A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

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Our top choices for Defiance hotels

A hotel room with a bed, a sofa, a coffee table, and wall art.
An indoor swimming pool with a clear view of the outside, a metal ladder, and a ceiling with recessed lighting.
A Sleep Inn & Suites hotel with a modern brick facade, a covered entrance, and a parking lot.
A restaurant with wooden tables and chairs, a blue wall with white floral patterns, and a counter with a coffee machine.

1. Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
O'Fallon
United States
Tim
CA $114
CA $134 total
includes taxes & fees
Oct 5 - Oct 6
Sleep Inn & Suites O'Fallon MO - Technology Drive
A multi-story hotel with a central entrance featuring a covered patio area.
A hotel room with a desk, chair, sofa, and a window with curtains.
A hotel with a swimming pool, outdoor seating, and a covered patio area.
A hotel room with a sofa, armchair, bedside table, lamp, TV, and a bed with patterned bedding.

2. Staybridge Suites O'Fallon Chesterfield by IHG

Staybridge Suites O'Fallon Chesterfield by IHG
O'Fallon
United States
Norman
CA $158
CA $186 total
includes taxes & fees
Oct 5 - Oct 6
Staybridge Suites O'Fallon Chesterfield by IHG
A hotel room with two beds, a desk with a chair, a television, and a window with curtains.
A reception desk with a modern design, featuring a blue geometric wall and a wooden finish.
A hotel lobby with a seating area, a reception desk, and a flat-screen TV mounted on the wall.
A Holiday Inn Express hotel with a brick facade, a covered entrance, and a clear sky.

3. Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
O'Fallon
United States
Greg
CA $127
CA $149 total
includes taxes & fees
Oct 11 - Oct 12
Holiday Inn Express St. Louis West - O'Fallon by IHG
An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.
A multi-story hotel with a brick facade, a covered outdoor seating area with a fire feature, and a sign indicating it is a Marriott property.
A hotel room with a sofa, a side table, a lamp, a flat-screen TV, and a bed with a red blanket.
A hotel room with a large bed, bedside lamps, a TV, a desk, and a bathroom.

4. TownePlace Suites by Marriott St. Louis Chesterfield

TownePlace Suites by Marriott St. Louis Chesterfield
Chesterfield
United States
Bobbi jo
CA $182
CA $213 total
includes taxes & fees
Oct 18 - Oct 19
TownePlace Suites by Marriott St. Louis Chesterfield
A modern dining area with a brick fireplace, yellow and blue chairs, and a blue sofa.
A picnic area with tables and benches, surrounded by grass and trees.
A hotel room with two beds, a desk, a mirror, and a wardrobe.
A hotel with a brick facade, multiple parking spaces, and a grassy area in the foreground.

5. Comfort Inn & Suites Chesterfield - St. Louis

Comfort Inn & Suites Chesterfield - St. Louis
Chesterfield
United States
Donna
CA $119
CA $144 total
includes taxes & fees
Oct 7 - Oct 8
Comfort Inn & Suites Chesterfield - St. Louis
A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.
A formal dining table set for six with a vase of white flowers, candles, and a view of buildings through large windows.
A hotel room with a large bed, a bedside lamp, a telephone, a mirror, and a bathroom with a sink and towel rack.
A spacious living area with a staircase, a large painting, and a chandelier.

6. The Wildwood Hotel

The Wildwood Hotel
Wildwood
United States
Ramona
CA $129
CA $151 total
includes taxes & fees
Oct 21 - Oct 22
The Wildwood Hotel
A spacious lobby with a stone fireplace, seating area, and a bar with high stools.
A hotel lobby with a seating area featuring two armchairs, a round coffee table, and a flat-screen TV mounted on a wooden wall.
A multi-story hotel with a central entrance, large windows, and a well-maintained lawn.
A hotel pantry stocked with beverages and snacks, a refrigerated display case, and a sign reading "The Market".

