Title: Book the Best Clarksville SPA Resorts from CA $159 - Spa Hotels in Clarksville, IN | Expedia.ca [Hotels in Clarksville](https://expedia.ca/Clarksville-Hotels.d9727.Travel-Guide-Hotels)[Vacation Rentals in Clarksville](https://expedia.ca/Clarksville-Vacation-Rentals.d9727.Travel-Guide-VacationRentals)[Flights to Clarksville](https://expedia.ca/Cheap-Flights-To-Clarksville.d9727.Travel-Guide-Flights)[Clarksville Car Rentals](https://expedia.ca/Car-Rentals-In-Clarksville.d9727.Car-Rental-Guide)[Clarksville Vacation Packages](https://expedia.ca/Clarksville.d9727.Destination-Travel-Guides) ![View of Louisville from the Falls of the Ohio at Golden Hour. #BVSblue](https://images.trvl-media.com/place/3108/df34b2a2-a0fe-4fea-b211-931e06d4c702.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Eric O ![](https://images.trvl-media.com/place/3108/df34b2a2-a0fe-4fea-b211-931e06d4c702.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Clarksville Spa Hotels Tonight [Mar 2 - Mar 3](https://www.expedia.ca/Hotel-Search?regionId=9727&startDate=2026-03-02&endDate=2026-03-03&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 3 - Mar 4](https://www.expedia.ca/Hotel-Search?regionId=9727&startDate=2026-03-03&endDate=2026-03-04&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 6 - Mar 8](https://www.expedia.ca/Hotel-Search?regionId=9727&startDate=2026-03-06&endDate=2026-03-08&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 13 - Mar 15](https://www.expedia.ca/Hotel-Search?regionId=9727&startDate=2026-03-13&endDate=2026-03-15&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Clarksville hotels with a spa ![32-inch Smart TV with cable channels](https://images.trvl-media.com/lodging/122000000/121880000/121877400/121877336/00e4c915.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch Smart TV with cable channels](https://images.trvl-media.com/lodging/122000000/121880000/121877400/121877336/a0c5fbcf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/122000000/121880000/121877400/121877336/071da00d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch Smart TV with cable channels](https://images.trvl-media.com/lodging/122000000/121880000/121877400/121877336/2ec829de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Reserve on Main [](https://www.expedia.ca/Louisville-Hotels-The-Reserve-On-Main.h121877336.Hotel-Information) Downtown Louisville 10/10 Exceptional (1 review) CA $225 CA $329 total includes taxes & fees Mar 4 - Mar 5 [](https://www.expedia.ca/Louisville-Hotels-The-Reserve-On-Main.h121877336.Hotel-Information) ![3 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/800000/795900/795844/54f0e03a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Casino](https://images.trvl-media.com/lodging/1000000/800000/795900/795844/a36c57b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/800000/795900/795844/506c167d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/800000/795900/795844/80fbdedc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Caesars Southern Indiana - A Caesars Rewards Destination [](https://www.expedia.ca/Elizabeth-Hotels-Caesars-Southern-Indiana.h795844.Hotel-Information) Elizabeth 8.2/10 Very good (1,004 reviews) - Refresh your spirit at this riverfront hotel with daily spa treatments and couples rooms, where aromatherapy and Ayurvedic therapies await. CA $119 CA $159 total includes taxes & fees Apr 1 - Apr 2 [](https://www.expedia.ca/Elizabeth-Hotels-Caesars-Southern-Indiana.h795844.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/107000000/106920000/106915400/106915308/95d9177a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Staircase](https://images.trvl-media.com/lodging/107000000/106920000/106915400/106915308/1e2d6baa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/107000000/106920000/106915400/106915308/94b6bd82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/107000000/106920000/106915400/106915308/62c45f98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Central Park Bed & Breakfast [](https://www.expedia.ca/Louisville-Hotels-Central-Park-Bed-Breakfast.h106915308.Hotel-Information) Old Louisville 9.2/10 Wonderful (68 reviews) - Rejuvenate at this Victorian bed & breakfast featuring deep soaking tubs, fireplaces in rooms, and personalized spa services. CA $172 CA $200 total includes taxes & fees Mar 11 - Mar 12 [](https://www.expedia.ca/Louisville-Hotels-Central-Park-Bed-Breakfast.h106915308.Hotel-Information) ![4 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/aa5bcd07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, iron/ironing board](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/9d86b349.