Title: Book the Best Santee Hotels with smoking rooms in 2026 from CA $94 | Expedia.ca [Santee Travel Guide](https://expedia.ca/Santee.dx9953)[Hotels in Santee](https://expedia.ca/Santee-Hotels.d9953.Travel-Guide-Hotels)[Vacation Rentals in Santee](https://expedia.ca/Santee-Vacation-Rentals.d9953.Travel-Guide-VacationRentals)[Flights to Santee](https://expedia.ca/Cheap-Flights-To-Santee.d9953.Travel-Guide-Flights)[Santee Car Rentals](https://expedia.ca/Car-Rentals-In-Santee.d9953.Car-Rental-Guide)[Santee Vacation Packages](https://expedia.ca/Santee.d9953.Destination-Travel-Guides) ![Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santee Hotels with smoking rooms Tonight [Jan 23 - Jan 24](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2026-01-23&endDate=2026-01-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Jan 24 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2026-01-24&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Jan 23 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2026-01-23&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Santee hotels with designated smoking areas ![Frette Italian sheets, premium bedding, pillowtop beds, blackout drapes](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/fc94b516.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/8e89959e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/2824d996.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/0b55a618.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Santee [](https://www.expedia.ca/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) Santee 8.0/10 Very good (1,010 reviews) "Clean rooms, nice staff, decent breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dale CA $142 CA $157 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) ![In-room safe, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/28717b40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/4ab49efd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/eeb5fa18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/6000000/5640000/5630800/5630775/5b7ee831.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travelodge by Wyndham Santee [](https://www.expedia.ca/Orangeburg-Hotels-Travelodge-By-Wyndham-Santee.h5630775.Hotel-Information) Santee 7.0/10 Good (688 reviews) "Nice quiet room and a delicious breakfast at a reasonable rate." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joseph B CA $85 CA $94 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/Orangeburg-Hotels-Travelodge-By-Wyndham-Santee.h5630775.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/95000000/94850000/94846800/94846723/f4d74712.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Miscellaneous](https://images.trvl-media.com/lodging/95000000/94850000/94846800/94846723/25be5d48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, a heated pool](https://images.trvl-media.com/lodging/95000000/94850000/94846800/94846723/0120967f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shower, hair dryer, towels, soap](https://images.trvl-media.com/lodging/95000000/94850000/94846800/94846723/8e450cea_edited_f3d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tranquil Getaways W/Heated Pool and Fishing [](https://www.expedia.ca/Santee-Hotels-Tranquil-Studio-Cottage-With-Heated-Pool-And-Fishing-Access.h94846723.Hotel-Information) Elloree 8.4/10 Very good (6 reviews) "Great property the pool was so fun! Mostly stayed on the property and lounged around for a nice relaxing stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tori P. CA $110 CA $260 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Santee-Hotels-Tranquil-Studio-Cottage-With-Heated-Pool-And-Fishing-Access.h94846723.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/2fd60881.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/2262fc91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/77599f7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/2000000/1060000/1050100/1050011/dc3438b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Santee [](https://www.expedia.ca/Orangeburg-Hotels-Super-8-By-Wyndham-Santee.h1050011.Hotel-Information) Santee 6.8/10 (441 reviews) "The staff was very friendly and helpful. Room was clean and beds were so comfortable. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kathy CA $103 CA $115 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Orangeburg-Hotels-Super-8-By-Wyndham-Santee.h1050011.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/d34bd120.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/41ed20e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/daa776a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/11700/11623/13247169.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ramada by Wyndham Santee I-95 [](https://www.expedia.ca/Orangeburg-Hotels-Clarion-Inn-Santee-I-95.h11623.Hotel-Information) Santee 6.4/10 (548 reviews) "The grounds and property were clean and you could tell they take pride in what they're offering." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eric CA $110 CA $122 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/Orangeburg-Hotels-Clarion-Inn-Santee-I-95.h11623.