7. Residence Inn by Marriott O'Fallon

Residence Inn by Marriott O'Fallon
O'Fallon
United States
Gerald
CA $186
CA $219 total
includes taxes & fees
Oct 18 - Oct 19
Residence Inn by Marriott O'Fallon
A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.
A hotel with a covered entrance, multiple flags, and a well-maintained lawn.
A spacious lobby with a sofa, a coffee station, and a reception desk.
A spacious lobby with a fireplace, comfortable seating, a large painting, and a view of the kitchen area.

8. Hilton Garden Inn St. Louis/O'Fallon MO

Hilton Garden Inn St. Louis/O'Fallon MO
O'Fallon
United States
Kassie
CA $154
CA $182 total
includes taxes & fees
Oct 18 - Oct 19
Hilton Garden Inn St. Louis/O'Fallon MO
Two people in a swimming pool with colorful inflatable rings.
A hotel room with a large bed, a desk, a TV, and a view of a pool through the glass door.
A buffet counter with a variety of food items, including pastries and beverages, and a person serving.
A lobby with a grand staircase, two patterned sofas, a glass coffee table, and a large mirror.

9. Holiday Inn St. Louis West Six Flags by IHG

Holiday Inn St. Louis West Six Flags by IHG
Eureka
United States
Rob
CA $167
CA $195 total
includes taxes & fees
Oct 18 - Oct 19
Holiday Inn St. Louis West Six Flags by IHG
An outdoor patio area with wicker furniture and a central fire feature.
A modern hotel lobby with a reception desk, seating area, and a television screen displaying a map.
A modern hotel lobby with a bar area, seating arrangements, and a reception desk.
A hotel room with a bed, a sofa, a desk, and a chair.

10. Courtyard by Marriott St. Louis Chesterfield

Courtyard by Marriott St. Louis Chesterfield
Chesterfield
United States
Kelly
CA $165
CA $192 total
includes taxes & fees
Oct 18 - Oct 19
Courtyard by Marriott St. Louis Chesterfield
A courtyard with a central seating area, surrounded by trees and a building with a pitched roof.
A reception desk with a "WELCOME TO THE SHOW ME STATE" sign, a wooden counter, and a Hilton Honors sign.
A store interior with a 'Treats' sign, snack shelves, and a chalkboard with a welcome message.
A modern hotel room with a large window, a desk with a flat-screen TV, a comfortable seating area, and a decorative wall piece.

11. Hampton Inn & Suites St. Louis/Chesterfield

Hampton Inn & Suites St. Louis/Chesterfield
Chesterfield
United States
Vijay
CA $162
CA $189 total
includes taxes & fees
Nov 1 - Nov 2
Hampton Inn & Suites St. Louis/Chesterfield
A spacious lobby with a central round table, two sofas, and a chandelier.
An indoor swimming pool area with clear signage indicating a depth of 3 feet and a no diving warning.
A hotel room with two beds, a patterned wall, and a view of the city through sheer curtains.
A buffet setup with various food items and a decorative vase of flowers.

12. Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield
Chesterfield
United States
Cassandra
CA $184
CA $214 total
includes taxes & fees
Oct 7 - Oct 8
Drury Plaza Hotel St. Louis Chesterfield
A modern kitchen area with a breakfast bar, a coffee machine, and a refrigerator displaying menu options.
A coffee station with two coffee machines and a display of coffee pods and cups.
A pool area with a blue pool lift chair, a pool user capacity sign, and a tiled wall.
A hotel room with two beds, a blue sofa, a small table, and a kitchenette.

13. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
Chesterfield
United States
Steven
CA $158
CA $184 total
includes taxes & fees
Nov 1 - Nov 2
Holiday Inn Express & Suites St. Louis - Chesterfield by IHG
A spacious lobby with a high ceiling, a dining area, and a kitchen in the background.
A hotel room with a bathroom, a bed, a nightstand, and a window.
A lobby with a checkered carpet, a marble coffee table, two armchairs with patterned cushions, a sofa, and a dining table with chairs.
A modern hotel lobby with a computer desk, a flat-screen TV, and a ceiling fan.

