Title: 10 Best Hotels in Santa Ana, Antigua Guatemala for 2026 | Expedia.ca

[Vacation Rentals in Antigua Guatemala](https://expedia.ca/Antigua-Guatemala-Vacation-Rentals.d180589.Travel-Guide-VacationRentals)[Flights to Antigua Guatemala](https://expedia.ca/Cheap-Flights-To-Antigua-Guatemala.d180589.Travel-Guide-Flights)[Things to do in Antigua Guatemala](https://expedia.ca/Things-To-Do-In-Antigua-Guatemala.d180589.Travel-Guide-Activities)[Santa Ana Car Rentals](https://expedia.ca/Car-Rentals-In-Santa-Ana.d553248635975847775.Car-Rental-Guide)[Santa Ana Vacations](https://expedia.ca/Santa-Ana.d553248635975847775.Destination-Travel-Guides)

![Iglesia de Nuestra Señora de Santa Ana, aldea Santa Ana en Antigua Guatemala.](https://images.trvl-media.com/place/553248635975847775/dbfc8e66-dcda-4ff9-9ea4-b39c7cec35ab.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/553248635975847775/dbfc8e66-dcda-4ff9-9ea4-b39c7cec35ab.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg)  
###  
Change your mind  
Book hotels with free cancellation
- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg)  
###  
Treat yourself  
Sign in to save 10% or more on thousands of hotels  
[Sign in](https://www.expedia.ca/login)
- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg)  
###  
Be picky  
Search almost a million properties worldwide

## Check prices for these dates

Tonight

[Jan 30 - Jan 31](https://www.expedia.ca/Hotel-Search?regionId=553248635975847775&startDate=2026-01-30&endDate=2026-01-31&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Jan 31 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=553248635975847775&startDate=2026-01-31&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=553248635975847775&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=553248635975847775&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Recommended

Price (low to high)

Distance

Star rating

## Our top choices for Santa Ana hotels

![Front of property](https://images.trvl-media.com/lodging/92000000/91820000/91818800/91818768/5ec870c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/92000000/91820000/91818800/91818768/2c2e8198.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Balcony view](https://images.trvl-media.com/lodging/92000000/91820000/91818800/91818768/6642638c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/92000000/91820000/91818800/91818768/1914e3c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Casa Buho B&B

[](https://www.expedia.ca/Antigua-Guatemala-Hotels-Casa-Buho-BB.h91818768.Hotel-Information)

Santa Ana

9.2/10

Wonderful

(49 reviews)

"Great place !!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Abner Israel Polanco

CA $73

CA $88 total

includes taxes & fees

Feb 7 - Feb 8

[](https://www.expedia.ca/Antigua-Guatemala-Hotels-Casa-Buho-BB.h91818768.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/37000000/36160000/36156100/36156032/7941cd12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![4 bedrooms, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/37000000/36160000/36156100/36156032/ba9c9f7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Flat-screen TV, DVD player](https://images.trvl-media.com/lodging/37000000/36160000/36156100/36156032/a433c511.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Food court](https://images.trvl-media.com/lodging/37000000/36160000/36156100/36156032/ccc0a892.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Villas Santa Ana-Ricardo

[](https://www.expedia.ca/Antigua-Guatemala-Hotels-Villas-Santa-Ana-Ricardo.h36156032.Hotel-Information)

Santa Ana

8.6/10

Excellent

(12 reviews)

"Space was clean and had a cozy vibe."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Evelin

[](https://www.expedia.ca/Antigua-Guatemala-Hotels-Villas-Santa-Ana-Ricardo.h36156032.Hotel-Information)

![Garden view](https://images.trvl-media.com/lodging/92000000/91820000/91818300/91818295/4afb3fa6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Double Room, Balcony, Mountain View](https://images.trvl-media.com/lodging/92000000/91820000/91818300/91818295/72ed609c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property - evening/night](https://images.trvl-media.com/lodging/92000000/91820000/91818300/91818295/1a5632cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Twin Room, Balcony, City View](https://images.trvl-media.com/lodging/92000000/91820000/91818300/91818295/f4dd18dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hostal Casa Buho

