Title: 10 Best Spa Resorts in South Carolina for 2025 | Expedia.ca [South Carolina Travel Guide](https://expedia.ca/South-Carolina.dx242)[South Carolina Hotels](https://expedia.ca/Destinations-In-South-Carolina.d242.Hotel-Destinations)[Vacation Rentals in South Carolina](https://expedia.ca/Destinations-In-South-Carolina.d242.Vacation-Rental-Destinations)[South Carolina Flights](https://expedia.ca/Destinations-In-South-Carolina.d242.Flight-Destinations)[South Carolina Car Rentals](https://expedia.ca/Destinations-In-South-Carolina.d242.Car-Rental-Destinations)[South Carolina Vacations](https://expedia.ca/South-Carolina.d242.Destination-Travel-Guides) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/46000/46799-Myrtle-Beach.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # South Carolina Spa Resorts ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South Carolina Spa Hotels Tonight [Oct 28 - Oct 29](https://www.expedia.ca/Hotel-Search?regionId=242&startDate=2025-10-28&endDate=2025-10-29&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 29 - Oct 30](https://www.expedia.ca/Hotel-Search?regionId=242&startDate=2025-10-29&endDate=2025-10-30&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=242&startDate=2025-10-31&endDate=2025-11-02&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=242&startDate=2025-11-07&endDate=2025-11-09&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top South Carolina Spa Hotels ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-South-Carolina-Spa-Hotel.0-0-d242-tSpaHotel.Hotel-Filter-Destinations)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-South-Carolina-Spa-Hotel.0-0-d242-tSpaHotel.Hotel-Filter-Destinations) ## Top South Carolina Hotel Reviews ## Explore a world of travel with Expedia - 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