Title: Book the Best LAKESIDE Hotels in Seneca in 2025 | Expedia.ca [Hotels in Seneca](https://expedia.ca/Seneca-Hotels.d6548.Travel-Guide-Hotels)[Vacation Rentals in Seneca](https://expedia.ca/Seneca-Vacation-Rentals.d6548.Travel-Guide-VacationRentals)[Flights to Seneca](https://expedia.ca/Cheap-Flights-To-Seneca.d6548.Travel-Guide-Flights)[Things to do in Seneca](https://expedia.ca/Things-To-Do-In-Seneca.d6548.Travel-Guide-Activities)[Seneca Car Rentals](https://expedia.ca/Car-Rentals-In-Seneca.d6548.Car-Rental-Guide)[Seneca Vacation Packages](https://expedia.ca/Seneca.d6548.Destination-Travel-Guides) ![Lake Keowee South Carolina](https://images.trvl-media.com/place/6548/8356140f-bae9-4afc-8d65-c18efc5581aa.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Lake Hotels in Seneca, SC from CA $186 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Seneca Lake Hotels Tonight [Nov 7 - Nov 8](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-11-07&endDate=2025-11-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 8 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-11-08&endDate=2025-11-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-11-07&endDate=2025-11-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=6548&startDate=2025-11-14&endDate=2025-11-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Seneca Lake Hotels ![Balcony](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/9fe06894.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/cc35e730.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/e45ab30f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/72000000/71600000/71594700/71594655/w4000h2662x0y0-18bf21d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites Seneca Clemson Univ Area Seneca 9.4/10 Exceptional (202) "Beautiful clean hotel. Staff was very welcoming. Breakfast area was very clean with many options. The river view is so beautiful. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Linda CA $169 CA $186 total includes taxes & fees Nov 12 - Nov 13 [](https://www.expedia.ca/Seneca-Hotels-Fairfield-Inn-Suites-By-Marriott-Seneca.h71594655.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/98000000/97060000/97053600/97053582/189a85ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/98000000/97060000/97053600/97053582/a01aaac4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/98000000/97060000/97053600/97053582/5f42512b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/98000000/97060000/97053600/97053582/a488f4e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lakeside Clemson Condo With 4K/Surround Sound/Xbox/Coffee Bar/Private Bathrooms Seneca 10/10 Exceptional (20) "Apartment was very clean, easy location, just what we needed." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Krystal Z. CA $154 CA $501 total includes taxes & fees Nov 11 - Nov 12 [](https://www.expedia.ca/Seneca-Hotels-Lakeside-Clemson-Condo-With-4KSurround-SoundXboxCoffee-BarPrivate-Bathrooms.h97053582.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/106000000/105770000/105769700/105769612/a25c3100.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/106000000/105770000/105769700/105769612/651434b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, travel crib, free WiFi, bed sheets](https://images.trvl-media.com/lodging/106000000/105770000/105769700/105769612/bd51a502.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/106000000/105770000/105769700/105769612/a5e27533.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson! Downtown 10/10 Exceptional (16) "The owner, John, is an exceptional host and made our stay even more enjoyable. The location is so convenient to Downtown Seneca restaurants and grocers. We would recommend this home as a fair value. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joann H. CA $211 CA $462 total includes taxes & fees Nov 12 - Nov 13 [](https://www.expedia.ca/Seneca-Hotels-Renovated-Bungalow-1-Block-From-Downtown-Seneca-8-Miles-From-Clemson.h105769612.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/8d32bcc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/57b2b9a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, table tennis](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/0e3d7d9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, table tennis](https://images.trvl-media.com/lodging/119000000/118710000/118705000/118704946/f8d80f2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 3-bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson Seneca 10/10 Exceptional (3) "everything was great. we were only here tor work so didnt get to enjoy much" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) kim C. CA $279 CA $418 total includes taxes & fees Nov 10 - Nov 11 [](https://www.expedia.ca/Seneca-Hotels-3-Bedroom-2-Bath-Home-Located-Minutes-From-Keowee-Mariana.h118704946.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/ce0e5825.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/a1808626.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/644a4539.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/25000000/24160000/24156000/24155990/825f9309.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Deepwater Cove on Lake Keowee. Complete with Dock and Kayaks. EV Charger Serenity Bay 9.8/10 Exceptional (128) "Once again our family had a wonderful annual to beautiful Lake Keowee this lovely home fit our family of 10 perfectly. Looking forward to next year " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Denise M. CA $423 CA $878 total includes taxes & fees Dec 7 - Dec 8 [](https://www.expedia.ca/Seneca-Hotels-Deepwater-Cove-On-Lake-Keowee-Complete-With-Dock-And-Kayaks-EV-Charger.h24155990.Hotel-Information) ![Smart TV, video games](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/ac405b8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, video games](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/f0fe695d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/3a34d432.