The best area to stay in Mesolongi is the town centre, particularly around the central square, Plateia Botsari, and the pedestrianised streets leading off it.
This area is the heart of Mesolongi, offering easy access to the main attractions, eateries, and shops. You'll find many of the town's historical sites, such as the Garden of Heroes, within a comfortable walking distance. The streets here are generally quieter, especially in the evenings, making for a pleasant stroll.
Couples will find this area particularly appealing due to its convenient location for exploring the town's history and enjoying evenings out. There are several traditional tavernas and cafes where you can experience Greek hospitality, often with outdoor seating great for people-watching.
For travellers interested in the town's unique natural surroundings, staying near the entrance to the Mesolongi-Aitoliko Lagoon offers proximity to the fascinating 'pelades' (fishermen's huts on stilts) and opportunities for birdwatching.