Book The Best Hotels in Mission Hill, SD for 2026 from CA $109 - Fully Refundable Options

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Go beyond your typical stay in Mission Hill

Pet friendly

Apartment

Pool

Condo

Hot tub

Family friendly

Cabin

Waterpark

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Mission Hill hotels

A lobby with a stone fireplace, leather seating, a bar area, and a staircase.

A bar area with a long counter, multiple stools, and hanging glassware.

A Best Western hotel with a modern facade, large glass windows, and a well-lit entrance.

A modern living room with a sofa set, a coffee table, and a rug.

1. Best Western Kelly Inn

Yankton

Susan

CA $149

CA $165 total

includes taxes & fees

Oct 11 - Oct 12

A hotel lobby with a reception desk, seating area, and a large window with a view of a building.

A hotel reception area with a long counter, coffee machines, and a television screen displaying a program.

A hotel room with two beds, a desk, a chair, and a framed picture on the wall.

A Comfort Inn hotel with a covered entrance, a parking lot, and a clear sky.

2. Comfort Inn Yankton SD

Yankton

Vanessa

CA $134

CA $148 total

includes taxes & fees

Oct 18 - Oct 19

An indoor swimming pool with clear blue water, surrounded by white chairs and tables.

A compact kitchenette with a microwave, coffee maker, and dishwasher. Adjacent is a small seating area with a sofa and a table.

A hotel room with a bed, a desk with a television, a chair, a lamp, and a window with curtains.

A buffet with various food items, including omelets and other dishes, arranged in metal serving trays.

3. Holiday Inn Express & Suites Yankton by IHG

Yankton

Jerome C.

CA $171

CA $189 total

includes taxes & fees

Oct 15 - Oct 16

A hotel room with two beds, a desk, a chair, a window with curtains, a wall-mounted TV, and a large wall art piece.

A multi-story hotel with a covered entrance, stone accents, and a parking lot.

A bathroom with a sink, mirror, towel rack, toilet, and shower curtain.

A breakfast area with a coffee machine, a TV, and a clock on the wall.

4. Super 8 by Wyndham Yankton

Yankton

Elzbieta

CA $109

CA $122 total

includes taxes & fees

Oct 4 - Oct 5

A modern living room with a fireplace, seating area, and large windows.

A modern reception area with wooden paneling, a reception desk, and a refrigerated display case.

A patio with outdoor seating, stone wall, and large windows.

A restaurant with a long counter, booths, and high tables.

5. Fairfield Inn & Suites by Marriott Yankton

Yankton

teresa

CA $182

CA $201 total

includes taxes & fees

Oct 11 - Oct 12

A hotel room with two beds, a desk, a chair, and a lamp.

A kitchen with wooden cabinets, a dining area with chairs, a refrigerator, and a microwave.

A hotel room with a sofa, a television, a desk with a chair, a lamp, a microwave, a framed picture, and a fireplace.

A hotel with multiple parking spaces, a lobby entrance, and a building facade with windows.

6. Econo Lodge Inn & Suites Yankton

Yankton

Susan Stanton

CA $107

CA $119 total

includes taxes & fees

Oct 13 - Oct 14

A vending machine with snacks and a refrigerator in a hallway.

A dining area with a long table and chairs, a marble backsplash, and wicker baskets on the wall.

A hotel room with two beds, a desk, a chair, a television, and artwork on the walls.

A reception desk with a stone wall backdrop, a Red Roof Inn sign, and a Dell computer monitor.

7. Red Roof Inn Vermillion - U of South Dakota

Vermillion

Kevin

CA $125

CA $139 total

includes taxes & fees

Sep 27 - Sep 28

A hotel room with a large bed, a separate bathroom with a bathtub, a desk with a television, and a view of trees through the window.

A bar area with a long counter, multiple bar stools, a television mounted on the wall, and a wine rack with various bottles.

A reception desk with a flat-screen TV, pendant lights, and a potted plant.

A living room with a stone fireplace, a flat-screen TV, and a patterned carpet.

8. Cobblestone Inn & Suites - Hartington

Hartington

Lynn

CA $140

CA $163 total

includes taxes & fees

Sep 24 - Sep 25

A diner with red cabinets, a checkered floor, and a television on the wall.

