Title: Book the Best LAKESIDE Hotels in Santee in 2025 | Expedia.ca [Santee Travel Guide](https://expedia.ca/Santee.dx9953)[Hotels in Santee](https://expedia.ca/Santee-Hotels.d9953.Travel-Guide-Hotels)[Vacation Rentals in Santee](https://expedia.ca/Santee-Vacation-Rentals.d9953.Travel-Guide-VacationRentals)[Flights to Santee](https://expedia.ca/Cheap-Flights-To-Santee.d9953.Travel-Guide-Flights)[Santee Car Rentals](https://expedia.ca/Car-Rentals-In-Santee.d9953.Car-Rental-Guide)[Santee Vacation Packages](https://expedia.ca/Santee.d9953.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/1/271db9a9db85f6f3488271b71d2f238f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Lake Hotels in Santee, SC from CA $98 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santee Lake Hotels Tonight [Nov 2 - Nov 3](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-11-02&endDate=2025-11-03&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 3 - Nov 4](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-11-03&endDate=2025-11-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-11-07&endDate=2025-11-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-11-14&endDate=2025-11-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Santee Lake Hotels ![Smart TV, offices](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/dc99579a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/339c1207.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/10896652.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/431d124d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95! Santee 10/10 Exceptional (36) "Amazing host, comfy furniture, the fenced in yard was perfect for our fur babies! Hope to stay here again. 1.2 miles away from I-95! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lauren B. CA $141 CA $458 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Santee-Hotels-This-House-Is-A-3-Bedroom.h91788460.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/4686cd8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/b105c391.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/a90b57ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/e9087580.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn Santee Santee 6.6/10 (631) "It's a quiet tuck back hotel. Although the front desk lady was extremely rude and tried to over charge me several times. The property manager was very professional." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Monica CA $88 CA $98 total includes taxes & fees Nov 4 - Nov 5 [](https://www.expedia.ca/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information) ![BBQ/picnic area](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/495c8e2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Marina](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/795ddf27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchenette](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/9d898fe9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/dd0654f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bells Marina & Resort Eutawville 8.6/10 Excellent (76) "I was pleased with my stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Luke [](https://www.expedia.ca/Eutawville-Hotels-Bells-Marina-Resort.h91244689.Hotel-Information) ![Smart TV](https://images.trvl-media.com/lodging/109000000/108020000/108017600/108017538/3d5346d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/109000000/108020000/108017600/108017538/8fe42751.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/109000000/108020000/108017600/108017538/deb83461.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/109000000/108020000/108017600/108017538/1e69568c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lakefront tiny cabin amazing view on Lake Marion! Pet friendly & sleeps 6 Summerton 10/10 Exceptional (13) "Absolutely loved the property, and the property manager was very friendly and answered all inquiries." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Derick CA $130 CA $253 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Summerton-Hotels-Cozy-Lakefront-Tiny-Cabin-On-Lake-Marion-With-An-Amazing-View-And-Pet-Friendly.h108017538.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/77000000/76600000/76591800/76591706/994fdf59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/77000000/76600000/76591800/76591706/38650b86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/77000000/76600000/76591800/76591706/aff09b01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/77000000/76600000/76591800/76591706/a7476a6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301 Bowman 10/10 Exceptional (30) "We thoroughly enjoyed our stay! The house had everything we needed plus a fèw extra surprises like candy that we enjoyed! Very clean and accessible to congaree and charleston which was exactly what we needed!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John L. CA $107 CA $228 total includes taxes & fees Nov 8 - Nov 9 [](https://www.expedia.ca/Beautiful-Country-Cottage-With-Ease-Of-Access-Minutes-To-I-26.h76591706.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/55000000/54180000/54171600/54171514/cebbaa06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/55000000/54180000/54171600/54171514/959f5275.