Title: Book The Best Hotels in La Mesa for 2026 from CA $69 - Fully Refundable Options - Hotels.com - Expedia.ca [Vacation Rentals in La Mesa](https://expedia.ca/La-Mesa-Vacation-Rentals.d553248635975862472.Travel-Guide-VacationRentals)[La Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-La-Mesa.d553248635975862472.Car-Rental-Guide)[La Mesa Vacation Packages](https://expedia.ca/La-Mesa.d553248635975862472.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in La Mesa Family friendly [](https://www.expedia.ca/Hotel-Search?destination=La+Mesa%2C+Panam%C3%A1+Province%2C+Panama®ionId=553248635975862472&latLong=9.167865%2C-79.281738&adults=2&startDate=2026-03-06&d1=2026-03-06&endDate=2026-03-08&d2=2026-03-08&travelerType=family_friendly) Ocean view [](https://www.expedia.ca/Hotel-Search?destination=La+Mesa%2C+Panam%C3%A1+Province%2C+Panama®ionId=553248635975862472&latLong=9.167865%2C-79.281738&adults=2&startDate=2026-03-06&d1=2026-03-06&endDate=2026-03-08&d2=2026-03-08&amenities=OCEAN_VIEW) Pool [](https://www.expedia.ca/Hotel-Search?destination=La+Mesa%2C+Panam%C3%A1+Province%2C+Panama®ionId=553248635975862472&latLong=9.167865%2C-79.281738&adults=2&startDate=2026-03-06&d1=2026-03-06&endDate=2026-03-08&d2=2026-03-08&amenities=POOL) Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=La+Mesa%2C+Panam%C3%A1+Province%2C+Panama®ionId=553248635975862472&latLong=9.167865%2C-79.281738&adults=2&startDate=2026-03-06&d1=2026-03-06&endDate=2026-03-08&d2=2026-03-08&amenities=PETS) Hot tub [](https://www.expedia.ca/Hotel-Search?destination=La+Mesa%2C+Panam%C3%A1+Province%2C+Panama®ionId=553248635975862472&latLong=9.167865%2C-79.281738&adults=2&startDate=2026-03-06&d1=2026-03-06&endDate=2026-03-08&d2=2026-03-08&amenities=HOT_TUB) Apart­ment [](https://www.expedia.ca/Hotel-Search?destination=La+Mesa%2C+Panam%C3%A1+Province%2C+Panama®ionId=553248635975862472&latLong=9.167865%2C-79.281738&adults=2&startDate=2026-03-06&d1=2026-03-06&endDate=2026-03-08&d2=2026-03-08&lodging=APARTMENT) Condo [](https://www.expedia.ca/Hotel-Search?destination=La+Mesa%2C+Panam%C3%A1+Province%2C+Panama®ionId=553248635975862472&latLong=9.167865%2C-79.281738&adults=2&startDate=2026-03-06&d1=2026-03-06&endDate=2026-03-08&d2=2026-03-08&lodging=CONDO) ## Check prices for these dates Tonight [Feb 20 - Feb 21](https://www.expedia.ca/Hotel-Search?regionId=553248635975862472&startDate=2026-02-20&endDate=2026-02-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 21 - Feb 22](https://www.expedia.ca/Hotel-Search?regionId=553248635975862472&startDate=2026-02-21&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Feb 20 - Feb 22](https://www.expedia.ca/Hotel-Search?regionId=553248635975862472&startDate=2026-02-20&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 27 - Mar 1](https://www.expedia.ca/Hotel-Search?regionId=553248635975862472&startDate=2026-02-27&endDate=2026-03-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for La Mesa hotels ![Family Quadruple Room](https://images.trvl-media.com/lodging/39000000/38720000/38713000/38712982/cf61e7af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laptop workspace, soundproofing, free WiFi, bed sheets](https://images.trvl-media.com/lodging/39000000/38720000/38713000/38712982/2ca645ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laptop workspace, soundproofing, free WiFi, bed sheets](https://images.trvl-media.com/lodging/39000000/38720000/38713000/38712982/50019413.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laptop workspace, soundproofing, free WiFi, bed sheets](https://images.trvl-media.com/lodging/39000000/38720000/38713000/38712982/6d2fc5cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### B&B Lodgings [](https://www.expedia.ca/Tocumen-Hotels-BB-Lodgings.h38712982.Hotel-Information) 24 de Diciembre 8.0/10 Very good (77 reviews) "The place is simple and comfortable, well kept, and offers a calm and relaxing atmosphere. The owner is extremely kind, polite, and welcoming, which made the experience even better. Although the location is a bit farther from the city center, it’s a great option if you’re looking for comfort and a peaceful stay. " ![Brazil](https://a.travel-assets.com/egds/marks/flags/br.svg) Piettro CA $63 CA $69 total includes taxes & fees Feb 26 - Feb 27 [](https://www.expedia.ca/Tocumen-Hotels-BB-Lodgings.h38712982.Hotel-Information) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/9000000/8840000/8836200/8836117/877d081d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/9000000/8840000/8836200/8836117/2f37bae5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, soundproofing](https://images.trvl-media.com/lodging/9000000/8840000/8836200/8836117/5f648ea5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/9000000/8840000/8836200/8836117/8103ef2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Crowne Plaza Panama Airport by IHG [](https://www.expedia.ca/Tocumen-Hotels-Crowne-Plaza-Panama-Airport.h8836117.Hotel-Information) Tocumen 8.6/10 Excellent (2,439 reviews) "Very friendly staff, impeccable room, free airport shuttle, nice food..... we had a great stay!" ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) Renildis CA $152 CA $167 total includes taxes & fees Mar 5 - Mar 6 [](https://www.expedia.ca/Tocumen-Hotels-Crowne-Plaza-Panama-Airport.h8836117.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/120000000/119870000/119860600/119860522/19fc3193.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/120000000/119870000/119860600/119860522/cc0414b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/120000000/119870000/119860600/119860522/febf3b4c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Double Room, Garden View](https://images.trvl-media.com/lodging/120000000/119870000/119860600/119860522/d2c4357e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### ORHO HOTEL BOUTIQUE PANAMA Airport [](https://www.expedia.ca/Tocumen-Hotels-ORHO-HOTEL-BOUTIQUE-PANAMA-Airport.h119860522.Hotel-Information) Tocumen 9.0/10 Wonderful (71 reviews) "Clean room, friendly staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richard CA $164 CA $213 total includes taxes & fees Feb 21 - Feb 22 [](https://www.expedia.ca/Tocumen-Hotels-ORHO-HOTEL-BOUTIQUE-PANAMA-Airport.h119860522.Hotel-Information) ![Classic Double Room](https://images.trvl-media.com/lodging/7000000/6470000/6461100/6461097/c427c56a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/7000000/6470000/6461100/6461097/9c6b201c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/7000000/6470000/6461100/6461097/61330da3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/7000000/6470000/6461100/6461097/73a42da0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Express Inn Panama International Airport Hostel [](https://www.expedia.ca/Tocumen-Hotels-Express-Inn-Panama-International-Airport-Hostel.h6461097.Hotel-Information) Tocumen 6.0/10 (670 reviews) "Good option close to airport. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Wendy CA $68 CA $75 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/Tocumen-Hotels-Express-Inn-Panama-International-Airport-Hostel.h6461097.Hotel-Information) ![Outdoor pool, open 7:00 AM to 10:30 PM, free cabanas, pool umbrellas](https://images.trvl-media.com/lodging/1000000/30000/26300/26240/b7e843b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool views, serves lunch and dinner](https://images.trvl-media.com/lodging/1000000/30000/26300/26240/700fef33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/1000000/30000/26300/26240/dc6a5657.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Poolside bar](https://images.trvl-media.com/lodging/1000000/30000/26300/26240/d73825f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Riande Aeropuerto Hotel & Casino [](https://www.expedia.ca/Tocumen-Hotels-Riande-Aeropuerto-Hotel-Casino.h26240.Hotel-Information) Tocumen 8.6/10 Excellent (1,854 reviews) "Very nice staff and confortable stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) MARIA CA $171 CA $188 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/Tocumen-Hotels-Riande-Aeropuerto-Hotel-Casino.h26240.Hotel-Information) ![Food and drink](https://images.trvl-media.com/lodging/5000000/4320000/4316400/4316336/c1dda5ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/5000000/4320000/4316400/4316336/afc6d0da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/5000000/4320000/4316400/4316336/1cf4d9ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/5000000/4320000/4316400/4316336/d12ac1da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Panama Metromall [](https://www.expedia.ca/San-Miguelito-Hotels-Courtyard-By-Marriott-Panama-Metromall.h4316336.Hotel-Information) San Antonio 8.8/10 Excellent (1,007 reviews) "Staff was good rooms clean just a good experience " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Adrian CA $144 CA $159 total includes taxes & fees Mar 6 - Mar 7 [](https://www.expedia.ca/San-Miguelito-Hotels-Courtyard-By-Marriott-Panama-Metromall.h4316336.