Zona Sur
Santa Cruz
Visit Zona Sur
Things to do
4D/3N Expedition: Che Guevara Route - Disconnect from the World
CA $1,118
per adult
Samaipata Fort Tour: Ancient Ruins in 1 Full Day
CA $418
per adult
3D/2N Getaway on the Che Guevara Route Live the Adventure!
CA $978
per adult
Zona Sur Hotel Deals
Ibis Santa Cruz DE LA Sierra
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
The price is CA $59 per night from Oct 30 to Oct 31
CA $59
CA $59 total
Oct 30 - Oct 31
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
9.4/10 Exceptional! (156 reviews)
"Amazed with the breakfast area,small but plenty of good food. Room small but clean,need to improve in amenities like soaps and lotions. Overall this place will be a five star hotel for the bolivian standars."
Reviewed on Oct 18, 2026
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Ave. San Martin, #455 Santa Cruz
Fully refundable
The price is CA $189 per night from Nov 16 to Nov 17
CA $189
CA $189 total
Nov 16 - Nov 17
Book a stay at this spa hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions ...
9/10 Wonderful! (416 reviews)
"Perfect place while in Santa Cruz! Comfortable and relaxed setting. 100%"
Reviewed on Oct 18, 2026
Marriott Santa Cruz de la Sierra Hotel
4to Anillo Entre Radial 23 Santa Cruz Santa Cruz
The price is CA $148 per night from Nov 15 to Nov 16
CA $148
CA $148 total
Nov 15 - Nov 16
Book a stay at this luxury hotel in Santa Cruz. Enjoy free parking, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff in our reviews. ...
Novotel Santa Cruz De La Sierra
AV ROCA CORONADO 901 Santa Cruz
The price is CA $180 per night from Oct 31 to Nov 1
CA $180
CA $180 total
Oct 31 - Nov 1
Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Parque Ecológico and Patio Design LifeStyle ...
9/10 Wonderful! (132 reviews)
"Love staying there…. Very clean and staff always willing to assist."
Reviewed on Oct 21, 2026
Camino Real Hotel
Av. San Martín y 4to. Anillo Santa Cruz
The price is CA $195 per night from Nov 23 to Nov 24
CA $195
CA $195 total
Nov 23 - Nov 24
Book a stay at this luxury hotel in Santa Cruz. Enjoy free breakfast, a full-service spa, and 2 bars/lounges. Popular attractions Ventura Mall and Centro Cultural ...
Sun Hotel
Av. Banzer Km 13 Santa Cruz Santa Cruz
The price is CA $137 per night from Oct 30 to Oct 31
CA $137
CA $137 total
Oct 30 - Oct 31
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and free parking. Popular attraction Play Land Amusement Park is ...
8.2/10 Very good! (414 reviews)
"Clean rooms, nice soft bed the shower water was warm not hot. The breakfast buffet was pretty good, omelets, cereal, fruit, ham, cheese pancakes, rolls and muffins etc. Airport transportation was there waiting(contact them ahead of your arrival) and available every hour to return."
Reviewed on Oct 19, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Zona Sur
Find the best Zona Sur areas and neighborhoods for the activities you enjoy most. Learn more about Zona Sur
Learn more about Zona Sur
Equipetrol
Though Equipetrol might not have many top sights, you can venture to the surrounding area to see attractions like Santa Cruz Zoo and Municipal Library.
Centro Histórico
If you're spending some time in Centro Histórico, Plaza 24 de Septiembre and La Recova Artisan Walk are top sights worth seeing.
Hamacas
While Hamacas isn't home to many top sights, Las Brisas Shopping Center and Santa Cruz Zoo are some notable places to visit nearby.
Urubó
While Urubó might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Guembe Biocenter and Ventura Mall.
