Title: Top Hotels in Knox County | Expedia.ca

[Vacation Rentals in Knox County](https://expedia.ca/Destinations-In-Knox-County.d553248635976432457.Vacation-Rental-Destinations)[Knox County Car Rentals](https://expedia.ca/Destinations-In-Knox-County.d553248635976432457.Car-Rental-Destinations)[Knox County Vacations](https://expedia.ca/Knox-County.d553248635976432457.Destination-Travel-Guides)

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## Check prices for these dates

Tonight

[Dec 24 - Dec 25](https://www.expedia.ca/Hotel-Search?regionId=553248635976432457&startDate=2025-12-24&endDate=2025-12-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Dec 25 - Dec 26](https://www.expedia.ca/Hotel-Search?regionId=553248635976432457&startDate=2025-12-25&endDate=2025-12-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=553248635976432457&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=553248635976432457&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Knox County hotels

![Smart TV](https://images.trvl-media.com/lodging/112000000/111060000/111053400/111053317/5541de84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/112000000/111060000/111053400/111053317/d961686e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, coffee/tea maker, toaster](https://images.trvl-media.com/lodging/112000000/111060000/111053400/111053317/8ce26e88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/112000000/111060000/111053400/111053317/038e8d64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Tiny Cozy Cottage in Edina, MO

[](https://www.expedia.ca/Edina-Hotels-Tiny-Cozy-Cottage-In-Edina.h111053317.Hotel-Information)

Edina

10/10

Exceptional

(10)

"Clean, adorable decor, personal contact with owner was very helpful."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mark B.

CA $105

CA $141 total

includes taxes & fees

Jan 4 - Jan 5, 2026

[](https://www.expedia.ca/Edina-Hotels-Tiny-Cozy-Cottage-In-Edina.h111053317.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/93000000/92900000/92897900/92897834/a756355b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/93000000/92900000/92897900/92897834/8c5a89c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, books](https://images.trvl-media.com/lodging/93000000/92900000/92897900/92897834/498c7144.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/93000000/92900000/92897900/92897834/00565a62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Edina Missouri New Cabin in Rural Area

[](https://www.expedia.ca/Edina-Hotels-Edina-Missouri-New-Cabin-In-Rural-Area.h92897834.Hotel-Information)

Edina

10/10

Exceptional

(32)

"Absolutely beautiful property perfect hosts. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Candace B.

[](https://www.expedia.ca/Edina-Hotels-Edina-Missouri-New-Cabin-In-Rural-Area.h92897834.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/33000000/32670000/32666300/32666255/f6665c52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/33000000/32670000/32666300/32666255/9004b27f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/33000000/32670000/32666300/32666255/9716f07a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/33000000/32670000/32666300/32666255/270-4043fcee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Lost Branch Lodge. Complete interior remodel, spring 2022!

[](https://www.expedia.ca/Brashear-Hotels-Lost-Branch-Lodge-Relaxation-In-A-Quiet.h32666255.Hotel-Information)

Brashear

10/10

Exceptional

(178)

"Everything was perfect!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Michael P.

[](https://www.expedia.ca/Brashear-Hotels-Lost-Branch-Lodge-Relaxation-In-A-Quiet.h32666255.Hotel-Information)

![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/124000000/123670000/123661900/123661862/7bee08c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/124000000/123670000/123661900/123661862/218af131.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/124000000/123670000/123661900/123661862/007781b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (3 Bedrooms) | Interior](https://images.trvl-media.com/lodging/124000000/123670000/123661900/123661862/48a710c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Newly Updated Countryside Home in South Gorin!

[](https://www.expedia.ca/South-Gorin-Hotels-Newly-Updated-Countryside-Home-In-South-Gorin.h123661862.Hotel-Information)

South Gorin

[](https://www.expedia.ca/South-Gorin-Hotels-Newly-Updated-Countryside-Home-In-South-Gorin.h123661862.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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## Top Knox County Hotel Reviews

![Hampton Inn Kirksville](https://images.trvl-media.com/lodging/20000000/20000000/19991900/19991846/388c1302_y.jpg)

### Hampton Inn Kirksville

10/10 Excellent

"Better than a typical hotel, premium bedding, great lobby space for families to gather."

[](https://expedia.ca/Macon-Hotels-Hampton-Inn-Kirksville.h19991846.Hotel-Information)

![Depot Inn and Suites](https://images.trvl-media.com/lodging/2000000/1800000/1790900/1790806/6c9e28fd_y.jpg)

### Depot Inn and Suites

10/10 Excellent

"Everything was amazing, the breakfast could've used a choice of meat but over all was fresh and delicious. Definitely going to come back"

[](https://expedia.ca/La-Plata-Hotels-Depot-Inn-And-Suites.h1790806.Hotel-Information)

![Super 8 by Wyndham Kirksville-University Area](https://images.trvl-media.com/lodging/1000000/130000/123600/123590/adba1fe4_y.jpg)

### Super 8 by Wyndham Kirksville-University Area

10/10 Excellent

"Will be staying here for future visits to Kirksville."

