Title: 10 Best Hotels in Santa Ana, Antigua Guatemala for 2026 | Expedia.ca [Vacation Rentals in Antigua Guatemala](https://expedia.ca/Antigua-Guatemala-Vacation-Rentals.d180589.Travel-Guide-VacationRentals)[Flights to Antigua Guatemala](https://expedia.ca/Cheap-Flights-To-Antigua-Guatemala.d180589.Travel-Guide-Flights)[Things to do in Antigua Guatemala](https://expedia.ca/Things-To-Do-In-Antigua-Guatemala.d180589.Travel-Guide-Activities)[Santa Ana Car Rentals](https://expedia.ca/Car-Rentals-In-Santa-Ana.d553248635975847775.Car-Rental-Guide)[Santa Ana Vacations](https://expedia.ca/Santa-Ana.d553248635975847775.Destination-Travel-Guides) ![Iglesia de Nuestra Señora de Santa Ana, aldea Santa Ana en Antigua Guatemala.](https://images.trvl-media.com/place/553248635975847775/dbfc8e66-dcda-4ff9-9ea4-b39c7cec35ab.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/553248635975847775/dbfc8e66-dcda-4ff9-9ea4-b39c7cec35ab.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Mar 23 - Mar 24](https://www.expedia.ca/Hotel-Search?regionId=553248635975847775&startDate=2026-03-23&endDate=2026-03-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 24 - Mar 25](https://www.expedia.ca/Hotel-Search?regionId=553248635975847775&startDate=2026-03-24&endDate=2026-03-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 27 - Mar 29](https://www.expedia.ca/Hotel-Search?regionId=553248635975847775&startDate=2026-03-27&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Apr 3 - Apr 5](https://www.expedia.ca/Hotel-Search?regionId=553248635975847775&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Star rating ## Our top choices for Santa Ana hotels ![Front of property](https://images.trvl-media.com/lodging/92000000/91820000/91818800/91818768/5ec870c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/92000000/91820000/91818800/91818768/2499f453.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/92000000/91820000/91818800/91818768/1914e3c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/92000000/91820000/91818800/91818768/2c2e8198.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Casa Buho B&B [](https://www.expedia.ca/Antigua-Guatemala-Hotels-Casa-Buho-BB.h91818768.Hotel-Information) Santa Ana 9.2/10 Wonderful (51 reviews) "Beautiful hotel with clean rooms and friendly staff. The only downsides are the distance to the center (a 30-minute walk) and the chickens and peacocks screaming early in the morning" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Patrick CA $90 CA $110 total includes taxes & fees Mar 24 - Mar 25 [](https://www.expedia.ca/Antigua-Guatemala-Hotels-Casa-Buho-BB.h91818768.Hotel-Information) ![Garden view](https://images.trvl-media.com/lodging/92000000/91820000/91818300/91818295/4afb3fa6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Single Room, 1 Single Bed (Buho 3)](https://images.trvl-media.com/lodging/92000000/91820000/91818300/91818295/2ee1db3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/92000000/91820000/91818300/91818295/1a5632cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Twin Room, Balcony, City View](https://images.trvl-media.com/lodging/92000000/91820000/91818300/91818295/f4dd18dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hostal Casa Buho [](https://www.expedia.ca/Antigua-Guatemala-Hotels-Hostal-Casa-Buho.h91818295.Hotel-Information) Santa Ana 8.6/10 Excellent (23 reviews) "A little too far from everything but as long as you have a car is ok plenty of parking there" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gustavo CA $64 CA $79 total includes taxes & fees Apr 6 - Apr 7 [](https://www.expedia.ca/Antigua-Guatemala-Hotels-Hostal-Casa-Buho.h91818295.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/37000000/36160000/36156100/36156032/7941cd12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Food court](https://images.trvl-media.com/lodging/37000000/36160000/36156100/36156032/ccc0a892.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV, DVD player](https://images.trvl-media.com/lodging/37000000/36160000/36156100/36156032/a433c511.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 bedrooms, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/37000000/36160000/36156100/36156032/ba9c9f7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Villas Santa Ana-Ricardo [](https://www.expedia.ca/Antigua-Guatemala-Hotels-Villas-Santa-Ana-Ricardo.h36156032.Hotel-Information) Santa Ana 8.8/10 Excellent (14 reviews) "Space was clean and had a cozy vibe." