A calm river with boats, lush greenery, and a clear blue sky.

Find Hotels by Hilton Hotels in Big Pine Key

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Oct 5 - Oct 6
Tomorrow
Oct 6 - Oct 7
This weekend
Oct 9 - Oct 11
Next weekend
Oct 16 - Oct 18
Save an average of 15% on thousands of hotels when you're signed in

Top Big Pine Key Hotel Reviews

Looe Key Reef Resort

Looe Key Reef Resort

8/10 Good
"This is a great inexpensive place to stay. Room was clean. Resort is showing some wear but is still good. Staff are very helpful with local recommendations. There is a great gas station next door with some items for sale in case you forget something. I would stay again."
Brandy 2-night trip
Posted 7 hours ago
Looe Key Reef Resort
Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort

10/10 Excellent
"Absolutely a phenomenal place to stay! Perfect! Comfy beds! Full kitchen so we cooked in since not much to choose from restaurants… saved funds! Love this place!!! Wow factor!!!"
Rhonda 6-night trip
Posted 21 hours ago
Tranquility Bay Beachfront Hotel and Resort
Yacht Haven Marina

Yacht Haven Marina

10/10 Excellent
"super clean! cozy and it has everything you need. Close to sombrero beach and 30sec in car to publix and walgreens. Host is super nice! Will definetely recomend. We saw tarpons and a manatee during the morning time!"
Alexander Bernardo 2-night trip
Posted 1 day ago
Yacht Haven Marina
Kingsail Resort

Kingsail Resort

10/10 Excellent
"El hotel nos encanto, nos registramos antes de la hora acordada, el personal es maravilloso, la habitación es una mini casa con todo los accesorios necesarios para su comodidad, las camas muy cómodas y limpias, el hospedaje incluye cayak sin costo adicional , ofrecen café free en la piscina, y un ranchon frente al mar con mesas y hasta parrilla para pasar el rato al aire libre. 100 % recomendado"
Armando Jesus 2-night trip
Posted 1 day ago
Kingsail Resort
Captain Pips Marina & Hideaway

Captain Pips Marina & Hideaway

10/10 Excellent
"Decent Mini golf and restaurant/bar on property and free kayaking across the bay full of nature like a nursery for all the upcoming sealife families, superior water quality and views. Not to mention the pool and the rental boats for exploring the islands and restaurants, a real hidden gem and a piece of paradise..."
Steven 4-night trip
Posted 1 day ago
Captain Pips Marina & Hideaway
Parmer's Resort

Parmer's Resort

10/10 Excellent
"Just a fantastic property, wonderful staff, great amenities, so many waterfront places to chill. Immaculate grounds with a laid back vibe, loved it!!"
Moira 1-night trip
Posted 2 days ago
Parmer's Resort
Old Wooden Bridge Resort and Marina

Old Wooden Bridge Resort and Marina

10/10 Excellent
"Best stop over before going to Key west. We enjoyed here a lot, parking our trailer was never a problem."
Daisybel 2-night trip
Posted 11 days ago
Old Wooden Bridge Resort and Marina

Explore a world of travel with Expedia