Name: 21C Museum Hotel St Louis
Price range: CA $183
Rating: 9

Your St. Ann Vacation

From its friendly locals to its laid-back lifestyle and beyond, there's much to like about St. Ann. Discover the wonders of this captivating city with a St. Ann vacation package that's customized for you. Ameristar Casino St. Charles, Hollywood Casino Amphitheatre and Historic Main Street are just a few of the many sights you'll want to explore during your trip to St. Ann. Check out Expedia's extensive range of travel options and begin planning your ultimate vacation to St. Ann today.

Top St. Ann Vacation Deals

Price found within the past 48 hours. Click for updated prices.

The Wildwood Hotel

CA $1,199

per person

Mar 19 - Mar 26

found 1 day ago

Roundtrip non-stop flight included

Edmonton (YEG) to St. Louis (STL)

9.2/10 Wonderful! (1,600 reviews)

Clean room and easy parking.

Reviewed on Feb 2, 2026

Hilton Garden Inn Chesterfield

CA $1,557

per person

Mar 21 - Mar 28

found 1 day ago

Roundtrip non-stop flight included

Edmonton (YEG) to St. Louis (STL)

8.2/10 Very Good! (779 reviews)

Staff was informative during check-in. Room was clean and the TV even had WELCOME with my name on it. Would stay here again.

Reviewed on Dec 22, 2025

Landing Apartments - Eureka

CA $1,822

per person

Mar 19 - Mar 26

found 1 day ago

Roundtrip non-stop flight included

Edmonton (YEG) to St. Louis (STL)

No reviews

The Cheshire

CA $1,527

per person

Mar 19 - Mar 26

found 1 day ago

Roundtrip non-stop flight included

Edmonton (YEG) to St. Louis (STL)

8.6/10 Excellent! (1,002 reviews)

I love the whole "English Tudor" vibe at the hotel. The room was clean and well-appointed. The staff is friendly and the hotel lounge is a fun place to unwind.

Reviewed on Feb 6, 2026

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Grand Center

CA $1,605

per person

Mar 19 - Mar 26

found 1 day ago

Roundtrip non-stop flight included

Edmonton (YEG) to St. Louis (STL)

8.8/10 Excellent! (1,022 reviews)

It was good and beautiful on the inside. Loved all the art. The bed was comfy and the room was like an apartment .The only thing that stunk is that there wasn't a microwave in the room. But there was one on the floor so it worked out.

Reviewed on Feb 3, 2026

Ready to book your vacation to St. Ann?

Choose your dates

St. Ann Hotel Deals

Pear Tree Inn St. Louis Airport

10810 Pear Tree Ln St. Ann MO

Fully refundableReserve now, pay when you stay

CA $123

CA $145 total

Feb 11 - Feb 12

includes taxes & fees

9.2/10 Wonderful! (2,806 reviews)

Clean rooms, comfy beds and convenient shuttle to the airport. The breakfast was good with plenty of options (both hot and cold) and plenty of food. The staff was very friendly and helpful.

Reviewed on Feb 4, 2026

Wingate by Wyndham St. Louis Airport

10820 Pear Tree Lane St. Ann MO

Fully refundableReserve now, pay when you stay

CA $132

CA $156 total

Feb 17 - Feb 18

includes taxes & fees

9.2/10 Wonderful! (1,514 reviews)

Nice breakfast, clean room

Reviewed on Feb 1, 2026

21C Museum Hotel St Louis

1528 Locust street St. Louis MO

Fully refundableReserve now, pay when you stay

CA $183

CA $221 total

Feb 22 - Feb 23

includes taxes & fees

9/10 Wonderful! (1,594 reviews)

Everything was great i can’t wait to stay again

Reviewed on Feb 6, 2026

See all 1,869 properties in St. Ann

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.