A calm river with boats, lush greenery, and a clear blue sky.

Find Hotels by Hilton Hotels in Big Pine Key

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Oct 5 - Oct 6
Tomorrow
Oct 6 - Oct 7
This weekend
Oct 9 - Oct 11
Next weekend
Oct 16 - Oct 18
Save an average of 15% on thousands of hotels when you're signed in

Top Big Pine Key Hotel Reviews

Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort

10/10 Excellent
"Absolutely a phenomenal place to stay! Perfect! Comfy beds! Full kitchen so we cooked in since not much to choose from restaurants… saved funds! Love this place!!! Wow factor!!!"
Rhonda 6-night trip
Posted 10 hours ago
Tranquility Bay Beachfront Hotel and Resort
Yacht Haven Marina

Yacht Haven Marina

10/10 Excellent
"super clean! cozy and it has everything you need. Close to sombrero beach and 30sec in car to publix and walgreens. Host is super nice! Will definetely recomend. We saw tarpons and a manatee during the morning time!"
Alexander Bernardo 2-night trip
Posted 13 hours ago
Yacht Haven Marina
Kingsail Resort

Kingsail Resort

10/10 Excellent
"El hotel nos encanto, nos registramos antes de la hora acordada, el personal es maravilloso, la habitación es una mini casa con todo los accesorios necesarios para su comodidad, las camas muy cómodas y limpias, el hospedaje incluye cayak sin costo adicional , ofrecen café free en la piscina, y un ranchon frente al mar con mesas y hasta parrilla para pasar el rato al aire libre. 100 % recomendado"
Armando Jesus 2-night trip
Posted 20 hours ago
Kingsail Resort
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

10/10 Excellent
"We had a great stay. Everything was clean and comfortable."
Lisandra 2-night trip
Posted 21 hours ago
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
Captain Pips Marina & Hideaway

Captain Pips Marina & Hideaway

10/10 Excellent
"Decent Mini golf and restaurant/bar on property and free kayaking across the bay full of nature like a nursery for all the upcoming sealife families, superior water quality and views. Not to mention the pool and the rental boats for exploring the islands and restaurants, a real hidden gem and a piece of paradise..."
Steven 4-night trip
Posted 22 hours ago
Captain Pips Marina & Hideaway
Looe Key Reef Resort

Looe Key Reef Resort

10/10 Excellent
"The room was super clean. The fact that we can keep a boat docked right behind our room is amazing. There is a tiki bar literally right in front of the room is a plus. Check out was easy and quick as well as check in. I mean best decision ever."
anneliss 2-night trip
Posted 2 days ago
Looe Key Reef Resort
Parmer's Resort

Parmer's Resort

10/10 Excellent
"Just a fantastic property, wonderful staff, great amenities, so many waterfront places to chill. Immaculate grounds with a laid back vibe, loved it!!"
Moira 1-night trip
Posted 2 days ago
Parmer's Resort
Old Wooden Bridge Resort and Marina

Old Wooden Bridge Resort and Marina

10/10 Excellent
"Best stop over before going to Key west. We enjoyed here a lot, parking our trailer was never a problem."
Daisybel 2-night trip
Posted 10 days ago
Old Wooden Bridge Resort and Marina

Explore a world of travel with Expedia