Name: 21C Museum Hotel St Louis
Price range: CA $182
Rating: 9

Your St. Ann Vacation

From its friendly locals to its laid-back lifestyle and beyond, there's much to like about St. Ann. Discover the wonders of this captivating city with a St. Ann vacation package that's customized for you. Ameristar Casino St. Charles, Hollywood Casino Amphitheatre and Historic Main Street are just a few of the many sights you'll want to explore during your trip to St. Ann. Check out Expedia's extensive range of travel options and begin planning your ultimate vacation to St. Ann today.

Top St. Ann Vacation Deals

Price found within the past 48 hours. Click for updated prices.

The Eagles Nest Inn

CA $762

per person

May 8 - May 11

found 24 hours ago

Roundtrip flight included

Toronto (YYZ) to St. Louis (STL)

9.4/10 Exceptional! (18 reviews)

Room was spacious and clean. Had a great stay. The restaurant was delicious.

Reviewed on Jan 16, 2026

The Cheshire

CA $1,554

per person

Mar 17 - Mar 23

found 1 day ago

Roundtrip flight included

Kelowna (YLW) to St. Louis (STL)

8.6/10 Excellent! (1,002 reviews)

I love the whole "English Tudor" vibe at the hotel. The room was clean and well-appointed. The staff is friendly and the hotel lounge is a fun place to unwind.

Reviewed on Feb 6, 2026

Hilton Garden Inn Chesterfield

CA $1,550

per person

Mar 17 - Mar 23

found 1 day ago

Roundtrip flight included

Kelowna (YLW) to St. Louis (STL)

8.2/10 Very Good! (779 reviews)

Staff was informative during check-in. Room was clean and the TV even had WELCOME with my name on it. Would stay here again.

Reviewed on Dec 22, 2025

Riverside Inn Hannibal

CA $939

per person

May 8 - May 11

found 24 hours ago

Roundtrip flight included

Toronto (YYZ) to St. Louis (STL)

9.4/10 Exceptional! (162 reviews)

Clean, spacious room with a big desk; fully functional kitchen (full size fridge, stove, dishwasher, dishes, pots and pans); large walk-in shower; and comfortable bed. Quiet (unlike larger chain hotels). Great view of the river. Delicious Mexican food downstairs. 11/10, will stay here again.

Reviewed on Nov 23, 2025

Lighthouse Inn & Suites

CA $941

per person

May 8 - May 11

found 24 hours ago

Roundtrip flight included

Toronto (YYZ) to St. Louis (STL)

8.8/10 Excellent! (23 reviews)

Nice room. Matched the pictures. Exactly what we were looking for.

Reviewed on Jan 18, 2026

Ready to book your vacation to St. Ann?

Choose your dates

St. Ann Hotel Deals

Pear Tree Inn St. Louis Airport

10810 Pear Tree Ln St. Ann MO

Fully refundableReserve now, pay when you stay

CA $122

CA $144 total

Feb 16 - Feb 17

includes taxes & fees

9.2/10 Wonderful! (2,806 reviews)

Clean rooms, comfy beds and convenient shuttle to the airport. The breakfast was good with plenty of options (both hot and cold) and plenty of food. The staff was very friendly and helpful.

Reviewed on Feb 4, 2026

Wingate by Wyndham St. Louis Airport

10820 Pear Tree Lane St. Ann MO

Fully refundableReserve now, pay when you stay

CA $131

CA $155 total

Feb 17 - Feb 18

includes taxes & fees

9.2/10 Wonderful! (1,516 reviews)

Great stay

Reviewed on Feb 3, 2026

21C Museum Hotel St Louis

1528 Locust street St. Louis MO

Fully refundableReserve now, pay when you stay

CA $182

CA $219 total

Feb 22 - Feb 23

includes taxes & fees

9/10 Wonderful! (1,594 reviews)

Everything was great i can’t wait to stay again

Reviewed on Feb 6, 2026

See all 1,873 properties in St. Ann

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.