[](https://www.expedia.ca/Antigua-Guatemala-Hotels-Hostal-Casa-Buho.h91818295.Hotel-Information)

Santa Ana

8.6/10

Excellent

(22 reviews)

"A little too far from everything but as long as you have a car is ok plenty of parking there"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Gustavo

CA $58

CA $73 total

includes taxes & fees

Mar 3 - Mar 4

[](https://www.expedia.ca/Antigua-Guatemala-Hotels-Hostal-Casa-Buho.h91818295.Hotel-Information)

![Garden](https://images.trvl-media.com/lodging/1000000/200000/199700/199610/52dae80b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/1000000/200000/199700/199610/642ec35f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Aerial view](https://images.trvl-media.com/lodging/1000000/200000/199700/199610/50216c27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/1000000/200000/199700/199610/b33c45f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hilton Guatemala City

[](https://www.expedia.ca/Guatemala-City-Hotels-Hilton-Guatemala-City.h199610.Hotel-Information)

25.9 km from Santa Ana

8.6/10

Excellent

(695 reviews)

"The hotel property in excellent condition and very quiet and safe."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Roger

CA $201

CA $245 total

includes taxes & fees

Mar 1 - Mar 2

[](https://www.expedia.ca/Guatemala-City-Hotels-Hilton-Guatemala-City.h199610.Hotel-Information)

![View from property](https://images.trvl-media.com/lodging/20000000/19760000/19751700/19751602/11511f6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/20000000/19760000/19751700/19751602/cd0d6a08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/20000000/19760000/19751700/19751602/72379712.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![46-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/20000000/19760000/19751700/19751602/13c5f80a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### AC Hotel by Marriott Guatemala City

[](https://www.expedia.ca/Guatemala-City-Hotels-AC-Hotel-By-Marriott-Guatemala-City.h19751602.Hotel-Information)

26.4 km from Santa Ana

8.6/10

Excellent

(1,001 reviews)

"Beautiful place!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Beth

CA $159

CA $194 total

includes taxes & fees

Feb 28 - Mar 1

[](https://www.expedia.ca/Guatemala-City-Hotels-AC-Hotel-By-Marriott-Guatemala-City.h19751602.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/46000000/45710000/45706700/45706673/f6e36ba7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Presidential Suite | Living area](https://images.trvl-media.com/lodging/46000000/45710000/45706700/45706673/743b34a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/46000000/45710000/45706700/45706673/0597268e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/46000000/45710000/45706700/45706673/678c108c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Vista Quince

[](https://www.expedia.ca/Guatemala-City-Hotels-Hotel-Vista-Quince.h45706673.Hotel-Information)

25.5 km from Santa Ana

8.6/10

Excellent

(236 reviews)

"Staff very pleasant and service oriented "

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

osbin

CA $202

CA $247 total

includes taxes & fees

Feb 3 - Feb 4

[](https://www.expedia.ca/Guatemala-City-Hotels-Hotel-Vista-Quince.h45706673.Hotel-Information)

![Restaurant](https://images.trvl-media.com/lodging/74000000/73580000/73570300/73570287/0af94433.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/74000000/73580000/73570300/73570287/4fb054a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/74000000/73580000/73570300/73570287/8f358ec2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium Studio](https://images.trvl-media.com/lodging/74000000/73580000/73570300/73570287/1dd2bd22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Villas Santander - Deluxe Stay

[](https://www.expedia.ca/Guatemala-City-Hotels-Villas-Santander-Deluxe-Stay.h73570287.Hotel-Information)

24.7 km from Santa Ana

7.4/10

Good

(230 reviews)

"The balcony view was a little scenic. Enjoyed how clean the rooms were "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Rosa

CA $47

CA $58 total

includes taxes & fees

Mar 1 - Mar 2

[](https://www.expedia.ca/Guatemala-City-Hotels-Villas-Santander-Deluxe-Stay.h73570287.Hotel-Information)

![Flat-screen TV](https://images.trvl-media.com/lodging/35000000/34730000/34724000/34723956/384072e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shower, towels, soap, shampoo](https://images.trvl-media.com/lodging/35000000/34730000/34724000/34723956/fd32dee5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/35000000/34730000/34724000/34723956/f37f0169.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Mini-fridge](https://images.trvl-media.com/lodging/35000000/34730000/34724000/34723956/63da5faa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Casa Mesa