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/21000000/20960000/20958600/20958573/3972c3df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/21000000/20960000/20958600/20958573/166e4001.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/21000000/20960000/20958600/20958573/db85bc00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch served; local and international cuisine](https://images.trvl-media.com/lodging/21000000/20960000/20958600/20958573/ea9ff933.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City [](https://www.expedia.ca/Panama-City-Hotels-The-Santa-Maria.h20958573.Hotel-Information) Juan Diaz 9.6/10 Exceptional (666 reviews) "As usual the stay was amazing in this hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jose CA $369 CA $405 total includes taxes & fees Mar 7 - Mar 8 [](https://www.expedia.ca/Panama-City-Hotels-The-Santa-Maria.h20958573.Hotel-Information) ![50-inch LED TV with satellite channels](https://images.trvl-media.com/lodging/105000000/104460000/104456900/104456900/81757b88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![50-inch LED TV with satellite channels](https://images.trvl-media.com/lodging/105000000/104460000/104456900/104456900/f23a333a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/105000000/104460000/104456900/104456900/bba49e63.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining room](https://images.trvl-media.com/lodging/105000000/104460000/104456900/104456900/dbfbf214.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Arcadia Condo Suites [](https://www.expedia.ca/Panama-City-Hotels-Arcadia-Condo-Suites.h104456900.Hotel-Information) Costa del Este 9.4/10 Exceptional (215 reviews) "Really loved this place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alejandra CA $113 CA $188 total includes taxes & fees Mar 4 - Mar 5 [](https://www.expedia.ca/Panama-City-Hotels-Arcadia-Condo-Suites.h104456900.Hotel-Information) ![Apartment, 3 Bedrooms, Accessible, Pool View | Pool](https://images.trvl-media.com/lodging/120000000/119470000/119462200/119462129/76eefaf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 3 Bedrooms, Accessible, Pool View | Interior](https://images.trvl-media.com/lodging/120000000/119470000/119462200/119462129/5864a396.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 3 Bedrooms, Accessible, Pool View](https://images.trvl-media.com/lodging/120000000/119470000/119462200/119462129/094709c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/120000000/119470000/119462200/119462129/3979bb6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charming 3 Bedroom Apartment in San Miguelito, Panama City [](https://www.expedia.ca/San-Miguelito-Hotels-Apto-3-Hab-Piscina-15-Tocumen-Min-Airport.h119462129.Hotel-Information) José Domingo Espinar 2.0/10 (1 review) "La habitacion terrible, edificio sucio ubicacion pesima " ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) caleb CA $125 CA $177 total includes taxes & fees Mar 22 - Mar 23 [](https://www.expedia.ca/San-Miguelito-Hotels-Apto-3-Hab-Piscina-15-Tocumen-Min-Airport.h119462129.Hotel-Information) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/6000000/5790000/5781900/5781845/23fa73c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/6000000/5790000/5781900/5781845/5a498bf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/6000000/5790000/5781900/5781845/234e399f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed](https://images.trvl-media.com/lodging/6000000/5790000/5781900/5781845/2fee40c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Westin Panama [](https://www.expedia.ca/Panama-City-Hotels-The-Westin-Panama.h5781845.Hotel-Information) Costa del Este 9.0/10 Wonderful (318 reviews) "Great hotel and services" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Pedro CA $305 CA $335 total includes taxes & fees Mar 7 - Mar 8 [](https://www.expedia.ca/Panama-City-Hotels-The-Westin-Panama.h5781845.Hotel-Information) ![Apartment](https://images.trvl-media.com/lodging/124000000/123400000/123391300/123391242/9f6bde45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment](https://images.trvl-media.com/lodging/124000000/123400000/123391300/123391242/046bf4b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment](https://images.trvl-media.com/lodging/124000000/123400000/123391300/123391242/b407ee76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment](https://images.trvl-media.com/lodging/124000000/123400000/123391300/123391242/cf36effb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfortable 2BR City Apartment [](https://www.expedia.ca/Panama-City-Hotels-Comfortable-2BR-City-Apartment.h123391242.Hotel-Information) San Francisco CA $234 CA $258 total includes taxes & fees Mar 23 - Mar 24 [](https://www.expedia.ca/Panama-City-Hotels-Comfortable-2BR-City-Apartment.h123391242.Hotel-Information) ![Apartment, 3 Bedrooms | Living area](https://images.trvl-media.com/lodging/89000000/88680000/88675400/88675323/9e5233d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 2 Bedrooms](https://images.trvl-media.com/lodging/89000000/88680000/88675400/88675323/9e64cab9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Apartment, 3 Bedrooms | Street view](https://images.trvl-media.com/lodging/89000000/88680000/88675400/88675323/cc8558b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/89000000/88680000/88675400/88675323/6445192b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Boutique Apartments Panamá Coco del Mar [](https://www.expedia.ca/Panama-City-Hotels-Boutique-Apartments-Panama-Coco-Del-Mar.h88675323.Hotel-Information) San Francisco 7.4/10 Good (170 reviews) "Clean room good place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gideon CA $100 CA $302 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/Panama-City-Hotels-Boutique-Apartments-Panama-Coco-Del-Mar.h88675323.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/122000000/121850000/121845700/121845688/6348c11c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Food and drink](https://images.trvl-media.com/lodging/122000000/121850000/121845700/121845688/bae38a01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/122000000/121850000/121845700/121845688/2cabe9a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Building design](https://images.trvl-media.com/lodging/122000000/121850000/121845700/121845688/7aadcdd0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dovle Residences by HMS-Preferred Member [](https://www.expedia.ca/Panama-City-Hotels-Dovle-Residences-By-HMS-Preferred-Member.h121845688.Hotel-Information) San Francisco 2.8/10 (3 reviews) "Inadequate heating in the pool , poor customer service. No hot water in the shower. It was a terrible experience but it’s a nice place, hopefully with better management can offer outstanding services " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Herbert CA $222 CA $244 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/Panama-City-Hotels-Dovle-Residences-By-HMS-Preferred-Member.h121845688.Hotel-Information) ![Daily buffet breakfast (PAB 21 per person)](https://images.trvl-media.com/lodging/1000000/10000/1200/1161/4e948961.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment rooms, sauna, hot tub, Turkish bath, body treatments](https://images.trvl-media.com/lodging/1000000/10000/1200/1161/58ea7ce3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/10000/1200/1161/c780324d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment rooms, sauna, hot tub, Turkish bath, body treatments](https://images.trvl-media.com/lodging/1000000/10000/1200/1161/f95b4a50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sheraton Grand Panama [](https://www.expedia.ca/Panama-City-Hotels-Sheraton-Grand-Panama.h1161.Hotel-Information) San Francisco 8.6/10 Excellent (1,005 reviews) "Good locatiion" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Caren CA $184 CA $202 total includes taxes & fees Mar 8 - Mar 9 [](https://www.expedia.ca/Panama-City-Hotels-Sheraton-Grand-Panama.h1161.