Book the Best Uptown SPA Resorts from CA $265 - Spa Hotels in Uptown, OH

A historic building with ornate architecture and a modern brick structure in the foreground.

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Our top choices for Uptown hotels with a spa

A modern hotel room with a bathroom, a sofa, and a bed.

A dining area with wooden tables and chairs, a wine cellar with wine racks, and a seating area with cushioned sofas.

A table with a glass of orange juice on a balcony overlooking a cityscape with buildings and a tower.

A hotel room with a wooden headboard, a bedside lamp, a laptop, and a framed picture on the wall.

1. 21c Museum Hotel Cincinnati

Downtown Cincinnati

Luxuriate in rejuvenating spa treatments and facials at this boutique hotel with 3 dedicated wellness rooms.

CA $216

CA $265 total

includes taxes & fees

Nov 5 - Nov 6

A reception area with a reception desk, two armchairs, and a round table.

A modern bar area with a large TV, shelves of bottles, and a view of a bridge.

A modern bar area with a circular seating arrangement, a central bar counter, and a decorative light fixture.

A large brick building with a prominent entrance and a sign reading "The Lyole Hotel."

2. The Lytle Park Hotel, Autograph Collection

Downtown Cincinnati

CA $495

CA $591 total

includes taxes & fees

Oct 22 - Oct 23

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Choose what matters most at spa hotels in Uptown

Pool

Breakfast included

Hot tub

4 stars

5 stars

Top Uptown Hotel Reviews

Country Inn & Suites by Radisson, Cincinnati Airport, KY

10/10 Excellent

"They picked us up from airport very quickly. Breakfast was great!"

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Find Spa Hotels in Uptown, OH from CA $265

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