Hotels in South Main, Houston

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Our top choices for South Main hotels

Wyndham Houston near NRG Park/Medical Center

Wyndham Houston near NRG Park/Medical Center
3.5 star property
South Main
7.2 out of 10, Good, (1,288 reviews)
"Would stay again!"
United States
Austin
The price is CA $136
CA $160 total
includes taxes & fees
Jun 1 - Jun 2
Wyndham Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center

Wingate Houston near NRG Park/Medical Center
3.0 star property
South Main
6.6 out of 10, (1,000 reviews)
"Good parking"
United States
joseph
The price is CA $109
CA $127 total
includes taxes & fees
May 31 - Jun 1
Wingate Houston near NRG Park/Medical Center

Comfort Suites Houston near Medical Center- NRG Stadium

Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
South Main
8.6 out of 10, Excellent, (1,000 reviews)
"Clean & comfortable, super nice staff, good breakfast options, convenient to MDA."
United States
Cleota
The price is CA $139
CA $163 total
includes taxes & fees
May 31 - Jun 1
Comfort Suites Houston near Medical Center- NRG Stadium

Quality Inn & Suites NRG Park - Medical Center

Quality Inn & Suites NRG Park - Medical Center
2.5 star property
South Main
6.6 out of 10, (1,003 reviews)
"Very clean rooms and excellent staff"
United States
Efrain
The price is CA $103
CA $120 total
includes taxes & fees
Jun 3 - Jun 4
Quality Inn & Suites NRG Park - Medical Center

Candlewood Suites Houston Medical Center by IHG

Candlewood Suites Houston Medical Center by IHG
2.5 star property
South Main
7.4 out of 10, Good, (865 reviews)
"My stay was perfect "
United States
Fredrick
The price is CA $114
CA $134 total
includes taxes & fees
Jun 1 - Jun 2
Candlewood Suites Houston Medical Center by IHG

Studio 6 Houston, TX – Pearland/Medical Center

Studio 6 Houston, TX – Pearland/Medical Center
2.0 star property
Southeast Houston, 12.9 km from South Main
9.6 out of 10, Exceptional, (87 reviews)
"The property was very clean and the staff was great. I would stay here again when back in town."
United States
Cruz
The price is CA $82
CA $96 total
includes taxes & fees
Jun 9 - Jun 10
Studio 6 Houston, TX – Pearland/Medical Center

Best Western Plus Pearland/Houston Medical Center Hotel

Best Western Plus Pearland/Houston Medical Center Hotel
2.5 star property
Southeast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (258 reviews)
"Clean room, and very helpful staff actually enjoyed our stay"
United States
Jessica
The price is CA $127
CA $148 total
includes taxes & fees
May 31 - Jun 1
Best Western Plus Pearland/Houston Medical Center Hotel

Courtyard by Marriott Houston Intercontinental Airport

Courtyard by Marriott Houston Intercontinental Airport
3.0 star property
31.8 km from South Main
9.0 out of 10, Wonderful, (1,214 reviews)
"Wonderful place to stay!"
United States
Lisa
The price is CA $163
CA $191 total
includes taxes & fees
Jun 7 - Jun 8
Courtyard by Marriott Houston Intercontinental Airport

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
Texas Medical Center, 4.4 km from South Main
8.4 out of 10, Very good, (1,939 reviews)
"Breakfast was wonderful and the front desk staff were very helpful."
United States
Reta
The price is CA $169
CA $199 total
includes taxes & fees
Jun 7 - Jun 8
Hilton Houston Plaza/Medical Center

Palace Inn Blue Edgebrook

Palace Inn Blue Edgebrook
3.0 star property
16.8 km from South Main
9.4 out of 10, Exceptional, (174 reviews)
"It was very clean"
United States
Jesus
The price is CA $111
CA $134 total
includes taxes & fees
May 31 - Jun 1
Palace Inn Blue Edgebrook