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/7000000/6580000/6577500/6577427/75c7ddd0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/7000000/6580000/6577500/6577427/02a8cee5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/7000000/6580000/6577500/6577427/8c2779b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![aloft, Suite, 2 Queen Beds, City View | Living room](https://images.trvl-media.com/lodging/7000000/6580000/6577500/6577427/8e89de30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aloft Panama [](https://www.expedia.ca/Panama-City-Hotels-Aloft-Panama.h6577427.Hotel-Information) San Francisco 8.6/10 Excellent (959 reviews) "Perfect stay for a few days at Panama!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maria CA $163 CA $179 total includes taxes & fees Feb 28 - Mar 1 [](https://www.expedia.ca/Panama-City-Hotels-Aloft-Panama.h6577427.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/92000000/91500000/91495500/91495486/b12b577d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop terrace](https://images.trvl-media.com/lodging/92000000/91500000/91495500/91495486/2fdde3f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 2 Bedrooms (17B) | Living area](https://images.trvl-media.com/lodging/92000000/91500000/91495500/91495486/f99400a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 2 Bedrooms (10C) | Living area](https://images.trvl-media.com/lodging/92000000/91500000/91495500/91495486/ea03f013.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Boutique Apartments Atlapa [](https://www.expedia.ca/Panama-City-Hotels-Boutique-Apartments-Atlapa.h91495486.Hotel-Information) San Francisco 8.0/10 Very good (30 reviews) "The place was clean nice an its comfortable an the view is to kill for amazing ‼️" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Odaine [](https://www.expedia.ca/Panama-City-Hotels-Boutique-Apartments-Atlapa.h91495486.Hotel-Information) ![Living area](https://images.trvl-media.com/lodging/123000000/122660000/122657100/122657050/87d5a99d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gym](https://images.trvl-media.com/lodging/123000000/122660000/122657100/122657050/1cbda3e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Apartment | Balcony](https://images.trvl-media.com/lodging/123000000/122660000/122657100/122657050/618d23dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/123000000/122660000/122657100/122657050/c9888658.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Living 73 Panamá by Boutique Apartments [](https://www.expedia.ca/Panama-City-Hotels-Living-73.h122657050.Hotel-Information) San Francisco CA $72 CA $282 total includes taxes & fees Feb 24 - Feb 25 [](https://www.expedia.ca/Panama-City-Hotels-Living-73.h122657050.Hotel-Information) ![Breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/9000000/8220000/8217000/8216939/7d8fcf8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/9000000/8220000/8217000/8216939/094aef75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/9000000/8220000/8217000/8216939/c826c327.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/9000000/8220000/8217000/8216939/94455d61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ramada Plaza by Wyndham Panama Punta Pacifica [](https://www.expedia.ca/Panama-City-Hotels-Ramada-Plaza-By-Wyndham-Panama-Punta-Pacifica.h8216939.Hotel-Information) San Francisco 9.6/10 Exceptional (1,157 reviews) "Clean, nice staff and super close to the airport " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leticia CA $145 CA $160 total includes taxes & fees Feb 21 - Feb 22 [](https://www.expedia.ca/Panama-City-Hotels-Ramada-Plaza-By-Wyndham-Panama-Punta-Pacifica.h8216939.Hotel-Information) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/126000000/125260000/125254200/125254156/92db291d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, Patio, Garden View | Exterior detail](https://images.trvl-media.com/lodging/126000000/125260000/125254200/125254156/6ac84ba2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/126000000/125260000/125254200/125254156/8406e25a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Double Room, Pool View](https://images.trvl-media.com/lodging/126000000/125260000/125254200/125254156/0837b667.