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/55000000/54940000/54931500/54931475/27e78d69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/55000000/54940000/54931500/54931475/e5b64ae6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/55000000/54940000/54931500/54931475/3ffa2f0e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/55000000/54940000/54931500/54931475/8229e487.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SpringHill Suites by Marriott Orangeburg [](https://www.expedia.ca/Orangeburg-Hotels-SpringHill-Suites-Orangeburg.h54931475.Hotel-Information) Orangeburg 8.8/10 Excellent (690 reviews) "Nice roomy clean rooms, staff were great, indoor heated pool was nice accomadation for this time of year for the kids. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lisa CA $178 CA $197 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Orangeburg-Hotels-SpringHill-Suites-Orangeburg.h54931475.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/57000000/56230000/56228900/56228813/962a9377.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/57000000/56230000/56228900/56228813/27b2c420.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/57000000/56230000/56228900/56228813/11ccce69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/57000000/56230000/56228900/56228813/11093b09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn St George, SC [](https://www.expedia.ca/Walterboro-St-George-Hotels-Red-Roof-Inn-St-George.h56228813.Hotel-Information) St. George 7.4/10 Good (647 reviews) "Great" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Swetlana CA $103 CA $115 total includes taxes & fees Feb 24 - Feb 25 [](https://www.expedia.ca/Walterboro-St-George-Hotels-Red-Roof-Inn-St-George.h56228813.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/3a41c72c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, hair dryer, towels](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/bc8b5a93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/b034ff09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/3000000/2920000/2911400/2911319/efa2345e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Peach Tree Inn [](https://www.expedia.ca/St-George-Hotels-Peach-Tree-Inn.h2911319.Hotel-Information) St. George 7.4/10 Good (154 reviews) "Clean rooms and pleasant staff. Could use newer towels. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Patricia CA $93 CA $100 total includes taxes & fees Feb 23 - Feb 24 [](https://www.expedia.ca/St-George-Hotels-Peach-Tree-Inn.h2911319.Hotel-Information) ![Standard Room Double Bed](https://images.trvl-media.com/lodging/121000000/120760000/120759500/120759451/31220fc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/121000000/120760000/120759500/120759451/edeeacb1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/121000000/120760000/120759500/120759451/0d89d19d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bathtub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/121000000/120760000/120759500/120759451/25c89b2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Inn of Manning [](https://www.expedia.ca/Manning-Hotels-Best-Inn-Of-Manning.h120759451.Hotel-Information) Manning 8.0/10 Very good (13 reviews) "Clean, comfortable, and efficient stay with friendly helpful staff and great value for your money." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Loren CA $101 CA $112 total includes taxes & fees Jan 29 - Jan 30 [](https://www.expedia.ca/Manning-Hotels-Best-Inn-Of-Manning.h120759451.Hotel-Information) ![Dining](https://images.trvl-media.com/lodging/69000000/68040000/68032100/68032053/876cda77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/69000000/68040000/68032100/68032053/bf924ead.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/69000000/68040000/68032100/68032053/ed7f19cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/69000000/68040000/68032100/68032053/26332b61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country living lake style near Santee [](https://www.expedia.ca/Sumter-Hotels-Country-Living-Lake-Style.h68032053.Hotel-Information) Summerton 10/10 Exceptional (41 reviews) "Great stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tim E. CA $130 CA $293 total includes taxes & fees Feb 6 - Feb 7 [](https://www.expedia.ca/Sumter-Hotels-Country-Living-Lake-Style.h68032053.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-07&endDate=2026-02-08®ionId=9953&adults=2&property_amenities_group_explore=designated_smoking_areas&sort=RECOMMENDED&openPlayBack=true) ## Top Santee Hotel Reviews ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [B&B in Bowman ](https://www.expedia.ca/Bowman-Bed-And-Breakfast.d553248634998681915-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Red Roof Inn Hotels in Bowman ](https://www.expedia.ca/Bowman-Hotels-Red-Roof-Inn.0-0-d553248634998681915--bRedRoofInn.Travel-Guide-Filter-Hotels) - [Bowman Hotels ](https://www.expedia.ca/Bowman-Hotels.d553248634998681915.Travel-Guide-Hotels) - [Apartments in Brookdale ](https://www.expedia.ca/Brookdale-Apartments.d553248634999003908-aaApartments.Travel-Guide-Accommodation) - [Hotels with Free Breakfast in Brookdale ](https://www.expedia.ca/Brookdale-Hotels-Hotels-With-Free-Breakfast.0-0-d553248634999003908-tHotelswithFreeBreakfast.Travel-Guide-Filter-Hotels) - 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