The best area to stay in San Francisco for most travellers is the city centre, particularly around Avenida Libertador and the main square, Plaza General San Martín.
This central area is the hub of activity and offers excellent convenience. You'll find a good selection of hotels, restaurants, and shops concentrated along Avenida Libertador and the surrounding streets. The Plaza General San Martín is a central landmark, great for a leisurely stroll and observing daily life.
Couples looking for a comfortable and well-connected base will find this area ideal. It's easy to explore the city's main attractions on foot from here, and there are numerous dining options for evenings out. The central location also provides good access to public transport if you wish to venture further afield.
For business travellers, staying in the city centre provides proximity to many commercial offices and meeting venues.