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Our top choices for Lyon hotels

A hotel dining area with a large wooden table, multiple chairs, a television, and wall-mounted lights.
A Hampton Inn with a modern beige facade, a flag, and a covered entrance.
A rectangular swimming pool with a blue interior, surrounded by a brick border and a metal railing.
A hotel room with a large bed, a bedside table with a lamp, a chair, a bench, and a patterned carpet.

1. Hampton Inn Clarksdale

Hampton Inn Clarksdale
Clarksdale
United States
Judy
CA $186
CA $202 total
includes taxes & fees
Nov 1 - Nov 2
Hampton Inn Clarksdale
A lobby with patterned carpet, two sofas, a round coffee table, a plant, and a framed picture on the wall.
A lobby with two armchairs, a round ottoman, a small table with two lamps, and a framed artwork on the wall.
A fitness room with an elliptical trainer, a treadmill, and a stationary bike.
A hotel with a covered outdoor area, columns, and a clear sky.

2. Quality Inn Clarksdale

Quality Inn Clarksdale
Clarksdale
United States
Blu
CA $110
CA $120 total
includes taxes & fees
Oct 22 - Oct 23
Quality Inn Clarksdale
A two-story brick building with large windows and a green door, featuring outdoor seating and a signboard.
A dining area with a table and four chairs, a potted plant, and a lamp.
A cozy room with a fireplace, a bar area with bottles and glasses, and a view of the street outside.
A window with the text "TRAVELERS HOTEL" and a reflection of a bar area with stools and a counter.

3. Travelers Hotel

Travelers Hotel
Clarksdale
United States
Reade
CA $191
CA $209 total
includes taxes & fees
Nov 1 - Nov 2
Travelers Hotel
A spacious living area with a sofa, armchairs, and a coffee table. Large windows with curtains provide a view of the outdoors.
A hotel room with two beds, a desk with a computer, a chair, a television, and two lamps.
A hotel reception area with a reception desk, a framed picture, a door with a keypad, and a blue mat at the entrance.
A dining area with a table, chairs, a television, a cabinet, and a floral centerpiece.

4. Americas Best Value Inn & Suites Clarksdale

Americas Best Value Inn & Suites Clarksdale
Clarksdale
United States
Darren
CA $114
CA $124 total
includes taxes & fees
Oct 2 - Oct 3
Americas Best Value Inn & Suites Clarksdale
A bar area with wooden bar stools and shelves with bottles and glasses.
A modern lounge area with a flat-screen TV, ceiling fans, and guitars on the wall.
A hallway with a white wall, wooden floor, a sofa, a lamp, and a rug.
A shower area with three white shower curtains tied to a central rod, beige tiled walls, and a tiled floor.

5. Auberge Clarksdale Blues Hostel

Auberge Clarksdale Blues Hostel
Clarksdale
United States
Brian
CA $157
CA $172 total
includes taxes & fees
Oct 25 - Oct 26
Auberge Clarksdale Blues Hostel
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Top Lyon Hotel Reviews

The Sunflower Penthouse on the River in Clarksdale

The Sunflower Penthouse on the River in Clarksdale

8/10 Good
"Great place to stay."
Mark W. 2-night trip
Posted 4 days ago
The Sunflower Penthouse on the River in Clarksdale
Quality Inn Clarksdale

Quality Inn Clarksdale

10/10 Excellent
"Nice place overall, clean and quiet and the front desk was very nice…"
Obie 1-night trip
Posted 5 days ago
Quality Inn Clarksdale
Hampton Inn Clarksdale

Hampton Inn Clarksdale

10/10 Excellent
"Staff was so helpful and very friendly and personable."
Jimmy 2-night trip
Posted 11 days ago
Hampton Inn Clarksdale
Only a mile from historic downtown Clarksdale!

Only a mile from historic downtown Clarksdale!

