" [](https://expedia.ca/San-Luis-Obispo-Hotels-Pismo-Lighthouse-Suites.h10966.Hotel-Information) ![Historic Santa Maria Inn](//images.trvl-media.com/lodging/1000000/30000/20400/20393/53eb999c_y.jpg) ### Historic Santa Maria Inn 10/10 Excellent "Very nostalgic atmosphere, and bed is so comfortable." [](https://expedia.ca/Santa-Maria-Hotels-Historic-Santa-Maria-Inn.h20393.Hotel-Information) ![Avila Village Inn](//images.trvl-media.com/lodging/2000000/1180000/1178000/1177942/eb1d5a6d_y.jpg) ### Avila Village Inn 10/10 Excellent "." [](https://expedia.ca/San-Luis-Obispo-Hotels-Avila-Village-Inn.h1177942.Hotel-Information) ![Motel 6 San Luis Obispo, CA - South](//images.trvl-media.com/lodging/1000000/900000/899300/899217/1a8caa90_y.jpg) ### Motel 6 San Luis Obispo, CA - South 10/10 Excellent "Decent motel 6" [](https://expedia.ca/San-Luis-Obispo-Hotels-Motel-6-San-Luis-Obispo.h899217.Hotel-Information) ![Motel 6 Santa Maria, CA - North](//images.trvl-media.com/lodging/1000000/1000000/996400/996393/5265532a_y.jpg) ### Motel 6 Santa Maria, CA - North 10/10 Excellent "Didn't Get The Guys Name. But He Had Glasses. Very Nice Guy. Check In Was So Easy. " [](https://expedia.ca/San-Luis-Obispo-Hotels-Motel-6-Santa-Maria.h996393.Hotel-Information) ![Sandcastle Hotel on the Beach](//images.trvl-media.com/lodging/1000000/50000/41000/40915/89d1e3f1_y.jpg) ### Sandcastle Hotel on the Beach 10/10 Excellent "All staff was very helpful and friendly. We didn't like having to pay for parking all three days we stayed there." [](https://expedia.ca/San-Luis-Obispo-Hotels-Sandcastle-Hotel-On-The-Beach.h40915.Hotel-Information) ![Best Western Casa Grande Inn](//images.trvl-media.com/lodging/1000000/30000/23100/23008/e16ece78_y.jpg) ### Best Western Casa Grande Inn 10/10 Excellent "The room was clean and quiet " [](https://expedia.ca/San-Luis-Obispo-Hotels-Best-Western-Casa-Grande-Inn.h23008.Hotel-Information) ![Shore Cliff Hotel](//images.trvl-media.com/lodging/1000000/10000/9800/9742/ff9d613b_y.jpg) ### Shore Cliff Hotel 10/10 Excellent "Better breakfast options" [](https://expedia.ca/San-Luis-Obispo-Hotels-Shore-Cliff-Hotel.h9742.Hotel-Information) ![SeaCrest OceanFront Hotel](//images.trvl-media.com/lodging/2000000/1370000/1365400/1365352/w3000h1999x0y0-15b2e131_y.jpg) ### SeaCrest OceanFront Hotel 10/10 Excellent "Great property " [](https://expedia.ca/San-Luis-Obispo-Hotels-SeaCrest-OceanFront-Hotel.h1365352.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - 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