The best area to stay in Río Sereno is near the town centre, particularly around the main road that leads to the border crossing with Costa Rica.This area is the heart of Río Sereno, offering the most convenience for travellers. You'll find the local shops, small eateries, and the main bus stops concentrated here. The general layout is straightforward, with most amenities accessible by foot along the main thoroughfare.For travellers looking for a convenient base for exploring the cross-border region, staying in the town centre is ideal. Its proximity to the border post makes day trips into Costa Rica straightforward, and you'll have easy access to local transport for exploring the Panamanian side of the Talamanca mountain range.Couples seeking a tranquil stopover before or after a border crossing will appreciate the relaxed pace of this area.