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/0261f02d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/23521baa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Galt House Hotel Trademark Collection by Wyndham [](https://www.expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) Downtown Louisville 9.0/10 Wonderful (4,087 reviews) - Riverside sanctuary offers rejuvenating spa treatments, panoramic fitness views, and river-facing balconies for a relaxing urban retreat. CA $172 CA $203 total includes taxes & fees Mar 30 - Mar 31 [](https://www.expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![Sauna, body treatments, aromatherapy, hot stone massages](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/4c7c479b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, cocktail bar, lobby lounge](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/78105fdd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 6:00 AM to 10:00 PM, cabanas (surcharge)](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/e2fb9d56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges, cocktail bar, lobby lounge](https://images.trvl-media.com/lodging/22000000/21110000/21106200/21106192/547de83e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Omni Louisville Hotel [](https://www.expedia.ca/Louisville-Hotels-Omni-Louisville-Hotel.h21106192.Hotel-Information) Downtown Louisville 9.2/10 Wonderful (1,782 reviews) - Immerse in spa bliss at this Louisville hotel where Mokara Spa offers therapeutic treatments and rooftop relaxation awaits. CA $250 CA $294 total includes taxes & fees Mar 29 - Mar 30 [](https://www.expedia.ca/Louisville-Hotels-Omni-Louisville-Hotel.h21106192.Hotel-Information) ![Room (Asleep in the Cyclone)](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/fdd94051.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/864ff441.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (Asleep in the Cyclone)](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/aaadeb96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/06213b95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 21c Museum Hotel Louisville [](https://www.expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) Downtown Louisville 9.4/10 Exceptional (1,005 reviews) - Experience a rejuvenating spa escape at this luxury boutique hotel with massage rooms and 24-hour fitness centre in downtown Louisville. CA $244 CA $294 total includes taxes & fees Mar 22 - Mar 23 [](https://www.expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-03-16&endDate=2026-03-17®ionId=9727&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Choose what matters most at spa hotels in Clarksville Pool Hot tub Breakfast included 4 stars 5 stars ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.ca/deals?rfrr=AFFINITY_SPRING_PROMO_9727) ## Top Clarksville Hotel Reviews ![Galt House Hotel Trademark Collection by Wyndham](https://images.trvl-media.com/lodging/1000000/200000/191500/191434/b5c46c3f_y.jpg) ### Galt House Hotel Trademark Collection by Wyndham 10/10 Excellent "Yes" [](https://expedia.ca/Louisville-Hotels-Galt-House-Hotel-Trademark-Collection-By-Wyndham.h191434.Hotel-Information) ![21c Museum Hotel Louisville](https://images.trvl-media.com/lodging/2000000/1420000/1413400/1413350/a9b7038a_y.jpg) ### 21c Museum Hotel Louisville 10/10 Excellent "clean rooms, outgoing and friendly staff. The vibe is warm and fun, love the penguins" [](https://expedia.ca/Louisville-Hotels-21c-Museum-Hotel-Louisville.h1413350.Hotel-Information) ![Drury Inn & Suites Louisville East](https://images.trvl-media.com/lodging/1000000/800000/793000/792962/d2587f53_y.jpg) ### Drury Inn & Suites Louisville East 10/10 Excellent "As a contractor I notice little details that were very impressive like the cast iron bathtubs and the caulking around the tub and the flooring. The food was also impressive along with the real silverware and plates. Finally, the service was terrific - from the desk, the food service and the cleaning staff. Will for sure be back!" [](https://expedia.ca/Louisville-Hotels-Drury-Inn-Suites-Louisville-East.h792962.Hotel-Information) ## Frequently asked questions ### Looking for a spa hotel in Clarksville? ### What's there to see and do in Clarksville? ### What is a Clarksville spa hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - Other - More ways to book - [5 Star Hotels in Duncan ](https://www.expedia.ca/5Star-Duncan-Georgetown-Hotels.s50-n553248635975849362-0.Travel-Guide-Filter-Hotels) - [Hotels near Atlantis Waterpark ](https://www.expedia.ca/Atlantis-Waterpark-Hotels.0-l553248621532656248-0.Travel-Guide-Filter-Hotels) - [Farmstay in Charlestown ](https://www.expedia.ca/Charlestown-Agritourism.d7184-aaAgritourism.Travel-Guide-Accommodation) - [Aparthotels in Charlestown ](https://www.expedia.ca/Charlestown-Apart-Hotels.d7184-aaApartHotels.Travel-Guide-Accommodation) - [Guest Houses in Charlestown ](https://www.expedia.ca/Charlestown-Guest-Houses.d7184-aaGuestHouses.Travel-Guide-Accommodation) - 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