10/10 Excellent
"Nice & quiet place to stay. Perfect for our anniversary weekend."
Jeni H. 1-night trip
Posted 12 days ago
Only a mile from historic downtown Clarksdale!
Get to BLUES-in' at Rusty's Roost, adjacent to downtown Clarksdale, MS

Get to BLUES-in' at Rusty's Roost, adjacent to downtown Clarksdale, MS

10/10 Excellent
"Very clean, very nice and comfortable, very pet friendly, washer and dryer worked well, host was very attentive, and property is very close to everything in clarksdale!!Very pleased!!"
STEPHANIE P. 3-night trip
Posted 1 month ago
Get to BLUES-in' at Rusty's Roost, adjacent to downtown Clarksdale, MS
Sunset Log Cabin

Sunset Log Cabin

10/10 Excellent
"Libby is a very professional and responsive host. The place was perfect for my needs, allowed my dog, easy to get to town, yet also a bit on outskirts so not surrounded by hustle and bustle. Pleasant, rustic vibe, relaxing, and would definitely stay again."
Matt S. 2-night trip
Posted 1 month ago
Sunset Log Cabin
Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale

Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale

10/10 Excellent
"My go to place to stay when I visit Clarksdale. Has everything you need. Very quiet street and close to everything downtown."
KENNETH M. 5-night trip
Posted 2 months ago
Casa D’Amore!!!! Adorable home less than 1/2 mile from downtown Clarksdale
The Governors Mansion in Clarksdale Mississippi. A Step Back in Time

The Governors Mansion in Clarksdale Mississippi. A Step Back in Time

10/10 Excellent
"There was a total of 15 of us, Siblings with our children. We had a great time with thoroughly enjoyed the pool and all the laughter just hanging out playing games and eating meals together. A great place for a lot of people."
Marietta M. 2-night trip
Posted 2 months ago
The Governors Mansion in Clarksdale Mississippi. A Step Back in Time
Auberge Clarksdale Blues Hostel

Auberge Clarksdale Blues Hostel

10/10 Excellent
"My first time in a hostel and was sort of dreading it, but it was lovely. Shared bathroom was more like a locker room. Great location to walk everywhere."
Shelly 2-night trip
Posted 2 months ago
Auberge Clarksdale Blues Hostel

More cheap stays in Lyon

Quality Inn Clarksdale

Quality Inn Clarksdale

818 South State Street Clarksdale MS
CA $110
CA $120 total
Oct 22 - Oct 23
includes taxes & fees
7.2/10 Good! (780 reviews)
Quality Inn Clarksdale
Americas Best Value Inn & Suites Clarksdale

Americas Best Value Inn & Suites Clarksdale

350 South State Street Clarksdale MS
CA $114
CA $124 total
Oct 2 - Oct 3
includes taxes & fees
6/10 (432 reviews)
Americas Best Value Inn & Suites Clarksdale
Auberge Clarksdale Blues Hostel

Auberge Clarksdale Blues Hostel

164 Delta Ave Clarksdale MS
CA $157
CA $172 total
Oct 25 - Oct 26
includes taxes & fees
9.6/10 Exceptional! (110 reviews)
Auberge Clarksdale Blues Hostel
Hampton Inn Clarksdale

Hampton Inn Clarksdale

15000 New Africa Rd Clarksdale MS
CA $186
CA $202 total
Nov 1 - Nov 2
includes taxes & fees
8.2/10 Very good! (411 reviews)
Hampton Inn Clarksdale
Travelers Hotel

Travelers Hotel

212 3rd St Clarksdale MS
CA $191
CA $209 total
Nov 1 - Nov 2
includes taxes & fees
Travelers Hotel
High Cotton Condos

High Cotton Condos

249 Delta Ave Clarksdale MS
Get rates
8.8/10 Excellent! (6 reviews)
High Cotton Condos

Hotels in Lyon with star rating

Frequently asked questions

What is the best area to stay in Lyon?
The best area to stay in Lyon, Mississippi, is near the intersection of Highway 61 and Highway 322, particularly around the few accommodations available in the town itself.This area is the most convenient for visitors as it's where you'll find the limited lodging options and easy access to the main roads. Lyon is a very small town, so the "best" area is essentially the most central and accessible part.For solo travellers or couples passing through, staying directly in Lyon offers a practical stop.
When is the best time to go to Lyon?
The best time to visit Lyon, Mississippi, is during the spring (April to May) and autumn (September to October) months.These periods offer pleasant weather, with mild temperatures and less humidity, making it ideal for exploring the area comfortably. You'll find it's a great time for outdoor activities without the intense heat of summer or the cooler temperatures of winter.Spring brings blooming flora and a generally uplifting atmosphere, great for those who enjoy strolls and appreciating natural beauty.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Lyon.
How much is the nightly rate at a Lyon hotel?
Prices for hotels in Lyon often vary, but you can find a great deal from CA $120 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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