[](https://expedia.ca/Macon-Hotels-Country-Club-Inn-Suites.h123590.Hotel-Information)

![Holiday Inn Express & Suites Kirksville - University Area by IHG](https://images.trvl-media.com/lodging/19000000/18060000/18057900/18057874/17367649_y.jpg)

### Holiday Inn Express & Suites Kirksville - University Area by IHG

10/10 Excellent

"Everything was awesome."

[](https://expedia.ca/Macon-Hotels-Holiday-Inn-Express-Suites-Kirksville-University-Area.h18057874.Hotel-Information)

![Super 8 by Wyndham Macon](https://images.trvl-media.com/lodging/1000000/40000/40000/39998/cd2644e5_y.jpg)

### Super 8 by Wyndham Macon

10/10 Excellent

"I had a handicap accessible room. The room was clean and set up well for my issues getting around. Staff were very polite. Bed was actually comfortable."

[](https://expedia.ca/Macon-Hotels-Super-8-By-Wyndham-Macon.h39998.Hotel-Information)

![Simple Rewards Inn Shelbina](https://images.trvl-media.com/lodging/2000000/1170000/1162500/1162434/8e4c4277_y.jpg)

### Simple Rewards Inn Shelbina

10/10 Excellent

"Was a lot nicer than I was expecting "

[](https://expedia.ca/Macon-Hotels-Simple-Rewards-Inn-Shelbina.h1162434.Hotel-Information)

![Knights Inn Kirksville](https://images.trvl-media.com/lodging/1000000/30000/22200/22159/fa987a1d_y.jpg)

### Knights Inn Kirksville

10/10 Excellent

"Room was clean… quiet… "

[](https://expedia.ca/Macon-Hotels-Knights-Inn-Kirksville.h22159.Hotel-Information)

![Edina Missouri New Cabin in Rural Area](https://images.trvl-media.com/lodging/93000000/92900000/92897900/92897834/a756355b_y.jpg)

### Edina Missouri New Cabin in Rural Area

10/10 Excellent

"Place was exactly as it looked! Perfect place for us! Hoping to be back next year "

[](https://expedia.ca/Edina-Hotels-Edina-Missouri-New-Cabin-In-Rural-Area.h92897834.Hotel-Information)

![Days Inn by Wyndham Kirksville](https://images.trvl-media.com/lodging/1000000/10000/4100/4031/9821cb76_y.jpg)

### Days Inn by Wyndham Kirksville

10/10 Excellent

"Clean room, amnesties,games), quiet "

[](https://expedia.ca/Macon-Hotels-Days-Inn-By-Wyndham-Kirksville.h4031.Hotel-Information)

## Explore a world of travel with Expedia

- Explore a world of travel with Expedia

### Top cities in Knox County

- [Edina Hotels ](https://expedia.ca/Edina-Hotels.d3000444857.Travel-Guide-Hotels)
- [Knox City Hotels ](https://expedia.ca/Knox-City-Hotels.d553248634983184107.Travel-Guide-Hotels)
- [Newark Hotels ](https://expedia.ca/Newark-Hotels.d553248634983173284.Travel-Guide-Hotels)
- [Novelty Hotels ](https://expedia.ca/Novelty-Hotels.d553248634983584874.Travel-Guide-Hotels)
- [Hurdland Hotels ](https://expedia.ca/Hurdland-Hotels.d3000349403.Travel-Guide-Hotels)

