Title: Santa Isabel Vacation Packages & Trips 2026  | Expedia.ca

[Hotels in Santa Isabel](https://expedia.ca/Santa-Isabel-Hotels.d553248635975869828.Travel-Guide-Hotels)[Vacation Rentals in Santa Isabel](https://expedia.ca/Santa-Isabel-Vacation-Rentals.d553248635975869828.Travel-Guide-VacationRentals)[Santa Isabel Car Rentals](https://expedia.ca/Car-Rentals-In-Santa-Isabel.d553248635975869828.Car-Rental-Guide)

![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_packages.jpeg?impolicy=fcrop&w=1200&h=300&q=medium)

# Santa Isabel Vacation Packages

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#### Your Santa Isabel Vacation

Our vacation packages to Santa Isabel give you endless opportunities to immerse yourself in new sights, sounds and sensations. And with all the details taken care of, you'll be free to enjoy your city adventure to the fullest. Make your trip to Santa Isabel even more fun and exciting by including some sightseeing. [Plaza Comercial La Cachanilla](https://www.expedia.ca/Plaza-Comercial-La-Cachanilla-Zona-Industrial.d6291021.Vacation-Attraction), [City Forest and Zoo](https://www.expedia.ca/City-Forest-And-Zoo-Mexicali.d6224745.Vacation-Attraction) and [Juventud 2000 Sport Center](https://www.expedia.ca/Juventud-2000-Sport-Center-Mexicali.d553248621551385142.Vacation-Attraction) are among the big attractions worth exploring. A few quick clicks is all it takes to put together the perfect Santa Isabel vacation on Expedia.

## Ready to book your vacation to Santa Isabel?

Choose your dates

## Santa Isabel Hotel Deals

![Hotel Araiza Mexicali](https://images.trvl-media.com/lodging/1000000/30000/22600/22592/c02f77f8_y.jpg?impolicy=resizecrop&rw=340&ch=150)

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Hotel Araiza Mexicali

Blvd. Benito Juarez 2220 Mexicali BC

Fully refundable

CA $173

CA $196 total

Apr 12 - Apr 13

includes taxes & fees

8.6/10 Excellent! (1,810 reviews)

Great service as always

Reviewed on Apr 3, 2026

[](https://expedia.ca/Hotel-Search?startDate=12%2F04%2F2026&endDate=13%2F04%2F2026&selected=22592&PinnedHotelID=22592&HadPinnedHotel=true&regionId=553248635975869828)

![Hotel Lucerna Mexicali](https://images.trvl-media.com/lodging/1000000/440000/437500/437408/b85b0cb3_y.jpg?impolicy=resizecrop&rw=340&ch=150)

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Hotel Lucerna Mexicali

Boulevard Benito Juarez 2151 Mexicali BC

Fully refundableReserve now, pay when you stay

CA $154

CA $174 total

Apr 12 - Apr 13

includes taxes & fees

9.2/10 Wonderful! (1,554 reviews)

I paid for an executive room and the condition of the room and bathroom was very poor. Paint was very poorly done. Carpet is old and lighting was not adequate. They need to upgrade their executive rooms.

Reviewed on Apr 2, 2026

[](https://expedia.ca/Hotel-Search?startDate=12%2F04%2F2026&endDate=13%2F04%2F2026&selected=437408&PinnedHotelID=437408&HadPinnedHotel=true&regionId=553248635975869828)

![City Express Plus by Marriott Mexicali](https://images.trvl-media.com/lodging/45000000/44950000/44945400/44945342/d08d8cef_y.jpg?impolicy=resizecrop&rw=340&ch=150)

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City Express Plus by Marriott Mexicali

Avenida Republica de Cuba 39 Mexicali BC

Fully refundableReserve now, pay when you stay

CA $121

CA $137 total

Apr 5 - Apr 6

includes taxes & fees

8.6/10 Excellent! (1,001 reviews)

Todo muy bien, solo falta un refrigerador pra los q ue tienen niños o familia, lo demás está perfecto

Reviewed on Apr 2, 2026

[](https://expedia.ca/Hotel-Search?startDate=05%2F04%2F2026&endDate=06%2F04%2F2026&selected=44945342&PinnedHotelID=44945342&HadPinnedHotel=true&regionId=553248635975869828)

[See all 71 properties in Santa Isabel](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=05%2F04%2F2026&endDate=06%2F04%2F2026&regionId=553248635975869828)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

All Inclusive Vacations

[](https://expedia.ca/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Beach Vacations

[](https://expedia.ca/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Family Vacations

[](https://expedia.ca/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Family_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Golf Vacations

[](https://expedia.ca/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Luxury Vacations

[](https://expedia.ca/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Romantic Vacations

[](https://expedia.ca/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click)

![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh)

Ski Vacations

[](https://expedia.ca/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click)

### Discover the most popular places to visit in Santa Isabel

#### Hospital de la Familia

Though Hospital de la Familia might be what brings you to town, perhaps you'll have a chance to explore more of Mexicali while you are here. 

[](https://expedia.ca/Hospital-De-La-Familia-Mexicali.d553248635977407856.Vacation-Attraction)

#### Juventud 2000 Sport Center

5/5(1 review)

Juventud 2000 Sport Center is just one of the places to see in Mexicali, so why not enjoy the other things to explore during your travels? Check out the shops and top-notch restaurants in this family-friendly area. 

[](https://expedia.ca/Juventud-2000-Sport-Center-Mexicali.d553248621551385142.Vacation-Attraction)

#### Hospital Almater SA de CV

Though Hospital Almater SA de CV might be what brings you to town, perhaps you'll have a chance to explore more of Mexicali while you are here. 

[](https://expedia.ca/Hospital-Almater-SA-De-CV-Mexicali.d553248635998002058.Vacation-Attraction)

## Explore a world of travel with Expedia

\* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.

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