[](https://www.expedia.ca/Guatemala-City-Hotels-Casa-Mesa.h34723956.Hotel-Information)

24.2 km from Santa Ana

8.6/10

Excellent

(35 reviews)

"Very good option for staying "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Adrian

CA $53

CA $66 total

includes taxes & fees

Feb 2 - Feb 3

[](https://www.expedia.ca/Guatemala-City-Hotels-Casa-Mesa.h34723956.Hotel-Information)

![Restaurant](https://images.trvl-media.com/lodging/108000000/107890000/107887500/107887467/dc9c1153.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/108000000/107890000/107887500/107887467/bc5e1e4c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Superior Room](https://images.trvl-media.com/lodging/108000000/107890000/107887500/107887467/bbd65795.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/108000000/107890000/107887500/107887467/a14d6810.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Villa Sicilia

[](https://www.expedia.ca/Guatemala-City-Hotels-Villa-Sicilia.h107887467.Hotel-Information)

24 km from Santa Ana

7.8/10

Good

(82 reviews)

"Everything was as advertised and good location "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jimmy

CA $37

CA $46 total

includes taxes & fees

Mar 3 - Mar 4

[](https://www.expedia.ca/Guatemala-City-Hotels-Villa-Sicilia.h107887467.Hotel-Information)

![Bar (on property)](https://images.trvl-media.com/lodging/29000000/28800000/28799600/28799554/7b58434e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property - evening/night](https://images.trvl-media.com/lodging/29000000/28800000/28799600/28799554/4243133c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Triple Room, Multiple Beds, Non Smoking](https://images.trvl-media.com/lodging/29000000/28800000/28799600/28799554/211dcc78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/29000000/28800000/28799600/28799554/2af7d80f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Ever Green Hotel

[](https://www.expedia.ca/Guatemala-City-Hotels-Ever-Green-Hotel.h28799554.Hotel-Information)

23.8 km from Santa Ana

8.8/10

Excellent

(70 reviews)

"Great room, nice location and decent complimentary breakfast. We would stay again. Great value"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Rony

[](https://www.expedia.ca/Guatemala-City-Hotels-Ever-Green-Hotel.h28799554.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480260/8beecce3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480260/aa4fc002.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480260/b4ca8240.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480260/6ca6bf74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Inmaculada Hotel

[](https://www.expedia.ca/Guatemala-City-Hotels-La-Inmaculada.h4480260.Hotel-Information)

23.7 km from Santa Ana

9.2/10

Wonderful

(618 reviews)

"Great staff, convenient location, hotel has everything it offers."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Colin

[](https://www.expedia.ca/Guatemala-City-Hotels-La-Inmaculada.h4480260.Hotel-Information)

![Hallway](https://images.trvl-media.com/lodging/10000000/9800000/9794400/9794391/47cb945c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/10000000/9800000/9794400/9794391/b95b0376.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior entrance](https://images.trvl-media.com/lodging/10000000/9800000/9794400/9794391/55234dae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/10000000/9800000/9794400/9794391/caa32b45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Ciudad Vieja

[](https://www.expedia.ca/Guatemala-City-Hotels-Hotel-Ciudad-Vieja.h9794391.Hotel-Information)

23.7 km from Santa Ana

9.2/10

Wonderful

(224 reviews)

"Great secure location near restaurants. Very quiet and great breakfast choices. Staff were attentive and arranged for taxis and an airport pickup."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Stephen

[](https://www.expedia.ca/Guatemala-City-Hotels-Hotel-Ciudad-Vieja.h9794391.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/16000000/15970000/15965300/15965234/2e158139.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/16000000/15970000/15965300/15965234/f9d884d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/16000000/15970000/15965300/15965234/a365a263.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior entrance](https://images.trvl-media.com/lodging/16000000/15970000/15965300/15965234/4d595efb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Meraki Boutique Hotel

