Title: La Mesa Car Rental - Search & Compare - Expedia.ca​ [La Mesa Travel Guide](https://expedia.ca/La-Mesa.dx553248635975862472)[Hotels in La Mesa](https://expedia.ca/La-Mesa-Hotels.d553248635975862472.Travel-Guide-Hotels)[Flights to La Mesa](https://expedia.ca/Cheap-Flights-To-La-Mesa.d553248635975862472.Travel-Guide-Flights)[La Mesa Vacation Packages](https://expedia.ca/La-Mesa.d553248635975862472.Destination-Travel-Guides) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_car.jpeg?impolicy=fcrop&w=1200&h=300&q=medium) # La Mesa Car Rental ## Search and Compare from Car Companies in La Mesa ## Featured car rental suppliers Compare from agencies ![car supplier logos](https://forever.travel-assets.com/flex/flexmanager/images/2022/05/16/BEXCA-car-suppliers-logo-desktop.jpg) - ![protection illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__protection.svg) ### Change your mind Penalty-free cancellation on many/select car rentals - ![trophy illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Treat yourself Members save 10% or more on over 1 million car rentals - ![package illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__package.svg) ### Shop smart Compare car suppliers to unlock big savings ## Top Car Deals in La Mesa \* Price found within the past 6 days. Click for updated prices. ### Economy Chevrolet Spark or similar - 4 people La Mesa, Panamá Province, PAN ![Chevrolet Spark](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_EC.png) [](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=La%20Mesa,%20Panam%C3%A1%20Province,%20Panama&dpln=553248635975862472&date1=07/04/2026&date2=09/04/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22economy%22]) ### Compact Ford Focus or similar - 4 people La Mesa, Panamá Province, PAN ![Ford Focus](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_CC.png) [](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=La%20Mesa,%20Panam%C3%A1%20Province,%20Panama&dpln=553248635975862472&date1=07/04/2026&date2=09/04/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22compact%22]) ### Midsize Toyota Corolla or similar - 5 people La Mesa, Panamá Province, PAN ![Toyota Corolla](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_IC.png) [](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=La%20Mesa,%20Panam%C3%A1%20Province,%20Panama&dpln=553248635975862472&date1=07/04/2026&date2=09/04/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22midsize%22]) ### SUV Jeep Compass or similar - 5 people La Mesa, Panamá Province, PAN ![Jeep Compass](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_SF.png) [](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=La%20Mesa,%20Panam%C3%A1%20Province,%20Panama&dpln=553248635975862472&date1=07/04/2026&date2=09/04/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22suv%22]) ### Don't see what you're looking for? See all car rentals in La Mesa [View all cars](https://expedia.ca/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=La%20Mesa,%20Panam%C3%A1%20Province,%20Panama&dpln=553248635975862472&date1=07/04/2026&date2=09/04/2026&crfrr=defaultFlex&SearchType=Place) ## Car Rental Information | Popular car types: | [SUV](https://www.expedia.ca/lp/b/car-rental/suv?rfrr=car.table.SUV), [Full Size](https://www.expedia.ca/lp/b/car-rental/fullsize?rfrr=car.table.FullSize), [Economy](https://www.expedia.ca/lp/b/car-rental/economy?rfrr=car.table.Economy) | | -------------------------------- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Car suppliers available: | | | Our best deal of the day: | | | Our second best deal of the day: | | | Our third best deal of the day: | | | From the airport to your hotel: | [Airport Transportation](https://www.expedia.ca/ground-transfers?rfrr=car.table.AirportTransportation) | ## Frequently asked questions ### How much is a rental car per day in La Mesa? ### Can I rent a car from Tocumen Intl. Airport (PTY)? ### What happens if I need to cancel my La Mesa car reservation? ### Where can I go on a road trip from La Mesa? > - You'll find Gatun Locks and countless other amazing attractions in Colon. From La Mesa, it's 72 kilometres away. > - Your next stop? Consider Penonome, which is around 137 kilometres away. 8 de Diciembre Park is one local highlight you shouldn't miss. > - Venao Beach is 225 kilometres from La Mesa and is one of the region's most breathtaking nature spots. Go for a walk around and enjoy the fresh air here. ### How do I find the best car rental deals in La Mesa with Expedia? ### What do you need to rent a car in La Mesa? ### What is the cheapest car rental in La Mesa? ### Can I rent a car for a month or longer in La Mesa? ### Where can I find a La Mesa car rental if I am younger than 25? ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app