A swamp with tall trees, water, and swans.

Lee County Vacation Rentals

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Our top choices for Lee County vacation rentals

A dining area with a table and chairs, a wooden floor, and a sliding door in the background.

1. Beautiful 1-bedroom apartment perfect for traveling professionals.

Beautiful 1-bedroom apartment perfect for traveling professionals.
Bishopville
The price is CA $163
CA $214 total
includes taxes & fees
Oct 4 - Oct 5
Beautiful 1-bedroom apartment perfect for traveling professionals.
A compact kitchen with white cabinets, a wooden countertop, a built-in microwave, and a refrigerator.

2. Camden Cottage

Camden Cottage
Camden
10.0 out of 10, Exceptional, (68 reviews)
"The location really is the highlight and the bed is excellent. "
United States
Paul C.
The price is CA $140
CA $252 total
includes taxes & fees
Oct 4 - Oct 5
Camden Cottage

3. Hampton Historic District Colonial Downtown

Hampton Historic District Colonial Downtown
Sumter
9.0 out of 10, Wonderful, (10 reviews)
"Great stay, easy check in process, just blocks from Main Street. Very friendly host! Would definitely stay again next time in the area."
United States
lindsey p.
Hampton Historic District Colonial Downtown
A brick pathway leading to a white building with a porch and a door labeled "Around Entrance."

4. Cozy 1-bedroom apartment at Greenleaf Villa. Downtown Camden, SC.

Cozy 1-bedroom apartment at Greenleaf Villa. Downtown Camden, SC.
Camden
10.0 out of 10, Exceptional, (19 reviews)
"Great place would definitely return"
United States
Brent U.
The price is CA $140
CA $212 total
includes taxes & fees
Sep 29 - Sep 30
Cozy 1-bedroom apartment at Greenleaf Villa. Downtown Camden, SC.
A bedroom with a sloped ceiling, skylight, wooden flooring, and a bed with pillows and a blanket.

5. Historic Camden Showstopper!! THE LITTLE GARDNER’S COTTAGE

Historic Camden Showstopper!! THE LITTLE GARDNER’S COTTAGE
Camden
10.0 out of 10, Exceptional, (10 reviews)
"Beautiful property. Cozy and quiet."
United States
Doug K.
The price is CA $156
CA $269 total
includes taxes & fees
Sep 28 - Sep 29
Historic Camden Showstopper!! THE LITTLE GARDNER’S COTTAGE
A kitchen with white cabinets, a central island, a chandelier, and a dining table with stools.

6. Pear Tree Farm. Peaceful, Country living at its best. 12 stables. Pet Friendly

Pear Tree Farm. Peaceful, Country living at its best. 12 stables. Pet Friendly
Rembert
9.4 out of 10, Exceptional, (40 reviews)
"Wonderful property. Very pet friendly with a large fenced yard. The pool was great. The house was full of toys and books for my granddaughter. I would highly recommend this property."
United States
Sherilyn S.
The price is CA $172
CA $354 total
includes taxes & fees
Sep 29 - Sep 30
Pear Tree Farm. Peaceful, Country living at its best. 12 stables. Pet Friendly
A hotel room with a bed, a desk with a chair, a television, and a mirror.

7. 2 Queen Beds | Smoking

2 Queen Beds | Smoking
Lugoff
The price is CA $111
CA $124 total
includes taxes & fees
Oct 5 - Oct 6
2 Queen Beds | Smoking
A hotel room with a bed, a nightstand, a phone, and a window with curtains.

8. 1 King Bed | Smoking, Micfridge

1 King Bed | Smoking, Micfridge
Lugoff
The price is CA $105
CA $118 total
includes taxes & fees
Oct 5 - Oct 6
1 King Bed | Smoking, Micfridge
A dining area with a wooden table and chairs, a chandelier, and a large mirror on the wall.

9. Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.

Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.
Florence
8.4 out of 10, Very good, (5 reviews)
"Convenient location"
United States
Bonney W.
The price is CA $226
CA $740 total
includes taxes & fees
Sep 28 - Sep 29
Charming 3-bedroom, 2.5 bath townhome. Largest with accommodations in Florence.
A room with a window, a television, and a cabinet.

10. The Sunny Cottage minutes to downtown

The Sunny Cottage minutes to downtown
Florence
The price is CA $211
CA $268 total
includes taxes & fees
Sep 29 - Sep 30
The Sunny Cottage minutes to downtown
A modern kitchen with stainless steel appliances, a gray sofa, and a ceiling fan.

11. The Urban Flats

The Urban Flats
4.0 star property
Florence
The price is CA $340
CA $593 total
includes taxes & fees
Oct 5 - Oct 6
The Urban Flats
A cabin with a deck, outdoor seating, a fire pit, and a staircase leading to a second level.

12. Horizons Sandhills

Horizons Sandhills
3.5 star property
Patrick
The price is CA $584
CA $636 total
includes taxes & fees
Sep 28 - Sep 29
Horizons Sandhills
A reception desk with a computer, a blue chair, and a colorful wall decoration.

13. 2 Queen Beds | Non-Smoking

2 Queen Beds | Non-Smoking
Lugoff
The price is CA $111
CA $124 total
includes taxes & fees
Oct 5 - Oct 6
2 Queen Beds | Non-Smoking
A reception desk with a computer, a blue chair, and a colorful wall decoration.

14. 1 King Bed | Non-Smoking

1 King Bed | Non-Smoking
Lugoff
The price is CA $97
CA $108 total
includes taxes & fees
Oct 5 - Oct 6
1 King Bed | Non-Smoking
A modern office space with a desk, chair, TV, and shelves.

15. 1 King Bed|Smoking|Lugoff, SC

1 King Bed|Smoking|Lugoff, SC
Lugoff
The price is CA $97
CA $108 total
includes taxes & fees
Oct 5 - Oct 6
1 King Bed|Smoking|Lugoff, SC
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Lee County Hotel Reviews

The Inn at the Crossroads

The Inn at the Crossroads

10/10 Excellent
"It was a great visit. We only stayed 2 nights as we had events in the area to attend."
Henretta 2-night trip
Posted 3 hours ago
The Inn at the Crossroads

Find out more about Lee County

Everything you need to know about Lee County vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Lee County vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Lee County vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. 

Lee County vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Lee County. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Lee County vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Lee County vacation rentals we have selected for you start as low as CA $212 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Lee County rentals

At Expedia, we put the best Lee County vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top Lee County rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Lee County vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Lee County. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.