A calm lake with a row of canoes on the shore and a single canoe on the water.

Find Hotels by Best Western in Southern Minnesota from CA $158

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Check prices for these dates

Tonight
Sep 1 - Sep 2
Tomorrow
Sep 2 - Sep 3
This weekend
Sep 4 - Sep 6
Next weekend
Sep 11 - Sep 13

Our top choices for Southern Minnesota Best Western

1. Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Rochester
United States
Margita
CA $137
CA $158 total
includes taxes & fees
Sep 24 - Sep 25
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

2. Best Western Fairmont

Best Western Fairmont
Fairmont
United States
Kalkidan
CA $178
CA $197 total
includes taxes & fees
Sep 10 - Sep 11
Best Western Fairmont
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Top Southern Minnesota Hotel Reviews

Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

10/10 Excellent
"We stayed here prior to appt at Mayo just 5 minutes away. Great location north of the Clinic. Hotel offers shuttle service to Gonda Bldg and St. Mary’s., very helpful either construction, Easy walk to dwtn area. Fresh breakfast and friendly checkin."
Meg 1-night trip
Posted 3 hours ago
Hyatt House Rochester/Mayo Clinic Area
Kahler Grand Hotel

Kahler Grand Hotel

10/10 Excellent
"Awesome hot tub and pool. Great views and area. Definitely would stay here again"
Carew 2-night trip
Posted 13 hours ago
Kahler Grand Hotel
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

10/10 Excellent
"The location is so convenient- literally right across the street from Mayo. The breakfast was nice and the staff were all friendly."
Steve 4-night trip
Posted 15 hours ago
Kahler Inn and Suites - Mayo Clinic Area
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

10/10 Excellent
"The experience here is wonderful as are all the staff. A special shout out to Q, as he really helped me with navigating the traffic at Mayo. I really liked it because I could walk to everything. While the decor could use a bit of freshening up, the staff, location, and amenities made up for it. I would definitely stay here again."
Stacy 1-night trip
Posted 15 hours ago
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

8/10 Good
"Property was older. Doors didn’t shut from the humidity from the pool area. Not enough space in the breakfast area. Had to stand every morning."
Elizabeth 2-night trip
Posted 16 hours ago
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Aspen Select

Aspen Select

10/10 Excellent
"Very good experience. Accommodating to our needs."
matthew 3-night trip
Posted 2 days ago
Aspen Select
St James Hotel, a Historic Hotel of America

St James Hotel, a Historic Hotel of America

8/10 Good
"Vert cool and unique stay! Loved the history and staff was friendly. My only complaint was worrying about a $50 fee you pay if you “check out at 11:01 “. Checkout is 11:00. I did not appreciate having a stress after enjoying a night out not to mention a very expensive hotel room already."
Tressa 1-night trip
Posted 3 days ago
St James Hotel, a Historic Hotel of America
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

8/10 Good
"Check out was very confusing. It took about a half hour and I am still not sure if the billing was correct. Food was fine."
Robert 3-night trip
Posted 4 days ago
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

10/10 Excellent
"This is my first time staying at Hotel Indigo. The staff was amazing. I had to keep adding nights and they were so accommodating. The room was just right. It was clean , well stocked and easy access to the Mayo Clinic. I really liked the front desk people. Super friendly and helpful. Love the attached restaurant!"
Lori 2-night trip
Posted 9 days ago
Hotel Indigo Rochester – Mayo Clinic Area by IHG

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