Mesopotamia Vacation Packages

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    Save up to CA $775 when you book a flight and hotel together*
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Mesopotamia Hotel Deals

O2 Hotel Gualeguaychú
O2 Hotel Gualeguaychú
2.5 out of 5
115 3 de Febrero, Gualeguaychú, Entre Ríos
Fully refundableReserve now, pay when you stay
The price is CA $60 per night from May 15 to May 16
CA $60
CA $60 total
includes taxes & fees
May 15 - May 16
7.2/10 Good! (37 reviews)
"Newly remodeled. Simple (no TV). Clean. Good A/C. Basic breakfast. Friendly staff. Nice rooms. Wifi was non-existent in the room on the 5th floor (despite the front desk resetting their routers), but great everywhere else. The place is in a nice and safe area with nearby restaurants. It’s not 10 ..."

Reviewed on Feb. 12, 2024

O2 Hotel Gualeguaychú
Hathor Concordia
Hathor Concordia
3 out of 5
Ruta Nacional 14-km 264.5, Concordia, Entre Rios
Fully refundableReserve now, pay when you stay
The price is CA $101 per night from May 14 to May 15
CA $101
CA $101 total
includes taxes & fees
May 14 - May 15
8.4/10 Very Good! (304 reviews)
"The hotel was very clean and quiet. It was a great stop in between Buenos Aires and Puerto Iguazu!! The restaurant had delicious food and great service and a nice selection of wine and beer. The front desk was very welcoming and answered all questions. Also the room itself was clean and had safety ..."

Reviewed on Mar. 14, 2024

Hathor Concordia
Club Valle Termal Resort
Club Valle Termal Resort
3 out of 5
Hnas. Bentancourt esq. Coronel Salas, Federacion, Entre Rios
The price is CA $64 per night from May 16 to May 17
CA $64
CA $64 total
includes taxes & fees
May 16 - May 17
Club Valle Termal Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Frequently asked questions

How much does a Mesopotamia vacation package cost?
Maybe less than you might think — from only , actually! By combining hotels, flights and car rentals into your own tailor-made package, your Mesopotamia escape is just a few clicks away.
How do I get a cheap travel package to Mesopotamia?
Crafting your own Mesopotamia vacation package with Expedia is a great way to save. We offer more than 550 partner airlines and 1,000,000 hotels across the globe. With such a broad range to choose from, you’ll have no worries creating your next dream adventure.
What are the top hotels in Mesopotamia?
Costarenas Hotel & Spa and Hotel Queguay know how to make their guests feel welcome in Colon. If your itinerary also includes Parana, check out Mayim Hotel Termal & Spa and Costarenas Hotel & Spa. Both are very popular with travelers.
How far in advance should I book my Mesopotamia vacation?
It all depends on the airline, but you can usually compare international fares on Expedia nearly a year in advance. While it’s generally a good idea to book ahead of time, lucky travelers occasionally nab a cheaper ticket just weeks before departure dates.
What does an Expedia Mesopotamia travel package include?
You can choose from a combination of hotels, rental cars and flights. Once you’ve made your booking, you can add the fun stuff like experiences and activities. Want to pick your fare class? That’s also easy to do. The choice is all yours when it comes to arranging your perfect Mesopotamia trip.
What should I know before booking a Mesopotamia travel package?
Booking all the parts of your getaway together is a smart way to save. Bundle your flights, car rentals and hotels into a convenient package. But it’s not just hotels. Expedia has all types of properties, including vacation rentals such as mountain cabins and serviced residences. The list is almost endless!
Can I choose my airline with a Mesopotamia Expedia vacation package?
Yes, and with over 550 airlines to select from worldwide, you’re not short on choice. Search the available options and find out which airline fits your budget and needs.
If I'm not able to travel, can I cancel my Mesopotamia vacation package?
Don’t worry if you’re rethinking your Mesopotamia vacation package — you can cancel or amend your booking. And if you’ve booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We realize life can throw the occasional spanner in the works, so head to our Customer Service Portal if that occurs. When you’re ready to make changes, we’ll take care of it.

Discover the most popular places to visit in Mesopotamia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.