5 Stars Hotels in Gainesville, Florida from CA $120
Change your mind
Be picky
Check availability on Gainesville 5 Star Hotels
Top Gainesville 5 Star Hotels
Explore similar 4-star hotels

DoubleTree by Hilton Gainesville
Gainesville and related destinations
Experience the university life, sports, and local cuisine in Gainesville!

Top Gainesville Hotel Reviews
Find out more about Gainesville
Find out more about Gainesville
Five Star Hotels in Gainesville
There's nothing wrong with enjoying the finer things in life. Indulge yourself on your next leisure time. After all, this is one of the Top 10 locations in Expedia's portfolio. You'll join the multitudes of vacationers who have made Gainesville so fashionable in the last year. We should also mention, the hotels in this area receive outstanding marks for guest services, so you know you'll be looked after during your getaway. You deserve the great vacation you're dreaming about. Book one of Expedia's luxurious 5-star hotels in Gainesville and get ready to be pampered like never before.
Get a Great Deal on 5-Star Hotels in Gainesville
Don't be afraid to live the high life while you're on vacation, along with pristine rooms. Excellent customer care, spacious rooms, and fabulous spa offerings are all on offer. We have a huge number of hotels in the region, and all of them offer outstanding amenities. Besides that, you'll find that these hotels are kept in fantastic condition and provide a fine place to kick back after your daily adventures. What kind of amenities will make your stay a wonderful one? A concierge to help you plan every detail of your day? A Swedish massage to help your cares fall away? Fluffy down pillows, piping hot coffees, and even space for your family pet in some cases...these hotels have it all. Want to see for yourself? Then explore the 31,943 reviews various guests have left on Expedia and get to know these places.
Can't wait to get outside? We've got you covered. You'll find lots of attractions to see in a sprawling city like this one, like visiting art galleries and taking in live performances. Say hi to the locals—they're sure to have advice on what kind of excitement you can find in town.
Make Your Escape to Gainesville
The results are in, and Gainesville 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. This is a great time to find 5-star hotel deals in Gainesville! Don't put off your dream vacation any longer. Choose one of the 5-star hotels in Gainesville today and settle down in the lap of luxury tomorrow.
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Gainesville Hotels by Star Rating
Hotels near Popular Gainesville Attractions
- Hotels near University of Florida
- Hotels near Ben Hill Griffin Stadium
- Hotels near Shands at the University of Florida
- Hotels near Gainesville Raceway
- Hotels near Sante Fe College
- Hotels near North Florida Regional Medical Center
- Hotels near Oaks Mall
- Hotels near Florida Museum of Natural History
- Hotels near University of Florida Bat Houses
- Hotels near Kanapaha Botanical Gardens
- Hotels near Thomas Center
- Hotels near San Felasco Hammock Preserve State Park
- Hotels near Devil's Milhopper Geological State Park
- Hotels near Regal Royal Park
- Hotels near Ironwood Golf Course
- Hotels near Hippodrome State Theatre
- Hotels near Samuel P. Harn Museum of Art
- Hotels near Curtis M. Phillips Center
- Hotels near Meadowbrook Golf Club
- Hotels near Kate's Fish Camp
More Hotel Options in Gainesville
- Beach Hotel in Gainesville
- Business Hotels in Gainesville
- Cheap Hotels in Gainesville
- Family Hotels in Gainesville
- Golf Hotels in Gainesville
- Historic Hotels in Gainesville
- Honeymoon Resorts and Hotels in Gainesville
- Hotel Wedding Venues in Gainesville
- Hotels & Resorts for Couples in Gainesville
- Hotels with Balconies in Gainesville
- Hotels with Bar in Gainesville
- Hotels with Early Check-in in Gainesville
- Hotels with Free Airport Shuttle in Gainesville
- Hotels with Free Breakfast in Gainesville
- Hotels with Free Parking in Gainesville
- Hotels with Hot Tubs in Gainesville
- Hotels with Kitchenettes in Gainesville
- Hotels with Tennis Courts in Gainesville
- Hotels with Wifi in Gainesville
- Hotels with a Pool in Gainesville
- Hotels with an Indoor Pool in Gainesville
- Hotels with smoking rooms in Gainesville
- Lake Hotels in Gainesville
- Luxury Hotels in Gainesville
- Mountain Hotels in Gainesville
- Pet-friendly Hotels in Gainesville
- Romantic Hotels in Gainesville
- Shopping Hotels in Gainesville
- Ski Hotels in Gainesville
- Spa Hotels in Gainesville
Explore more hotels
- Red Roof Inn PLUS+ Gainesville
- Comfort Suites Gainesville near University
- Hilton University of Florida Conference Center Gainesville
- Days Inn by Wyndham Gainesville University I-75
- Quality Inn Gainesville near University
- Drury Inn & Suites Gainesville
- Hampton Inn & Suites Gainesville-Downtown
- SpringHill Suites by Marriott Gainesville
- Super 8 by Wyndham Gainesville I-75 Hospital University Area
- University Inn Gainesville
- WoodSpring Suites Gainesville I-75
- Hilton Garden Inn Gainesville
- Staybridge Suites Gainesville I-75 by IHG
- Holiday Inn Express & Suites Gainesville I-75 by IHG
- Gator Town Inn
- Baymont By Wyndham Gainesville I-75
- Aloft Gainesville University Area
- Sweetwater Branch Inn
- Extended Stay America Select Suites Gainesville I-75
- Travelodge by Wyndham Gainesville
More ways to book
Expedia's Latest Trends
- Hotels in Panama City Beach
- Hotels in St. Augustine
- Hotels in Key West
- Oceanfront Hotels in Cocoa Beach
- Beach Hotel in Siesta Key
- Hotels in Key Largo
- Hotels in Fort Myers Beach
- All Inclusive Resorts and Hotels in Key West
- Hotels in Naples
- Hotels in Daytona Beach
- Hotels in Marco Island
- Hotels in West Palm Beach
- Hotels in Fort Myers
- Hotels in Sarasota