A swamp with tall trees, water, and swans.

Lee County Vacation Rentals

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Our top choices for Lee County vacation rentals

A modern kitchen with stainless steel appliances, a gray sofa, and a ceiling fan.

1. The Urban Flats

The Urban Flats
4.0 star property
Florence
The price is CA $306
CA $555 total
includes taxes & fees
Nov 16 - Nov 17
The Urban Flats
A compact kitchen with white cabinets, a wooden countertop, a built-in microwave, and a refrigerator.

2. Pet-Friendly Hunt Country Cottage with Pool on 7.5 Acres

Pet-Friendly Hunt Country Cottage with Pool on 7.5 Acres
Camden
10.0 out of 10, Exceptional, (74 reviews)
"The location really is the highlight and the bed is excellent. "
United States
Paul C.
Pet-Friendly Hunt Country Cottage with Pool on 7.5 Acres
A wooden sauna with a view of a lake, featuring a central firebox and benches.

3. Horizons Sandhills

Horizons Sandhills
4.0 star property
Patrick
The price is CA $356
CA $388 total
includes taxes & fees
Nov 16 - Nov 17
Horizons Sandhills
A brick pathway leading to a white building with a porch and a door labeled "Around Entrance."

4. Cozy 1-bedroom apartment at Greenleaf Villa. Downtown Camden, SC.

Cozy 1-bedroom apartment at Greenleaf Villa. Downtown Camden, SC.
Camden
10.0 out of 10, Exceptional, (21 reviews)
"Great place would definitely return"
United States
Brent U.
The price is CA $141
CA $201 total
includes taxes & fees
Nov 15 - Nov 16
Cozy 1-bedroom apartment at Greenleaf Villa. Downtown Camden, SC.
A kitchen with white cabinets, a central island, a chandelier, and a dining table with stools.

5. Pear Tree Farm. Peaceful, Country living at its best. 12 stables. Pet Friendly

Pear Tree Farm. Peaceful, Country living at its best. 12 stables. Pet Friendly
Rembert
9.4 out of 10, Exceptional, (43 reviews)
"We are only about an hour away and it is one of the most peaceful and enjoyable trips we take. Stayed there several times and alway look forward to coming back."
United States
david g.
The price is CA $173
CA $341 total
includes taxes & fees
Nov 23 - Nov 24
Pear Tree Farm. Peaceful, Country living at its best. 12 stables. Pet Friendly
A room with a window, a television, and a cabinet.

6. The Sunny Cottage minutes to downtown

The Sunny Cottage minutes to downtown
Florence
9.0 out of 10, Wonderful, (2 reviews)
"Thank you for being a kind host. We appreciate you providing housing for us during this work event."
United States
Lowlan B.
The price is CA $212
CA $258 total
includes taxes & fees
Nov 16 - Nov 17
The Sunny Cottage minutes to downtown
A hotel room with a bed, bedside table, and a window with curtains.

7. 1 King Bed | Non-Smoking

1 King Bed | Non-Smoking
Lugoff
10.0 out of 10, Exceptional, (3 reviews)
"My stay included a restful spot with good air conditioning that ensured peaceful nights without any interruptions."
United States
Anonymous traveller
The price is CA $85
CA $96 total
includes taxes & fees
Nov 16 - Nov 17
1 King Bed | Non-Smoking
A spacious living room with a large leather sofa, a coffee table, and a rug. There is a dining area with a table and chairs, and a kitchen area with a countertop and appliances.

8. Perfect Stop • Near I-95, Downtown & Civic Center and Darlington

Perfect Stop • Near I-95, Downtown & Civic Center and Darlington
Florence
10.0 out of 10, Exceptional, (14 reviews)
"We had a wonderful stay. We plan to take a trip around the same time next year and will definitely see if this home is available! "
United States
Taryn S.
The price is CA $317
CA $386 total
includes taxes & fees
Nov 23 - Nov 24
Perfect Stop • Near I-95, Downtown & Civic Center and Darlington
A dining area with a wooden table and chairs, a chandelier, and a large mirror on the wall.

9. Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.

Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.
Florence
8.8 out of 10, Excellent, (6 reviews)
"Convenient location"
United States
Bonney W.
The price is CA $217
CA $696 total
includes taxes & fees
Nov 16 - Nov 17
Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.
A modern kitchen with white cabinetry, a central island, and stainless steel appliances. There is a dining area with a table and chairs, and a cozy seating area with a sofa and a fireplace.

10. Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's

Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's
Florence
10.0 out of 10, Exceptional, (65 reviews)
"we only stayed over night but wverything was great"
United States
jim j.
The price is CA $313
CA $381 total
includes taxes & fees
Nov 16 - Nov 17
Take a rest in Florence .Ideal for i95 traveler and Florence Center and Buc-ee's
A wooden sauna with a fire burning inside, surrounded by benches and a view of a lake.

11. Forest Villa at Horizons Sandhills

Forest Villa at Horizons Sandhills
Patrick
The price is CA $403
CA $462 total
includes taxes & fees
Nov 19 - Nov 20
Forest Villa at Horizons Sandhills
A hotel room with a bed, bedside table, and a window with curtains.

12. 1 King Bed | Smoking, Micfridge

1 King Bed | Smoking, Micfridge
Lugoff
10.0 out of 10, Exceptional, (2 reviews)
"The bed gave firm support but stayed pleasant all through the night."
United States
Anonymous traveller
The price is CA $94
CA $105 total
includes taxes & fees
Nov 16 - Nov 17
1 King Bed | Smoking, Micfridge
A hotel room with two beds, a dark headboard, and a window with blinds.

13. 2 Queen Beds | Non-Smoking

2 Queen Beds | Non-Smoking
Lugoff
10.0 out of 10, Exceptional, (3 reviews)
"Staff at reception processed our check-ins quickly every time we arrived!"
United States
Anonymous traveller
The price is CA $99
CA $111 total
includes taxes & fees
Nov 16 - Nov 17
2 Queen Beds | Non-Smoking
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Lee County Hotel Reviews

Quality Inn & Suites Florence Civic Center

Quality Inn & Suites Florence Civic Center

10/10 Excellent
"Great trip. Easy access to food and shopping! Great staff"
David 1-night trip
Posted 10 hours ago
Quality Inn & Suites Florence Civic Center

Find out more about Lee County

Everything you need to know about Lee County vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Lee County vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Lee County vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. 

Lee County vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Lee County. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Lee County vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Lee County vacation rentals we have selected for you start as low as CA $201 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Lee County rentals

At Expedia, we put the best Lee County vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top Lee County rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Lee County vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Lee County. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.