Title: 10 Best Hotels in Santa Ana, Antigua Guatemala for 2026 | Expedia.ca

[Vacation Rentals in Antigua Guatemala](https://expedia.ca/Antigua-Guatemala-Vacation-Rentals.d180589.Travel-Guide-VacationRentals)[Flights to Antigua Guatemala](https://expedia.ca/Cheap-Flights-To-Antigua-Guatemala.d180589.Travel-Guide-Flights)[Things to do in Antigua Guatemala](https://expedia.ca/Things-To-Do-In-Antigua-Guatemala.d180589.Travel-Guide-Activities)[Santa Ana Car Rentals](https://expedia.ca/Car-Rentals-In-Santa-Ana.d553248635975847775.Car-Rental-Guide)[Santa Ana Vacations](https://expedia.ca/Santa-Ana.d553248635975847775.Destination-Travel-Guides)

![Iglesia de Nuestra Señora de Santa Ana, aldea Santa Ana en Antigua Guatemala.](https://images.trvl-media.com/place/553248635975847775/dbfc8e66-dcda-4ff9-9ea4-b39c7cec35ab.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/553248635975847775/dbfc8e66-dcda-4ff9-9ea4-b39c7cec35ab.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg)  
###  
Change your mind  
Book hotels with free cancellation
- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg)  
###  
Treat yourself  
Sign in to save 10% or more on thousands of hotels  
[Sign in](https://www.expedia.ca/login)
- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg)  
###  
Be picky  
Search almost a million properties worldwide

## Check prices for these dates

Tonight

[Feb 2 - Feb 3](https://www.expedia.ca/Hotel-Search?regionId=553248635975847775&startDate=2026-02-02&endDate=2026-02-03&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Feb 3 - Feb 4](https://www.expedia.ca/Hotel-Search?regionId=553248635975847775&startDate=2026-02-03&endDate=2026-02-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=553248635975847775&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Feb 13 - Feb 15](https://www.expedia.ca/Hotel-Search?regionId=553248635975847775&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Recommended

Price (low to high)

Distance

Star rating

## Our top choices for Santa Ana hotels

![Front of property](https://images.trvl-media.com/lodging/92000000/91820000/91818800/91818768/5ec870c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Balcony view](https://images.trvl-media.com/lodging/92000000/91820000/91818800/91818768/6642638c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Courtyard](https://images.trvl-media.com/lodging/92000000/91820000/91818800/91818768/2499f453.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/92000000/91820000/91818800/91818768/1914e3c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Casa Buho B&B

[](https://www.expedia.ca/Antigua-Guatemala-Hotels-Casa-Buho-BB.h91818768.Hotel-Information)

Santa Ana

9.2/10

Wonderful

(49 reviews)

"Great place !!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Abner Israel Polanco

CA $73

CA $89 total

includes taxes & fees

Feb 4 - Feb 5

[](https://www.expedia.ca/Antigua-Guatemala-Hotels-Casa-Buho-BB.h91818768.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/37000000/36160000/36156100/36156032/7941cd12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![4 bedrooms, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/37000000/36160000/36156100/36156032/ba9c9f7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Family Villa, 4 Bedrooms | Terrace/patio](https://images.trvl-media.com/lodging/37000000/36160000/36156100/36156032/39c1518b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Flat-screen TV, DVD player](https://images.trvl-media.com/lodging/37000000/36160000/36156100/36156032/a433c511.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Villas Santa Ana-Ricardo

[](https://www.expedia.ca/Antigua-Guatemala-Hotels-Villas-Santa-Ana-Ricardo.h36156032.Hotel-Information)

Santa Ana

8.6/10

Excellent

(12 reviews)

"Space was clean and had a cozy vibe."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Evelin

[](https://www.expedia.ca/Antigua-Guatemala-Hotels-Villas-Santa-Ana-Ricardo.h36156032.Hotel-Information)

![Garden view](https://images.trvl-media.com/lodging/92000000/91820000/91818300/91818295/4afb3fa6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Twin Room, Balcony, City View](https://images.trvl-media.com/lodging/92000000/91820000/91818300/91818295/f4dd18dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Basic Single Room, 1 Single Bed (Buho 3)](https://images.trvl-media.com/lodging/92000000/91820000/91818300/91818295/2ee1db3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property - evening/night](https://images.trvl-media.com/lodging/92000000/91820000/91818300/91818295/1a5632cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hostal Casa Buho

