A calm lake with a row of canoes on the shore and a single canoe on the water.

Find Hotels by Best Western in Southern Minnesota from CA $158

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Check prices for these dates

Tonight
Sep 1 - Sep 2
Tomorrow
Sep 2 - Sep 3
This weekend
Sep 4 - Sep 6
Next weekend
Sep 11 - Sep 13

Our top choices for Southern Minnesota Best Western

1. Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Rochester
United States
Margita
CA $137
CA $158 total
includes taxes & fees
Sep 21 - Sep 22
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

2. Best Western Fairmont

Best Western Fairmont
Fairmont
United States
Kalkidan
CA $178
CA $197 total
includes taxes & fees
Sep 10 - Sep 11
Best Western Fairmont
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Top Southern Minnesota Hotel Reviews

St James Hotel, a Historic Hotel of America

St James Hotel, a Historic Hotel of America

10/10 Excellent
"Really enjoyed the Port bar. The food at Scarlett was excellent. A nice quiet place to stay."
Lisa 4-night trip
Posted less than an hour ago
St James Hotel, a Historic Hotel of America
Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area

10/10 Excellent
"Staff here were very friendly and kind; our son was seen at Mayo Clinic and we were running late to do our check out but we called and asked if we could move it up to another hour and they were kind enough to say yes and that made this trip easier and stress free. Highly recommended!!"
Edwin 1-night trip
Posted 1 hour ago
Hyatt House Rochester/Mayo Clinic Area
Kahler Inn and Suites - Mayo Clinic Area

Kahler Inn and Suites - Mayo Clinic Area

8/10 Good
"Breakfast was good and parking was a dood benefit"
Greg 2-night trip
Posted 2 hours ago
Kahler Inn and Suites - Mayo Clinic Area
Kahler Grand Hotel

Kahler Grand Hotel

10/10 Excellent
"The heat was not adjustable. Fan kept running"
Clarice 2-night trip
Posted 2 hours ago
Kahler Grand Hotel
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

10/10 Excellent
"The experience here is wonderful as are all the staff. A special shout out to Q, as he really helped me with navigating the traffic at Mayo. I really liked it because I could walk to everything. While the decor could use a bit of freshening up, the staff, location, and amenities made up for it. I would definitely stay here again."
Stacy 1-night trip
Posted 18 hours ago
Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

Best Western Rochester Hotel Mayo Clinic Area/St. Mary's

8/10 Good
"Property was older. Doors didn’t shut from the humidity from the pool area. Not enough space in the breakfast area. Had to stand every morning."
Elizabeth 2-night trip
Posted 19 hours ago
Best Western Rochester Hotel Mayo Clinic Area/St. Mary's
Aspen Select

Aspen Select

10/10 Excellent
"Very good experience. Accommodating to our needs."
matthew 3-night trip
Posted 2 days ago
Aspen Select
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys

8/10 Good
"Check out was very confusing. It took about a half hour and I am still not sure if the billing was correct. Food was fine."
Robert 3-night trip
Posted 4 days ago
SpringHill Suites by Marriott Rochester-Mayo Clinic/St Marys
Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG

10/10 Excellent
"This is my first time staying at Hotel Indigo. The staff was amazing. I had to keep adding nights and they were so accommodating. The room was just right. It was clean , well stocked and easy access to the Mayo Clinic. I really liked the front desk people. Super friendly and helpful. Love the attached restaurant!"
Lori 2-night trip
Posted 9 days ago
Hotel Indigo Rochester – Mayo Clinic Area by IHG

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