Book The Best Hotels in Irene, SD for 2026 from CA $107 - Fully Refundable Options

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Go beyond your typical stay in Irene

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Our top choices for Irene hotels

An indoor swimming pool with blue-tiled walls and a wooden ceiling.

A hotel lobby with a stone fireplace, comfortable seating, and a television mounted on the wall.

A two-story building with a covered entrance and a stone facade.

A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a television.

1. Gateway Park Hotel and Suites

Tea

Pamela

CA $145

CA $158 total

includes taxes & fees

Oct 22 - Oct 23

A spacious kitchen with a large island, modern pendant lights, and a ceiling fan.

A modern kitchen with stainless steel appliances, dark wood cabinets, and a tiled floor.

A spacious room with wooden walls and ceiling, featuring a large chandelier, multiple windows, and a central seating area with tables and chairs.

A modern kitchen with dark cabinets, stainless steel appliances, and a large window.

2. Lewis and Clark Resort

Yankton

Jeff

CA $160

CA $170 total

includes taxes & fees

Nov 1 - Nov 2

A hotel lobby with a reception desk, seating area, and a large window with a view of a building.

A Comfort Inn hotel with a covered entrance, a parking lot, and a clear sky.

A hotel room with two beds, a desk, a chair, and a framed picture on the wall.

A hotel reception area with a long counter, coffee machines, and a television screen displaying a program.

3. Comfort Inn Yankton SD

Yankton

Vanessa

CA $132

CA $146 total

includes taxes & fees

Nov 8 - Nov 9

A lobby with a stone fireplace, leather seating, a bar area, and a staircase.

A modern living room with a sofa set, a coffee table, and a rug.

An indoor swimming pool with a slide, a basketball hoop, and a covered seating area.

A Best Western hotel with a modern facade, large glass windows, and a well-lit entrance.

4. Best Western Kelly Inn

Yankton

Susan

CA $150

CA $166 total

includes taxes & fees

Oct 26 - Oct 27

A reception desk with a blue and white geometric wall design, a wooden accent panel, and a sign for Holiday Inn Express & Suites.

A hotel room with a desk, two chairs, a sofa, a lamp, and a window with curtains.

An indoor swimming pool with clear blue water, surrounded by white chairs and tables.

A hotel room with a bed, a desk with a television, a chair, a lamp, and a window with curtains.

5. Holiday Inn Express & Suites Yankton by IHG

Yankton

Angela

CA $167

CA $184 total

includes taxes & fees

Nov 9 - Nov 10

A hotel with a covered outdoor area, multiple windows, and a stone pillar.

A hotel room with a bed, a desk with a chair, a television, a lamp, and a window with curtains.

A hotel room with a bed, bedside lamps, a small desk, a microwave, and a kitchenette.

An indoor swimming pool with clear lane markings, lounge chairs, and umbrellas.

6. Best Western Vermillion Inn

Vermillion

Jody

CA $136

CA $150 total

includes taxes & fees

Nov 1 - Nov 2

A hotel room with two beds, a desk, a chair, and a lamp.

A hotel room with a sofa, a television, a desk with a chair, a lamp, a microwave, a framed picture, and a fireplace.

A swimming pool with a tiled floor, a pool ladder, and lounge chairs.

A living room with a brown leather sofa, a brown leather armchair, a round coffee table, a red doormat, a window with curtains, and an air conditioning unit.

7. Econo Lodge Inn & Suites Yankton

Yankton

Kandy

CA $96

CA $107 total

includes taxes & fees

Nov 8 - Nov 9

A hotel room with two beds, a desk, a chair, a window with curtains, a wall-mounted TV, and a large wall art piece.

A bathroom with a sink, mirror, towel rack, toilet, and shower curtain.

A breakfast area with a coffee machine, a TV, and a clock on the wall.

A reception area with a counter, a mounted sign, a wall-mounted picture, a door, and a potted plant.

8. Super 8 by Wyndham Yankton

Yankton

Jennifer

CA $122

CA $135 total

includes taxes & fees

Nov 1 - Nov 2

A modern living room with a fireplace, seating area, and large windows.

A Fairfield by Marriott hotel with a modern design, featuring a prominent entrance and a stone facade.

A modern reception area with wooden paneling, a reception desk, and a refrigerated display case.

A restaurant with a long counter, booths, and high tables.

9. Fairfield Inn & Suites by Marriott Yankton

Yankton

James

CA $171

CA $188 total

includes taxes & fees

Nov 8 - Nov 9

A hotel reception area with a coffee station, a flat-screen TV displaying 'Free Wi-Fi All Rooms,' and various food and drink items.

A vending machine with Pepsi branding in a hallway with a staircase.

A Red Roof Inn with an indoor pool and free WiFi.

A hotel room with two beds, a desk, a chair, a television, and artwork on the walls.

10. Red Roof Inn Vermillion - U of South Dakota

Vermillion

Kevin

CA $140

CA $155 total

includes taxes & fees

Oct 20 - Oct 21

A hotel room with a large bed, a separate bathroom with a bathtub, a desk with a chair, and a window with blinds.

A hotel hallway with carpeted floors, white doors, and a ceiling light fixture.

A hotel hallway with carpeted flooring, a wall with a geometric design, and an elevator.

A breakfast bar with cereal and fruit options, a kettle, and condiments.