Crystal Inn Northeast Houston Downtown I-610

Crystal Inn Northeast Houston Downtown I-610
2.5 star property
Northside, 18.9 km from South Main
8.4 out of 10, Very good, (205 reviews)
"Great price and nice rooms"
United States
Armando
The price is CA $84
CA $98 total
includes taxes & fees
Jun 1 - Jun 2
Crystal Inn Northeast Houston Downtown I-610

Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Hampton Inn & Suites Houston-Bush Intercontinental Aprt
3.0 star property
31.8 km from South Main
8.8 out of 10, Excellent, (1,910 reviews)
"Nice overnight stay. Great for close to airport!!!"
United States
Jaime
The price is CA $126
CA $148 total
includes taxes & fees
Jun 7 - Jun 8
Hampton Inn & Suites Houston-Bush Intercontinental Aprt

Palace Inn Blue 290 W 43rd & Bingle Rd

Palace Inn Blue 290 W 43rd & Bingle Rd
2.5 star property
19.4 km from South Main
9.0 out of 10, Wonderful, (68 reviews)
"We loved it, very nice employees and very clean."
United States
Jorge
The price is CA $119
CA $139 total
includes taxes & fees
Jun 6 - Jun 7
Palace Inn Blue 290 W 43rd & Bingle Rd

Tru by Hilton Houston Webster NASA

Tru by Hilton Houston Webster NASA
2.5 star property
30.7 km from South Main
9.0 out of 10, Wonderful, (1,000 reviews)
"Definitely will stay here again. Great location near Great Wolf Lodge."
United States
Deanndra
The price is CA $158
CA $185 total
includes taxes & fees
Jun 7 - Jun 8
Tru by Hilton Houston Webster NASA

Best Western Plus Manvel Inn & Suites

Best Western Plus Manvel Inn & Suites
2.5 star property
22.6 km from South Main
8.8 out of 10, Excellent, (792 reviews)
"Very nice day very clean never been in a room with a hot tub nice and convenient. Lovely stay"
United States
emira
The price is CA $123
CA $139 total
includes taxes & fees
Jun 30 - Jul 1
Best Western Plus Manvel Inn & Suites

La Quinta Inn & Suites by Wyndham Houston Bush IAH South

La Quinta Inn & Suites by Wyndham Houston Bush IAH South
3.0 star property
31.2 km from South Main
8.2 out of 10, Very good, (2,046 reviews)
"Clean convenient close to airport and food"
United States
Brian
The price is CA $107
CA $125 total
includes taxes & fees
Jun 2 - Jun 3
La Quinta Inn & Suites by Wyndham Houston Bush IAH South

Holiday Inn Express Hotel & Suites - Houston Space Center by IHG

Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
2.5 star property
30.8 km from South Main
9.0 out of 10, Wonderful, (1,001 reviews)
"Wonderful enjoyed the stay and breakfast clean rooms"
United States
Albert
The price is CA $145
CA $169 total
includes taxes & fees
Jun 8 - Jun 9
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG

Spark by Hilton Houston Bush Intercontinental Airport

Spark by Hilton Houston Bush Intercontinental Airport
3.0 star property
31.2 km from South Main
8.6 out of 10, Excellent, (1,003 reviews)
"Great option close to the airport! "
United States
Lisa
The price is CA $123
CA $144 total
includes taxes & fees
Jun 7 - Jun 8
Spark by Hilton Houston Bush Intercontinental Airport

Hotel Royale

Hotel Royale
2.0 star property
20.9 km from South Main
9.2 out of 10, Wonderful, (40 reviews)
"Room was very clean and convenient for my short stay. Would recommend for business trips. "
United States
Jerome
The price is CA $102
CA $119 total
includes taxes & fees
Jun 5 - Jun 6
Hotel Royale

Hyatt Place Houston/Sugar Land

Hyatt Place Houston/Sugar Land
3.0 star property
21.4 km from South Main
8.8 out of 10, Excellent, (1,900 reviews)
"Great location and nice walking trail behind the property!"
United States
michael
The price is CA $146
CA $168 total
includes taxes & fees
Jun 7 - Jun 8
Hyatt Place Houston/Sugar Land
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in South Main