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Coconut Lodge [](https://www.expedia.ca/Las-Cumbres-Hotels-Coconut-Lodge.h125254156.Hotel-Information) Las Cumbres CA $94 CA $104 total includes taxes & fees Mar 7 - Mar 8 [](https://www.expedia.ca/Las-Cumbres-Hotels-Coconut-Lodge.h125254156.Hotel-Information) ![Apartment](https://images.trvl-media.com/lodging/124000000/123400000/123391300/123391241/cdb96e4e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment](https://images.trvl-media.com/lodging/124000000/123400000/123391300/123391241/68f0c531.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment](https://images.trvl-media.com/lodging/124000000/123400000/123391300/123391241/1e48baf2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment](https://images.trvl-media.com/lodging/124000000/123400000/123391300/123391241/e241f701.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dovle 312 in Ciudad de Panam [](https://www.expedia.ca/Panama-City-Hotels-Urban-2BR-Apt-In-Central-Area.h123391241.Hotel-Information) San Francisco CA $237 CA $260 total includes taxes & fees Feb 25 - Feb 26 [](https://www.expedia.ca/Panama-City-Hotels-Urban-2BR-Apt-In-Central-Area.h123391241.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-03-06&endDate=2026-03-07®ionId=553248635975862472&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.ca/deals?rfrr=HTG_SPRING_PROMO_553248635975862472) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FLa-Mesa-Hotels.d553248635975862472.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FLa-Mesa-Hotels.d553248635975862472.Travel-Guide-Hotels) ## Top La Mesa Hotel Reviews ## Recent Reviews in La Mesa ![Crowne Plaza Panama Airport by IHG](https://images.trvl-media.com/lodging/9000000/8840000/8836200/8836117/877d081d_y.jpg) ### Crowne Plaza Panama Airport by IHG 10/10 Excellent "Only stayed one night to catch my flight from the airport. Sooo close! We didn’t at the restaurant! Pool area was awesome! I would return again if needed. " [](https://expedia.ca/Tocumen-Hotels-Crowne-Plaza-Panama-Airport.h8836117.Hotel-Information) ![Sheraton Grand Panama](https://images.trvl-media.com/lodging/1000000/10000/1200/1161/179e52b4_y.jpg) ### Sheraton Grand Panama 10/10 Excellent "That was good" [](https://expedia.ca/Panama-City-Hotels-Sheraton-Grand-Panama.h1161.Hotel-Information) ![Ramada Plaza by Wyndham Panama Punta Pacifica](https://images.trvl-media.com/lodging/9000000/8220000/8217000/8216939/803aefa9_y.jpg) ### Ramada Plaza by Wyndham Panama Punta Pacifica 10/10 Excellent "The rooms were spotless. The entire staff was warm, friendly and provided excellent service. The restaurant was exceptional." [](https://expedia.ca/Panama-City-Hotels-Ramada-Plaza-By-Wyndham-Panama-Punta-Pacifica.h8216939.Hotel-Information) ![ORHO HOTEL BOUTIQUE PANAMA Airport](https://images.trvl-media.com/lodging/120000000/119870000/119860600/119860522/febf3b4c_y.jpg) ### ORHO HOTEL BOUTIQUE PANAMA Airport 10/10 Excellent "Cool place. Good food close. Safe. Very kind service. " [](https://expedia.ca/Tocumen-Hotels-ORHO-HOTEL-BOUTIQUE-PANAMA-Airport.h119860522.Hotel-Information) ![Arcadia Condo Suites](https://images.trvl-media.com/lodging/105000000/104460000/104456900/104456900/dbfa0534_y.jpg) ### Arcadia Condo Suites 10/10 Excellent "Suite was very spacious, nicely furnished, and well equipped. Room was quiet. Vews were spectacular. Appliances were all new and in top quality condition. I'd rate 4.5 out of 5 if I could, only because the master bathroom could have had more attention by property management before my occupancy but there was nothing terrible..things like a very loose toilet seat, long hair from previous tenant still on floor and wall...small one-offs in an otherwise perfect experience. The gym was clean, well equipped and accessorized. Desk staff were efficient. Location is super convenient to shopping. Overall great, comfortable stay. I'd def return!" [](https://expedia.ca/Panama-City-Hotels-Arcadia-Condo-Suites.h104456900.Hotel-Information) ![Riande Aeropuerto Hotel & Casino](https://images.trvl-media.com/lodging/1000000/30000/26300/26240/b7e843b8_y.jpg) ### Riande Aeropuerto Hotel & Casino 10/10 Excellent "Clean, quiet, friendly staff." [](https://expedia.ca/Tocumen-Hotels-Riande-Aeropuerto-Hotel-Casino.h26240.Hotel-Information) ![Aloft Panama](https://images.trvl-media.com/lodging/7000000/6580000/6577500/6577427/75c7ddd0_y.jpg) ### Aloft Panama 10/10 Excellent "I would definitely come back again." [](https://expedia.ca/Panama-City-Hotels-Aloft-Panama.h6577427.Hotel-Information) ![Boutique