[](https://www.expedia.ca/Antigua-Guatemala-Hotels-Hostal-Casa-Buho.h91818295.Hotel-Information)

Santa Ana

8.6/10

Excellent

(22 reviews)

"A little too far from everything but as long as you have a car is ok plenty of parking there"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Gustavo

CA $59

CA $74 total

includes taxes & fees

Feb 23 - Feb 24

[](https://www.expedia.ca/Antigua-Guatemala-Hotels-Hostal-Casa-Buho.h91818295.Hotel-Information)

![Garden](https://images.trvl-media.com/lodging/1000000/200000/199700/199610/52dae80b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/1000000/200000/199700/199610/2e2e9d46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/1000000/200000/199700/199610/b33c45f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Aerial view](https://images.trvl-media.com/lodging/1000000/200000/199700/199610/50216c27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hilton Guatemala City

[](https://www.expedia.ca/Guatemala-City-Hotels-Hilton-Guatemala-City.h199610.Hotel-Information)

25.9 km from Santa Ana

8.6/10

Excellent

(696 reviews)

"The hotel property in excellent condition and very quiet and safe."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Roger

CA $198

CA $241 total

includes taxes & fees

Mar 1 - Mar 2

[](https://www.expedia.ca/Guatemala-City-Hotels-Hilton-Guatemala-City.h199610.Hotel-Information)

![View from property](https://images.trvl-media.com/lodging/20000000/19760000/19751700/19751602/11511f6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![46-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/20000000/19760000/19751700/19751602/13c5f80a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/20000000/19760000/19751700/19751602/cd0d6a08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/20000000/19760000/19751700/19751602/72379712.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### AC Hotel by Marriott Guatemala City

[](https://www.expedia.ca/Guatemala-City-Hotels-AC-Hotel-By-Marriott-Guatemala-City.h19751602.Hotel-Information)

26.4 km from Santa Ana

8.6/10

Excellent

(1,005 reviews)

"Beautiful place!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Beth

CA $161

CA $196 total

includes taxes & fees

Feb 20 - Feb 21

[](https://www.expedia.ca/Guatemala-City-Hotels-AC-Hotel-By-Marriott-Guatemala-City.h19751602.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/46000000/45710000/45706700/45706673/f6e36ba7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, open 8:00 AM to 10:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/46000000/45710000/45706700/45706673/589a4c1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/46000000/45710000/45706700/45706673/678c108c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/46000000/45710000/45706700/45706673/0597268e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Vista Quince

[](https://www.expedia.ca/Guatemala-City-Hotels-Hotel-Vista-Quince.h45706673.Hotel-Information)

25.5 km from Santa Ana

8.6/10

Excellent

(236 reviews)

"Staff very pleasant and service oriented "

![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg)

osbin

CA $204

CA $249 total

includes taxes & fees

Feb 3 - Feb 4

[](https://www.expedia.ca/Guatemala-City-Hotels-Hotel-Vista-Quince.h45706673.Hotel-Information)

![Restaurant](https://images.trvl-media.com/lodging/74000000/73580000/73570300/73570287/0af94433.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/74000000/73580000/73570300/73570287/8f358ec2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/74000000/73580000/73570300/73570287/4fb054a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium Studio](https://images.trvl-media.com/lodging/74000000/73580000/73570300/73570287/1dd2bd22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Villas Santander - Deluxe Stay

[](https://www.expedia.ca/Guatemala-City-Hotels-Villas-Santander-Deluxe-Stay.h73570287.Hotel-Information)

24.7 km from Santa Ana

7.4/10

Good

(231 reviews)

"The balcony view was a little scenic. Enjoyed how clean the rooms were "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Rosa

CA $48

CA $58 total

includes taxes & fees

Feb 3 - Feb 4

[](https://www.expedia.ca/Guatemala-City-Hotels-Villas-Santander-Deluxe-Stay.h73570287.Hotel-Information)

![Flat-screen TV](https://images.trvl-media.com/lodging/35000000/34730000/34724000/34723956/384072e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/35000000/34730000/34724000/34723956/f37f0169.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Comfort Single Room, 5 Bedrooms](https://images.trvl-media.com/lodging/35000000/34730000/34724000/34723956/67f13e40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Mini-fridge](https://images.trvl-media.com/lodging/35000000/34730000/34724000/34723956/63da5faa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Casa Mesa

[](https://www.expedia.ca/Guatemala-City-Hotels-Casa-Mesa.h34723956.Hotel-Information)