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Evelin [](https://www.expedia.ca/Antigua-Guatemala-Hotels-Villas-Santa-Ana-Ricardo.h36156032.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/50000/48600/48502/26383134.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/50000/48600/48502/0cced0a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/50000/48600/48502/11a701a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/50000/48600/48502/c9c02249.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tikal Futura Hotel & Convention Center [](https://www.expedia.ca/Guatemala-City-Hotels-Grand-Tikal-Futura-Hotel.h48502.Hotel-Information) 20.1 km from Santa Ana 9.2/10 Wonderful (1,003 reviews) "The room was very nice and clean, very goods staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Benigno CA $154 CA $188 total includes taxes & fees Apr 12 - Apr 13 [](https://www.expedia.ca/Guatemala-City-Hotels-Grand-Tikal-Futura-Hotel.h48502.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/104000000/103130000/103126800/103126773/0239c2b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Studio Suite 202](https://images.trvl-media.com/lodging/104000000/103130000/103126800/103126773/a3415621.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/104000000/103130000/103126800/103126773/7e15e911.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103130000/103126800/103126773/18a9bd9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Mestizo Cortijo [](https://www.expedia.ca/Ciudad-Vieja-Hotels-Mestizo-Cortijo.h103126773.Hotel-Information) 4.3 km from Santa Ana 8.8/10 Excellent (120 reviews) "Great place awesome rooms" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Luis CA $174 CA $213 total includes taxes & fees Mar 31 - Apr 1 [](https://www.expedia.ca/Ciudad-Vieja-Hotels-Mestizo-Cortijo.h103126773.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/92000000/91140000/91130800/91130792/f60c91dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/92000000/91140000/91130800/91130792/d7e139fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Down comforters, free WiFi, bed sheets](https://images.trvl-media.com/lodging/92000000/91140000/91130800/91130792/28208420.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/92000000/91140000/91130800/91130792/b6b791ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### L'Aurora Inn Hostel [](https://www.expedia.ca/Guatemala-City-Hotels-LAurora-Inn-Hostel.h91130792.Hotel-Information) 20.8 km from Santa Ana 9.0/10 Wonderful (42 reviews) "Very polite and accommodating staff. The breakfast is delicious and rooms are very clean." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lucia [](https://www.expedia.ca/Guatemala-City-Hotels-LAurora-Inn-Hostel.h91130792.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/20000000/19760000/19751700/19751602/11511f6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 2 Double Beds, Balcony](https://images.trvl-media.com/lodging/20000000/19760000/19751700/19751602/535c370d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/20000000/19760000/19751700/19751602/cd0d6a08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![46-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/20000000/19760000/19751700/19751602/13c5f80a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### AC Hotel by Marriott Guatemala City [](https://www.expedia.ca/Guatemala-City-Hotels-AC-Hotel-By-Marriott-Guatemala-City.h19751602.Hotel-Information) 26.4 km from Santa Ana 8.6/10 Excellent (1,001 reviews) "Convenient Great location Great for business travel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Patricia CA $150 CA $184 total includes taxes & fees Apr 4 - Apr 5 [](https://www.expedia.ca/Guatemala-City-Hotels-AC-Hotel-By-Marriott-Guatemala-City.h19751602.Hotel-Information) ![Family Quadruple Room](https://images.trvl-media.com/lodging/80000000/79570000/79566100/79566041/ef1cf5c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/80000000/79570000/79566100/79566041/996b87f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/80000000/79570000/79566100/79566041/7272e809.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/80000000/79570000/79566100/79566041/19872600.