A dam, river, forest, and agricultural fields.

Santee Vacation Rentals

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
In two months
In three months
In four months

Our top choices for Santee vacation rentals

LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks

LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks
Santee
8.4 out of 10, Very good, (5 reviews)
"We recently stayed at this condo, and while the location was absolutely amazing, the overall cleanliness and upkeep were very disappointing.When we arrived at check-in time (4 PM), the cleaning staff was still there. After getting inside, we noticed that every bed had black hair on the sheets that appeared to be dog hair. I reached out to the host, and while they did arrange for the cleaner to return, it wasn’t until around 9 PM that night. The cleaner apologized and mentioned she usually lint...
United States
Kayla V.
The price is CA $259
CA $683 total
includes taxes & fees
Aug 15 - Aug 16
LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks

Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!

Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
Santee
10.0 out of 10, Exceptional, (15 reviews)
"Annual golf trip with old friends. Perfect accommodations & location. Hope to stay again"
United States
Greg M.
The price is CA $323
CA $717 total
includes taxes & fees
Aug 15 - Aug 16
Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!

2 Full Beds Non-Smoking

2 Full Beds Non-Smoking
St George, SC
The price is CA $118
CA $131 total
includes taxes & fees
Jul 27 - Jul 28
2 Full Beds Non-Smoking

Country living lake style near Santee

Country living lake style near Santee
Summerton
10.0 out of 10, Exceptional, (46 reviews)
"Clean, private, well maintained. Adequate parking for boaters. Excellent location for lake bound vacationers. Host very responsive."
United States
Jeffrey
The price is CA $133
CA $299 total
includes taxes & fees
Aug 15 - Aug 16
Country living lake style near Santee

Country Resting Spot just off I95. 12 miles west on hwy 6.

Country Resting Spot just off I95. 12 miles west on hwy 6.
Elloree
9.4 out of 10, Exceptional, (23 reviews)
"Amazing "
United States
Fisher R.
The price is CA $176
CA $261 total
includes taxes & fees
Jul 26 - Jul 27
Country Resting Spot just off I95. 12 miles west on hwy 6.

Bells Marina & Resort

Bells Marina & Resort
2.5 star property
Eutawville
8.6 out of 10, Excellent, (96 reviews)
"Comfortable and quiet! The AC and cozy beds made up for the room being a little dusty. A couple of things to note for future guests: the lake has a lot of weeds, and while I didn't see any, there are warning signs that alligators are in the area. A swimming pool would be an excellent addition for guests who don't have a boat."
United States
Judith
The price is CA $111
CA $127 total
includes taxes & fees
Jul 27 - Jul 28
Bells Marina & Resort

Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301

Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301
Bowman
9.8 out of 10, Exceptional, (33 reviews)
"Will stay again."
United States
Robert B.
The price is CA $108
CA $229 total
includes taxes & fees
Jul 22 - Jul 23
Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301

Pet friendly country cottage with large fenced-in yard & horses on property

Pet friendly country cottage with large fenced-in yard & horses on property
Holly Hill
10.0 out of 10, Exceptional, (151 reviews)
"Nice place, friendly hosts!"
United States
Dan R.
The price is CA $158
CA $286 total
includes taxes & fees
Jul 20 - Jul 21
Pet friendly country cottage with large fenced-in yard & horses on property

Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston

Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston
Holly Hill
10.0 out of 10, Exceptional, (14 reviews)
"Great stay!"
United States
Hayden S.
The price is CA $176
CA $226 total
includes taxes & fees
Aug 9 - Aug 10
Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston

Blue Bird Manor 3-bedroom house located in the heart of Orangeburg

Blue Bird Manor 3-bedroom house located in the heart of Orangeburg
Orangeburg
9.4 out of 10, Exceptional, (3 reviews)
"Absolutely loved it such an adorable home a host had a a quick response as well as tips! Very happy with our stay"
United States
jessie j.
The price is CA $215
CA $309 total
includes taxes & fees
Jul 19 - Jul 20
Blue Bird Manor 3-bedroom house located in the heart of Orangeburg

Modern apartment overlooking historic downtown Elloree, SC.

Modern apartment overlooking historic downtown Elloree, SC.
Elloree
The price is CA $161
CA $259 total
includes taxes & fees
Jul 20 - Jul 21
Modern apartment overlooking historic downtown Elloree, SC.