14. Quality Inn Near Six Flags St. Louis

Quality Inn Near Six Flags St. Louis
Pacific
United States
Rachel
CA $140
CA $160 total
includes taxes & fees
Oct 26 - Oct 27
Quality Inn Near Six Flags St. Louis
An indoor swimming pool with a hot tub, clear signage, and a view of the outside through large windows.
A hotel room with two beds, a desk with a TV, a chair, and a lamp.
A modern hotel room with a grey sofa, a wooden coffee table, a flat-screen TV, a wooden dresser, and a large window with curtains.
A modern dining area with yellow and blue chairs, a flat-screen TV, and a kitchen area with appliances.

15. Comfort Inn Near Six Flags St. Louis

Comfort Inn Near Six Flags St. Louis
Pacific
United States
Amber
CA $140
CA $161 total
includes taxes & fees
Oct 26 - Oct 27
Comfort Inn Near Six Flags St. Louis
A modern kitchen with a bar area, wooden cabinets, and pendant lighting.
A hotel room with three computer workstations, each with a monitor, keyboard, and a lamp.
A hotel room with two beds, a sofa, a small table, a lamp, and a framed abstract painting on the wall.
A swimming pool with a tiled deck, a sunlit room with a view, and a seating area with chairs.

16. Hyatt Place St. Louis/Chesterfield

Hyatt Place St. Louis/Chesterfield
Chesterfield
United States
Chelsea
CA $179
CA $207 total
includes taxes & fees
Oct 18 - Oct 19
Hyatt Place St. Louis/Chesterfield
A Super 8 hotel with a flat facade, multiple windows, and a parking lot.
A hotel room with a flat-screen TV, a wooden dresser, a beige sofa, a teal carpet, and a window with curtains.
A bathroom with a shower, a small white stool, and a towel rack.
A breakfast area with wooden cabinets, a coffee station, and a dining table with chairs.

17. Super 8 by Wyndham Eureka/Six Flags Nearby

Super 8 by Wyndham Eureka/Six Flags Nearby
Eureka
United Kingdom
Claire
CA $95
CA $111 total
includes taxes & fees
Oct 18 - Oct 19
Super 8 by Wyndham Eureka/Six Flags Nearby
A spacious living room with a large painting, a fireplace, a staircase, and modern furniture.
An outdoor patio with a beige sofa set, two armchairs, and a table.
A hotel room with a large bed, two sofas, a desk, and a TV.
A swimming pool with tiled edges and a hot tub area, surrounded by windows and chairs.

18. Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
Washington
United States
Michael Macumber
CA $183
CA $208 total
includes taxes & fees
Oct 5 - Oct 6
Best Western Plus Washington Hotel
An outdoor patio with a built-in grill, seating area, and stone walls.
An indoor swimming pool with clear glass walls, sunlit seating area, and lifeguard station.
A modern lobby with a stone accent wall, a flat-screen TV, a reception desk, seating area with sofas and ottomans, and a patterned rug.
A spacious lounge area with a stone fireplace, comfortable seating, and a large TV screen.

19. Residence Inn by Marriott St. Louis Chesterfield

Residence Inn by Marriott St. Louis Chesterfield
Chesterfield
United States
Chelsea
CA $268
CA $314 total
includes taxes & fees
Oct 17 - Oct 18
Residence Inn by Marriott St. Louis Chesterfield
A modern kitchen with stainless steel appliances, a central island with stools, and a wine cooler.
A Hilton Garden Inn with a brick facade, a covered entrance, and landscaped gardens.
A swimming pool with a lifebuoy on the wall, poolside chairs, and a sign with pool rules.
A spacious lobby with a seating area, a reception desk, and a kitchen area.

20. Hilton Garden Inn Chesterfield

Hilton Garden Inn Chesterfield
Chesterfield
United States
Brian
CA $144
CA $168 total
includes taxes & fees
Nov 1 - Nov 2
Hilton Garden Inn Chesterfield
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Stay near popular Defiance attractions

A glass of red wine on a wooden table with a vineyard in the background.
Photo by Pages of Travel

Chandler Hill Vineyards

7.8/10 (7 reviews)
You can enjoy a tasting or tour at Chandler Hill Vineyards during your travels to Defiance. While in this romantic area, you can savor the top-notch restaurants.
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A wooden dock extending into a pond with lily pads, surrounded by lush greenery and a clear blue sky.