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hostal Donde Regina [](https://www.expedia.ca/Guatemala-City-Hotels-Hostal-Donde-Regina.h79566041.Hotel-Information) 21 km from Santa Ana 9.0/10 Wonderful (184 reviews) "Spotless room and good staff service" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christian [](https://www.expedia.ca/Guatemala-City-Hotels-Hostal-Donde-Regina.h79566041.Hotel-Information) ![Garden](https://images.trvl-media.com/lodging/75000000/74650000/74641700/74641639/29a47aac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/75000000/74650000/74641700/74641639/5bb7bed4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/75000000/74650000/74641700/74641639/217fd81a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/75000000/74650000/74641700/74641639/e0906945.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Good Hotel Guatemala City [](https://www.expedia.ca/Guatemala-City-Hotels-Good-Hotel-Guatemala-City.h74641639.Hotel-Information) 23.9 km from Santa Ana 9.4/10 Exceptional (305 reviews) "Clean and minimalist decor . Soft sheets and good amenities. Comfortable bed and pillows. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Satvinder CA $159 CA $194 total includes taxes & fees Apr 19 - Apr 20 [](https://www.expedia.ca/Guatemala-City-Hotels-Good-Hotel-Guatemala-City.h74641639.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/46000000/45710000/45706700/45706673/f6e36ba7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 8:00 AM to 10:00 PM, pool umbrellas](https://images.trvl-media.com/lodging/46000000/45710000/45706700/45706673/589a4c1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Presidential Suite | Living area](https://images.trvl-media.com/lodging/46000000/45710000/45706700/45706673/743b34a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/46000000/45710000/45706700/45706673/0597268e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Vista Quince [](https://www.expedia.ca/Guatemala-City-Hotels-Hotel-Vista-Quince.h45706673.Hotel-Information) 25.5 km from Santa Ana 8.6/10 Excellent (246 reviews) "We really enjoyed our stay, everything was great- we will be returning " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lucy CA $164 CA $202 total includes taxes & fees Apr 3 - Apr 4 [](https://www.expedia.ca/Guatemala-City-Hotels-Hotel-Vista-Quince.h45706673.Hotel-Information) ![Living area](https://images.trvl-media.com/lodging/113000000/112370000/112361800/112361776/7ad5e666.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/113000000/112370000/112361800/112361776/894b9d7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/113000000/112370000/112361800/112361776/a2b86bf4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/113000000/112370000/112361800/112361776/5170aa0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Indian Palace [](https://www.expedia.ca/Antigua-Guatemala-Hotels-Indian-Palace.h112361776.Hotel-Information) 2.8 km from Santa Ana 8.8/10 Excellent (43 reviews) "The most beautiful room I’ve ever stayed in, the staff was excellent and was in a very safe area! I will most definitely stay there again the next time I go to Guatemala " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James CA $116 CA $143 total includes taxes & fees Mar 25 - Mar 26 [](https://www.expedia.ca/Antigua-Guatemala-Hotels-Indian-Palace.h112361776.Hotel-Information) ![Indoor pool, outdoor pool, sun loungers](https://images.trvl-media.com/lodging/7000000/6450000/6442800/6442800/1d42b970.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; Fusion cuisine, pool views ](https://images.trvl-media.com/lodging/7000000/6450000/6442800/6442800/a663805b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/7000000/6450000/6442800/6442800/e3eb72b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/7000000/6450000/6442800/6442800/9956d973.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kawilal Hotel [](https://www.expedia.ca/Amatitlan-Hotels-Kawilal-Hotel.h6442800.Hotel-Information) 13.9 km from Santa Ana 9.0/10 Wonderful (137 reviews) "The property is absolutely gorgeous and the staff is wonderful. On site restaurant is small but a decent amount to select from to eat. Rooms are clean and comfortable. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rochelle CA $185 CA $226 total includes taxes & fees Apr 12 - Apr 13 [](https://www.expedia.ca/Amatitlan-Hotels-Kawilal-Hotel.h6442800.