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Individually decorated, individually furnished, desk, laptop workspace
Comfort Suites Houston near Medical Center- NRG Stadium
2.5 star property
8.6
Excellent
1,000 reviews
View
Exterior
Candlewood Suites Houston Medical Center by IHG
2.5 star property
7.4
Good
865 reviews
View
Premium bedding, pillowtop beds, in-room safe, individually decorated
Wyndham Houston near NRG Park/Medical Center
3.5 star property
7.2
Good
1,288 reviews
View
Lobby
Wingate Houston near NRG Park/Medical Center
3.0 star property
6.6
1,000 reviews
View
Hypo-allergenic bedding, in-room safe, individually decorated
Quality Inn & Suites NRG Park - Medical Center
2.5 star property
6.6
1,003 reviews
View

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Gerald D. Hines Waterwall Park.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

Top South Main Hotel Reviews

Frequently asked questions

What are the best hotels in South Main that travellers recommend?
For highly recommended hotels in South Main, consider the Wyndham Houston near NRG Park/Medical Center, Wingate Houston near NRG Park/Medical Center, Quality Inn & Suites NRG Park - Medical Center, and Comfort Suites Houston near Medical Centre- NRG Stadium.

The 3.5-star Wyndham Houston near NRG Park/Medical Center, with a 7.2 rating, is often praised by guests for its amazing staff, comfortable beds, and clean, big rooms. It also features an outdoor pool with sun loungers and is conveniently located close to NRG Astrodome (0.9 km), NRG Park (0.7 km), and NRG Arena (0.8 km).

The 3-star Wingate Houston near NRG Park/Medical Center is another great option. Guests frequently highlight the friendly and extremely polite staff, the free continental breakfast, and the comfortable, clean rooms. It is very close to NRG Astrodome (0.7 km), NRG Park (0.5 km), and NRG Arena (0.7 km).

The Quality Inn & Suites NRG Park - Medical Center is top for its excellent customer service and hospitality, along with clean rooms and a convenient location. This hotel offers free to-go breakfast and some rooms feature a balcony. It is situated near NRG Astrodome (1.0 km), NRG Park (0.8 km), and NRG Arena (0.9 km).

Finally, the Comfort Suites Houston near Medical Centre- NRG Stadium, with an excellent 8.6 rating, is known for its friendly and helpful staff, comfortable and clean rooms, and a great complimentary full breakfast. It also provides fitness facilities and is conveniently located near NRG Astrodome (1.0 km), NRG Park (0.8 km), and NRG Arena (1.4 km).
What are the best family hotels in South Main?
For family hotels in South Main, consider the Wingate Houston near NRG Park/Medical Center, the Wyndham Houston near NRG Park/Medical Center, and the Comfort Suites Houston near Medical Centre- NRG Stadium.

The 3-star Wingate Houston near NRG Park/Medical Center is a great option, located just 0.5 km from NRG Park. Guests appreciate the friendly and extremely polite staff, as well as the free and good breakfast. The comfortable and clean rooms with good beds contribute to a pleasant stay, and it also features a pool for family enjoyment.

Another excellent choice is the 3.5-star Wyndham Houston near NRG Park/Medical Center, rated 7.2. Situated only 0.7 km from NRG Park, this hotel offers child-friendly window design and free cribs, making it suitable for families with young children. Guests frequently mention the great and amazing staff, the superb location, and the clean, big rooms with comfortable beds.

The Comfort Suites Houston near Medical Centre- NRG Stadium, with an 8.6 rating, is also highly recommended. This hotel is conveniently located 0.8 km from NRG Park and features child-friendly window design. Guests consistently praise the comfortable and clean rooms, the friendly and helpful staff, and the great breakfast.
What are the top pet-friendly hotels in South Main?
For highly-rated pet-friendly hotels in South Main, consider the Wingate Houston near NRG Park/Medical Center, the Wyndham Houston near NRG Park/Medical Center, Candlewood Suites Houston Medical Center by IHG, and the Quality Inn & Suites NRG Park - Medical Center.

