Mayo Clinic Vacation Packages

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    Save up to CA $1,096 when you book a flight and hotel together*
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Top Holiday Package Deals in Mayo Clinic

Price found within the past 48 hours. Click for updated prices.
Scottsdale Plaza Resort

Scottsdale Plaza Resort

4 out of 5
Save 100% on your flight
per person
Sep 6 - Sep 13
found 1 day ago
Roundtrip non-stop flight included
Edmonton (YEG) to Phoenix (PHX)
9/10 Wonderful! (2,284 reviews)
Excellent amenities and proximity to restaurants and town events. The villa I stayed in was nice. Housekeeping woke me up when I requested them not to several times for two days.

Reviewed on Jul. 12, 2025

Westgate Painted Mountain Golf Resort

Westgate Painted Mountain Golf Resort

4 out of 5
East Mesa
per person
Sep 6 - Sep 13
found 1 day ago
Roundtrip non-stop flight included
Edmonton (YEG) to Phoenix (PHX)
8.2/10 Very Good! (1,005 reviews)
Very nice place for this price it's just amazing.

Reviewed on Jul. 15, 2025

Hotel Valley Ho

Hotel Valley Ho

4.5 out of 5
Old Town
Save 100% on your flight
per person
Sep 20 - Sep 27
found 1 day ago
Roundtrip non-stop flight included
Edmonton (YEG) to Phoenix (PHX)
9.6/10 Exceptional! (1,764 reviews)
Wonderful customer service!

Reviewed on Jul. 16, 2025

Mountain Shadows Resort Scottsdale

Mountain Shadows Resort Scottsdale

4.5 out of 5
Save 100% on your flight
per person
Sep 6 - Sep 13
found 1 day ago
Roundtrip non-stop flight included
Edmonton (YEG) to Phoenix (PHX)
9.6/10 Exceptional! (1,002 reviews)
We have been here multiple times and love it every time! It’s our go to place for this couple.

Reviewed on Jul. 14, 2025

Creekside Inn Sedona

Creekside Inn Sedona

4 out of 5
Chapel
Save 100% on your flight
per person
Sep 11 - Sep 16
found 1 day ago
Roundtrip flight included
Vancouver (YVR) to Phoenix (PHX)
9.8/10 Exceptional! (56 reviews)
This place is amazing and the staff super friendly 👍

Reviewed on Jun. 8, 2025

Where to stay in Mayo Clinic

Find the best Mayo Clinic areas and neighborhoods for the activities you enjoy most. Learn more about Mayo Clinic
Downtown Phoenix showing signage and night scenes

Downtown Phoenix

3 out of top 10 points of interest in this area
3.5/5(148 area reviews)

A true urban neighborhood, Downtown Phoenix boasts major sports venues like Chase Field and Footprint Center, as well as cultural attractions such as the Arizona Science Center and Phoenix Art Museum. Easily accessible via Valley Metro Light Rail, enjoy walkable streets, friendly cafes, and local businesses.

Find hotels in Downtown Phoenix

Mayo Clinic Hotel Deals

Talking Stick Resort

Talking Stick Resort

4 out of 5
9800 E. Talking Stick Way, Scottsdale, AZ
Fully refundableReserve now, pay when you stay
The price is CA $163 per night from Jul 21 to Jul 22
CA $163
CA $225 total
Jul 21 - Jul 22
includes taxes & fees
9.2/10 Wonderful! (3,500 reviews)
"Beautiful hotel. Very clean. Professional employees."

Reviewed on Jul. 15, 2025

Talking Stick Resort
Arizona Grand Resort & Spa

Arizona Grand Resort & Spa

4 out of 5
8000 S. Arizona Grand Parkway, Phoenix, AZ
Fully refundableReserve now, pay when you stay
The price is CA $144 per night from Jul 22 to Jul 23
CA $144
CA $287 total
Jul 22 - Jul 23
includes taxes & fees
8.4/10 Very Good! (1,989 reviews)
"Pros: our room was very close to the water park which was perfect for us since we were traveling with small children. There is a door separating the bedroom from the main room which is nice for privacy. The balcony was very nice and included seating. The pools were very clean and the temperature ..."

Reviewed on Jul. 14, 2025

Arizona Grand Resort & Spa
Hilton Phoenix Resort at the Peak

Hilton Phoenix Resort at the Peak

4 out of 5
7677 N 16th St, Phoenix, AZ
Fully refundableReserve now, pay when you stay
The price is CA $163 per night from Jul 20 to Jul 21
CA $163
CA $238 total
Jul 20 - Jul 21
includes taxes & fees
7.6/10 Good! (3,120 reviews)
"Really love it!"

