Cherokee Vacation Rentals

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Check prices for these dates

In two weeks
Nov 20 - Nov 22
In two months
Jan 1 - Jan 3
In three months
Jan 29 - Jan 31
In four months
Feb 26 - Feb 28

Our top choices for Cherokee vacation rentals

A covered patio with two wicker chairs, a blue rug, and a potted plant.

1. The 72 Rendezvous

The 72 Rendezvous
Cherokee
10.0 out of 10, Exceptional, (1 review)
"72 Rendezvous was a a whole vibe. The decor was fun and cozy. If you’re attending a wedding at Riverton this is a great home base due to its proximity to the venue. The beds were super comfy and we have everything we needed. The host, Rhonda, quickly responded to all of my questions and was very accommodating. Would definitely recommend!"
United States
Jennifer W.
The price is CA $203
CA $409 total
includes taxes & fees
Nov 10 - Nov 11
The 72 Rendezvous
A cozy cabin interior with wooden walls, a white door, a sofa, a dining table, and a kitchen area.

2. Country Bliss

Country Bliss
Tishomingo
10.0 out of 10, Exceptional, (26 reviews)
"Love this place"
United States
Randall S.
The price is CA $125
CA $227 total
includes taxes & fees
Nov 8 - Nov 9
Country Bliss
A modern kitchen with a stainless steel refrigerator, black cabinets, a brick wall, and wooden flooring.

3. Iuka Downtown Historic King Loft B

Iuka Downtown Historic King Loft B
Iuka
10.0 out of 10, Exceptional, (4 reviews)
"Property was exactly as described. We enjoyed our weekend and would not hesitate to stay again. When we arrived, we texted with Cooper to get the code and he responded right away."
United States
Kelly K.
The price is CA $140
CA $282 total
includes taxes & fees
Nov 9 - Nov 10
Iuka Downtown Historic King Loft B
A room with wooden walls, a ceiling fan, a table, a sofa, and a television.

4. Rustic Fish Camp Cabin on Pickwick Lake! with marina, private beach, boat slip!

Rustic Fish Camp Cabin on Pickwick Lake! with marina, private beach, boat slip!
Iuka
The price is CA $151
CA $255 total
includes taxes & fees
Nov 9 - Nov 10
Rustic Fish Camp Cabin on Pickwick Lake! with marina, private beach, boat slip!
A small, two-story wooden structure with a red door and a porch.

5. The Gypsy Queen

The Gypsy Queen
Tishomingo
9.6 out of 10, Exceptional, (4 reviews)
"Cute funky fun little cottage. We loved it"
United States
Ashley P.
The price is CA $175
CA $291 total
includes taxes & fees
Nov 8 - Nov 9
The Gypsy Queen
A small, dark-colored building with a covered patio area, wooden chairs, and a bench.

6. Romantic Cozy Cottage 0.8 miles from JP Coleman State Park / Pickwick / Iuka

Romantic Cozy Cottage 0.8 miles from JP Coleman State Park / Pickwick / Iuka
Iuka
9.6 out of 10, Exceptional, (5 reviews)
"Super cute tiny home and really close to JP Coleman boat ramp. I would stay again and again!"
United States
EMILY B.
The price is CA $167
CA $258 total
includes taxes & fees
Nov 9 - Nov 10
Romantic Cozy Cottage 0.8 miles from JP Coleman State Park / Pickwick / Iuka
A living room with a TV mounted on the wall, a ceiling fan, a wooden floor, and a door leading to another room.

7. Charming 2-bedroom house with AC, WiFi in wonderful Florence

Charming 2-bedroom house with AC, WiFi in wonderful Florence
Florence
8.8 out of 10, Excellent, (6 reviews)
"Adorable house, great location, awesome host, very comfortable "
United States
Jamie S.
The price is CA $76
CA $372 total
includes taxes & fees
Nov 9 - Nov 10
Charming 2-bedroom house with AC, WiFi in wonderful Florence
A kitchen with white cabinets, a coffee maker, a bowl of coffee pods, and a window with sheer curtains.