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/91000000/90830000/90830000/90829983/1d7acc7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cafe](https://images.trvl-media.com/lodging/91000000/90830000/90830000/90829983/71d98fc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business Triple Room](https://images.trvl-media.com/lodging/91000000/90830000/90830000/90829983/71f5020b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/91000000/90830000/90830000/90829983/a14707cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### L Aurora Inn [](https://www.expedia.ca/Guatemala-City-Hotels-L-Aurora-Inn.h90829983.Hotel-Information) 21 km from Santa Ana 9.0/10 Wonderful (122 reviews) "Comfortable room, very close to the airport, and a nice breakfast" ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) ANITA [](https://www.expedia.ca/Guatemala-City-Hotels-L-Aurora-Inn.h90829983.Hotel-Information) ![Outdoor banquet area](https://images.trvl-media.com/lodging/1000000/10000/2500/2495/321f0a1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/2500/2495/e348ecdc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor wedding](https://images.trvl-media.com/lodging/1000000/10000/2500/2495/3ec8ef4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/2500/2495/4c5f3e54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Barceló Guatemala City [](https://www.expedia.ca/Guatemala-City-Hotels-Barcelo-Guatemala-City.h2495.Hotel-Information) 22.7 km from Santa Ana 9.2/10 Wonderful (3,262 reviews) "Always a very nice stay and and conveniently close to the airport" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Romilio CA $142 CA $173 total includes taxes & fees Apr 12 - Apr 13 [](https://www.expedia.ca/Guatemala-City-Hotels-Barcelo-Guatemala-City.h2495.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/123000000/122970000/122962400/122962301/4109fa55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/123000000/122970000/122962400/122962301/b0fcbdb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/123000000/122970000/122962400/122962301/8827643d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/123000000/122970000/122962400/122962301/6208102c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel y Restaurante Vista Verde [](https://www.expedia.ca/Santa-Lucia-Milpas-Altas-Hotels-Hotel-Y-Restaurante-Vista-Verde.h122962301.Hotel-Information) 5.9 km from Santa Ana 10/10 Exceptional (5 reviews) "Great room (#3) with high quality mattress, nice towels and pretty bathroom, lacks some toiletries, quiete place with awesome graden views, property rune by their owners, highly recommended! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sergio CA $80 CA $99 total includes taxes & fees Apr 12 - Apr 13 [](https://www.expedia.ca/Santa-Lucia-Milpas-Altas-Hotels-Hotel-Y-Restaurante-Vista-Verde.h122962301.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/17000000/16230000/16223700/16223612/0de61393.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/17000000/16230000/16223700/16223612/52a25915.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Triple Room, 3 Single Beds](https://images.trvl-media.com/lodging/17000000/16230000/16223700/16223612/f5243e18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/17000000/16230000/16223700/16223612/de4de24c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### In & Out Hotel [](https://www.expedia.ca/Guatemala-City-Hotels-In-Out-Hotel.h16223612.Hotel-Information) 20.9 km from Santa Ana 8.6/10 Excellent (842 reviews) "Kind staff perfect location" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Sabrina CA $72 CA $88 total includes taxes & fees Apr 9 - Apr 10 [](https://www.expedia.ca/Guatemala-City-Hotels-In-Out-Hotel.h16223612.Hotel-Information) ![Breakfast and lunch served](https://images.trvl-media.com/lodging/6000000/5350000/5342800/5342769/dd8efa7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/6000000/5350000/5342800/5342769/028c8647.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/6000000/5350000/5342800/5342769/2de05618.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/6000000/5350000/5342800/5342769/a4d0e3bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dai Nonni Hotel [](https://www.expedia.ca/Guatemala-City-Hotels-Dai-Nonni-Hotel.h5342769.Hotel-Information) 22.4 km from Santa Ana 9.2/10 Wonderful (352 reviews) "Hotel is clean quiet and the staff was awesome I recommend this place breakfast was also really good " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Juan CA $81 CA $100 total includes taxes & fees Apr 3 - Apr 4 [](https://www.expedia.ca/Guatemala-City-Hotels-Dai-Nonni-Hotel.h5342769.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/20000000/19320000/19317600/19317570/443e134d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/20000000/19320000/19317600/19317570/ac35c64b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/20000000/19320000/19317600/19317570/b1a04679.