4 Stars Hotels in Mebane, North Carolina from CA $156

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Nov 13 - Nov 14
Tomorrow
Nov 14 - Nov 15
This weekend
Nov 13 - Nov 15
Next weekend
Nov 20 - Nov 22

Our top choices for Mebane 4-star hotels

An outdoor seating area with wicker chairs, a fire feature, and a large umbrella.

1. DoubleTree Suites by Hilton Raleigh - Durham

DoubleTree Suites by Hilton Raleigh - Durham
4.0 star property
Durham
9.2 out of 10, Wonderful, (1,002 reviews)
"Would stay again."
United States
Sierra
The price is CA $164
CA $186 total
includes taxes & fees
Nov 23 - Nov 24
DoubleTree Suites by Hilton Raleigh - Durham
A hallway with wooden paneling, a tiled floor, and three spherical light fixtures.

2. 21c Museum Hotel Durham

21c Museum Hotel Durham
4.0 star property
Downtown Durham
8.4 out of 10, Very good, (1,005 reviews)
"Gorgeous art galleries and friendly staff. Our room was clean and spacious and our stay was lovely. We will be back for sure!"
United States
Jennifer
The price is CA $191
CA $224 total
includes taxes & fees
Nov 29 - Nov 30
21c Museum Hotel Durham
An outdoor seating area with sofas, chairs, and a fire pit, adjacent to a modern building with large windows.

3. JB Duke Hotel

JB Duke Hotel
4.0 star property
Durham
9.4 out of 10, Exceptional, (753 reviews)
"Clean, great shampoo/ shower products, welcome my small service dog. Great quiet location."
United States
David Elliott
The price is CA $258
CA $293 total
includes taxes & fees
Nov 30 - Dec 1
JB Duke Hotel
A hotel entrance with a stone facade, large wooden doors, and a view into the interior.

4. Washington Duke Inn & Golf Club

Washington Duke Inn & Golf Club
4.0 star property
Durham
9.6 out of 10, Exceptional, (1,000 reviews)
"Location."
United States
James
The price is CA $342
CA $388 total
includes taxes & fees
Nov 15 - Nov 16
Washington Duke Inn & Golf Club
An outdoor cafe with tables and chairs, umbrellas, and a bicycle parked nearby.

5. The Durham Hotel

The Durham Hotel
4.0 star property
Downtown Durham
9.0 out of 10, Wonderful, (787 reviews)
"Generally we had a good experience in this hotel."
United States
Yiching
The price is CA $248
CA $281 total
includes taxes & fees
Dec 14 - Dec 15
The Durham Hotel
A hotel entrance with a blue awning, two chairs, a small table, and a bar area with bottles.

6. Graduate by Hilton Chapel Hill

Graduate by Hilton Chapel Hill
4.0 star property
Downtown Chapel Hill
9.2 out of 10, Wonderful, (1,000 reviews)
"Great location, nicely priced with friendly and helpful staff."
United States
Tigerron
The price is CA $233
CA $264 total
includes taxes & fees
Nov 29 - Nov 30
Graduate by Hilton Chapel Hill
A corridor with a checkered floor, blue benches with cushions, and potted plants.

7. The Carolina Inn, a Destination by Hyatt Hotel

The Carolina Inn, a Destination by Hyatt Hotel
4.5 star property
Chapel Hill
9.6 out of 10, Exceptional, (1,000 reviews)
"Historical inn. Excellent hospitality. Walking distance to UNC campus and to many bars and restaurants."
United States
Stephanie Pauline
The price is CA $284
CA $323 total
includes taxes & fees
Nov 22 - Nov 23
The Carolina Inn, a Destination by Hyatt Hotel
An outdoor dining area with tables set for four, surrounded by a brick pathway and lush greenery.

8. Rizzo Center, a Destination by Hyatt Hotel

Rizzo Center, a Destination by Hyatt Hotel
4.0 star property
Chapel Hill
9.6 out of 10, Exceptional, (1,005 reviews)
"The Rizzo is fabulous! The staff is amazing and so helpful! The rooms are so nice! Definitely our go to property in Chapel Hill!"
United States
Mary
The price is CA $205
CA $233 total
includes taxes & fees
Dec 14 - Dec 15
Rizzo Center, a Destination by Hyatt Hotel
A bar area with wooden bar stools, pendant lighting, and a counter with a glass display. There are tables and chairs in the background, and the room has a wooden floor.

