The ON Residence is exactly where you want to stay in Thessaloniki, right by the water and near to everything. The ride from the airport in a taxi costs about 40 Euros and takes less than 30 minutes to get to this beautifully clean spacious and modern hotel.
No, they are not paying me to write this, but the ON Residence is the nicest hotel I stayed in during my recent trip to Greece. Everything about it was well designed and done better than anywhere else, and the price was very reasonable. Walking into your room is just one of those experiences where you say "Ah" and all the stress of traveling there seems to drain away.
In Greece, every hotel has a fantastic breakfast, yet the ON Residence takes it to a whole new level and the staff all seemed very well trained, fluent in English and eager to please.
The area around the hotel has lots of restaurants and bars. The only thing I'd say is that if you want a more traditional eating experience, you are probably best off going a couple of streets back from the road that follows the coast, where trendy fare tends to dominate, and you will find the real thing. Your tastebuds will thank you for finding it!
There may be other great hotels in Thessaloniki, but it would be very hard to beat the location, comfort, service and affordability of the ON Residence. If I'm ever in Thessaloniki again, I know where I'm staying, and I'm not going to bother trying to find something better. I don't think it exists.