[](https://www.expedia.ca/Guatemala-City-Hotels-Meraki-Boutique-Hotel.h15965234.Hotel-Information)

23.4 km from Santa Ana

9.0/10

Wonderful

(411 reviews)

"Cute hotel, comfortable room, and kind staff. Its in a great location too. We will be staying here again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Elizabeth

CA $105

CA $128 total

includes taxes & fees

Feb 21 - Feb 22

[](https://www.expedia.ca/Guatemala-City-Hotels-Meraki-Boutique-Hotel.h15965234.Hotel-Information)

![Free daily full breakfast](https://images.trvl-media.com/lodging/5000000/4200000/4199400/4199381/f3b90b0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/5000000/4200000/4199400/4199381/f6af0001.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/5000000/4200000/4199400/4199381/eade1d7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Executive Room, Kitchenette](https://images.trvl-media.com/lodging/5000000/4200000/4199400/4199381/3b9a15f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Santander Plaza

[](https://www.expedia.ca/Guatemala-City-Hotels-Hotel-Santander-Plaza.h4199381.Hotel-Information)

23.3 km from Santa Ana

8.2/10

Very good

(572 reviews)

"Breakfast was delicious with a lot of options to choose, staff very kind good service "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Monica

CA $133

CA $162 total

includes taxes & fees

Feb 4 - Feb 5

[](https://www.expedia.ca/Guatemala-City-Hotels-Hotel-Santander-Plaza.h4199381.Hotel-Information)

![Breakfast, lunch, dinner served; international cuisine, garden views ](https://images.trvl-media.com/lodging/1000000/30000/27900/27811/2f64c7c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, Multiple Beds, Non Smoking (VIP Floor)](https://images.trvl-media.com/lodging/1000000/30000/27900/27811/ce1d9853.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Serves lunch, dinner, and happy hour](https://images.trvl-media.com/lodging/1000000/30000/27900/27811/ceef98f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/27900/27811/f29bc6f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Clarion Suites Guatemala City

[](https://www.expedia.ca/Guatemala-City-Hotels-Clarion-Suites-Guatemala-City.h27811.Hotel-Information)

23.3 km from Santa Ana

9.2/10

Wonderful

(1,006 reviews)

"Great location, good size room, very helpful staff."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Hugo

CA $150

CA $183 total

includes taxes & fees

Feb 27 - Feb 28

[](https://www.expedia.ca/Guatemala-City-Hotels-Clarion-Suites-Guatemala-City.h27811.Hotel-Information)

![Garden](https://images.trvl-media.com/lodging/75000000/74650000/74641700/74641639/29a47aac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/75000000/74650000/74641700/74641639/5bb7bed4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/75000000/74650000/74641700/74641639/217fd81a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior detail](https://images.trvl-media.com/lodging/75000000/74650000/74641700/74641639/e0906945.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Good Hotel Guatemala City

[](https://www.expedia.ca/Guatemala-City-Hotels-Good-Hotel-Guatemala-City.h74641639.Hotel-Information)

23.9 km from Santa Ana

9.4/10

Exceptional

(275 reviews)

"Really liked this location is great "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Malika

CA $156

CA $191 total

includes taxes & fees

Mar 2 - Mar 3

[](https://www.expedia.ca/Guatemala-City-Hotels-Good-Hotel-Guatemala-City.h74641639.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/20000000/19320000/19317600/19317570/443e134d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/20000000/19320000/19317600/19317570/5a710f41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bars/lounges, poolside bar](https://images.trvl-media.com/lodging/20000000/19320000/19317600/19317570/4f464bef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/20000000/19320000/19317600/19317570/ac35c64b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hyatt Centric Guatemala City

[](https://www.expedia.ca/Guatemala-City-Hotels-Hyatt-Centric-Guatemala-City.h19317570.Hotel-Information)

23.3 km from Santa Ana

9.6/10

Exceptional

(828 reviews)

"Great location. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Christian

CA $205

CA $250 total

includes taxes & fees

Feb 28 - Mar 1

[](https://www.expedia.ca/Guatemala-City-Hotels-Hyatt-Centric-Guatemala-City.h19317570.Hotel-Information)