A Prairie Inn with a covered entrance and brick facade.

A reception area with a stone counter, a seating area with sofas, and a door labeled "Hotel Lobby".

A Prairie Inn building with a covered parking area and a signboard.

9. Prairie Inn

Vermillion

Kara

CA $100

CA $109 total

includes taxes & fees

Sep 28 - Sep 29

A grand staircase with wooden railings and a red flag, leading to a room with a patterned ceiling and string lights.

A bedroom with a bed, bedside table, lamp, and a window with blinds.

A bed with a metal headboard, two pillows, a bedside table with a lamp, and a window with curtains.

A neatly made bed with a patterned bedspread and pillows, a bedside lamp, and a window with closed blinds.

10. The Historic Argo Hotel

Crofton

Deborah

CA $236

CA $265 total

includes taxes & fees

Sep 25 - Sep 26

A hotel with a covered outdoor area, multiple windows, and a stone pillar.

An indoor swimming pool with clear lane markings, lounge chairs, and umbrellas.

A hotel lobby with a leather sofa, a patterned rug, a wooden cabinet, and a dining area with a table and chairs.

A hotel room with a bed, a desk with a chair, a television, a lamp, and a window with curtains.

11. Best Western Vermillion Inn

Vermillion

Mary

CA $135

CA $149 total

includes taxes & fees

Oct 11 - Oct 12

A spacious kitchen with a large island, modern pendant lights, and a ceiling fan.

A spacious room with wooden walls and ceiling, featuring a large chandelier, multiple windows, and a central seating area with tables and chairs.

A modern kitchen with dark cabinets, stainless steel appliances, and a large window.

A modern kitchen with stainless steel appliances, dark wood cabinets, and a tiled floor.

12. Lewis and Clark Resort

Yankton

Jeff

CA $167

CA $176 total

includes taxes & fees

Sep 27 - Sep 28

A hotel room with a large bed, a separate bathroom with a bathtub, a desk with a chair, and a window with blinds.

A coffee station with two coffee machines and a variety of coffee pods and cups.

A conference room with a long table, multiple chairs, a projector screen, and a kitchen area.

A hotel hallway with carpeted flooring, a wall with a geometric design, and an elevator.

13. Holiday Inn Express Hotel & Suites Vermillion by IHG

Vermillion

Stephanie

CA $216

CA $238 total

includes taxes & fees

Sep 24 - Sep 25

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Mission Hill attractions

Lincoln Park

Explore the great outdoors at Lincoln Park, a lovely green space in Mission Hill.

See properties

Top Mission Hill Hotel Reviews

Econo Lodge Inn & Suites Yankton

10/10 Excellent

"Clean and helpful staff."

Best Western Vermillion Inn

10/10 Excellent

"Staff was excellent and went above and beyond to accommodate our request! We will look forward to staying again."

Prairie Inn

8/10 Good

"X"

Holiday Inn Express & Suites Yankton by IHG

8/10 Good

"Nice hotel, room was clean and nicely decorated. Bed was super comfy. They had a nice happy hour with free beer and wine which was a nice touch. I missed the breakfast because I slept in. It was hard to do because the maids were a little aggressive to clean the room in the morning, knocking on the door at 8 am and again at 9 am. I would stay there again but would hang a do not disturb tag on the door."

Fairfield Inn & Suites by Marriott Yankton

10/10 Excellent

"Great place!!!"

Modern Lewis and Clark lake home with lake views and 3 min drive to the beach!

10/10 Excellent

"Everything was great!"

Fully furnished lake house with cozy spaces, full kitchen, and lake views.

10/10 Excellent

"Great location to host our company retreat! The house was spacious and offered plenty of room. Appreciated all the outdoor chairs available to use. We enjoyed sitting around the outdoor firepit at night."

Super 8 by Wyndham Yankton

8/10 Good

"Just kind of old but served us with what we required."

Cozy cabin near Lewis and Clark Lake and CJ’s at the Lake

10/10 Excellent

"Checked all the boxes for what we needed for this stay, thanks Tony !"