Santee Vacation Packages

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Your Santee Vacation

Enjoy unforgettable adventures when you book a vacation package to Santee. Whether you're a foodie, art buff or just a traveler who loves discovering new places, there's something for everyone in this lively city. If your trip to Santee includes some sightseeing, don't miss famous attractions like Santee State Park, Santee Cooper Country Club and Santee Outlets. Stop daydreaming and start traveling. Browse the many options on Expedia today and put your Santee vacation plans into action!

Top Santee Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Executive Inn Ridgeway I-77
Hilton Columbia Center
Holiday Inn Express & Suites Columbia Downtown - The Vista by IHG
Fairfield Inn and Suites by Marriott Columbia
Staybridge Suites Columbia by IHG

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Santee Hotel Deals

Baymont by Wyndham Santee

Baymont by Wyndham Santee

2.5 out of 5
249 Britain Street Santee SC
Fully refundableReserve now, pay when you stay
The price is CA $103 per night from Feb 10 to Feb 11
CA $103
CA $114 total
Feb 10 - Feb 11
includes taxes & fees
7.8/10 Good! (1,418 reviews)
Great service

Reviewed on Feb 3, 2026

Baymont by Wyndham Santee
Tru By Hilton Santee

Tru By Hilton Santee

2.5 out of 5
263 Britain St. and 273 Britain St. Santee SC
Fully refundableReserve now, pay when you stay
The price is CA $149 per night from Feb 16 to Feb 17
CA $149
CA $165 total
Feb 16 - Feb 17
includes taxes & fees
9/10 Wonderful! (711 reviews)
Very clean!

Reviewed on Feb 3, 2026

Tru By Hilton Santee
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

2.5 out of 5
9060 Old Number Six Hwy Santee SC
Fully refundableReserve now, pay when you stay
The price is CA $179 per night from Feb 22 to Feb 23
CA $179
CA $198 total
Feb 22 - Feb 23
includes taxes & fees
9.6/10 Exceptional! (1,000 reviews)
Everything was great

Reviewed on Feb 1, 2026

Hampton Inn Santee-I-95
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.