Orangeburg SC|Full Bed

Orangeburg SC|Full Bed
Orangeburg SC
10.0 out of 10, Exceptional, (40 reviews)
"Small details like extra toiletries added a nice touch to our experience."
United States
Anonymous traveller
The price is CA $98
CA $118 total
includes taxes & fees
Jul 17 - Jul 18
Orangeburg SC|Full Bed

Cozy Camping Cabin on Lake Marion near Congaree Nat Park

Cozy Camping Cabin on Lake Marion near Congaree Nat Park
Rimini
8.4 out of 10, Very good, (16 reviews)
"Great place to stay. "
United States
Scott J.
The price is CA $119
CA $199 total
includes taxes & fees
Aug 8 - Aug 9
Cozy Camping Cabin on Lake Marion near Congaree Nat Park

Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8

Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8
Summerton
10.0 out of 10, Exceptional, (1 review)
"A Perfect Family Getaway!Our stay at this beautiful Summerton cabin was everything we hoped for and more. It provided the perfect opportunity to step back into a simpler time, unplug, and truly focus on making memories together as a family.The host family is wonderful. We purchased some of their farm-fresh goodies ahead of time, and having them waiting for us at the cabin when we arrived was a fantastic touch. A major highlight of our trip was getting to see all of the farm animals and the farm...
United States
Max N.
The price is CA $309
CA $745 total
includes taxes & fees
Jul 19 - Jul 20
Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8

Cabin at the lake in Rimini, SC

Cabin at the lake in Rimini, SC
Rimini
7.4 out of 10, Good, (8 reviews)
"Great view, excellent communication with the owners, relaxing, peaceful. "
United States
Christie
The price is CA $119
CA $199 total
includes taxes & fees
Aug 12 - Aug 13
Cabin at the lake in Rimini, SC

Lakeside Glamping Tent with Kayaks & Spacious Deck in Eutaw Springs, South Carolina

Lakeside Glamping Tent with Kayaks & Spacious Deck in Eutaw Springs, South Carolina
Eutaw Springs
The price is CA $199
CA $279 total
includes taxes & fees
Jul 26 - Jul 27
Lakeside Glamping Tent with Kayaks & Spacious Deck in Eutaw Springs, South Carolina

Turtle Cove - Lake Living on Lake Marion

Turtle Cove - Lake Living on Lake Marion
Summerton
The price is CA $215
CA $657 total
includes taxes & fees
Aug 4 - Aug 5
Turtle Cove - Lake Living on Lake Marion

Tiny Home Retreat with Lake Views & Private Patio in Eutaw Springs, South Carolina

Tiny Home Retreat with Lake Views & Private Patio in Eutaw Springs, South Carolina
Eutaw Springs
The price is CA $236
CA $297 total
includes taxes & fees
Jul 29 - Jul 30
Tiny Home Retreat with Lake Views & Private Patio in Eutaw Springs, South Carolina

Beautiful brick home w/ large porch and 3 bedrooms

Beautiful brick home w/ large porch and 3 bedrooms
Bowman
9.2 out of 10, Wonderful, (5 reviews)
"A great home and very peaceful!! The host is very friendly and very easy to work with. I recommend this home for a stay 100 percent!!We plan on staying there again when we are in the area, such a great value!!"
United States
Troy K.
The price is CA $232
CA $422 total
includes taxes & fees
Aug 15 - Aug 16
Beautiful brick home w/ large porch and 3 bedrooms

Boat House (private Cabin) - Boat House (Private Cabin)

Boat House (private Cabin) - Boat House (Private Cabin)
Eutawville
10.0 out of 10, Exceptional, (1 review)
"This was a 1-night stop over for us, on the way to Florida. Unfortunately, we only had saltwater poles, or we would have loved to try our luck at fishing the lake. Fish were popping the water everywhere. We really enjoyed watching the gators cruising the lake as well! 1st for us. This was just a simple, no frills campground, but would love to ho back one day. Lodge was clean, and enjoyed sitting on the quiet back deck."
United States
Jaime W.
The price is CA $292
CA $451 total
includes taxes & fees
Aug 14 - Aug 15
Boat House (private Cabin) - Boat House (Private Cabin)
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Santee Hotel Reviews

Find out more about Santee

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Santee. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

Explore a world of travel with Expedia

Frequently asked questions

Can I find vacation rentals in Santee?

Yes, we offer vacation rentals near the most popular points of interest in Santee, or you can select a more remote option if you'd like a relaxing place to stay. Tourists appreciate the top-notch restaurants and coffeehouses in Santee. Make sure you have time to check out the golf courses and lake views during your trip.

What are some of the best vacation home rentals in Santee?

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!: Visitors like this Santee vacation home rental. It is located on a lake and has a patio, a selection of games, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Another good choice for your trip to Santee is Patio + Pool Table: Lake Marion Getaway.

How many vacation rentals are there in Santee?

Expedia has 7 vacation rentals for your stay in Santee.

What can I see and do in Santee?

While you're exploring the area, Lake Marion and Santee National Wildlife Refuge are a couple of picturesque spots to get outside and enjoy nature. Santee Cooper Country Club and Santee State Park are other places to visit while you're in town.

What are vacation rentals like in Santee?

Vacation rentals are private accommodations you can book for several days or more in Santee. Vacation rentals feature amenities like kitchens and laundry facilities so you'll feel just like you're at home. If you're concerned about a sanitized environment, a vacation rental can provide a sense of safety away from public hotel elevators and bustling concierge desks while still allowing you the experience of travel. You'll also get more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is a great choice for family gatherings.