24.2 km from Santa Ana

8.6/10

Excellent

(36 reviews)

"Very good option for staying "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Adrian

CA $53

CA $66 total

includes taxes & fees

Feb 5 - Feb 6

[](https://www.expedia.ca/Guatemala-City-Hotels-Casa-Mesa.h34723956.Hotel-Information)

![Restaurant](https://images.trvl-media.com/lodging/108000000/107890000/107887500/107887467/dc9c1153.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/108000000/107890000/107887500/107887467/ec2dd167.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/108000000/107890000/107887500/107887467/bc5e1e4c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Superior Room](https://images.trvl-media.com/lodging/108000000/107890000/107887500/107887467/bbd65795.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Villa Sicilia

[](https://www.expedia.ca/Guatemala-City-Hotels-Villa-Sicilia.h107887467.Hotel-Information)

24 km from Santa Ana

7.8/10

Good

(82 reviews)

"Everything was as advertised and good location "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jimmy

CA $38

CA $47 total

includes taxes & fees

Mar 4 - Mar 5

[](https://www.expedia.ca/Guatemala-City-Hotels-Villa-Sicilia.h107887467.Hotel-Information)

![Bar (on property)](https://images.trvl-media.com/lodging/29000000/28800000/28799600/28799554/7b58434e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/29000000/28800000/28799600/28799554/2af7d80f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room amenity](https://images.trvl-media.com/lodging/29000000/28800000/28799600/28799554/81a7b00d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property - evening/night](https://images.trvl-media.com/lodging/29000000/28800000/28799600/28799554/4243133c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Ever Green Hotel

[](https://www.expedia.ca/Guatemala-City-Hotels-Ever-Green-Hotel.h28799554.Hotel-Information)

23.8 km from Santa Ana

8.8/10

Excellent

(70 reviews)

"Great room, nice location and decent complimentary breakfast. We would stay again. Great value"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Rony

[](https://www.expedia.ca/Guatemala-City-Hotels-Ever-Green-Hotel.h28799554.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480260/8beecce3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480260/6ca6bf74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480260/aa4fc002.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480260/b4ca8240.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Inmaculada Hotel

[](https://www.expedia.ca/Guatemala-City-Hotels-La-Inmaculada.h4480260.Hotel-Information)

23.7 km from Santa Ana

9.2/10

Wonderful

(618 reviews)

"Great staff, convenient location, hotel has everything it offers."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Colin

CA $124

CA $151 total

includes taxes & fees

Feb 4 - Feb 5

[](https://www.expedia.ca/Guatemala-City-Hotels-La-Inmaculada.h4480260.Hotel-Information)

![Hallway](https://images.trvl-media.com/lodging/10000000/9800000/9794400/9794391/47cb945c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Double Room, 1 Bedroom, Courtyard View](https://images.trvl-media.com/lodging/10000000/9800000/9794400/9794391/650d816a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/10000000/9800000/9794400/9794391/b95b0376.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior entrance](https://images.trvl-media.com/lodging/10000000/9800000/9794400/9794391/55234dae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Ciudad Vieja

[](https://www.expedia.ca/Guatemala-City-Hotels-Hotel-Ciudad-Vieja.h9794391.Hotel-Information)

23.7 km from Santa Ana

9.2/10

Wonderful

(224 reviews)

"Great secure location near restaurants. Very quiet and great breakfast choices. Staff were attentive and arranged for taxis and an airport pickup."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Stephen

CA $110

CA $135 total

includes taxes & fees

Mar 1 - Mar 2

[](https://www.expedia.ca/Guatemala-City-Hotels-Hotel-Ciudad-Vieja.h9794391.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/16000000/15970000/15965300/15965234/2e158139.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily cooked-to-order breakfast](https://images.trvl-media.com/lodging/16000000/15970000/15965300/15965234/c1510ee0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior entrance](https://images.trvl-media.com/lodging/16000000/15970000/15965300/15965234/4d595efb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/16000000/15970000/15965300/15965234/a365a263.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Meraki Boutique Hotel

[](https://www.expedia.ca/Guatemala-City-Hotels-Meraki-Boutique-Hotel.h15965234.Hotel-Information)

23.4 km from Santa Ana

9.0/10

Wonderful

(412 reviews)

"Cute hotel, comfortable room, and kind staff. Its in a great location too. We will be staying here again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Elizabeth

CA $105

CA $128 total

includes taxes & fees

Feb 21 - Feb 22

[](https://www.expedia.ca/Guatemala-City-Hotels-Meraki-Boutique-Hotel.h15965234.Hotel-Information)