9. The Colonial Inn, an Ascend Collection Hotel

The Colonial Inn, an Ascend Collection Hotel
4.0 star property
Hillsborough
9.6 out of 10, Exceptional, (330 reviews)
"Beautiful renovated rooms great showers and quiet with a great location right downtown"
United States
Erica
The price is CA $156
CA $177 total
includes taxes & fees
Nov 22 - Nov 23
The Colonial Inn, an Ascend Collection Hotel
A modern kitchen with a central island, wooden chairs, and a large window overlooking a cityscape.

10. Landing Apartments Durham

Landing Apartments Durham
4.0 star property
Downtown Durham
8.8 out of 10, Excellent, (33 reviews)
"The apartment was just like the pictures! We would recommend this for anyone"
United States
Katherine
Landing Apartments Durham
A modern kitchen with a central island, bar stools, and a dining area with a sofa and chairs.

11. 2 Mi to Duke University: Townhome in Durham!

2 Mi to Duke University: Townhome in Durham!
4.0 star property
Durham
2 Mi to Duke University: Townhome in Durham!
A rustic log cabin with a porch, wooden steps, and a door.

12. Arrowhead Inn

Arrowhead Inn
4.5 star property
Durham
9.8 out of 10, Exceptional, (126 reviews)
"Wonderful place to stay!"
United States
Ozcan
Arrowhead Inn
A glass entrance to a building with a paved pathway leading to a fountain surrounded by flowers.

13. The Siena Hotel, Autograph Collection

The Siena Hotel, Autograph Collection
4.0 star property
Chapel Hill
9.4 out of 10, Exceptional, (919 reviews)
"Great stay. Would absolutely stay again. "
United States
Anthony
The Siena Hotel, Autograph Collection
A modern kitchen with a large island, stainless steel appliances, and white cabinetry.

14. 2 Mi to Duke & 3 Mi to Downtown: Durham Townhome

2 Mi to Duke & 3 Mi to Downtown: Durham Townhome
4.0 star property
Durham
2 Mi to Duke & 3 Mi to Downtown: Durham Townhome

Top Mebane Hotel Reviews

An outdoor seating area with sofas, chairs, and a fire pit, adjacent to a modern building with large windows.
JB Duke Hotel

JB Duke Hotel

JB Duke Hotel
Durham

10/10 Excellent

Great location, super convenient to university, great staff and clean room.
Canada
Sophia
Reviewed July 22, 2026
JB Duke Hotel

Find out more about Mebane

If you’re looking for a spot with great rates, just-for-you amenities, and a world of luxurious little perks, the best 4 Stars hotels in Mebane are calling your name. Known for providing first-rate service in amazing locations, each of the Mebane 4 Stars hotels lets discerning travelers bask in an unforgettable experience.

Kick back in your spacious room. Relax in the lobby’s sumptuous surroundings. Start the day with delicious room service, and then use the complimentary body care items to freshen up before you head out for the day.

It’s all waiting for you at the top four star hotels in Mebane. Plus, when you book with Expedia.ca, you might find a cheap deal on a 4 Stars hotel in Mebane, North Carolina, neighbourhoods near the most popular attractions, so you can see the sights and bask in the discounts all in one trip. Whether you’re planning a romantic retreat or simply want to experience everything the area has to offer, the top Mebane hotels with 4 Stars provide everything you need to unwind in style.

Frequently Asked Questions

How much does it cost to stay in a 4-star hotel in Mebane?

To lock in a 4-star hotel in Mebane that fits your budget, make use of Expedia's handy filters. Take a look at the available options during your vacation dates and use our pricing filter to set your maximum rate. You can also list your results by the most economical retreat first.

  • Search for the lowest price from CA $156

What's the difference between 5-star and 4-star hotels in Mebane?

Offering a welcoming traveller experience and upmarket décor, 4-star hotels are a wonderful option for your Mebane break. These types of stays generally come with loads of useful amenities that make it easy to unpack and recharge — think 24-hour room service, pools and gyms. Or enjoy even more lavishness at a 5-star hotel designed to pamper with high-end perks and amenities. Round-the-clock concierge service, oversized bathrooms and gourmet dining are typically included at these deluxe properties.

Does Mebane have any 4-star all-inclusive resorts?

Enjoy a stress-free vacation experience where everything is included in the one rate by using our "All inclusive" filter. Staying within budget is simple when your room, meals and many activities are already taken care of. Want more options? Browse the amazing deals on our standard 4-star resorts in and around Mebane.

Are there any 4-star casino hotels in Mebane?

Shuffle between your room and the craps table with ease by using our handy filter tool to find 4-star casino hotels in and around Mebane. Celebrating with somebody special? Narrow your search further by selecting amenities with a wow-factor, like a pool or view.

Explore a world of travel with Expedia