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/55000000/54180000/54171600/54171514/0ddde0a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/55000000/54180000/54171600/54171514/3ed00b84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Lake House at Turtle Cove: Cozy relaxing lake home with dock on wooded lot. Eutawville 10/10 Exceptional (39) "Very nice place to stay. We had everything we needed for the comforts of home. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Coleen J. CA $227 CA $434 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Eutawville-Hotels-Vrbo-Property.h54171514.Hotel-Information) ![1 bedroom, in-room safe, WiFi, bed sheets](https://images.trvl-media.com/lodging/88000000/87980000/87972600/87972565/fb69157a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, hair dryer, bathrobes, towels](https://images.trvl-media.com/lodging/88000000/87980000/87972600/87972565/w449h683x288y0-8fb90fc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, hair dryer, bathrobes, towels](https://images.trvl-media.com/lodging/88000000/87980000/87972600/87972565/fe737fd1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/88000000/87980000/87972600/87972565/w449h683x287y0-8c43cd49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Private entrance charming room with clawfoot tub. Elloree 4.0/10 (1) "This pains me to write because this could’ve been a great little stopping point, however the bathtub was actually filthy. It smelled like urine and there is a dark grey film that needs to be scrubbed off. I get that old tubs can have stains but these are not stains and could’ve been removed with cleaner and elbow grease. I had camped for a week and just wanted to take a nice hot bath; I did not get to take one. Also I would add a sign for the cottage because it was confusing as to which door it... ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gregory P. CA $210 CA $297 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Elloree-Hotels-Private-Entrance-Charming-Room-With-Clawfoot-Tub.h87972565.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-16&endDate=2025-11-17®ionId=9953&adults=2&location_highlights_explore=on_lake&sort=RECOMMENDED&openPlayBack=true) ## Top Santee Hotel Reviews ![Comfort Inn & Suites Santee](//images.trvl-media.com/lodging/1000000/520000/518500/518401/8e89959e_y.jpg) ### Comfort Inn & Suites Santee 10/10 Excellent "I like the smell" [](https://expedia.ca/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) ![Hampton Inn Santee-I-95](//images.trvl-media.com/lodging/1000000/210000/203700/203667/5f0a1276_y.jpg) ### Hampton Inn Santee-I-95 10/10 Excellent "every thing was great" [](https://expedia.ca/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information) ![Best Western Plus Santee Inn](//images.trvl-media.com/lodging/1000000/30000/21900/21863/6d1459c3_y.jpg) ### Best Western Plus Santee Inn 10/10 Excellent "This is a great place to stop on our drive South. It has gotten more expensive. " [](https://expedia.ca/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) ![Red Roof Inn Santee](//images.trvl-media.com/lodging/1000000/860000/856700/856695/4686cd8f_y.jpg) ### Red Roof Inn Santee 10/10 Excellent "Great " [](https://expedia.ca/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information) ## Frequently asked questions ### Why book your lakeside hotel in Santee with Expedia? > Finding your perfect lakeside hotel in Santee is a breeze with Expedia. Taking the kids on a break? Make your way to the filters to search for stays with family-friendly amenities. If you're on a budget, click on how much you'd like to spend and your preferred hotel star rating. Whatever your vacation plans, you'll always get the best deal around. ### How can I find cheap lakeside hotels in Santee? > Expedia makes it a breeze to locate cheap lake hotels in Santee. Simply use our convenient filter tool to choose your budget and preferred hotel star rating. You can also search for your ideal lakeside stay based on popular locations, neighborhoods and more. ### What is there to do in Santee near my lakeside hotel? > The perfect travel accessory is a well-planned schedule. [Santee State Park](https://www.expedia.ca/Santee-State-Park-Santee.d6140632.Vacation-Attraction) is a good place to kick off your adventures in Santee. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [B&B in Bowman](https://www.expedia.ca/Bowman-Bed-And-Breakfast.d553248634998681915-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Red Roof Inn Hotels in Bowman](https://www.expedia.ca/Bowman-Hotels-Red-Roof-Inn.0-0-d553248634998681915--bRedRoofInn.Travel-Guide-Filter-Hotels) - [Bowman Hotels](https://www.expedia.ca/Bowman-Hotels.d553248634998681915.Travel-Guide-Hotels) - [Apartments in Brookdale](https://www.expedia.ca/Brookdale-Apartments.d553248634999003908-aaApartments.Travel-Guide-Accommodation) - [Hotels with Free Breakfast in Brookdale](https://www.expedia.ca/Brookdale-Hotels-Hotels-With-Free-Breakfast.0-0-d553248634999003908-tHotelswithFreeBreakfast.Travel-Guide-Filter-Hotels) - [Farmstay in Cameron](https://www.expedia.ca/Cameron-Agritourism.d553248634998916920-aaAgritourism.Travel-Guide-Accommodation) - 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