![Free daily full breakfast](https://images.trvl-media.com/lodging/5000000/4200000/4199400/4199381/f3b90b0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Executive Room, Kitchenette](https://images.trvl-media.com/lodging/5000000/4200000/4199400/4199381/3b9a15f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Executive Room, Kitchenette | Private kitchenette](https://images.trvl-media.com/lodging/5000000/4200000/4199400/4199381/228edb39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/5000000/4200000/4199400/4199381/eade1d7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Santander Plaza

[](https://www.expedia.ca/Guatemala-City-Hotels-Hotel-Santander-Plaza.h4199381.Hotel-Information)

23.3 km from Santa Ana

8.2/10

Very good

(573 reviews)

"Breakfast was delicious with a lot of options to choose, staff very kind good service "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Monica

CA $134

CA $163 total

includes taxes & fees

Feb 5 - Feb 6

[](https://www.expedia.ca/Guatemala-City-Hotels-Hotel-Santander-Plaza.h4199381.Hotel-Information)

![Breakfast, lunch, dinner served; international cuisine, garden views ](https://images.trvl-media.com/lodging/1000000/30000/27900/27811/2f64c7c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Serves lunch, dinner, and happy hour](https://images.trvl-media.com/lodging/1000000/30000/27900/27811/ceef98f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, Multiple Beds, Non Smoking (VIP Floor)](https://images.trvl-media.com/lodging/1000000/30000/27900/27811/ce1d9853.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/27900/27811/f29bc6f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Clarion Suites Guatemala City

[](https://www.expedia.ca/Guatemala-City-Hotels-Clarion-Suites-Guatemala-City.h27811.Hotel-Information)

23.3 km from Santa Ana

9.2/10

Wonderful

(1,011 reviews)

"Great location, good size room, very helpful staff."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Hugo

CA $150

CA $183 total

includes taxes & fees

Feb 27 - Feb 28

[](https://www.expedia.ca/Guatemala-City-Hotels-Clarion-Suites-Guatemala-City.h27811.Hotel-Information)

![Garden](https://images.trvl-media.com/lodging/75000000/74650000/74641700/74641639/29a47aac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior detail](https://images.trvl-media.com/lodging/75000000/74650000/74641700/74641639/e0906945.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hair dryer, towels, soap, shampoo](https://images.trvl-media.com/lodging/75000000/74650000/74641700/74641639/3ac76e7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/75000000/74650000/74641700/74641639/217fd81a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Good Hotel Guatemala City

[](https://www.expedia.ca/Guatemala-City-Hotels-Good-Hotel-Guatemala-City.h74641639.Hotel-Information)

23.9 km from Santa Ana

9.4/10

Exceptional

(276 reviews)

"Great restaurant in house, friendly staff! Nice stay, and the money goes to a great cause"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Nathaniel

CA $158

CA $192 total

includes taxes & fees

Mar 2 - Mar 3

[](https://www.expedia.ca/Guatemala-City-Hotels-Good-Hotel-Guatemala-City.h74641639.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/20000000/19320000/19317600/19317570/443e134d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/20000000/19320000/19317600/19317570/b1a04679.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/20000000/19320000/19317600/19317570/5a710f41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bars/lounges, poolside bar](https://images.trvl-media.com/lodging/20000000/19320000/19317600/19317570/4f464bef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hyatt Centric Guatemala City

[](https://www.expedia.ca/Guatemala-City-Hotels-Hyatt-Centric-Guatemala-City.h19317570.Hotel-Information)

23.3 km from Santa Ana

9.6/10

Exceptional

(828 reviews)

"Great location. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Christian

CA $207

CA $252 total

includes taxes & fees

Feb 28 - Mar 1

[](https://www.expedia.ca/Guatemala-City-Hotels-Hyatt-Centric-Guatemala-City.h19317570.Hotel-Information)

![View from property](https://images.trvl-media.com/lodging/1000000/900000/898800/898717/4d4a4357.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/900000/898800/898717/b9627998.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/1000000/900000/898800/898717/e3d83327.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast, lunch, dinner served; Italian cuisine ](https://images.trvl-media.com/lodging/1000000/900000/898800/898717/4ccbd159.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Plus Hotel Stofella

[](https://www.expedia.ca/Guatemala-City-Hotels-Best-Western-Plus-Hotel-Stofella.h898717.Hotel-Information)

