The best area to stay in São Nicolau is generally within the town centre, particularly around the main square, Praça da Matriz.
This central area is the heart of São Nicolau, where you'll find most of the town's key landmarks and amenities. It's quite compact and easy to navigate on foot, with the historic Igreja Matriz de São Nicolau (Mother Church of São Nicolau) being a prominent feature. The surrounding streets host local shops, small eateries, and guesthouses.
For couples seeking a quiet and authentic experience, staying near Praça da Matriz is ideal. You'll be well-placed to explore the town's historical sites, enjoy local cuisine at nearby restaurants, and experience the relaxed pace of life. The proximity to the church means you're at the cultural core of the area.
Travellers interested in the region's history, particularly the Jesuit Missions, will find this central location very convenient.