The best area to stay in Tupiza is usually right in the town centre, particularly around the main plaza, Plaza de la Independencia.This area is the heart of Tupiza, offering easy access to almost everything. You'll find most of the hotels, restaurants, and tour operators clustered around Calle Avaroa and Avenida Chichas, which intersect near the plaza. The town centre is compact and very walkable, making it easy to explore on foot.For travellers looking for convenience and a central base for exploring the region, staying near Plaza de la Independencia is ideal. Most tours to the Eduardo Avaroa Andean Fauna National Reserve and the Salt Flats depart from this area, and you'll have no trouble finding places to eat or pick up supplies.