Title: Book the Best LAKESIDE Hotels in Santee in 2025 | Expedia.ca [Santee Travel Guide](https://expedia.ca/Santee.dx9953)[Hotels in Santee](https://expedia.ca/Santee-Hotels.d9953.Travel-Guide-Hotels)[Vacation Rentals in Santee](https://expedia.ca/Santee-Vacation-Rentals.d9953.Travel-Guide-VacationRentals)[Flights to Santee](https://expedia.ca/Cheap-Flights-To-Santee.d9953.Travel-Guide-Flights)[Santee Car Rentals](https://expedia.ca/Car-Rentals-In-Santee.d9953.Car-Rental-Guide)[Santee Vacation Packages](https://expedia.ca/Santee.d9953.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/1/271db9a9db85f6f3488271b71d2f238f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Lake Hotels in Santee, SC ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santee Lake Hotels Tonight [Oct 3 - Oct 4](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-10-03&endDate=2025-10-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 4 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-10-04&endDate=2025-10-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-10-03&endDate=2025-10-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-10-10&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Santee Lake Hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/4686cd8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/b105c391.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/8136c59d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856700/856695/a90b57ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn Santee Santee 6.6/10 (626) "Despite offering breakfast, it was lackluster " CA $98 CA $108 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/77000000/76600000/76591800/76591706/994fdf59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/77000000/76600000/76591800/76591706/38650b86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/77000000/76600000/76591800/76591706/a7476a6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/77000000/76600000/76591800/76591706/aff09b01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301 Bowman 10/10 Exceptional (30) "We thoroughly enjoyed our stay! The house had everything we needed plus a fèw extra surprises like candy that we enjoyed! Very clean and accessible to congaree and charleston which was exactly what we needed!" CA $107 CA $227 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Beautiful-Country-Cottage-With-Ease-Of-Access-Minutes-To-I-26.h76591706.Hotel-Information) ![Smart TV](https://images.trvl-media.com/lodging/109000000/108020000/108017600/108017538/3d5346d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/109000000/108020000/108017600/108017538/deb83461.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/109000000/108020000/108017600/108017538/8fe42751.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/109000000/108020000/108017600/108017538/f4e6785a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lakefront tiny cabin amazing view on Lake Marion! Pet friendly & sleeps 6 Summerton 9.8/10 Exceptional (10) "Absolutely loved the property, and the property manager was very friendly and answered all inquiries." CA $124 CA $247 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Summerton-Hotels-Cozy-Lakefront-Tiny-Cabin-On-Lake-Marion-With-An-Amazing-View-And-Pet-Friendly.h108017538.Hotel-Information) ![BBQ/picnic area](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/495c8e2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, coffee/tea maker, blender](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/9d898fe9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, down comforters](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/dd0654f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Marina](https://images.trvl-media.com/lodging/92000000/91250000/91244700/91244689/795ddf27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bells Marina & Resort Eutawville 8.6/10 Excellent (75) "Had a great stay" CA $120 CA $133 total includes taxes & fees Oct 21 - Oct 22 [](https://www.expedia.ca/Eutawville-Hotels-Bells-Marina-Resort.h91244689.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/55000000/54180000/54171600/54171514/cebbaa06.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/55000000/54180000/54171600/54171514/0ddde0a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/55000000/54180000/54171600/54171514/3ed00b84.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/55000000/54180000/54171600/54171514/959f5275.