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CA $300 Cheap Flights from Des Moines (DSM) to Jacksonville (JAX)

View CA $300 flight on Sun, Sep 27, 2026Opens in a new window

Popular airlines from Des Moines International Airport (DSM) to Jacksonville International Airport (JAX)

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Cheap flights from Des Moines (DSM) to Jacksonville (JAX)

Prices were available within the past 7 days and start at CA $300 for one-way flights and CA $563 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Sun, Sep 27 - Thu, Oct 1
DSM
Des Moines
JAX
Jacksonville
CA $563 Roundtrip, found 4 hours ago
CA $563
Roundtrip
found 4 hours ago
Select Delta flight, departing Sun, Sep 27 from Des Moines to Jacksonville, returning Thu, Oct 1, priced at CA $563 found 4 hours ago
Delta
Sun, Sep 27 - Thu, Oct 1
DSM
Des Moines
JAX
Jacksonville
CA $599 Roundtrip, found 4 hours ago
CA $599
Roundtrip
found 4 hours ago
Select Delta flight, departing Sun, Sep 27 from Des Moines to Jacksonville, returning Thu, Oct 1, priced at CA $599 found 4 hours ago
American Airlines
Sun, Sep 27 - Thu, Oct 1
DSM
Des Moines
JAX
Jacksonville
CA $619 Roundtrip, found 4 hours ago
CA $619
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Sun, Sep 27 from Des Moines to Jacksonville, returning Thu, Oct 1, priced at CA $619 found 4 hours ago
Delta
Sun, Sep 27 - Thu, Oct 1
DSM
Des Moines
JAX
Jacksonville
CA $626 Roundtrip, found 4 hours ago
CA $626
Roundtrip
found 4 hours ago
Select Delta flight, departing Sun, Sep 27 from Des Moines to Jacksonville, returning Thu, Oct 1, priced at CA $626 found 4 hours ago
Delta
Sun, Sep 27 - Thu, Oct 1
DSM
Des Moines
JAX
Jacksonville
CA $633 Roundtrip, found 4 hours ago
CA $633
Roundtrip
found 4 hours ago
Select Delta flight, departing Sun, Sep 27 from Des Moines to Jacksonville, returning Thu, Oct 1, priced at CA $633 found 4 hours ago
American Airlines
Sun, Sep 27 - Thu, Oct 1
DSM
Des Moines
JAX
Jacksonville
CA $642 Roundtrip, found 4 hours ago
CA $642
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Sun, Sep 27 from Des Moines to Jacksonville, returning Thu, Oct 1, priced at CA $642 found 4 hours ago
American Airlines
Sun, Sep 27 - Thu, Oct 1
DSM
Des Moines
JAX
Jacksonville
CA $657 Roundtrip, found 4 hours ago
CA $657
Roundtrip
found 4 hours ago
Select American Airlines flight, departing Sun, Sep 27 from Des Moines to Jacksonville, returning Thu, Oct 1, priced at CA $657 found 4 hours ago
United
Sun, Sep 27 - Thu, Oct 1
DSM
Des Moines
JAX
Jacksonville
CA $662 Roundtrip, found 4 hours ago
CA $662
Roundtrip
found 4 hours ago
Select United flight, departing Sun, Sep 27 from Des Moines to Jacksonville, returning Thu, Oct 1, priced at CA $662 found 4 hours ago
Delta
Sun, Sep 27 - Thu, Oct 1
DSM
Des Moines
JAX
Jacksonville
CA $677 Roundtrip, found 4 hours ago
CA $677
Roundtrip
found 4 hours ago
Select Delta flight, departing Sun, Sep 27 from Des Moines to Jacksonville, returning Thu, Oct 1, priced at CA $677 found 4 hours ago
United
Sun, Sep 27 - Thu, Oct 1
DSM
Des Moines
JAX
Jacksonville
CA $683 Roundtrip, found 4 hours ago
CA $683
Roundtrip
found 4 hours ago
Select United flight, departing Sun, Sep 27 from Des Moines to Jacksonville, returning Thu, Oct 1, priced at CA $683 found 4 hours ago

Find the cheapest month to fly from Des Moines (DSM) to Jacksonville (JAX)

January is typically the cheapest month to fly

From CA $384 - CA $577 per traveller.