### Hotels near popular Attractions

- [Hotels near Truman State University ](https://expedia.ca/Truman-State-University-Hotels.0-l553248621561636575-0.Travel-Guide-Filter-Hotels)
- [Hotels near A.T. Still University ](https://expedia.ca/AT-Still-University-Hotels.0-l553248621561636576-0.Travel-Guide-Filter-Hotels)
- [Hotels near Thousand Hills State Park ](https://expedia.ca/Thousand-Hills-State-Park-Hotels.0-l553248621532649029-0.Travel-Guide-Filter-Hotels)
- [Hotels near Long Branch State Park ](https://expedia.ca/Long-Branch-State-Park-Hotels.0-l6316230-0.Travel-Guide-Filter-Hotels)
- [Hotels near La Plata Golf Course ](https://expedia.ca/La-Plata-Golf-Course-Hotels.0-l553248634680215491-0.Travel-Guide-Filter-Hotels)
- [Hotels near Maples Repertory Theatre ](https://expedia.ca/Maples-Repertory-Theatre-Hotels.0-l553248621561876916-0.Travel-Guide-Filter-Hotels)
- [Hotels near West Winery ](https://expedia.ca/West-Winery-Hotels.0-l553248621532649021-0.Travel-Guide-Filter-Hotels)
- [Hotels near Stephen's Park ](https://expedia.ca/Stephens-Park-Hotels.0-l6316232-0.Travel-Guide-Filter-Hotels)
- [Hotels near Shelby Coutny Historical Society and Museum ](https://expedia.ca/Shelby-Coutny-Historical-Society-And-Museum-Hotels.0-l6317032-0.Travel-Guide-Filter-Hotels)
- [Hotels near Jackson Street Park ](https://expedia.ca/Jackson-Street-Park-Hotels.0-l553248621561766871-0.Travel-Guide-Filter-Hotels)

### More Accommodation Types in Knox County

- [Vacation Homes in Knox County ](https://expedia.ca/Knox-County-Private-Vacation-Homes.d553248635976432457-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Cottages in Knox County ](https://expedia.ca/Knox-County-Cottages.d553248635976432457-aaCottages.Travel-Guide-Accommodation)
- [Cabin Rentals in Knox County ](https://expedia.ca/Knox-County-Cabins.d553248635976432457-aaCabins.Travel-Guide-Accommodation)
- [Motels in Knox County ](https://expedia.ca/Knox-County-Motels.d553248635976432457-aaMotels.Travel-Guide-Accommodation)
- [Lodges in Knox County ](https://expedia.ca/Knox-County-Lodges.d553248635976432457-aaLodges.Travel-Guide-Accommodation)

### Explore more hotels

- [Tiny Cozy Cottage in Edina, MO ](https://expedia.ca/Edina-Hotels-Tiny-Cozy-Cottage-In-Edina.h111053317.Hotel-Information)
- [Edina Missouri New Cabin in Rural Area ](https://expedia.ca/Edina-Hotels-Edina-Missouri-New-Cabin-In-Rural-Area.h92897834.Hotel-Information)
- [Super 8 by Wyndham Kirksville-University Area ](https://expedia.ca/Macon-Hotels-Country-Club-Inn-Suites.h123590.Hotel-Information)
- [Hampton Inn Kirksville ](https://expedia.ca/Macon-Hotels-Hampton-Inn-Kirksville.h19991846.Hotel-Information)
- [Super 8 by Wyndham Macon ](https://expedia.ca/Macon-Hotels-Super-8-By-Wyndham-Macon.h39998.Hotel-Information)
- [Depot Inn and Suites ](https://expedia.ca/La-Plata-Hotels-Depot-Inn-And-Suites.h1790806.Hotel-Information)
- [Days Inn by Wyndham Kirksville ](https://expedia.ca/Macon-Hotels-Days-Inn-By-Wyndham-Kirksville.h4031.Hotel-Information)
- [Holiday Inn Express & Suites Kirksville - University Area by IHG ](https://expedia.ca/Macon-Hotels-Holiday-Inn-Express-Suites-Kirksville-University-Area.h18057874.Hotel-Information)
- [Baymont by Wyndham Kirksville University Area ](https://expedia.ca/Macon-Hotels-Baymont-By-Wyndham-Kirksville-University-Area.h125458.Hotel-Information)
- [Americas Best Value Inn & Suites Macon at Sunset Dr ](https://expedia.ca/Macon-Hotels-Americas-Best-Value-Inn-Suites-Macon-At-Sunset-Dr.h22238.Hotel-Information)

[See a list of all hotels in Knox County](https://expedia.ca/All-Knox-County-Hotels.d553248635976432457.Travel-Guide-City-All-Hotels)

### More ways to book

- [Book Hotels in Knox County on Expedia.com ](https://www.expedia.com/Destinations-In-Knox-County.d553248635976432457.Hotel-Destinations)

### Expedia's Latest Trends

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Flights

- [Flights to Orange County](https://expedia.ca/Destinations-In-Orange-County.d603224.Flight-Destinations)
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Cars

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- [Car rental Kansas City Airport (MCI)](https://expedia.ca/Car-Rentals-In-Kansas-City-Intl.d4801357.Car-Rental-Guide)

Cruises

- [Cruises from San Diego County](https://expedia.ca/Cruises-from-San-Diego-County.d178304.Cruise-Departure-Port)

Activities

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Packages

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General

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- [Visit Downtown Kansas City](https://expedia.ca/Kansas-City-Downtown-Kansas-City.dx6058828)
- [Visit Parkville](https://expedia.ca/Parkville.dx9973)
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