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/20000000/19320000/19317600/19317570/5a710f41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Centric Guatemala City [](https://www.expedia.ca/Guatemala-City-Hotels-Hyatt-Centric-Guatemala-City.h19317570.Hotel-Information) 23.3 km from Santa Ana 9.4/10 Exceptional (861 reviews) "Hotel was beautiful and impeccable! Staff was amazing! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nordy CA $174 CA $212 total includes taxes & fees Mar 30 - Mar 31 [](https://www.expedia.ca/Guatemala-City-Hotels-Hyatt-Centric-Guatemala-City.h19317570.Hotel-Information) ![Deluxe Room](https://images.trvl-media.com/lodging/112000000/111260000/111258500/111258468/36a740b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Double Room | Bathroom](https://images.trvl-media.com/lodging/112000000/111260000/111258500/111258468/845b5f74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Double or Twin Room | Bathroom](https://images.trvl-media.com/lodging/112000000/111260000/111258500/111258468/4cd12b1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room](https://images.trvl-media.com/lodging/112000000/111260000/111258500/111258468/e3ea72d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Casa Aurora [](https://www.expedia.ca/Guatemala-City-Hotels-Casa-Aurora.h111258468.Hotel-Information) 20.9 km from Santa Ana 8.8/10 Excellent (164 reviews) "Close to the airport and clean roomand staff are very friendly ." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Darren CA $72 CA $88 total includes taxes & fees Mar 30 - Mar 31 [](https://www.expedia.ca/Guatemala-City-Hotels-Casa-Aurora.h111258468.Hotel-Information) ![Standard Single Room, 1 Queen Bed, Courtyard View | Garden view](https://images.trvl-media.com/lodging/4000000/4000000/3994900/3994817/68e679b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free full breakfast](https://images.trvl-media.com/lodging/4000000/4000000/3994900/3994817/71b4c383.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/4000000/4000000/3994900/3994817/43f38e1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/4000000/4000000/3994900/3994817/d68c5dfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Casa Carmel Bed and Breakfast [](https://www.expedia.ca/Guatemala-City-Hotels-Casa-Carmel-Bed-And-Breakfast.h3994817.Hotel-Information) 24.2 km from Santa Ana 9.6/10 Exceptional (123 reviews) "The owner picked us up at the airport and let us check in several hours earlier without charging us a fee. Beautiful property. Breakfast is included. Very considerate and friendly." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Juan CA $101 CA $124 total includes taxes & fees Apr 22 - Apr 23 [](https://www.expedia.ca/Guatemala-City-Hotels-Casa-Carmel-Bed-And-Breakfast.h3994817.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-04-06&endDate=2026-04-07®ionId=553248635975847775&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Where to stay in Santa Ana Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. - Historic Center - Barrio de La Concepción ![Palacio de los Capitanes](https://images.trvl-media.com/place/180589/fc58d3a6-5e27-409e-a639-5492bec1e04d.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) Photo by Jacques Cramatte ![The famous Arc of Santa Catalina, representative of the city of Antigua.](https://images.trvl-media.com/place/180589/16b3a27b-0679-4c68-b13b-1f8208f5ce99.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) Photo by Sergio Camalich ![Panoramic inside the ruins of Antigua's Cathedral, one of the many buildings that collapsed after the earthquake that destroyed the city in 1773.](https://images.trvl-media.com/place/180589/1dda07b1-9d1c-4f3b-b652-12e488ea88b5.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) Photo by Sergio Camalich ![Miss this place.....](https://images.trvl-media.com/place/180589/bdad9440-569d-4a69-9b92-bade05839ad6.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) Photo by Iv' Larios ![Antigua Guatemala is even more charming in the early morning! 🌄<3](https://images.trvl-media.com/place/180589/8425f0a7-c8ab-4484-80f4-558c512ae49f.