A modern glass building with a curved facade and a sign reading "The Kentucky Center".

Find Spa Hotels in Southern Indiana from CA $127

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Check availability on Southern Indiana Spa Hotels

This weekend
Oct 30 - Nov 1
Next weekend
Nov 6 - Nov 8

Our top choices for Southern Indiana hotels with a spa

A hot tub with a pool, indoor seating area, and a view of the pool.

1. Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination

Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination
3.5 star property
Elizabeth
8.2 out of 10, Very good, (1,008 reviews)
  • cleanliness
    Refresh your spirit at this riverfront hotel with daily spa treatments and couples rooms, where aromatherapy and Ayurvedic therapies await.
The price is CA $106
CA $146 total
includes taxes & fees
Nov 1 - Nov 2
Caesars Southern Indiana Hotel & Casino - A Caesars Rewards Destination
A classical gold statue in front of a multi-story building with large windows and a brick facade.

2. 21c Museum Hotel Louisville

21c Museum Hotel Louisville
4.5 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,000 reviews)
  • cleanliness
    Experience a rejuvenating spa escape at this luxury boutique hotel with massage rooms and 24-hour fitness centre in downtown Louisville.
The price is CA $213
CA $258 total
includes taxes & fees
Nov 22 - Nov 23
21c Museum Hotel Louisville
A balcony with a view of a river, a bridge, and a cityscape.

3. Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (4,421 reviews)
  • cleanliness
    Riverside sanctuary offers rejuvenating spa treatments, panoramic fitness views, and river-facing balconies for a relaxing urban retreat.
The price is CA $191
CA $224 total
includes taxes & fees
Nov 9 - Nov 10
Galt House Hotel Trademark Collection by Wyndham
A spacious lobby with a high ceiling, a central chandelier, and seating areas with tables and chairs.

4. Omni Louisville Hotel

Omni Louisville Hotel
4.0 star property
Downtown Louisville
9.4 out of 10, Exceptional, (2,210 reviews)
  • cleanliness
    Immerse in spa bliss at this Louisville hotel where Mokara Spa offers therapeutic treatments and rooftop relaxation awaits.
The price is CA $285
CA $335 total
includes taxes & fees
Nov 16 - Nov 17
Omni Louisville Hotel
A treatment room with a massage table, a desk with a computer, and a large mirror.

5. Belterra Casino Resort

Belterra Casino Resort
3.5 star property
Florence
8.6 out of 10, Excellent, (1,001 reviews)
  • cleanliness
    Experience soothing river views and rejuvenating spa treatments at this hotel with indoor and outdoor pools.
The price is CA $157
CA $193 total
includes taxes & fees
Nov 15 - Nov 16
Belterra Casino Resort
A hotel lobby with a chandelier, wooden railings, a reception desk, and a large arched doorway.

6. Quality Inn Seymour I-65

Quality Inn Seymour I-65
2.5 star property
Seymour
7.0 out of 10, Good, (653 reviews)
  • cleanliness
    Revitalize your body and spirit in this tranquil hotel featuring a full-service daily spa, indoor pool, and 24-hour fitness centre.
The price is CA $113
CA $127 total
includes taxes & fees
Nov 26 - Nov 27
Quality Inn Seymour I-65
A glass-top table with a fire feature, a copper pot, and a woven chair on a patio.

7. Pillow and Paddock B&B

Pillow and Paddock B&B
3.5 star property
La Grange
10.0 out of 10, Exceptional, (52 reviews)
  • cleanliness
    Relax in a cozy bed and breakfast retreat with a steamy hot tub, rejuvenating spa services, and a peaceful garden sanctuary.
The price is CA $451
CA $498 total
includes taxes & fees
Nov 6 - Nov 7
Pillow and Paddock B&B
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in Southern Indiana

Pool
Breakfast included

Top Southern Indiana Hotel Reviews

Ramada by Wyndham Sellersburg/Louisville North

Ramada by Wyndham Sellersburg/Louisville North

8/10 Good
"We stayed in a king bedroom unit. It was more than generous in size. The bed was comfortable and the bedding was nice. It was easy off and on to the highway. The pet fee was reasonable too. It looked recently updated. The tile floor in the entryway of the room didn't look the cleanest. Looked like the mop water was dirty. But overall it was good and we'll stay again."
claire 1-night trip
Posted 12 hours ago
Ramada by Wyndham Sellersburg/Louisville North