A river with a yellow boat, surrounded by tall buildings and a bridge.

CA $542 Cheap Flights from Panama City (PTY) to Chicago (CHI)

View CA $542 flight on Tue, Mar 16, 2027

Popular airlines from Tocumen Intl. Airport (PTY) to Chicago

  • Be in the know

    Get alerts if flight prices drop or rise*

  • Book smarter

    Save up to 30% on select hotels after you book a flight*

  • Earn twice

    Earn your airline miles on top of our rewards

    Sign in

    • Cheap Flights from Panama City to Chicago (PTY-CHI)

    Prices were available within the past 7 days and start at CA $542 for one-way flights and CA $1,169 for roundtrip, for the period specified. Prices and availability are subject to change.

    All deals

    One way

    Roundtrip

    Select American Airlines flight, departing Sat, Dec 19 from Panama City to Chicago, returning Sun, Jan 3, priced at CA $1,169 Found 2 days ago

    Sat, Dec 19 - Sun, Jan 3 · PTY · ORD · Roundtrip

    Select American Airlines flight, departing Tue, Nov 24 from Panama City to Chicago, returning Tue, Dec 1, priced at CA $1,196 Found 2 days ago

    Tue, Nov 24 - Tue, Dec 1 · PTY · ORD · Roundtrip

    Select Avianca flight, departing Mon, Nov 23 from Panama City to Chicago, returning Mon, Nov 30, priced at CA $1,233 Found 3 days ago

    Mon, Nov 23 - Mon, Nov 30 · PTY · ORD · Roundtrip

    Select American Airlines flight, departing Mon, Nov 23 from Panama City to Chicago, returning Mon, Nov 30, priced at CA $1,239 Found 3 days ago

    Mon, Nov 23 - Mon, Nov 30 · PTY · ORD · Roundtrip

    Select Delta flight, departing Sat, Dec 19 from Panama City to Chicago, returning Sun, Jan 3, priced at CA $1,242 Found 2 days ago

    Sat, Dec 19 - Sun, Jan 3 · PTY · ORD · Roundtrip

    Select American Airlines flight, departing Sat, Dec 19 from Panama City to Chicago, returning Sun, Jan 3, priced at CA $1,280 Found 2 days ago

    Sat, Dec 19 - Sun, Jan 3 · PTY · ORD · Roundtrip

    Select American Airlines flight, departing Mon, Nov 23 from Panama City to Chicago, returning Mon, Nov 30, priced at CA $1,300 Found 3 days ago

    Mon, Nov 23 - Mon, Nov 30 · PTY · ORD · Roundtrip

    Select American Airlines flight, departing Tue, Nov 24 from Panama City to Chicago, returning Tue, Dec 1, priced at CA $1,348 Found 2 days ago

    Tue, Nov 24 - Tue, Dec 1 · PTY · ORD · Roundtrip

    Select Copa flight, departing Wed, Nov 25 from Panama City to Chicago, returning Wed, Dec 2, priced at CA $1,455 Found 1 day ago

    Wed, Nov 25 - Wed, Dec 2 · PTY · ORD · Roundtrip

    Select United flight, departing Wed, Nov 25 from Panama City to Chicago, returning Wed, Dec 2, priced at CA $1,469 Found 1 day ago

    Wed, Nov 25 - Wed, Dec 2 · PTY · ORD · Roundtrip

    Book with confidence

    Panama City to Chicago Flights

    The easy way to book your flights from Panama City to Chicago

    With Expedia, it’s simple to find and book flights to Chicago from Panama City whether you’re traveling for business or pleasure. Enter your travel dates, hit search, and choose your flight from 6 airlines that cover this route. There are nonstop flights to CHI-All Airports, too.

    Choose your preferred carrier and cabin class with the advanced search tool and select your ideal departure time. Then, if you want, you can see just nonstop or refundable flights. And if you’re traveling last minute, just enter the date to check out flights from Panama City to Chicago today, tomorrow, or this week.

    Save dollars with cheap flights from Tocumen Intl., PTY to CHI-All Airports, CHI

    Sort your search results by price to find great deals on your flight from Panama City to Chicago—you get all your cheapest options first. Grab yourself a bargain now—the lowest price on flights to Chicago from Panama City currently is just CA $1,169 rising to CA $1,469.

    Here are more money-saving tips:

    • Fly in December when flight prices are normally at their lowest
    • Book about a month to 6 weeks before you travel for the best prices to Chicago
    • Avoid peak season and weekends when flights can cost more
    • Early morning and late-night flights are sometimes cheaper, so try varying your travel times
    • One surefire way to save money on your flight is to book your flight and hotel together with Expedia. Sometimes, the savings are so large that the flight is basically free!

    Reasons to choose Expedia for your flight to Chicago from Panama City

    Whatever your destination, budget, or reason to travel, in just one quick search, you can choose from loads of flights, airlines, and cabin classes. The filters make it quick and easy to find your ideal flights, and if you choose one of the flexible options, you won’t be charged to change your flight. So book your flight to Chicago with Expedia today.

    Travel information

    Origin airportTocumen Intl. Airport
    Destination airportChicago Midway Airport
    Distance3,729 km away
    Airlines servingDelta
    Popular airlineDelta
    Roundtrip priceCA $1,169

    Explore a world of travel with Expedia

    *Available to Expedia members.