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) Photo by Backpack ME [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=911355684795535360) ![Historic Center map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:o%7EzwAthyhPXoK_%40%7Di%40ri%40a%40j%40fv%40yj%40f%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=r_Zy9R--c8e6nlgWjV2_dDRw1Is=) ### Historic Center While visiting Historic Center, you might make a stop by sights like Central Park and Santa Catalina Arch. [See properties](https://www.expedia.ca/Hotel-Search?regionId=911355684795535360) ![Cross and Volcan de Agua View From Cerro de la Cruz, Antigua, Sacatepequez Department, Guatemala](https://images.trvl-media.com/place/911356092010033152/29d5145e-703b-47ae-817d-6e4cfbcb485c.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![View from Cerro de la Cruz on Antigua Guatemala and Volcano Agua](https://images.trvl-media.com/place/911356092010033152/875dc836-eb92-4b2e-81e0-fbe56f556edb.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![This hotel is also a museum and was built on the ruins of a Spanish monastery in Antigua, Guatemala. Great Spa, superb romantic place. My wife truly enjoyed #lifeatexpedia](https://images.trvl-media.com/place/180589/aca31832-8f26-4ecb-b496-fddf02fc87c2.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) Photo by Pablo Sala ![Only a small part of the GIANT outdoor grounds. This is a hotel you can reserve and stay at, even thought it is literally inside the old church ruins, with museums onsite. Very inexpensive for American dollars. ](https://images.trvl-media.com/place/180589/5effe0ed-8eab-43a9-b1fa-46350c8247ae.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) Photo by Nikaela Brown [](https://www.expedia.ca/Hotel-Search?pwaOverlay=map®ionId=911356092010033152) ![Barrio de La Concepción map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:mqzwAlqwhPIwL%60E%7DHfFdBW%60SgKL&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=Z_eq5PTC3hcK7WdhMP04Ad5umoE=) ### Barrio de La Concepción While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum. [See properties](https://www.expedia.ca/Hotel-Search?regionId=911356092010033152) ## Top Santa Ana Hotel Reviews ![Clarion Suites Guatemala City](https://images.trvl-media.com/lodging/1000000/30000/27900/27811/2f64c7c6_y.jpg) ### Clarion Suites Guatemala City 10/10 Excellent "Rooms were very clean and spacious. The breakfast was excellent. Definitely worth the price." [](https://expedia.ca/Guatemala-City-Hotels-Clarion-Suites-Guatemala-City.h27811.Hotel-Information) ![Adriatika Hotel & Residence](https://images.trvl-media.com/lodging/9000000/8340000/8336300/8336251/9c9c2090_y.jpg) ### Adriatika Hotel & Residence 10/10 Excellent "Clean rooms " [](https://expedia.ca/Guatemala-City-Hotels-Adriatika-Hotel-Boutique.h8336251.Hotel-Information) ![Hotel Biltmore Guatemala](https://images.trvl-media.com/lodging/2000000/1400000/1397600/1397563/4c3ed87e_y.jpg) ### Hotel Biltmore Guatemala 4/10 Poor "I couldn´t sleep because me room was in front of the elevator, and they have a sofa close the room, and was the meeting area. people were talking always. I recomended the hotel take off the sofa ther; is imposible sleep, the room isnot acustic " [](https://expedia.ca/Guatemala-City-Hotels-Hotel-Biltmore-Guatemala.h1397563.Hotel-Information) ![Hotel Posada de Don Rodrigo Antigua](https://images.trvl-media.com/lodging/4000000/3950000/3949000/3948905/cf0309b4_y.jpg) ### Hotel Posada de Don Rodrigo Antigua 10/10 Excellent "Outstanding all around…..just needs small wash rags" [](https://expedia.ca/Antigua-Guatemala-Hotels-Hotel-Posada-De-Don-Rodrigo-Antigua.h3948905.Hotel-Information) ![Hotel Las Americas](https://images.trvl-media.com/lodging/18000000/17410000/17403700/17403610/861f04e5_y.jpg) ### Hotel Las Americas 10/10 Excellent "Súper reliable place to stay, conveniently located and always clean and comfortable. " [](https://expedia.ca/Guatemala-City-Hotels-Hotel-Las-Americas.h17403610.Hotel-Information) ![Best Western Plus Hotel Stofella](https://images.trvl-media.com/lodging/1000000/900000/898800/898717/4d4a4357_y.jpg) ### Best Western Plus Hotel Stofella 8/10 Good "Excellent for budget business travel. Has all the required services " [](https://expedia.ca/Guatemala-City-Hotels-Best-Western-Plus-Hotel-Stofella.h898717.Hotel-Information) ![Wyndham Garden Guatemala City](https://images.trvl-media.com/lodging/1000000/30000/26600/26567/7c46a4a4_y.jpg) ### Wyndham Garden Guatemala City 10/10 Excellent "was clean spacious and super perfect, will recommend this to anyone whose visiting." [](https://expedia.ca/Guatemala-City-Hotels-Wyndham-Garden-Guatemala-City.h26567.Hotel-Information) ![Holiday Inn Guatemala City by IHG](https://images.trvl-media.com/lodging/1000000/10000/1300/1234/fc36525d_y.jpg) ### Holiday Inn Guatemala City by IHG 10/10 