Title: Visit Santa Cruz Tlaxcala: Best of Santa Cruz Tlaxcala Tourism | Expedia Travel Guide - Expedia.ca [Hotels in Santa Cruz Tlaxcala](https://expedia.ca/Santa-Cruz-Tlaxcala-Hotels.d553248635640693398.Travel-Guide-Hotels)[Vacation Rentals in Santa Cruz Tlaxcala](https://expedia.ca/Santa-Cruz-Tlaxcala-Vacation-Rentals.d553248635640693398.Travel-Guide-VacationRentals)[Santa Cruz Tlaxcala Car Rentals](https://expedia.ca/Car-Rentals-In-Santa-Cruz-Tlaxcala.d553248635640693398.Car-Rental-Guide)[Santa Cruz Tlaxcala Vacation Packages](https://expedia.ca/Santa-Cruz-Tlaxcala.d553248635640693398.Destination-Travel-Guides) # Santa Cruz Tlaxcala ## Travel Guide ## Visit Santa Cruz Tlaxcala - Santa Cruz Tlaxcala Hotel Deals - Vacation Rentals in Santa Cruz Tlaxcala ![Ramada Encore Puebla Mexico](https://images.trvl-media.com/lodging/17000000/16610000/16608300/16608261/72886336_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Ramada Encore Puebla Mexico Lateral del Anillo Periferico Coronango PUE CA $92 CA $110 total Jan 6 - Jan 7 includes taxes & fees Book a stay at this business-friendly hotel in Coronango. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ... 9.2/10 Wonderful! (1,006 reviews) Staff was great and friendly Working on Bathrooms Reviewed on Dec 18, 2025 [](https://expedia.ca/Hotel-Search?startDate=06%2F01%2F2026&endDate=07%2F01%2F2026&selected=16608261&PinnedHotelID=16608261&HadPinnedHotel=true®ionId=553248635640693398) ![Gran Hotel de Puebla by HNF](https://images.trvl-media.com/lodging/19000000/18150000/18147500/18147426/9a0d0041_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Gran Hotel de Puebla by HNF Blvd Hermanos Serdan, 794 Puebla PUE CA $82 CA $98 total Jan 11 - Jan 12 includes taxes & fees Book a stay at this luxury hotel in Puebla. Enjoy free WiFi, free parking, and 2 restaurants. Our guests praise the helpful staff and the property condition ... 9.2/10 Wonderful! (485 reviews) Everything was excellent! Reviewed on Nov 5, 2025 [](https://expedia.ca/Hotel-Search?startDate=11%2F01%2F2026&endDate=12%2F01%2F2026&selected=18147426&PinnedHotelID=18147426&HadPinnedHotel=true®ionId=553248635640693398) ![NH Puebla Finsa](https://images.trvl-media.com/lodging/19000000/18130000/18124600/18124564/60dca45a_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### NH Puebla Finsa Av. Moratilla 132-1 Puebla PUE CA $71 CA $85 total Jan 29 - Jan 30 includes taxes & fees Book a stay at this business-friendly hotel in Puebla. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Zócalo de Puebla and Angelopolis ... 9/10 Wonderful! (380 reviews) Slippery shower No kleenex No soap Uncomfortable pillows Reviewed on Aug 10, 2025 [](https://expedia.ca/Hotel-Search?startDate=29%2F01%2F2026&endDate=30%2F01%2F2026&selected=18124564&PinnedHotelID=18124564&HadPinnedHotel=true®ionId=553248635640693398) [See all 214 properties in Santa Cruz Tlaxcala](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=06%2F01%2F2026&endDate=07%2F01%2F2026®ionId=553248635640693398) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Luxurious Casa Residencial Privada](https://images.trvl-media.com/lodging/94000000/93060000/93054700/93054694/a84cd9b6_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Luxurious Casa Residencial Privada San Miguel Contla MEX Stay at this vacation home in Santa Cruz Tlaxcala. Enjoy laundry facilities and balconies. [](https://expedia.ca/Santa-Cruz-Tlaxcala-Hotels-Luxurious-Casa-Residencial-Privada.h93054694.Hotel-Information) ![Pietro Santo](https://images.trvl-media.com/lodging/85000000/84030000/84020700/84020693/d2345181_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Pietro Santo Sta Isa Tetlahuaca Km2 San Miguel Xoxtla Santeagueda TLAX Stay at this apartment in Tetlatlahuca. Enjoy free WiFi and a 24-hour front desk. Popular attractions Outlet Puebla Premier and Cacaxtla are located nearby. 9.2/10 Wonderful! (141 reviews) Very nice hotel. And excellent service. Valquirico is a wonderful destination for dining shopping and walking around. The hotel is located right in the center. Reviewed on Aug 28, 2025 [](https://expedia.ca/Santeagueda-Hotels-Pietro-Santo.h84020693.Hotel-Information) ![Loft Carrara](https://images.trvl-media.com/lodging/113000000/113000000/112994400/112994326/6f2e3c31_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Loft Carrara C. de Los Morales 117 Val'Quirico Centro Val'Quirico TLAX Stay at this apartment in Tetlatlahuca. Enjoy free WiFi. Popular attractions Outlet Puebla Premier and Cacaxtla are located nearby. 10/10 Exceptional! (6 reviews) Muy bonito el lugar y limpio Reviewed on Nov 24, 2025 [](https://expedia.ca/Tetlatlahuca-Hotels-Loft-Carrara.h112994326.Hotel-Information) [See all properties in Santa Cruz Tlaxcala](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=553248635640693398&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Santa Cruz Tlaxcala hotel availability [Tonight ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635640693398&startDate=2026-01-05&endDate=2026-01-06)[Jan 5 - Jan 6](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635640693398&startDate=2026-01-05&endDate=2026-01-06) [Tomorrow night ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635640693398&startDate=2026-01-06&endDate=2026-01-07)[Jan 6 - Jan 7](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635640693398&startDate=2026-01-06&endDate=2026-01-07) [This weekend ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635640693398&startDate=09%2F01%2F2026&endDate=11%2F01%2F2026)[Jan 9 - Jan 11](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635640693398&startDate=09%2F01%2F2026&endDate=11%2F01%2F2026) [Next weekend ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635640693398&startDate=16%2F01%2F2026&endDate=18%2F01%2F2026)[Jan 16 - Jan 18](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635640693398&startDate=16%2F01%2F2026&endDate=18%2F01%2F2026) ## Cities near Santa Cruz Tlaxcala ![Photo by Elena Kostoulakis](https://mediaim.expedia.com/destination/2/eb6043a0304b1ad98077d79c2b295e80.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Apizaco ![Tlaxcala which includes heritage elements](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/228000/228152-Tlaxcala-Province.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Tlaxcala ## Explore a world of travel with Expedia - 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