Title: Book the Best Santee Hotels with smoking rooms in 2025 from CA $97 | Expedia.ca [Santee Travel Guide](https://expedia.ca/Santee.dx9953)[Hotels in Santee](https://expedia.ca/Santee-Hotels.d9953.Travel-Guide-Hotels)[Vacation Rentals in Santee](https://expedia.ca/Santee-Vacation-Rentals.d9953.Travel-Guide-VacationRentals)[Flights to Santee](https://expedia.ca/Cheap-Flights-To-Santee.d9953.Travel-Guide-Flights)[Santee Car Rentals](https://expedia.ca/Car-Rentals-In-Santee.d9953.Car-Rental-Guide)[Santee Vacation Packages](https://expedia.ca/Santee.d9953.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/1/271db9a9db85f6f3488271b71d2f238f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Smoking Hotels in Santee, SC from CA $97 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santee Hotels with smoking rooms Tonight [Nov 5 - Nov 6](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-11-05&endDate=2025-11-06&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 6 - Nov 7](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-11-06&endDate=2025-11-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-11-07&endDate=2025-11-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-11-14&endDate=2025-11-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Santee Hotels with smoking rooms ![Lobby](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/8e89959e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/2824d996.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/ddfa8a2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Frette Italian sheets, premium bedding, pillowtop beds, blackout drapes](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/6e319d52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Santee Santee 8.0/10 Very good (1003) "I like the smell" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dawn CA $150 CA $166 total includes taxes & fees Nov 17 - Nov 18 [](https://www.expedia.ca/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/4ab49efd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/eeb5fa18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bathtub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/ebe97e99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/756c72ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travelodge by Wyndham Santee Santee 7.0/10 Good (664) "Clean, comfortable, convenient stop on highway " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) William Brian CA $87 CA $97 total includes taxes & fees Nov 11 - Nov 12 [](https://www.expedia.ca/Orangeburg-Hotels-Travelodge-By-Wyndham-Santee.h5630775.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/95000000/94850000/94846800/94846723/f4d74712.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, a heated pool](https://images.trvl-media.com/lodging/95000000/94850000/94846800/94846723/0120967f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, hair dryer, towels, soap](https://images.trvl-media.com/lodging/95000000/94850000/94846800/94846723/8a7a4587.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Miscellaneous](https://images.trvl-media.com/lodging/95000000/94850000/94846800/94846723/d9d6fcd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tranquil Studio Cottage with Heated Pool and Fishing Access Elloree 8.4/10 Very good (6) "Was nice. Some confusion about the use of in-home bathroom (as there is no shower in tiny home). Noted to not swim in pond d/t snakes but there were also small alligators. Overall, it was quite enjoyable and peaceful. Says it can sleep 4 but would only sleep 2 comfortably and maybe a small child in the "loft," but I couldn't even look into the loft as there was no apparent latter to get up to it. Tiny home is in back yard of the large family home (a little closer than I expected)." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ashley D. CA $126 CA $315 total includes taxes & fees Nov 6 - Nov 7 [](https://www.expedia.ca/Santee-Hotels-Tranquil-Studio-Cottage-With-Heated-Pool-And-Fishing-Access.h94846723.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/2fd60881.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/2262fc91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/aa634b56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/77599f7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Santee Santee 6.8/10 (436) "It's a very quiet hotel. My room was very spacious. And the bed was very comfortable." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Monica CA $105 CA $117 total includes taxes & fees Nov 11 - Nov 12 [](https://www.expedia.ca/Orangeburg-Hotels-Super-8-By-Wyndham-Santee.h1050011.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/41ed20e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/740d6803.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/d34bd120.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/23463ec8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ramada by Wyndham Santee I-95 Santee 6.2/10 (538) "The grounds and property were clean and you could tell they take pride in what they're offering." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eric CA $98 CA $109 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Orangeburg-Hotels-Clarion-Inn-Santee-I-95.h11623.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/18900/18873/2eadf4bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18900/18873/a66aad1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/18900/18873/816f12dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/18900/18873/e088653f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham St George St. George 7.6/10 Good (1000) "Very pleasant stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Annie CA $89 CA $98 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/St-George-Hotels-Days-Inn-By-Wyndham-St-George.h18873.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/55000000/54940000/54931500/54931475/27e78d69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/55000000/54940000/54931500/54931475/e5b64ae6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/55000000/54940000/54931500/54931475/e0b4742d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/55000000/54940000/54931500/54931475/8229e487.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SpringHill Suites by Marriott Orangeburg Orangeburg 8.8/10 Excellent (660) "Clean room, friendly staff, restaurants very close, breakfast had bold coffee!!!! Loved this hotel" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Christie CA $172 CA $191 total includes taxes & fees Nov 11 - Nov 12 [](https://www.expedia.ca/Orangeburg-Hotels-SpringHill-Suites-Orangeburg.h54931475.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/57000000/56230000/56228900/56228813/962a9377.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/57000000/56230000/56228900/56228813/8f5fb158.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/57000000/56230000/56228900/56228813/e6902cd8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/57000000/56230000/56228900/56228813/d3f2bbda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn St George, SC St. George 7.4/10 Good (616) "Check in was fantastic and easy… killed 2 roaches on the wall and found a dead one on the underside of the spare bed’s pillow…" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David CA $91 CA $101 total includes taxes & fees Nov 16 - Nov 17 [](https://www.expedia.ca/Walterboro-St-George-Hotels-Red-Roof-Inn-St-George.h56228813.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/300000/297200/297104/97d6098f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/300000/297200/297104/02857169.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/300000/297200/297104/159dba3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/300000/297200/297104/a152b78a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sleep Inn Orangeburg Orangeburg 7.8/10 Good (372) "It was a good night sleep" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) amy CA $118 CA $131 total includes taxes & fees Nov 13 - Nov 14 [](https://www.expedia.ca/Orangeburg-Hotels-Sleep-Inn-Orangeburg.h297104.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/3a41c72c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/a844f756.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/ea2cde47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/f65392f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Peach Tree Inn St. George 7.4/10 Good (128) "OK for the price. Convenient location right off I-95. Rooms are dated but functional. The “continental breakfast” consisted of coffee, corn flakes and fruit loops." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Robert [](https://www.expedia.ca/St-George-Hotels-Peach-Tree-Inn.h2911319.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. 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