Excellent "Muy buen servicio " [](https://expedia.ca/Guatemala-City-Hotels-Holiday-Inn-Guatemala-City.h1234.Hotel-Information) ![Hotel Soleil La Antigua](https://images.trvl-media.com/lodging/2000000/1520000/1517400/1517336/a514483d_y.jpg) ### Hotel Soleil La Antigua 10/10 Excellent "Nice place to stay " [](https://expedia.ca/Antigua-Guatemala-Hotels-Hotel-Soleil-La-Antigua.h1517336.Hotel-Information) ## Frequently asked questions ### What are the best hotels in Santa Ana that travellers recommend? > This 3-star bed and breakfast has an excellent 9.2 rating. Guests frequently mention the kind staff and appreciate the amenities such as a kitchen, a balcony, and the convenience of free and secured self-parking. The Casa Buho B&B also offers charming mountain views. It is conveniently located near several points of interest, including the Jade Maya Factory and Museum, just 1.2 kilometres away, and the Casa Santo Domingo Museum, which is 1.3 kilometres from the property. ### What are the best budget hotels in Santa Ana? > The 3-star Casa Buho B&B, with an impressive 9.2 rating, offers free WiFi, complimentary toiletries, and free self-parking. Guests can enjoy a kitchen for self-catering and rooms with mountain views. It is conveniently located near several attractions, including Iglesia de la Escuela de Cristo (0.8 km) and Museo del Hermano Pedro (1.2 km). Guests frequently highlight the kind staff. > > > Another great option is the 3-star Hostal Casa Buho, rated 8.6\. This hotel also provides free WiFi, complimentary toiletries, and free self-parking. It features a kitchen and rooms that offer mountain views and a mountain site location. Similar to Casa Buho B&B, it is close to many points of interest, such as Iglesia de la Escuela de Cristo (0.8 km) and Museo del Hermano Pedro (1.2 km). ### What are the most romantic hotels in Santa Ana for couples? > The 3-star Casa Buho B&B, with a high rating of 9.2, offers a lovely setting with mountain views and complimentary WiFi. Guests frequently mention the kind staff and appreciate the convenience of a kitchen and free self-parking. It is also well-located, being just 1.4 km from the Palace of the Captains-General and 1.3 km from the Casa Santo Domingo Museum. > > > Another excellent option is the 3-star Hostal Casa Buho, rated 8.6\. This hotel also boasts impressive mountain views and provides a kitchen, free WiFi, and complimentary self-parking. It shares a similar convenient location, being 1.4 km from the Palace of the Captains-General and 1.3 km from the Casa Santo Domingo Museum. ### What are the best hotels in Santa Ana near Casa Santo Domingo Museum? > The 3-star Casa Buho B&B, with a superb rating of 9.2, is located just 1.3 km from the Casa Santo Domingo Museum. Guests frequently highlight the kind staff, and the accommodation offers conveniences such as a kitchen, free WiFi, and complimentary self-parking. Many rooms also provide pleasant mountain views. > > > Another great option is the 3-star Hostal Casa Buho, rated 8.6, which is also 1.3 km from the Casa Santo Domingo Museum. This hostal provides a kitchen, free WiFi, and free self-parking. Guests can enjoy mountain views and a site location located in the mountains. ### When is the best time to go to Santa Ana? > This period offers consistently pleasant weather, with clear skies and comfortable temperatures, typically ranging from 18°C to 28°C. This makes it ideal for exploring the natural beauty and outdoor activities the region offers, such as visiting Finca El Pilar or hiking Pacaya Volcano. You'll find it easier to get around, as roads are in better condition and there's less chance of rain interrupting your plans. > > > For couples looking for a relaxed yet active getaway, the dry season is perfect. You can enjoy strolls through the coffee plantations, take scenic hikes without worrying about muddy trails, and dine al fresco in the evenings. The consistent sunshine makes for excellent photography opportunities, capturing the lush landscapes and charming local architecture. > > > Travellers interested in cultural experiences will also find the dry season suitable. Many local festivals and events take place during these months, and the dry weather ensures comfortable conditions for attending market days or exploring historical sites like the ruins of Antigua, which is a short drive away. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Santa Ana hotel booking with Expedia? ### How much is the nightly rate at a Santa Ana hotel?