Reviewed on Jul. 16, 2025

Hilton Phoenix Resort at the Peak
See all 13,193 properties in Mayo Clinic
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

All Inclusive Vacations

All Inclusive Vacations

Beach Vacations

Beach Vacations

Family Vacations

Family Vacations

Frequently asked questions

How much does a Mayo Clinic vacation package cost?
Starting from as low as CA $563, a package is your gateway to low-priced travel. Customize your Mayo Clinic trip by choosing from our extensive range of hotels, flights and rental cars.
How do I get a cheap travel package to Mayo Clinic?
Our Mayo Clinic vacation packages promise plenty of savings for the savvy globetrotter. For the best deals, simply combine your flights, hotels and activities into an affordable package. But low prices are just the beginning of your next unforgettable adventure. Book with Expedia and and you'll have over 550 airlines and 1,000,000 properties throughout the world to pick from. No matter your budget or style, there's a vacation package that's perfect for you.
Where should I stay in Mayo Clinic?
Cross Tournament Players Club of Scottsdale off your must-see list and then stay right near it. Soak up the exciting vibe around this terrific attraction and drop by whenever the mood strikes!
What are the top hotels in Mayo Clinic?
Whether you plan to stay for a night or a week in Mayo Clinic, you'll get a great night's rest at Sonesta Select Scottsdale at Mayo Clinic Campus. This option is popular with plenty of travelers.
How far in advance should I book my Mayo Clinic vacation?
Search Expedia to compare international flights as early as possible. In most cases, you can purchase a seat up to 12 months prior to departure. If it's too early for your preferred carrier, or you have to book last minute, don't despair. Cheap fares to Mayo Clinic sometimes occur within weeks of departure.
What does an Expedia Mayo Clinic travel package include?
It all depends on what sort of trip you have in the works. Mayo Clinic vacation deals can include car rentals, hotels and flights. You can mix and match to find the travel package that suits your style and budget. You can also add on activities and experiences after you've booked to score even bigger discounts.
What should I know before booking a Mayo Clinic travel package?
When you book your flights, hotels and car rentals together, you'll walk away with awesome discounts. Whether you're planning a beach break in a villa or want to stay in a fancy hotel in the city, Expedia will help make it happen.
Can I choose my airline with a Mayo Clinic Expedia vacation package?
You can, and with over 550 airlines to choose from all over the world, you've got lots of choice. Take a look at the available options and find out which airline fits your budget and needs.
If I'm not able to travel, can I cancel my Mayo Clinic vacation package?
You sure can, and we'll help you every step of the way. You may be able to cancel and rebook your Mayo Clinic vacation package at no cost if you booked in the last 24 hours. But you may incur a fee from your hotel, airline or car rental company if you booked more than 24 hours ago. If your travel plans suddenly change, have a look at our Customer Service Portal for further information.

Discover the most popular places to visit in Mayo Clinic

Arizona State University

Arizona State University

4.5/5(96 reviews)

Explore the campus of Arizona State University, a top college in Tempe. Amble around the area's lakeside or seek out the jogging trails.

Arizona State University
Phoenix Convention Center

Phoenix Convention Center

4/5(61 reviews)

During your trip, find out what's happening at Phoenix Convention Center, a top convention center in Phoenix. Experience the fascinating museums and acclaimed theater scene in this vibrant area.

Phoenix Convention Center
Grand Canyon University

Grand Canyon University

4/5(33 reviews)

Enjoy the collegiate vibe with a visit to Grand Canyon University, a well-known college in Phoenix. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

Grand Canyon University

Things to do

Phoenix: Self-Drive ATV/UTV Rental in the Sonoran Desert

Phoenix: Self-Drive ATV/UTV Rental in the Sonoran Desert

CA $140
per traveller
100% of travellers recommend
Phoenix: Self-Drive ATV/UTV Rental in the Sonoran Desert
Let's Fly!

Sunrise Hot Air Balloon Ride in Phoenix with Breakfast

CA $272
per adult
100% of travellers recommend
Sunrise Hot Air Balloon Ride in Phoenix with Breakfast
Phoenix Sunrise Hot Air Balloon Ride

Phoenix Sunrise Hot Air Balloon Ride

CA $286
per adult
94% of travellers recommend
Phoenix Sunrise Hot Air Balloon Ride
See all activities in Phoenix
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.