8. Boat Parking & Shore Power, Dog-Friendly Duplex, Fenced Yard Near Pickwick Lake

Boat Parking & Shore Power, Dog-Friendly Duplex, Fenced Yard Near Pickwick Lake
Sheffield
9.2 out of 10, Wonderful, (10 reviews)
"Nice clean property. Conveniently located within 2-20 mins of shopping and restaurants."
United States
Kristy
The price is CA $91
CA $226 total
includes taxes & fees
Nov 11 - Nov 12
Boat Parking & Shore Power, Dog-Friendly Duplex, Fenced Yard Near Pickwick Lake
A living room with a brick wall, a ceiling fan, a sofa, and a coffee table.

9. Iuka Historic Downtown King Loft C

Iuka Historic Downtown King Loft C
Iuka
10.0 out of 10, Exceptional, (5 reviews)
"Wonderful place to stay"
United States
Sherry B.
The price is CA $140
CA $273 total
includes taxes & fees
Nov 30 - Dec 1
Iuka Historic Downtown King Loft C
A wooden deck with a view of a lake and forest.

10. Lake House on Cedar Creek Lake - Hoot Hoot Holler Hideaway

Lake House on Cedar Creek Lake - Hoot Hoot Holler Hideaway
Russellville
10.0 out of 10, Exceptional, (7 reviews)
"Beautiful place. Such a peaceful weekend."
United States
Linda N.
The price is CA $170
CA $393 total
includes taxes & fees
Nov 9 - Nov 10
Lake House on Cedar Creek Lake - Hoot Hoot Holler Hideaway
A living room with two sofas, a fireplace, a television, and a window with curtains.

11. The Cozy Cottage of Florence!

The Cozy Cottage of Florence!
Florence
8.8 out of 10, Excellent, (15 reviews)
"The cottage was comfortable and very centrally located"
United States
Sarah K.
The price is CA $88
CA $384 total
includes taxes & fees
Nov 10 - Nov 11
The Cozy Cottage of Florence!
A rustic wooden cabin with a balcony, surrounded by trees and a fire pit area.

12. Fern Hollow Treehouse, rustic escape cozy romantic

Fern Hollow Treehouse, rustic escape cozy romantic
Tishomingo
9.8 out of 10, Exceptional, (44 reviews)
"Very quiet and a relaxing place to hang out."
United States
John B.
The price is CA $245
CA $367 total
includes taxes & fees
Nov 8 - Nov 9
Fern Hollow Treehouse, rustic escape cozy romantic
A living room with a blue sofa, a glass coffee table, a green chair, and a floral rug.

13. Pet-friendly 3-bedroom house in Florence, AL two mile from UNA!

Pet-friendly 3-bedroom house in Florence, AL two mile from UNA!
Florence
7.0 out of 10, Good, (2 reviews)
"We really enjoyed our stay. The host was very accommodating and the area was nice quite and very close to everything to do in the area."
United States
David L.
The price is CA $130
CA $264 total
includes taxes & fees
Nov 16 - Nov 17
Pet-friendly 3-bedroom house in Florence, AL two mile from UNA!
A rustic wooden interior with a dining table and chairs, a hanging light fixture, and a door with a window.

14. The Loft on Main

The Loft on Main
Belmont
9.8 out of 10, Exceptional, (23 reviews)
"Second time to stay and it was great!!"
United States
Jan W.
The price is CA $139
CA $243 total
includes taxes & fees
Nov 8 - Nov 9
The Loft on Main
A modern living room with a sofa, a coffee table, and a kitchen area in the background.

15. Golden Hour Loft in the Heart of Downtown Florence

Golden Hour Loft in the Heart of Downtown Florence
Florence
10.0 out of 10, Exceptional, (5 reviews)
"This was my second time staying, and I would definitely stay again. Place is exactly as described in the listing. Host was very easy to get in contact with for any issues. "
United States
Jodi W.
The price is CA $175
CA $347 total
includes taxes & fees
Nov 8 - Nov 9
Golden Hour Loft in the Heart of Downtown Florence
A wooden swing chair under a covered area overlooking a lake with a dock and trees in the background.

16. Stenson Hollow Lake Condo

Stenson Hollow Lake Condo
Muscle Shoals
9.6 out of 10, Exceptional, (118 reviews)
"Property was great, right on the river. Beautiful location for a quiet weekend."
United States
Kyle S.
The price is CA $133
CA $282 total
includes taxes & fees
Nov 15 - Nov 16
Stenson Hollow Lake Condo
A wooden deck with a table and chairs overlooking a calm lake, surrounded by trees.