The 3-star Wingate Houston near NRG Park/Medical Center is a great option, allowing dogs and other pets. Guests frequently highlight the friendly and polite staff, the comfortable and clean rooms, and the good complimentary breakfast. It is conveniently located near NRG Park, NRG Astrodome, and NRG Arena.

Another excellent choice is the 3.5-star Wyndham Houston near NRG Park/Medical Center, which permits pets. This hotel, rated 7.2, is praised for its great and amazing staff, superb location, and clean, big rooms with comfortable beds. It offers free WiFi and is also close to NRG Park, NRG Astrodome, and NRG Arena.

The Candlewood Suites Houston Medical Center by IHG also permits pets and has a review rating of 7.4. This hotel provides free WiFi and free self-parking. It is situated near NRG Park, NRG Astrodome, and NRG Arena.

Finally, the Quality Inn & Suites NRG Park - Medical Center welcomes pets. This hotel offers free breakfast, including a to-go option, free self-parking, and a complimentary area shuttle. Guests often compliment the excellent and clean rooms, the convenient location, and the excellent customer service and hospitality. It is also very close to NRG Park, NRG Astrodome, and NRG Arena.
What are the most romantic hotels in South Main for couples?
For a romantic stay in South Main, the Quality Inn & Suites NRG Park - Medical Center is a good choice for couples.

The Quality Inn & Suites NRG Park - Medical Center offers suites that provide extra space and comfort. Guests have consistently praised the excellent and clean rooms, as well as the convenient location of the hotel. It provides complimentary breakfast and free toiletries, adding to the convenience of your stay. The hotel also offers free self-parking and a free area shuttle, making it easy to explore the surroundings. With NRG Astrodome just 1.0 km away and NRG Arena 0.9 km away, there's plenty to see and do nearby.
What are the best hotels in South Main near NRG Park?
When looking for hotels in South Main near NRG Park, the Wyndham Houston near NRG Park/Medical Center and the Wingate Houston near NRG Park/Medical Center are excellent options, particularly for families.

The 3.5-star Wyndham Houston near NRG Park/Medical Center, with a rating of 7.2, boasts a superb location, being just 0.7 km from NRG Park. Guests frequently praise the amazing staff, the clean and spacious rooms, and the comfortable beds. It also offers child-friendly window designs and free cribs, making it a great choice for those travelling with children.

Another highly-rated option is the 3-star Wingate Houston near NRG Park/Medical Center. While its rating is not provided, it is consistently praised for its good location, just 0.5 km from NRG Park. This hotel offers a pool, connecting rooms, and complimentary continental breakfast, which guests often describe as good. The staff are noted for being friendly and extremely polite, and the rooms are comfortable and clean.
When is the best time to go to South Main?
The best time to go to South Main is during the spring (March to May) and autumn (September to November) months.

These seasons offer pleasant weather, with comfortable temperatures that are ideal for exploring the area's outdoor attractions and walking around. Spring brings blooming flowers and a refreshing atmosphere, while autumn provides cooler temperatures and often clear skies, superb for enjoying the local parks and open-air markets.

For those planning a romantic getaway, spring is particularly lovely. The milder weather allows for leisurely strolls along the riverwalk and enjoying al fresco dining without the intense summer heat. The natural beauty of the area is at its peak, creating a beautiful backdrop for couples.

Families travelling with children might find autumn more appealing. The slightly cooler temperatures are more comfortable for kids, especially when visiting attractions like the local nature centres or attending outdoor festivals.
Can I cancel my hotel reservation on Expedia?
Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right South Main hotel for you.
How can I save on a South Main hotel booking with Expedia?
With Expedia, you'll unlock our lowest prices by becoming a member. It's free and easy to join, and you can even access member perks too. Just remember to sign in to get our best prices on South Main hotels. Another way to save is by booking your hotel and flights together on Expedia, where bundling can lead to significant savings.
How much is the nightly rate at a South Main hotel?
Hotel prices in South Main often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.

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