11. Holiday Inn Express Hotel & Suites Vermillion by IHG

Vermillion

Stephanie

CA $156

CA $172 total

includes taxes & fees

Oct 25 - Oct 26

A reception area with a stone counter, a seating area with sofas, and a door labeled "Hotel Lobby".

A hotel room with two beds, a desk, a TV, and a lamp.

A spacious lobby with a large window, a reception desk, a sofa, and a coffee table.

A Prairie Inn with a covered entrance and brick facade.

12. Prairie Inn

Vermillion

Cori

CA $106

CA $115 total

includes taxes & fees

Oct 20 - Oct 21

A wooden cabin interior with a spiral staircase, a dining area, a living room with a sofa, and a kitchen.

A wooden cabin with a loft bedroom, a staircase, and a view of the outside.

A wooden interior with a hallway leading to a bedroom, a chevron-patterned wall art, and a ceiling light.

A building with a green roof, a sign reading 'Northwood Nest,' outdoor seating with wooden chairs, and a picnic table.

13. Family-friendly log cabin style house by Lewis & Clark Lake at DJ's Resort

Yankton

Linda

A hotel room with two beds, a desk, a TV, a window with curtains, and a large wall painting.

A reception area with a counter, a mounted horse racing poster, a framed welcome sign, and a plant on the counter.

A small kitchenette with a coffee machine, a toaster, and a microwave. There are two tables with chairs, a trash can, and a clock on the wall.

A modern bathroom with a sink, toilet, and shower.

14. Super 8 by Wyndham Yankton

Yankton

Hal

A hotel room with two beds, a large framed waterfall painting, a lamp, and a window with curtains.

A lobby with a reception desk, two armchairs, a coffee table, and potted plants.

A small kitchenette with wooden cabinets, a microwave, and a shelf with various items.

A hotel sign with the name "Super 8" and a blank board below it.

15. Super 8 by Wyndham Beresford

Beresford

Gilbert

CA $103

CA $112 total

includes taxes & fees

Oct 20 - Oct 21

A grand staircase with wooden railings and a red flag, leading to a room with a patterned ceiling and string lights.

A bedroom with a bed, bedside table, lamp, and a window with blinds.

A bed with a metal headboard, two pillows, a bedside table with a lamp, and a window with curtains.

A neatly made bed with a patterned bedspread and pillows, a bedside lamp, and a window with closed blinds.

16. The Historic Argo Hotel

Crofton

John

CA $221

CA $247 total

includes taxes & fees

Oct 28 - Oct 29

A hotel room with two beds, a desk, a chair, and a small sofa.

A swimming pool with a tiled deck, a changing room, and a small seating area.

A living room with a brown leather sofa, a smaller brown leather armchair, a round coffee table, and a radiator.

17. Econo Lodge Inn & Suites Yankton, SD

Yankton

A hotel room with a large bed, a separate bathroom with a bathtub, a desk, and a television.

A room with a sofa, an ottoman, a framed picture on the wall, and a dining table with chairs.

A compact kitchen with wooden cabinets, a microwave, a refrigerator, a granite countertop, and a dining area with a chair.

A bar area with a marble countertop, bar stools, and a wine display.

18. Grandstay Hotel and Suites Tea Sioux Falls

Tea

A bathroom with a toilet, bidet, and dark wooden vanity with a mirror.

A bathroom with a red bathtub, a white sink, and a red sofa.

19. Peaceful bed & breakfast with AC in charming Crofton

Crofton

CA $247

CA $315 total

includes taxes & fees

Oct 20 - Oct 21

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Top Irene Hotel Reviews

Comfort Inn Yankton SD

10/10 Excellent

"Exactly what we paid for. Great value for the amount spent"

Super 8 by Wyndham Yankton

10/10 Excellent

"Very clean, they have done a lot of updates since the last time I stayed at the property"

Best Western Kelly Inn

10/10 Excellent

"Clean room, hotel itself was clean, hotel staff was excellent, right there willing to help if need be, maintenance man was absolutely great, helped me with a minor infraction, I just thought the staff in the restaurant could have a little more ambition , otherwise I loved the stay!"

Lewis and Clark Resort

10/10 Excellent

"Had a great time except for the neighbors keeping us up until 2-3:00 am. Kitchen floor was not very clean."

Cozy Abode in Historic Yankton - Heart of the City

10/10 Excellent

"Very comfortable little converted storefront right in the heart of downtown. Cool little place, convenient parking. We enjoyed our stay."

Haven by the Lake

10/10 Excellent

"My children and grandchildren enjoyed the stay. Grandchildren wanted to know when they could come back to stay again. They especially loved watching the turkeys and even got close enough to get a picture of a young buck deer."

Charming Lake House within Walking Distance from Lake

10/10 Excellent

"It was a great place to stay , it was nice the kids had their own area to hang out"

Modern Lewis and Clark lake home with lake views and 3 min drive to the beach!

10/10 Excellent

"Everything was great!"

ThePinecone - luxury vacation rental awesome deck with view & amenities for 2-18

10/10 Excellent

"Such a beautiful view with a great open yard and huge deck to enjoy the view! We loved the beautiful kitchen and dining room space. The beds were comfortable and it was a wonderful space"

More cheap stays in Irene

Econo Lodge Inn & Suites Yankton

2410 Broadway Ave Yankton SD

CA $96

CA $107 total

Nov 8 - Nov 9

includes taxes & fees