An aerial view of a coastal landscape with a dam, farmland, and dense forests.

Santee Vacation Rentals

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Our top choices for Santee vacation rentals

1. Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Santee
10.0 out of 10, Exceptional, (46 reviews)
"Comfortable home with fenced in yard for dogs is a plus. The house had everything needed for a stay. Furniture was comfy. House is an hour drive from congaree NP. Many opportunities nearby to connect with nature."
United States
Jessica C.
The price is CA $163
CA $490 total
includes taxes & fees
Oct 21 - Oct 22
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

2. Lake Marion Condo, Boat Slip Included, Pet Friendly

Lake Marion Condo, Boat Slip Included, Pet Friendly
Santee
10.0 out of 10, Exceptional, (1 review)
"My husband, son and I booked a relatively last-minute weekend trip. Gabriel was great, and fast about answering my questions. The unit was easy to find and gain entry to. It is very clean, quiet, and accessible to the water; a very short walk to the on-prem docks and the covered porch is very nice. We had an enjoyable stay and liked the area."
United States
Katie A.
The price is CA $249
CA $472 total
includes taxes & fees
Oct 17 - Oct 18
Lake Marion Condo, Boat Slip Included, Pet Friendly

3. LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks

LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks
Santee
9.0 out of 10, Wonderful, (8 reviews)
"We had a wonderful stay. Couldn't have asked for better location. It was beautiful, close to everything and perfect for our family."
United States
Michelle H.
The price is CA $297
CA $735 total
includes taxes & fees
Oct 18 - Oct 19
LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks

4. Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!

Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
Santee
10.0 out of 10, Exceptional, (16 reviews)
"Annual golf trip with old friends. Perfect accommodations & location. Hope to stay again"
United States
Greg M.
The price is CA $327
CA $723 total
includes taxes & fees
Oct 21 - Oct 22
Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!

5. Lakefront tiny cabin amazing view on Lake Marion! Pet friendly.

Lakefront tiny cabin amazing view on Lake Marion! Pet friendly.
Summerton
8.8 out of 10, Excellent, (37 reviews)
"Great place to stay on the lake! "
United States
Troy S.
The price is CA $109
CA $231 total
includes taxes & fees
Oct 15 - Oct 16
Lakefront tiny cabin amazing view on Lake Marion! Pet friendly.

6. Bells Marina & Resort

Bells Marina & Resort
2.5 star property
Eutawville
8.6 out of 10, Excellent, (103 reviews)
"Love it"
United States
Mark
The price is CA $103
CA $119 total
includes taxes & fees
Oct 21 - Oct 22
Bells Marina & Resort

7. Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301

Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301
Bowman
9.8 out of 10, Exceptional, (37 reviews)
"The place was excellent. The bed was really nice and comfortable. I'd definitely stay again."
United States
Joseph
The price is CA $109
CA $231 total
includes taxes & fees
Oct 17 - Oct 18
Beautiful country cottage with ease of access! Minutes to I-26, I-95 and Hwy 301

8. Country living lake style near Santee

Country living lake style near Santee
Summerton
10.0 out of 10, Exceptional, (46 reviews)
"Very convenient to the lake."
United States
John P.
The price is CA $155
CA $333 total
includes taxes & fees
Oct 26 - Oct 27
Country living lake style near Santee

9. Relax and unwind near Lake Marion - 2-bedroom 1.5 bath cabin getaway.

Relax and unwind near Lake Marion - 2-bedroom 1.5 bath cabin getaway.
Summerton
10.0 out of 10, Exceptional, (3 reviews)
"This property is absolutely gorgeous! The pics don't do it justice. Very nice and quiet neighbor. Would recommend it anytime"
United States
Judy v.
The price is CA $189
CA $376 total
includes taxes & fees
Oct 19 - Oct 20
Relax and unwind near Lake Marion - 2-bedroom 1.5 bath cabin getaway.

10. Quiet 1-bedroom apartment in charming Elloree, SC

Quiet 1-bedroom apartment in charming Elloree, SC
Elloree
The price is CA $160
CA $258 total
includes taxes & fees
Oct 15 - Oct 16
Quiet 1-bedroom apartment in charming Elloree, SC

11. Cozy Camping Cabin on Lake Marion near Congaree Nat Park

Cozy Camping Cabin on Lake Marion near Congaree Nat Park
Rimini
8.2 out of 10, Very good, (17 reviews)
"Great place to stay. "
United States
Scott J.
The price is CA $127
CA $205 total
includes taxes & fees
Oct 28 - Oct 29
Cozy Camping Cabin on Lake Marion near Congaree Nat Park

12. Cabin at the lake in Rimini, SC

Cabin at the lake in Rimini, SC
Rimini
7.4 out of 10, Good, (8 reviews)
"Great view, excellent communication with the owners, relaxing, peaceful. "
United States
Christie
The price is CA $114
CA $194 total
includes taxes & fees
Oct 15 - Oct 16
Cabin at the lake in Rimini, SC

13. Modern apartment overlooking historic downtown Elloree, SC.

Modern apartment overlooking historic downtown Elloree, SC.
Elloree
The price is CA $178
CA $276 total
includes taxes & fees
Oct 15 - Oct 16
Modern apartment overlooking historic downtown Elloree, SC.

