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When you long for adventure, book a Mesopotamia vacation package. Get set to enjoy culture, nature, festivals, and much more in this vibrant destination. A trip to Mesopotamia wouldn't be complete without getting to some of its leading cities, starting with Corrientes. Two of the top attractions here include Museo de Artesanías Tradicionales Folclóricas and Casinos del Litoral. Concordia is another favourite with Mesopotamia travellers. Visitors to this exciting city love Termas Del Ayui and Concordia Speedway. Whether you're travelling on a shoestring or want to splurge, Expedia are here to help you customize your next Mesopotamia vacation.
Price found within the past 48 hours. Click for updated prices.
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Jan 24 - Jan 30
Palermo
5 nights
9.6/10 - Exceptional (1,001 reviews)
"Amazing location and super helpful staff with good attention to little details. The rooms were clean and cute, the breakfast was delicious and the general vibe was great."
Reviewed November 11, 2026
Roundtrip • Toronto (YYZ) - Buenos Aires (EZE)
YYZ - EZE • 1 stop EZE - YYZ • 1 stop
CA $1,863
per traveller
found 1 day ago
Jan 14 - Jan 21
El Centro
6 nights
9.8/10 - Exceptional (259 reviews)
Roundtrip • Montreal (YUL) - Buenos Aires (EZE)
YUL - EZE • 2 stops EZE - YUL • 2 stops
CA $2,082
per traveller
found 23 hours ago
Jan 14 - Jan 21
Palermo
6 nights
9.2/10 - Wonderful (397 reviews)
Roundtrip • Montreal (YUL) - Buenos Aires (EZE)
YUL - EZE • 2 stops EZE - YUL • 2 stops
CA $1,911
per traveller
found 23 hours ago
Jan 14 - Jan 21
Puerto Madero
6 nights
9.6/10 - Exceptional (405 reviews)
Roundtrip • Montreal (YUL) - Buenos Aires (EZE)
YUL - EZE • 2 stops EZE - YUL • 2 stops
CA $2,071
per traveller
found 23 hours ago
Jan 14 - Jan 21
Recoleta
6 nights
9.4/10 - Exceptional (531 reviews)
"Las instalaciones son muy buenas sin embargo considero que deben de mejorar algunas cosas del cuarto. Cortinas y alfombras. Además el room services no tiene whisky después que cierra el bar del hotel, ilógico que un hotel con esa categoría tenga un problema tan sencillo de resolver."
Reviewed November 5, 2026
Roundtrip • Montreal (YUL) - Buenos Aires (EZE)
YUL - EZE • 2 stops EZE - YUL • 2 stops
Save 100% on your flight
CA $3,726
per traveller
found 23 hours ago
Rating: 8.0/10 (2 reviews)
Explore the great outdoors at El Palmar National Park, a lovely green space in Ubajay.
Rating: 9.0/10 (4 reviews)
Enjoy an outing to Costanera de Corrientes during your stay in Corrientes. You can enjoy the restaurants while in the area.
Learn about the local history of Municipo de Itatí when you take a trip to Basilica Nuestra Senora De Itati.
Rating: 10.0/10 (2 reviews)
Bring your family to Termas de Federacion and have a fun-filled day at this amusement park in Federacion. Stroll along the beaches or discover the area's waterfalls.
You can take time to visit Concepción del Uruguay City Racetrack during your travels to Concepción del Uruguay. Experience the area's art scene and museums.
Bring your family to Termas Concepcion Entrerios and enjoy the excitement of this amusement park in Concepción del Uruguay. Experience the area's art scene and museums.
Rating: 8.8/10 (5 reviews)
Why not spend a lazy afternoon at Isla Cambacua Beach during your trip to Concepción del Uruguay? Experience the area's art scene and museums.
If a restful vacation is part of your travel plans, Victoria Beach might be the perfect place to seek out during your trip to Victoria. Make some time to visit the monuments while you're in the area.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
See all properties in Mesopotamia
Maybe less than you might think — from only CA $1,863, actually! By combining hotels, flights and car rentals into your own tailor-made package, your Mesopotamia escape is just a few clicks away.
Crafting your own Mesopotamia vacation package with Expedia is a great way to save. We offer more than 550 partner airlines and 1,000,000 hotels across the globe. With such a broad range to choose from, you'll have no worries creating your next dream adventure.
Costarenas Hotel & Spa and Hotel Queguay know how to make their guests feel welcome in Colon. If your itinerary also includes Parana, check out Mayim Hotel Termal & Spa and Costarenas Hotel & Spa. Both are very popular with travelers.
It all depends on the airline, but you can usually compare international fares on Expedia nearly a year in advance. While it's generally a good idea to book ahead of time, lucky travelers occasionally nab a cheaper ticket just weeks before departure dates.
You can choose from a combination of hotels, rental cars and flights. Once you've made your booking, you can add the fun stuff like experiences and activities. Want to pick your fare class? That's also easy to do. The choice is all yours when it comes to arranging your perfect Mesopotamia trip.
Booking all the parts of your getaway together is a smart way to save. Bundle your flights, car rentals and hotels into a convenient package. But it's not just hotels. Expedia has all types of properties, including vacation rentals such as mountain cabins and serviced residences. The list is almost endless!
Yes, and with over 550 airlines to select from worldwide, you're not short on choice. Search the available options and find out which airline fits your budget and needs.
Don't worry if you're rethinking your Mesopotamia vacation package — you can cancel or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We realize life can throw the occasional spanner in the works, so head to our Customer Service Portal if that occurs. When you're ready to make changes, we'll take care of it.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.