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/108000000/107520000/107517300/107517282/9b76782a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium Seneca 9.6/10 Exceptional (7) "Perfect for visiting Clemson student. Great location, clean, and well stocked. Owners were very responsive. Would definitely stay here again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer F. CA $541 CA $1,081 total includes taxes & fees Nov 11 - Nov 12 [](https://www.expedia.ca/Seneca-Hotels-Beautiful-Updated-Clemson-Lake-House-5-Mins-From-Downtown-Clemson-And-The-Stadium.h107517282.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/9000000/8480000/8475000/8474950/49a2146a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/9000000/8480000/8475000/8474950/05d8cd44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/9000000/8480000/8475000/8474950/e43af84f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lunch, dinner, brunch served; American cuisine ](https://images.trvl-media.com/lodging/9000000/8480000/8475000/8474950/199642a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Clemson University's James F. Martin Inn Clemson 9.6/10 Exceptional (952) "Great place to stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mindi CA $210 CA $233 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Anderson-Hotels-Clemson-Universitys-James-F-Martin-Inn.h8474950.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/78000000/77140000/77135100/77135065/fcdb429f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/78000000/77140000/77135100/77135065/69e36617.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fireplace](https://images.trvl-media.com/lodging/78000000/77140000/77135100/77135065/da608f95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/78000000/77140000/77135100/77135065/4a939cc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Romantic Farm Getaway Piedmont 10/10 Exceptional (45) "We had a great time. Great hospitality, tranquil. Just what we needed for a quick trip away from the kids!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jacalyn B. CA $191 CA $349 total includes taxes & fees Nov 28 - Nov 29 [](https://www.expedia.ca/Piedmont-Hotels-Experience-A-Stay-At-The-Southern-Belle-Glamp-Site.h77135065.Hotel-Information) ![Pool](https://images.trvl-media.com/lodging/106000000/105490000/105489100/105489096/96f9fed7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/106000000/105490000/105489100/105489096/dd0e647b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/106000000/105490000/105489100/105489096/baee0ed0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, coffee/tea maker](https://images.trvl-media.com/lodging/106000000/105490000/105489100/105489096/0f807340.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Glamping with a partial lake view, 30 minutes to Clemson University Westminster 9.4/10 Exceptional (14) "The camper was very clean and the set up was very nice. Didn’t have a view of the lake, but all in all had a very nice stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Scott S. CA $140 CA $307 total includes taxes & fees Nov 11 - Nov 12 [](https://www.expedia.ca/Westminster-Hotels-Glamping-With-A-Partial-Lake-View.h105489096.Hotel-Information) ![Outdoor spa tub](https://images.trvl-media.com/lodging/81000000/80020000/80018300/80018274/66bedfb1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/81000000/80020000/80018300/80018274/b0a5a6fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/81000000/80020000/80018300/80018274/6a9a51e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, DVD player, books](https://images.trvl-media.com/lodging/81000000/80020000/80018300/80018274/02c108b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lake Hartwell cottage - Hot Tub! WE CURRENTLY HAVE NO LAKE WATER UNTIL IT RAINS Anderson 9.8/10 Exceptional (80) "The home had all the amenities and was very clean." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tamara R. CA $159 CA $455 total includes taxes & fees Nov 11 - Nov 12 [](https://www.expedia.ca/Anderson-Hotels-A-Frame-Cottage-W-Hot-Tub-On-Lake-Hartwell.h80018274.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-21&endDate=2025-11-22®ionId=6548&adults=2&location_highlights_explore=on_lake&sort=RECOMMENDED&openPlayBack=true) ## Top Seneca Hotel Reviews ![Hampton Inn & Suites Seneca-Clemson Area](//images.trvl-media.com/lodging/7000000/6700000/6696900/6696886/1436aba9_y.jpg) ### Hampton Inn & Suites Seneca-Clemson Area 10/10 Excellent "Great spacious room" [](https://expedia.ca/Anderson-Hotels-Hampton-Inn-Suites-Seneca-Clemson-Area.h6696886.Hotel-Information) ![Best Western Seneca-Clemson](//images.trvl-media.com/lodging/1000000/520000/517600/517561/d223eeb0_y.jpg) ### Best Western Seneca-Clemson 10/10 Excellent "Did not participate in breakfast" [](https://expedia.ca/Anderson-Hotels-Best-Western-Seneca-Clemson.h517561.Hotel-Information) ![Days Inn by Wyndham Seneca / Clemson Area](//images.trvl-media.com/lodging/1000000/20000/14900/14854/9f69229a_y.jpg) ### Days Inn by Wyndham Seneca / Clemson Area 10/10 Excellent "Clean, friendly.. great service and lots to do " [](https://expedia.ca/Anderson-Hotels-Days-Inn-By-Wyndham-Seneca-Clemson-Area.h14854.Hotel-Information) ## Frequently asked questions ### Why book your lakeside hotel in Seneca with Expedia? > Expedia has unbeatable deals on lakeside hotels in Seneca. But our awesome prices are just the start. You'll find a wide variety of hotels to pick from and clever search filters that make it easy to find your ideal stay. ### How can I find cheap lakeside hotels in Seneca? > Spend your vacation near the water without spending big with Expedia. To find cheap lakeside hotels in Seneca, use our filter tool to choose your price per night budget. Eager to stay in a particular area? 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