![View from property](https://images.trvl-media.com/lodging/1000000/900000/898800/898717/4d4a4357.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast, lunch, dinner served; Italian cuisine ](https://images.trvl-media.com/lodging/1000000/900000/898800/898717/4ccbd159.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/900000/898800/898717/641dbe3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/1000000/900000/898800/898717/e3d83327.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Plus Hotel Stofella

[](https://www.expedia.ca/Guatemala-City-Hotels-Best-Western-Plus-Hotel-Stofella.h898717.Hotel-Information)

23.3 km from Santa Ana

8.8/10

Excellent

(1,001 reviews)

"Great breakfast buffet"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Loyell

CA $127

CA $155 total

includes taxes & fees

Feb 21 - Feb 22

[](https://www.expedia.ca/Guatemala-City-Hotels-Best-Western-Plus-Hotel-Stofella.h898717.Hotel-Information)

![4 restaurants, breakfast, lunch, dinner served; international cuisine](https://images.trvl-media.com/lodging/1000000/560000/558200/558105/2667faa0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room dining](https://images.trvl-media.com/lodging/1000000/560000/558200/558105/9d0818a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![4 restaurants, breakfast, lunch, dinner served; international cuisine](https://images.trvl-media.com/lodging/1000000/560000/558200/558105/44052a3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![4 restaurants, breakfast, lunch, dinner served; international cuisine](https://images.trvl-media.com/lodging/1000000/560000/558200/558105/16df8b19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### InterContinental Real Guatemala by IHG

[](https://www.expedia.ca/Guatemala-City-Hotels-Real-InterContinental-Guatemala.h558105.Hotel-Information)

23.2 km from Santa Ana

9.2/10

Wonderful

(1,002 reviews)

"Very nice room and service was great! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Henry

CA $214

CA $278 total

includes taxes & fees

Feb 15 - Feb 16

[](https://www.expedia.ca/Guatemala-City-Hotels-Real-InterContinental-Guatemala.h558105.Hotel-Information)

![Superior Double Room](https://images.trvl-media.com/lodging/1000000/60000/53200/53194/334ae02e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/60000/53200/53194/e619ca3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Twin Room | In-room dining](https://images.trvl-media.com/lodging/1000000/60000/53200/53194/31f3861d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/60000/53200/53194/91881a9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Royal Palace

[](https://www.expedia.ca/Guatemala-City-Hotels-Hotel-Royal-Palace.h53194.Hotel-Information)

24.5 km from Santa Ana

8.2/10

Very good

(149 reviews)

"The hotel is well located there is a lot of stores and restaurants with in a walking distance."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

luis

CA $124

CA $152 total

includes taxes & fees

Feb 3 - Feb 4

[](https://www.expedia.ca/Guatemala-City-Hotels-Hotel-Royal-Palace.h53194.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-14&endDate=2026-02-15&regionId=553248635975847775&adults=2&sort=RECOMMENDED&openPlayBack=true)

## Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. 

- Historic Center
- Barrio de La Concepción

![](https://mediaim.expedia.com/destination/1/74ddc5a8bc392ba990ada31c1bf76007.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://mediaim.expedia.com/destination/1/bd4f4cf2ac6696e4d9dd7a1c5261170e.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://mediaim.expedia.com/destination/1/b494c5622ebb15c1dd7e91ce76ce75f2.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://mediaim.expedia.com/destination/1/3d9e1f30df3a11ff4ad43007765de7e3.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://mediaim.expedia.com/destination/1/b2651b17b5e3f38b232fea61824aba4c.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=911355684795535360)

![Historic Center map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:o%7EzwAthyhPXoK_%40%7Di%40ri%40a%40j%40fv%40yj%40f%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=r_Zy9R--c8e6nlgWjV2_dDRw1Is=)

### Historic Center

While visiting Historic Center, you might make a stop by sights like Central Park and Santa Catalina Arch. 

[See properties](https://www.expedia.ca/Hotel-Search?regionId=911355684795535360)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=911356092010033152)

![Barrio de La Concepción map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:mqzwAlqwhPIwL%60E%7DHfFdBW%60SgKL&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=Z_eq5PTC3hcK7WdhMP04Ad5umoE=)

### Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum. 