Apartments Panamá Coco del Mar](https://images.trvl-media.com/lodging/89000000/88680000/88675400/88675323/b51e58b2_y.jpg) ### Boutique Apartments Panamá Coco del Mar 10/10 Excellent "Condo was awesome, killer view, host communication very good, especially for Panama. A few small lagniappes would've been awesome. Paper towels. Dish soap, hand towels and washcloths.. we didn't cook much but could use a little special touch. The apartment was amazing" [](https://expedia.ca/Panama-City-Hotels-Boutique-Apartments-Panama-Coco-Del-Mar.h88675323.Hotel-Information) ![The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City](https://images.trvl-media.com/lodging/21000000/20960000/20958600/20958573/d80494b9_y.jpg) ### The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City 10/10 Excellent "It was my first time staying at the hotel and it was wonderful!! The check in was great and the staff I ran into the two days I stayed were great and very kind " [](https://expedia.ca/Panama-City-Hotels-The-Santa-Maria.h20958573.Hotel-Information) ## More cheap stays in La Mesa ![B&B Lodgings](https://images.trvl-media.com/lodging/39000000/38720000/38713000/38712982/6dc250bd_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### B&B Lodgings C. Tercera El Valle de Cerro Azul 24 de Diciembre Panamá Province CA $63 CA $69 total Feb 26 - Feb 27 includes taxes & fees 8/10 Very Good! (77 reviews) [](https://expedia.ca/Tocumen-Hotels-BB-Lodgings.h38712982.Hotel-Information) ![Arcadia Condo Suites](https://images.trvl-media.com/lodging/105000000/104460000/104456900/104456900/dbfa0534_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Arcadia Condo Suites Calle rio mar Panama City Panamá Province CA $113 CA $188 total Mar 4 - Mar 5 includes taxes & fees 9.4/10 Exceptional! (215 reviews) [](https://expedia.ca/Panama-City-Hotels-Arcadia-Condo-Suites.h104456900.Hotel-Information) ![ORHO HOTEL BOUTIQUE PANAMA Airport](https://images.trvl-media.com/lodging/120000000/119870000/119860600/119860522/febf3b4c_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### ORHO HOTEL BOUTIQUE PANAMA Airport Av. Domingo Díaz Tocumen Provincia de Panamá CA $164 CA $213 total Feb 21 - Feb 22 includes taxes & fees 9/10 Wonderful! (71 reviews) [](https://expedia.ca/Tocumen-Hotels-ORHO-HOTEL-BOUTIQUE-PANAMA-Airport.h119860522.Hotel-Information) ![Blue Dream in San Francisco](https://images.trvl-media.com/lodging/114000000/113940000/113939800/113939742/b75a1c95_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Blue Dream in San Francisco Panama City Panamá Province [Get rates](https://expedia.ca/Hotel-Search?startDate=06%2F03%2F2026&endDate=07%2F03%2F2026&selected=113939742&PinnedHotelID=113939742&HadPinnedHotel=true®ionId=553248635975862472) [](https://expedia.ca/Panama-City-Hotels-Blue-Dream-In-San-Francisco.h113939742.Hotel-Information) ![Apartment in San Francisco](https://images.trvl-media.com/lodging/110000000/109210000/109203500/109203460/fd14bd54_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Apartment in San Francisco Panama City Panamá Province [Get rates](https://expedia.ca/Hotel-Search?startDate=06%2F03%2F2026&endDate=07%2F03%2F2026&selected=109203460&PinnedHotelID=109203460&HadPinnedHotel=true®ionId=553248635975862472) 8/10 Very Good! (1 review) [](https://expedia.ca/Panama-City-Hotels-Apartment-In-San-Francisco.h109203460.Hotel-Information) ![The Camp at Kalu Yala](https://images.trvl-media.com/lodging/71000000/70850000/70847500/70847418/e2dc8d48_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### The Camp at Kalu Yala San Martín San Martín Panama Province [Get rates](https://expedia.ca/Hotel-Search?startDate=06%2F03%2F2026&endDate=07%2F03%2F2026&selected=70847418&PinnedHotelID=70847418&HadPinnedHotel=true®ionId=553248635975862472) [](https://expedia.ca/Kalu-Yala.h70847418.Hotel-Information) ## Frequently asked questions ### Where is the best place to stay in La Mesa? ### What are some of the best vacation home rentals in La Mesa? ### If I need to cancel my hotel reservation in La Mesa, will I receive a refund? ### What is staying in La Mesa like? ### What are the top places to visit in La Mesa? ### What's the weather like in La Mesa? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - 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