23.3 km from Santa Ana

8.8/10

Excellent

(1,001 reviews)

"Great breakfast buffet"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Loyell

CA $128

CA $156 total

includes taxes & fees

Feb 20 - Feb 21

[](https://www.expedia.ca/Guatemala-City-Hotels-Best-Western-Plus-Hotel-Stofella.h898717.Hotel-Information)

![4 restaurants, breakfast, lunch, dinner served; international cuisine](https://images.trvl-media.com/lodging/1000000/560000/558200/558105/2667faa0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![4 restaurants, breakfast, lunch, dinner served; international cuisine](https://images.trvl-media.com/lodging/1000000/560000/558200/558105/4f903582.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![4 restaurants, breakfast, lunch, dinner served; international cuisine](https://images.trvl-media.com/lodging/1000000/560000/558200/558105/16df8b19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room dining](https://images.trvl-media.com/lodging/1000000/560000/558200/558105/9d0818a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### InterContinental Real Guatemala by IHG

[](https://www.expedia.ca/Guatemala-City-Hotels-Real-InterContinental-Guatemala.h558105.Hotel-Information)

23.2 km from Santa Ana

9.2/10

Wonderful

(1,004 reviews)

"Very nice room and service was great! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Henry

CA $216

CA $281 total

includes taxes & fees

Feb 27 - Feb 28

[](https://www.expedia.ca/Guatemala-City-Hotels-Real-InterContinental-Guatemala.h558105.Hotel-Information)

![Superior Double Room](https://images.trvl-media.com/lodging/1000000/60000/53200/53194/334ae02e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/60000/53200/53194/91881a9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Twin Room | In-room dining](https://images.trvl-media.com/lodging/1000000/60000/53200/53194/31f3861d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/60000/53200/53194/e619ca3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hotel Royal Palace

[](https://www.expedia.ca/Guatemala-City-Hotels-Hotel-Royal-Palace.h53194.Hotel-Information)

24.5 km from Santa Ana

8.2/10

Very good

(149 reviews)

"The hotel is well located there is a lot of stores and restaurants with in a walking distance."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

luis

CA $125

CA $153 total

includes taxes & fees

Feb 4 - Feb 5

[](https://www.expedia.ca/Guatemala-City-Hotels-Hotel-Royal-Palace.h53194.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-16&endDate=2026-02-17&regionId=553248635975847775&adults=2&sort=RECOMMENDED&openPlayBack=true)

## Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. 

- Historic Center
- Barrio de La Concepción

![](https://mediaim.expedia.com/destination/1/74ddc5a8bc392ba990ada31c1bf76007.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://mediaim.expedia.com/destination/1/bd4f4cf2ac6696e4d9dd7a1c5261170e.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://mediaim.expedia.com/destination/1/b494c5622ebb15c1dd7e91ce76ce75f2.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://mediaim.expedia.com/destination/1/3d9e1f30df3a11ff4ad43007765de7e3.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://mediaim.expedia.com/destination/1/b2651b17b5e3f38b232fea61824aba4c.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=911355684795535360)

![Historic Center map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:o%7EzwAthyhPXoK_%40%7Di%40ri%40a%40j%40fv%40yj%40f%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=r_Zy9R--c8e6nlgWjV2_dDRw1Is=)

### Historic Center

While visiting Historic Center, you might make a stop by sights like Central Park and Santa Catalina Arch. 

[See properties](https://www.expedia.ca/Hotel-Search?regionId=911355684795535360)

[](https://www.expedia.ca/Hotel-Search?pwaOverlay=map&regionId=911356092010033152)

![Barrio de La Concepción map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:mqzwAlqwhPIwL%60E%7DHfFdBW%60SgKL&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=Z_eq5PTC3hcK7WdhMP04Ad5umoE=)

### Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum. 

[See properties](https://www.expedia.ca/Hotel-Search?regionId=911356092010033152)

## Top Santa Ana Hotel Reviews

![Hotel Biltmore Guatemala](https://images.trvl-media.com/lodging/2000000/1400000/1397600/1397563/1b77a837_y.jpg)

### Hotel Biltmore Guatemala

10/10 Excellent

"Very helpful staff. Room was bright and clean"

[](https://expedia.ca/Guatemala-City-Hotels-Hotel-Biltmore-Guatemala.h1397563.Hotel-Information)

![Hotel Museo Spa Casa Santo Domingo](https://images.trvl-media.com/lodging/2000000/1250000/1246600/1246555/20929971_y.jpg)

