Name: Cozy Cottage on Historic Route 66, minutes away from Wineries & Restaurants.
Price range: CA $105
Rating: 10

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Your St. James Vacation

Our vacation packages to St. James give you the power to customize your own adventure. Tailor your journey to your interests and style and make the most of your time in this lively city. Make your trip to St. James even more exciting by including some sightseeing. Maramec Spring Park, St. James Winery and Fall Creek Rock Shop are some of the leading attractions you'll want to explore. Whoever you're taking a break with and whatever you plan to spend, your dream St. James vacation is just a few clicks away with Expedia.

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St. James Hotel Deals

Greenlight Inn & Suites

110 N Outer Rd St. James MO

Fully refundableReserve now, pay when you stay

CA $94

CA $107 total

Jun 21 - Jun 22

includes taxes & fees

8.6/10 Excellent! (513 reviews)

"I was pleasantly surprised by this hotel. From the outside, it didn't look like anything special, but it exceeded my expectations in several ways. The check-in process was quick, easy, and the staff was friendly and welcoming. The room was very clean, comfortable, and well-maintained, which immediately ..."

Reviewed on Jun 13, 2026

Economy Inn

102 N Outer Rd St. James MO

Fully refundableReserve now, pay when you stay

CA $70

CA $79 total

Jun 15 - Jun 16

includes taxes & fees

8.2/10 Very Good! (495 reviews)

"It was a pleasant experience"

Reviewed on Jun 10, 2026

Cozy Cottage on Historic Route 66, minutes away from Wineries & Restaurants.

Saint James MO

CA $105

CA $225 total

Jun 16 - Jun 17

includes taxes & fees

10/10 Exceptional! (64 reviews)

"Great find in St. James! We really enjoyed our stay - the property was very centrally located and easy to find, immaculately clean and the water pressure was lovely. The kitchen was very well stocked which allowed us to cook meals during our stay and the laundry was perfect for our multi city trip. ..."

Reviewed on Jun 13, 2026

See all 211 properties in St. James

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.