17. A little piece of Heaven

A little piece of Heaven
Muscle Shoals
9.8 out of 10, Exceptional, (51 reviews)
"Very clean with a great view of the water. Great place for a short stay. "
United States
Tracy P.
The price is CA $125
CA $317 total
includes taxes & fees
Nov 10 - Nov 11
A little piece of Heaven
A white house with a covered porch, a visible door, and a window with shutters.

18. #424 DOWNTOWN FLORENCE HOME CLOSE TO EVERYTHING!

#424 DOWNTOWN FLORENCE HOME CLOSE TO EVERYTHING!
Florence
8.4 out of 10, Very good, (26 reviews)
"i loveddd everything about this house the front room was so big and the couches was do nice,and the rooms wass beautiful no complaints from any of my other guest"
United States
amariah
The price is CA $138
CA $337 total
includes taxes & fees
Nov 27 - Nov 28
#424 DOWNTOWN FLORENCE HOME CLOSE TO EVERYTHING!
A kitchen with white cabinets, a double sink, and a window with blinds.

19. ReNew At JW's & bring your Dog too!

ReNew At JW's & bring your Dog too!
East Florence
9.6 out of 10, Exceptional, (14 reviews)
"The house is laid out very well, and the neighborhood is close to everything and quiet at night. The fenced yard was perfect for the pups. We would stay here again."
United Kingdom
Nicole L.
The price is CA $106
CA $238 total
includes taxes & fees
Nov 9 - Nov 10
ReNew At JW's & bring your Dog too!
A compact RV kitchen with a central island, built-in cabinets, and a sofa in the living area.

20. Crossroads to Pickwick Glamping

Crossroads to Pickwick Glamping
Iuka
9.8 out of 10, Exceptional, (11 reviews)
"Was very clean, the host was very nice, Made our trip really enjoyable"
United States
sharon
The price is CA $150
CA $255 total
includes taxes & fees
Nov 9 - Nov 10
Crossroads to Pickwick Glamping
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cherokee Hotel Reviews

A bedroom with a brick wall, a dark blue headboard, and patterned pillows.
The Stricklin Hotel

The Stricklin Hotel

The Stricklin Hotel
Florence

10/10 Excellent

Excellent accommodation, great location for what we were looking to do, incredible hosts, ideal to be co-located with a fabulous breakfast restaurant. The bonus was the late hours socializing downstairs in the bar-bowling alley-karaoke-darts area. Brilliant! Highly recommended.
Canada
David
Reviewed October 29, 2026
The Stricklin Hotel

Find out more about Cherokee

Everything you need to know about Cherokee vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Cherokee vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Cherokee vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Cherokee vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Cherokee. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in .

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Cherokee vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Cherokee vacation rentals we have selected for you start as low as CA $75 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Cherokee rentals

At Expedia, we put the best Cherokee vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Cherokee rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Cherokee vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Cherokee. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently Asked Questions

Can I find vacation rentals in Cherokee?

Yes, you can find vacation rentals near popular points of interest in Cherokee, or you can select a secluded option if you're looking for a relaxing stay.

What are some of the best vacation rentals in Cherokee?

Rustic Cabin overlooking Pickwick Lake: This Cherokee vacation home rental is located on a lake and offers a barbecue grill, air-conditioning, and laundry facilities to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a fridge, a stovetop, and a microwave. Our travelers also rate RIVERTON LAKESIDE COTTAGE ON PICKWICK LAKE as a favorite home for rent in Cherokee.

How many vacation rentals are there in Cherokee?

Choose from 6 Expedia vacation rentals in Cherokee for a memorable vacation.

What can I see and do in Cherokee?

Pickwick Lake and Tennessee River are a couple of lovely local spots to get outside and enjoy nature. Cane Creek Canyon Nature Preserve and Ivy Green are a couple of places you'll find in the larger area.

What are vacation rentals like in Cherokee?

Vacation rentals are privately owned accommodations you can reserve for several days or longer in Cherokee. Vacation rentals offer amenities like WiFi and washers and dryers so you'll have a home away from home. If you're concerned about a sanitized environment, a vacation rental can provide a sense of safety away from public hotel elevators and busy reception areas while still allowing you the excitement and enjoyment of travel. You'll also find more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for family trips.