August A. Busch Memorial Conservation Area

8.6/10 (7 reviews)
Explore the great outdoors at August A. Busch Memorial Conservation Area, a lovely green space in Defiance. While in this family-friendly area, you can savor the top-notch restaurants.
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Sugar Creek Winery

8.0/10 (1 review)
You can enjoy a tasting or tour at Sugar Creek Winery during your travels to Defiance. While in this romantic area, you can savor the top-notch restaurants.
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Historic Daniel Boone Home and Heritage Center

9.6/10 (4 reviews)
You can spend time exploring the galleries in Historic Daniel Boone Home and Heritage Center in Defiance. Stroll along the area's lakeside or simply enjoy its wineries.
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Broemmelsiek Park

Broemmelsiek Park is just one of the places to see in Defiance, so why not enjoy the other things to explore during your travels? Amble around this family-friendly area's gardens or experience its festivals.
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Yellow Farmhouse Winery

You can enjoy a tasting or tour at Yellow Farmhouse Winery during your travels to Defiance. While in this romantic area, you can savor the top-notch restaurants.
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Matson Hill Park Trailhead

You can take time to visit Matson Hill Park Trailhead during your travels to Defiance. While you're in the area, wander around the parks.
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Hamburg Trail Trailhead

You can take time to visit Hamburg Trail Trailhead during your travels to Hamburg.
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Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Top Defiance Hotel Reviews

Sonesta ES Suites St. Louis - Chesterfield

Sonesta ES Suites St. Louis - Chesterfield

8/10 Good
"Very clean and worked well for us. Polite staff. Breakfast was good with several hot choices. We were there two nights and there was no housekeeping so ask for extra towels if needed. After our stay I got several phone calls from Sonesta asking for a review. I would rather get an e-mail. Otherwise, a good price and there was no cancellation fee."
Cindy 2-night trip
Posted 12 hours ago
Sonesta ES Suites St. Louis - Chesterfield
Drury Plaza Hotel St. Louis Chesterfield

Drury Plaza Hotel St. Louis Chesterfield

10/10 Excellent
"Very comfortable hotel & really helpful staff."
Kristina 2-night trip
Posted 15 hours ago
Drury Plaza Hotel St. Louis Chesterfield
Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters

10/10 Excellent
"Good location, clean and friendly staff"
Mark 1-night trip
Posted 20 hours ago
Drury Inn & Suites St. Louis St. Peters
Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive

10/10 Excellent
"The stay here was excellent. Incredibly clean hotel. The breakfast had a great selection of fresh hot items. The hotel staff were engaging, courteous and helpful. I will be back."
Lucas 2-night trip
Posted 1 day ago
Sleep Inn & Suites O'Fallon MO - Technology Drive
Hyatt Place St. Louis/Chesterfield

Hyatt Place St. Louis/Chesterfield

10/10 Excellent
"The hotel was very nice, modern, clean, comfortable. Hot breakfast was scrambled eggs, turkey bacon and pancake strips. Thanks!"
Michael 1-night trip
Posted 2 days ago
Hyatt Place St. Louis/Chesterfield
Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis

10/10 Excellent
"Beds are very comfortable."
Jamie 2-night trip
Posted 2 days ago
Drury Inn & Suites Southwest St. Louis
Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

8/10 Good
"nice size free parking spots in the garage. Breakfast was slim. one morning just had sausage and eggs and waffles. next morning had biscuits and gravy and waffles. hotel was clean staffing was friendly. location was good. The cookies were delicious."
Scott 2-night trip
Posted 2 days ago
Country Inn & Suites by Radisson, St. Charles Historic District
Studio 6 Extended Stay - St Louis, MO - Westport/Craig Road