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Lake House at Turtle Cove: Cozy relaxing lake home with dock on wooded lot. Eutawville 10/10 Exceptional (39) "Excellent place to stay. Nice and cozy spot. Neighbors are very nice as well. Very clean and neat place " CA $226 CA $432 total includes taxes & fees Oct 4 - Oct 5 [](https://www.expedia.ca/Eutawville-Hotels-Vrbo-Property.h54171514.Hotel-Information) ![1 bedroom, in-room safe, WiFi, bed sheets](https://images.trvl-media.com/lodging/88000000/87980000/87972600/87972565/fb69157a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, hair dryer, bathrobes, towels](https://images.trvl-media.com/lodging/88000000/87980000/87972600/87972565/w449h683x288y0-8fb90fc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/88000000/87980000/87972600/87972565/5115418d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, hair dryer, bathrobes, towels](https://images.trvl-media.com/lodging/88000000/87980000/87972600/87972565/fe737fd1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Private entrance charming room with clawfoot tub. Elloree 4.0/10 (1) "This pains me to write because this could’ve been a great little stopping point, however the bathtub was actually filthy. It smelled like urine and there is a dark grey film that needs to be scrubbed off. I get that old tubs can have stains but these are not stains and could’ve been removed with cleaner and elbow grease. I had camped for a week and just wanted to take a nice hot bath; I did not get to take one. Also I would add a sign for the cottage because it was confusing as to which door it... CA $209 CA $299 total includes taxes & fees Oct 5 - Oct 6 [](https://www.expedia.ca/Elloree-Hotels-Private-Entrance-Charming-Room-With-Clawfoot-Tub.h87972565.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-17&endDate=2025-10-18®ionId=9953&adults=2&location_highlights_explore=on_lake&sort=RECOMMENDED&openPlayBack=true) ## Top Santee Hotel Reviews ![Hampton Inn Santee-I-95](//images.trvl-media.com/lodging/1000000/210000/203700/203667/5f0a1276_y.jpg) ### Hampton Inn Santee-I-95 10/10 Excellent "We had a nice and courteous and friendly. Bed was comfortable " [](https://expedia.ca/Orangeburg-Hotels-Hampton-Inn-Santee-I-95.h203667.Hotel-Information) ![Best Western Plus Santee Inn](//images.trvl-media.com/lodging/1000000/30000/21900/21863/6d1459c3_y.jpg) ### Best Western Plus Santee Inn 10/10 Excellent "This was our second stay at Best Western+ Santee, and the service was as great as the first time. The hotel is aesthetically beautiful and very clean. Our favorite is the morning down home breakfast that’s served fresh every morning. Mrs. Barbara is amazing, as she puts love and care into her cooking, as everything is delicious, and displayed nicely and the dining area is always immaculate and clean, resort style. There’s nowhere else we’d rather stay when we travel to South Carolina." [](https://expedia.ca/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) ![Comfort Inn & Suites Santee](//images.trvl-media.com/lodging/1000000/520000/518500/518401/8e89959e_y.jpg) ### Comfort Inn & Suites Santee 10/10 Excellent "Pleasant people to work with, friendly and gracious. Hotel is well maintained and CLEAN. Fridge was cold, shower was hot, bed was comfortable, breakfast was nice! This was an overnight stay on a two day driving trip. Definitely gave us a good start to our second day " [](https://expedia.ca/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) ![Red Roof Inn Santee](//images.trvl-media.com/lodging/1000000/860000/856700/856695/4686cd8f_y.jpg) ### Red Roof Inn Santee 10/10 Excellent "Great " [](https://expedia.ca/Orangeburg-Hotels-Red-Roof-Inn-Santee.h856695.Hotel-Information) ## Frequently asked questions ### Why book your lakeside hotel in Santee with Expedia? > Finding your perfect lakeside hotel in Santee is a breeze with Expedia. Taking the kids on a break? Make your way to the filters to search for stays with family-friendly amenities. If you're on a budget, click on how much you'd like to spend and your preferred hotel star rating. Whatever your vacation plans, you'll always get the best deal around. ### How can I find cheap lakeside hotels in Santee? > Expedia makes it a breeze to locate cheap lake hotels in Santee. Simply use our convenient filter tool to choose your budget and preferred hotel star rating. You can also search for your ideal lakeside stay based on popular locations, neighborhoods and more. ### What is there to do in Santee near my lakeside hotel? > The perfect travel accessory is a well-planned schedule. [Santee State Park](https://www.expedia.ca/Santee-State-Park-Santee.d6140632.Vacation-Attraction) is a good place to kick off your adventures in Santee. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [B&B in Bowman](https://www.expedia.ca/Bowman-Bed-And-Breakfast.d553248634998681915-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Red Roof Inn Hotels in Bowman](https://www.expedia.ca/Bowman-Hotels-Red-Roof-Inn.0-0-d553248634998681915--bRedRoofInn.Travel-Guide-Filter-Hotels) - [Bowman Hotels](https://www.expedia.ca/Bowman-Hotels.d553248634998681915.Travel-Guide-Hotels) - [Apartments in Brookdale](https://www.expedia.ca/Brookdale-Apartments.d553248634999003908-aaApartments.Travel-Guide-Accommodation) - [Hotels with Free Breakfast in Brookdale](https://www.expedia.ca/Brookdale-Hotels-Hotels-With-Free-Breakfast.0-0-d553248634999003908-tHotelswithFreeBreakfast.Travel-Guide-Filter-Hotels) - [Farmstay in Cameron](https://www.expedia.ca/Cameron-Agritourism.d553248634998916920-aaAgritourism.Travel-Guide-Accommodation) - 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