Name: Ameristar Casino Resort and Spa
Price range: CA $220
Rating: 8.6

Your Defiance Vacation

Its lively atmosphere, progressive thinking and friendly locals are among the many reasons to book a vacation package to Defiance. Whatever brings you to this rural city, you're bound to have an awesome time. If your trip to Defiance includes a little sightseeing, visit major attractions such as Chandler Hill Vineyards, Historic Daniel Boone Home and Heritage Center and Montelle Winery. Whoever you're taking time off with and whether your budget is big or small, your ultimate Defiance vacation is just a few clicks away with Expedia.

Top Defiance Vacation Deals

Price found within the past 48 hours. Click for updated prices.

Motel 6 Hannibal, MO

CA $974

per person

Jul 6 - Jul 10

found 18 hours ago

Roundtrip non-stop flight included

Montreal (YUL) to St. Louis (STL)

7.4/10 Good! (1,003 reviews)

Have stayed here before and will stay here again 😄

Reviewed on May 25, 2026

Riverside Inn Hannibal

CA $1,276

per person

Jul 6 - Jul 10

found 18 hours ago

Roundtrip non-stop flight included

Montreal (YUL) to St. Louis (STL)

9.4/10 Exceptional! (174 reviews)

Beautiful room and great location. Walkable to the river front and the shops downtown.

Reviewed on May 22, 2026

Lighthouse Inn & Suites

CA $1,379

per person

Jul 6 - Jul 10

found 18 hours ago

Roundtrip non-stop flight included

Montreal (YUL) to St. Louis (STL)

9/10 Wonderful! (28 reviews)

Nice room. Matched the pictures. Exactly what we were looking for.

Reviewed on Jan 18, 2026

Garden House Bed and Breakfast

CA $1,108

per person

Jul 6 - Jul 10

found 18 hours ago

Roundtrip non-stop flight included

Montreal (YUL) to St. Louis (STL)

8.4/10 Very Good! (43 reviews)

Very welcoming hosts, they went the extra mile and had a very comfortable bed! There were lots of cool antiques and they knew a lot of history on the home itself. We would recommend staying here again.

Reviewed on Mar 23, 2026

The Eagles Nest Inn

CA $1,179

per person

Jul 6 - Jul 10

found 18 hours ago

Roundtrip non-stop flight included

Montreal (YUL) to St. Louis (STL)

9.4/10 Exceptional! (23 reviews)

No front desk, all transactions were done remotely! If there was any issue, it would have to be done over the phone! Thankfully everything was fine, but I not a fan of getting instructions on my phone to check in! What if my phone wasn’t working or not charged since I was on the road! It was a wonderful room, but should be informed that there is no one at the hotel!

Reviewed on May 5, 2026

Ready to book your vacation to Defiance?

Choose your dates

Defiance Hotel Deals

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

1088 South Highway Drive Fenton MO

Fully refundableReserve now, pay when you stay

CA $137

CA $158 total

Jun 1 - Jun 2

includes taxes & fees

7.8/10 Good! (1,316 reviews)

"Clean room"

Reviewed on May 30, 2026

Hollywood Casino & Hotel St. Louis

777 Casino Center Drive Maryland Heights MO

Fully refundableReserve now, pay when you stay

CA $179

CA $229 total

Jun 2 - Jun 3

includes taxes & fees

8.4/10 Very Good! (2,210 reviews)

"Enjoyed our stay. Room was nice, clean. No valet was a disappointment and the wait at one of the restaurants was insane for how many open tables were available."

Reviewed on May 28, 2026

Ameristar Casino Resort and Spa

1 Ameristar Blvd St. Charles MO

Fully refundableReserve now, pay when you stay

CA $220

CA $280 total

Jul 1 - Jul 2

includes taxes & fees

8.6/10 Excellent! (1,001 reviews)

"I would have like to know that the indoor pool closes at 6pm. The pool was part of the reason stayed. When called previously the staff told us later hours."

Reviewed on May 28, 2026

See all 867 properties in Defiance

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.