Studio 6 Extended Stay - St Louis, MO - Westport/Craig Road

8/10 Good
"Hotel is in a safe, convenient location. NO elevator, but there was an entrance with no steps on the first level. The hallway is a little grody but the room was very clean and arranged in a very convenient way. Lots of space to set things out to organize. Full kitchen but no utensils or cooking pans or dishes. I suppose they would be stolen if they were provided. I did not need them anyway. No ice machine, but ice trays to make your own ice in the freezer. Nice TV with lots of channels. Comfortable bed but lumpy pillow. Nice shower and bathroom. Basically it was perfect for my purposes as I was attending a meeting just down the street at a more expensive hotel. Families do live there and there was more noise in the hall than some would probably like. I ignored it. The office does not open until 9 in the morning and I had to be at my meeting before that time on the day of checkout. So, I had to return in the afternoon as I wanted my checkout paper. The staff was very nice and very helpful."
Nelta 2-night trip
Posted 3 days ago
Studio 6 Extended Stay - St Louis, MO - Westport/Craig Road
Drury Plaza Hotel St. Louis Creve Coeur

Drury Plaza Hotel St. Louis Creve Coeur

10/10 Excellent
"Clean, staff was nice, food was good"
Eryn 2-night trip
Posted 3 days ago
Drury Plaza Hotel St. Louis Creve Coeur

More cheap stays in Defiance

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive

1147 Technology Drive O'Fallon MO
CA $114
CA $134 total
Oct 5 - Oct 6
includes taxes & fees
9/10 Wonderful! (1,128 reviews)
Sleep Inn & Suites O'Fallon MO - Technology Drive
Quality Inn Foristell

Quality Inn Foristell

12 Highway W Foristell MO
CA $123
CA $139 total
Nov 1 - Nov 2
includes taxes & fees
Quality Inn Foristell
Country Inn & Suites by Radisson, St. Peters, MO

Country Inn & Suites by Radisson, St. Peters, MO

3877 Veterans Memorial Pkwy St. Charles MO
CA $123
CA $141 total
Nov 1 - Nov 2
includes taxes & fees
8/10 Very good! (1,000 reviews)
Country Inn & Suites by Radisson, St. Peters, MO
Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis

1400 S 5th St St. Charles MO
CA $139
CA $160 total
Oct 18 - Oct 19
includes taxes & fees
Comfort Suites St Charles - St Louis
Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters

3720 W Clay St St. Charles MO
CA $169
CA $194 total
Oct 4 - Oct 5
includes taxes & fees
8.2/10 Very good! (1,000 reviews)
Hampton Inn St. Charles St. Peters
Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

1190 S Main St St. Charles MO
CA $197
CA $226 total
Nov 1 - Nov 2
includes taxes & fees
9.4/10 Exceptional! (1,091 reviews)
Country Inn & Suites by Radisson, St. Charles Historic District

Hotels in Defiance with star rating

Frequently asked questions

What is the best area to stay in Defiance?
The best area to stay in Defiance is directly within the village centre, particularly near the intersection of Highway F and Femme Osage Creek Road.This area is the heart of Defiance, offering a collection of local businesses, dining options, and access to the Katy Trail. It's a small, walkable village with a relaxed pace, surrounded by scenic vineyards and rolling hills. The historic Defiance Roadhouse is a popular landmark here.For couples looking for a romantic getaway, the village centre is ideal. You'll find boutique accommodation options, often with a focus on local wines and cuisine. It's great for enjoying leisurely meals, exploring the nearby wineries, and taking peaceful walks along the Katy Trail.Solo travellers seeking a peaceful retreat and outdoor activities will also find the village centre appealing.
When is the best time to go to Defiance?
The best times to go to Defiance are during the spring (late April to early June) and autumn (September to October) when the weather is pleasant and the natural beauty of the area is at its peak.Spring offers mild temperatures, making it ideal for outdoor activities like cycling and hiking along the Katy Trail. The vineyards begin to bud, and the countryside is lush and green. This period is particularly good for couples who enjoy scenic walks and wine tasting without the summer crowds.Autumn brings cooler, crisp air and the stunning transformation of the leaves, creating a picturesque backdrop for exploring the region. Many local wineries also host harvest festivals during this time. For those who appreciate outdoor beauty and a relaxed pace, this season provides an excellent experience.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Defiance.
How much is the nightly rate at a Defiance hotel?
Prices for hotels in Defiance often vary, but you can find a great deal from CA $111 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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