Frequently asked questions

How much does a flight from Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.) cost?
You can find one-way and return flights from DSM to JAX with Expedia. Flight prices vary based on the month and day of the week you want to travel, as well as the airline and how far in advance you book your ticket. Filter your search on Expedia by "Price (lowest to highest)" to see our cheapest fares first, and use the Price Tracking tool to receive alerts when DSM to JAX ticket fares go up or down.
What is the cheapest month to fly from Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.)?
If you're looking for the cheapest time to fly from Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.), July is typically your best bet. You can expect average return fares around CA$403 during this month. July often sees lower prices because it's a shoulder season for some travel, and airlines may offer deals to fill seats. Other budget-friendly months to consider for this route include January and September.
Which airlines fly direct from Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.)?
Enter DSM to JAX and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
What is the cheapest airline that flies from Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.)?
Southwest Airlines is one of the cheapest airlines offering connecting return flights from Des Moines Intl. (DSM) to Jacksonville Intl. (JAX), with prices starting from around CA$385 for flights that can be booked for departure within the next year, typically with a layover in Lambert-St. Louis Intl. (STL). These prices are for one adult in economy/coach class. Use Expedia's search tool to compare the prices and schedules of airlines that fly this route to find the best option for your plans and budget.
How do I find cheap flights from Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.)?
To find a cheap flight from Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best time to fly from Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.)?
The cheapest months to fly from Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.) are typically July and September, with average return flights around CA$403. These months can offer a good balance of affordability, allowing you to find reasonable fares for your trip.
How many flights per day from Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.)?
There are approximately 37 connecting flights per day from Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.). Some common connection points include O'Hare Intl. (ORD), Denver Intl. (DEN), and Hartsfield-Jackson Atlanta Intl. (ATL).
What is the earliest flight from Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.)?
The earliest flight from Des Moines International Airport (DSM) to Jacksonville International Airport (JAX) typically departs around 5:00 AM local time. This flight is operated by American Airlines. This is a seasonal service, active in March and April. An early departure like this can help you make the most of your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.)?
You'll typically find the most flights from Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.) on a Friday, with around 27 flights available. This gives you a good selection of options for your travel plans. Major airlines on this route include American Airlines, United, and Delta. Fridays offer notably more flight options compared to other days of the week, making it a popular choice for travellers.
What are the most popular departure times for flights from Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.)?
The most popular departure times for flights from Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.) are in the early morning, from 6am to 9am. Many major carriers, including American Airlines, United and Delta, offer flights during this window. Many travellers prefer this because it allows for an early arrival at your destination, giving you more time to enjoy your day in Jacksonville.
How long does it take to fly from Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.)?
There are no nonstop flights from Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.). The distance between these two cities is approximately 1629 kilometres. Flights with one stop typically take around 5 hours 30 minutes. If you have two or more stops, your travel time will be longer, usually around 9 hours 18 minutes. Keep in mind that actual flight times can vary due to factors like routing, weather, and wind patterns.
Can you fly business or first class from Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.)?
First class cabins are available on Delta, United, and American Airlines.
How do I earn miles on a Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.) flight with Expedia?
It's easy to earn miles on a Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Jacksonville, FL (JAX) from Des Moines, IA (DSM)?
If you're planning to travel to Jacksonville from Des Moines Intl. (DSM), you can fly directly into Jacksonville Intl. (JAX). Some flights may connect through major hubs like O'Hare Intl. (ORD), Denver Intl. (DEN), or Lambert-St. Louis Intl. (STL) before reaching Jacksonville. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.) at the last minute?
Typically, booking a last minute flight from Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.) flight and hotel package?
Securing a Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.)?
If you booked your Des Moines, IA (DSM-Des Moines Intl.) to Jacksonville, FL (JAX-Jacksonville Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Des Moines Intl.
Destination airport
Jacksonville Intl.
Roundtrip price
CA $563
Distance
1619 km
Average flight time
2 hours 34 mins

Book with confidence

Des Moines to Jacksonville Flights

The easy way to book your flights from Des Moines to Jacksonville 

With Expedia, it’s simple to find and book flights to Jacksonville from Des Moines whether you’re traveling for business or pleasure. Enter your travel dates, hit search, and choose your flight from 20 airlines that cover this route. There are nonstop flights to Jacksonville Intl., too.  

Choose your preferred carrier and cabin class with the advanced search tool and select your ideal departure time. Then, if you want, you can see just nonstop or refundable flights. And if you’re traveling last minute, just enter the date to check out flights from Des Moines to Jacksonville today, tomorrow, or this week.  

 

Save dollars with cheap flights from Des Moines Intl., DSM to Jacksonville Intl., JAX 

Sort your search results by price to find great deals on your flight from Des Moines to Jacksonville—you get all your cheapest options first. Grab yourself a bargain now—the lowest price on flights to Jacksonville from Des Moines currently is just CA $563 rising to CA $683.  

Here are more money-saving tips: 

  • Fly in September when flight prices are normally at their lowest 
  • Book about a month to 6 weeks before you travel for the best prices to Jacksonville  
  • Avoid peak season and weekends when flights can cost more
  • Early morning and late-night flights are sometimes cheaper, so try varying your travel times 
  • One surefire way to save money on your flight is to book your flight and hotel together with Expedia. Sometimes, the savings are so large that the flight is basically free! 

 

Reasons to choose Expedia for your flight to Jacksonville from Des Moines 

Whatever your destination, budget, or reason to travel, in just one quick search, you can choose from loads of flights, airlines, and cabin classes. The filters make it quick and easy to find your ideal flights, and if you choose one of the flexible options, you won’t be charged to change your flight. So book your flight to Jacksonville with Expedia today.

Des Moines to Jacksonville Flights

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*Available to Expedia members.