### Hotel Museo Spa Casa Santo Domingo

10/10 Excellent

"From the moment I stepped into Casa Santo Domingo, I felt like I had entered another world. This place is not just a museum — it’s an experience that wraps you in history, beauty, and tranquility all at once. Walking through the ancient stone corridors and peaceful courtyards, I could feel the soul of Antigua all around me. Every corner tells a story, and every detail feels thoughtfully preserved and lovingly presented. The museum exhibits are fascinating and diverse, blending colonial art, archaeological treasures, and contemporary pieces in a way that feels natural and inspiring. I loved how the ruins themselves are part of the display — it makes the history feel alive rather than distant. The gardens are breathtaking, perfect for slowing down, reflecting, and simply soaking in the atmosphere. It’s one of those rare places where you don’t feel rushed; instead, you’re invited to wander and truly connect. What made my visit especially memorable was the sense of calm and wonder I felt throughout the entire experience. Casa Santo Domingo manages to be grand yet intimate, educational yet deeply emotional. I left feeling inspired, grateful, and completely in love with Guatemala’s rich cultural heritage. This is a must-visit in Antigua — a place I would happily return to again and again. "

[](https://expedia.ca/Antigua-Guatemala-Hotels-Hotel-Museo-Spa-Casa-Santo-Domingo.h1246555.Hotel-Information)

![Hyatt Centric Guatemala City](https://images.trvl-media.com/lodging/20000000/19320000/19317600/19317570/b1a04679_y.jpg)

### Hyatt Centric Guatemala City

10/10 Excellent

"Excellent location, Cortes’s staff, beautiful installations, good wifi, shower, gym, just an excellent combination for an enjoyable stay."

[](https://expedia.ca/Guatemala-City-Hotels-Hyatt-Centric-Guatemala-City.h19317570.Hotel-Information)

![Hotel Camino Real Antigua](https://images.trvl-media.com/lodging/4000000/3090000/3085000/3084914/17346378_y.jpg)

### Hotel Camino Real Antigua

10/10 Excellent

"What an amazing hotel, we just loved everything about our stay."

[](https://expedia.ca/Antigua-Guatemala-Hotels-Hotel-Camino-Real-Antigua.h3084914.Hotel-Information)

![Clarion Suites Guatemala City](https://images.trvl-media.com/lodging/1000000/30000/27900/27811/e487f2b2_y.jpg)

### Clarion Suites Guatemala City

10/10 Excellent

"Friendly, informative and professional staff, excellent food, very clean room. Food in the restaurant, excellent, we had to wait a little longer though but overall we’re happy with our stay at Clarions Hotel."

[](https://expedia.ca/Guatemala-City-Hotels-Clarion-Suites-Guatemala-City.h27811.Hotel-Information)

![Barceló Guatemala City](https://images.trvl-media.com/lodging/1000000/10000/2500/2495/78fae458_y.jpg)

### Barceló Guatemala City

10/10 Excellent

"Clean rooms. Very friendly and helpful staff. Super comfy beds as well! "

[](https://expedia.ca/Guatemala-City-Hotels-Barcelo-Guatemala-City.h2495.Hotel-Information)

![Hotel Soleil La Antigua](https://images.trvl-media.com/lodging/2000000/1520000/1517400/1517336/93bfa68c_y.jpg)

### Hotel Soleil La Antigua

10/10 Excellent

"Amazing place "

[](https://expedia.ca/Antigua-Guatemala-Hotels-Hotel-Soleil-La-Antigua.h1517336.Hotel-Information)

![Hotel Las Americas](https://images.trvl-media.com/lodging/18000000/17410000/17403700/17403610/111c1f7f_y.jpg)

### Hotel Las Americas

10/10 Excellent

"Good "

[](https://expedia.ca/Guatemala-City-Hotels-Hotel-Las-Americas.h17403610.Hotel-Information)

![El Carmen Hotel](https://images.trvl-media.com/lodging/2000000/1220000/1211500/1211421/97e9d009_y.jpg)

### El Carmen Hotel

10/10 Excellent

"Staff were pleasant and helpful. Hotel is in a nice location "

[](https://expedia.ca/Antigua-Guatemala-Hotels-El-Carmen-Hotel.h1211421.Hotel-Information)

## Frequently asked questions

### What's it like in Santa Ana?

### What's a favorite hotel to stay in Santa Ana?

### How many hotels will I be able to find in Santa Ana?

### If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?

### What are the top things to see and do in Santa Ana?