14. Country Resting Spot just off I95. 12 miles west on hwy 6.

Country Resting Spot just off I95. 12 miles west on hwy 6.
Elloree
9.4 out of 10, Exceptional, (25 reviews)
"Everyone was pleased and said they would stay here again."
United States
Tom B.
The price is CA $169
CA $254 total
includes taxes & fees
Oct 21 - Oct 22
Country Resting Spot just off I95. 12 miles west on hwy 6.

15. Pet friendly country cottage with large fenced-in yard & horses on property

Pet friendly country cottage with large fenced-in yard & horses on property
Holly Hill
10.0 out of 10, Exceptional, (164 reviews)
"Great place to stay on our trip!"
United States
Thomas G.
The price is CA $160
CA $290 total
includes taxes & fees
Oct 15 - Oct 16
Pet friendly country cottage with large fenced-in yard & horses on property

16. Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston

Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston
Holly Hill
10.0 out of 10, Exceptional, (15 reviews)
"Great stay!"
United States
Hayden S.
The price is CA $178
CA $229 total
includes taxes & fees
Oct 20 - Oct 21
Charming 2-bedroom cottage close to I26 and I95; 1 hr from Charleston

17. Turtle Cove - Lake Living on Lake Marion

Turtle Cove - Lake Living on Lake Marion
Summerton
10.0 out of 10, Exceptional, (1 review)
"Great quiet and cozy home with a nice backyard and porch with the easy water access by dock. Really enjoyed our stay."
United States
Judith H.
The price is CA $177
CA $632 total
includes taxes & fees
Oct 15 - Oct 16
Turtle Cove - Lake Living on Lake Marion

18. Beautiful brick home w/ large porch and 3 bedrooms

Beautiful brick home w/ large porch and 3 bedrooms
Bowman
9.2 out of 10, Wonderful, (5 reviews)
"A great home and very peaceful!! The host is very friendly and very easy to work with. I recommend this home for a stay 100 percent!!We plan on staying there again when we are in the area, such a great value!!"
United States
Troy K.
The price is CA $211
CA $403 total
includes taxes & fees
Oct 20 - Oct 21
Beautiful brick home w/ large porch and 3 bedrooms

19. Sweet Marion - Dock + Boat Ramp + Hot Tub!

Sweet Marion - Dock + Boat Ramp + Hot Tub!
Summerton
8.8 out of 10, Excellent, (26 reviews)
"We had a lot of fun. The place was pleasant, clean and well put together. The hot tub and other amenities such as the kayaks were a lot of fun, and the natural entertainments provided by the creek and all its animals was wonderful. The hosts responded quickly to any inquiry, and they were friendly and efficient. I definitely stay there again."
United States
Mei-Li B.
The price is CA $195
CA $747 total
includes taxes & fees
Oct 19 - Oct 20
Sweet Marion - Dock + Boat Ramp + Hot Tub!

20. Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8

Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8
Summerton
10.0 out of 10, Exceptional, (2 reviews)
"A Perfect Family Getaway!Our stay at this beautiful Summerton cabin was everything we hoped for and more. It provided the perfect opportunity to step back into a simpler time, unplug, and truly focus on making memories together as a family.The host family is wonderful. We purchased some of their farm-fresh goodies ahead of time, and having them waiting for us at the cabin when we arrived was a fantastic touch. A major highlight of our trip was getting to see all of the farm animals and the farm...
United States
Max N.
Private Farm Stay on 30-Acres with Fish Pond + Sleeps 8
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santee Hotel Reviews

Find out more about Santee

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Santee. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

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Frequently asked questions

Can I find vacation rentals in Santee?

Yes, we offer vacation rentals near the most popular points of interest in Santee, or you can select a more remote option if you'd like a relaxing place to stay. Tourists appreciate the top-notch restaurants and coffeehouses in Santee. Make sure you have time to check out the golf courses and lake views during your trip.

What are some of the best vacation home rentals in Santee?

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!: This highly rated vacation home rental in Santee is located on a lake and has a patio, a selection of games, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family.

How many vacation rentals are there in Santee?

Expedia has 9 vacation rentals for your stay in Santee.

What can I see and do in Santee?

While you're exploring the area, Lake Marion and Taw Caw Creek Park are a couple of picturesque spots to get outside and enjoy nature. Santee Cooper Country Club and Santee State Park are other places to visit while you're in town.

What are vacation rentals like in Santee?

Vacation rentals are private accommodations you can book for several days or more in Santee. Vacation rentals feature amenities like kitchens and laundry facilities so you'll feel just like you're at home. If you're concerned about a sanitized environment, a vacation rental can provide a sense of safety away from public hotel elevators and bustling concierge desks while still allowing you the experience of travel. You'll also get more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is a great choice for family gatherings.