[See properties](https://www.expedia.ca/Hotel-Search?regionId=911356092010033152)

## Top Santa Ana Hotel Reviews

![Barceló Guatemala City](https://images.trvl-media.com/lodging/1000000/10000/2500/2495/78fae458_y.jpg)

### Barceló Guatemala City

10/10 Excellent

"Clean rooms. Very friendly and helpful staff. Super comfy beds as well! "

[](https://expedia.ca/Guatemala-City-Hotels-Barcelo-Guatemala-City.h2495.Hotel-Information)

![Hotel Las Americas](https://images.trvl-media.com/lodging/18000000/17410000/17403700/17403610/111c1f7f_y.jpg)

### Hotel Las Americas

10/10 Excellent

"Good "

[](https://expedia.ca/Guatemala-City-Hotels-Hotel-Las-Americas.h17403610.Hotel-Information)

![Hotel Biltmore Guatemala](https://images.trvl-media.com/lodging/2000000/1400000/1397600/1397563/1b77a837_y.jpg)

### Hotel Biltmore Guatemala

10/10 Excellent

"Very nice they allowed an early check in great service and room service served from westin delicious burger and chicken kieve"

[](https://expedia.ca/Guatemala-City-Hotels-Hotel-Biltmore-Guatemala.h1397563.Hotel-Information)

![Hotel Posada de Don Rodrigo Antigua](https://images.trvl-media.com/lodging/4000000/3950000/3949000/3948905/058db2db_y.jpg)

### Hotel Posada de Don Rodrigo Antigua

10/10 Excellent

"The location was good and the courtyard was amazing "

[](https://expedia.ca/Antigua-Guatemala-Hotels-Hotel-Posada-De-Don-Rodrigo-Antigua.h3948905.Hotel-Information)

![Wyndham Garden Guatemala City](https://images.trvl-media.com/lodging/1000000/30000/26600/26567/449c3cd0_y.jpg)

### Wyndham Garden Guatemala City

10/10 Excellent

"Amazing "

[](https://expedia.ca/Guatemala-City-Hotels-Wyndham-Garden-Guatemala-City.h26567.Hotel-Information)

![Hotel Museo Spa Casa Santo Domingo](https://images.trvl-media.com/lodging/2000000/1250000/1246600/1246555/20929971_y.jpg)

### Hotel Museo Spa Casa Santo Domingo

10/10 Excellent

"Amazing property beautiful views and grounds large spacious room w a jacuzzi! Lovely staff and restaurant i wish i had more time in antigua and could check out the spa! Ill be back and stay here again "

[](https://expedia.ca/Antigua-Guatemala-Hotels-Hotel-Museo-Spa-Casa-Santo-Domingo.h1246555.Hotel-Information)

![Tikal Futura Hotel & Convention Center](https://images.trvl-media.com/lodging/1000000/50000/48600/48502/11a701a2_y.jpg)

### Tikal Futura Hotel & Convention Center

10/10 Excellent

"Beautiful place to stay with amazing views! "

[](https://expedia.ca/Guatemala-City-Hotels-Grand-Tikal-Futura-Hotel.h48502.Hotel-Information)

![Adriatika Hotel & Residence](https://images.trvl-media.com/lodging/9000000/8340000/8336300/8336251/98bd4948_y.jpg)

### Adriatika Hotel & Residence

10/10 Excellent

"everything is great"

[](https://expedia.ca/Guatemala-City-Hotels-Adriatika-Hotel-Boutique.h8336251.Hotel-Information)

![Clarion Suites Guatemala City](https://images.trvl-media.com/lodging/1000000/30000/27900/27811/e487f2b2_y.jpg)

### Clarion Suites Guatemala City

10/10 Excellent

"Great room immaculate "

[](https://expedia.ca/Guatemala-City-Hotels-Clarion-Suites-Guatemala-City.h27811.Hotel-Information)

## Frequently asked questions

### What's it like in Santa Ana?

### What's a favorite hotel to stay in Santa Ana?

### How many hotels will I be able to find in Santa Ana?

### If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?

### What are the top things to see and do in Santa Ana?