Book The Best Hotels in La Mesa for 2026 from CA $66 - Fully Refundable Options

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Go beyond your typical stay in La Mesa

Pet friendly

Apartment

Spa

Condo

Pool

Hot tub

Family friendly

Waterpark

Check prices for these dates

Tonight

Tomorrow

Next weekend

In two weeks

Our top choices for La Mesa hotels

A room with a bed, a desk with a chair, a television, and a door.

A bathroom with a bathtub, a sink, a window, and towels.

A bathroom with a black toilet, a black sink, a shower curtain, and a window.

A hotel room with a bed, a desk, a TV, and a kitchenette.

1. Tocumen Comfort Stay

24 de Diciembre

CA $65

CA $71 total

includes taxes & fees

Oct 14 - Oct 15

A room with two beds, a desk with chairs, a television, and a window with blinds.

A small kitchenette with a microwave, a coffee maker, and a refrigerator. There are two chairs and a sofa.

A bathroom with a sink, toilet, and shower curtain.

A compact kitchen with a microwave, two stools, a small refrigerator, and a flat-screen TV mounted on the wall.

2. B&B Lodgings

24 de Diciembre

Pedro

CA $70

CA $77 total

includes taxes & fees

Nov 4 - Nov 5

A room with a bed, a desk with a computer, a TV, and a fan.

A bedroom with two beds, a ceiling fan, an air conditioning unit, and a mirror on the wall.

A bathroom with a black toilet, a black bidet, a sink with a black basin, and a towel rack with folded towels.

A room with a tiled floor, a flat-screen TV mounted on the wall, a small refrigerator, a microwave, and two bar stools.

3. PLEASANT HOSTAL PANAMA

24 de Diciembre

CA $60

CA $66 total

includes taxes & fees

Oct 16 - Oct 17

A modern cabin with a sloped roof, surrounded by trees, and a gravel path leading to the entrance.

A modern outdoor seating area with a hammock and two chairs, a wooden deck, and a glass wall offering a view of the surrounding trees.

A modern kitchen with a built-in stove, a sink, and a shelf with dishes and a potted plant.

A modern room with a bed, a small table, and a chair. There is a window with a view of trees and a hammock outside.

4. Tiny Cabin

Panamá

CA $190

CA $209 total

includes taxes & fees

Oct 27 - Oct 28

A hotel room with two single beds, a small table with a chair, a TV mounted on the wall, and a marble-patterned headboard.

A rectangular swimming pool with blue tiles and a brick border.

A modern interior with a staircase, a seating area with a bench and tables, and a counter with a sign reading "NISATO".

A modern building with a tiled patio, a mural with palm trees and the word "Panama," and a large window.

5. Express Inn Panama International Airport Hostel

Tocumen Airport

Oscar

CA $70

CA $77 total

includes taxes & fees

Oct 14 - Oct 15

A spacious lobby with a high ceiling, modern lighting fixtures, and a glass entrance leading to a lower level.

A swimming pool with a clear water surface, surrounded by a covered area with lounge chairs and a bar area.

A modern dining area with a wooden table and chairs, a built-in bookshelf, and a decorative hanging light fixture.

A modern restaurant with checkered flooring, wooden chairs, and large windows offering a view of greenery.

6. Crowne Plaza Panama Airport by IHG

Tocumen Airport

Duran

CA $191

CA $219 total

includes taxes & fees

Nov 10 - Nov 11

A bedroom with a large bed, a nightstand, a dresser, and decorative wall art.

A multi-level interior with a wooden staircase, decorative lighting, and a blue wall.

A room with a cream-colored sofa with gold accents, a red carpet, and a small table with candles.

A cozy living room with a television, a lamp, and a sofa.

7. ORHO Hotel Boutique 15 Minutes from PTY Airport

Tocumen Airport

Teri

CA $127

CA $170 total

includes taxes & fees

Oct 18 - Oct 19

A modern living room with a sofa, a coffee table, a flat-screen TV, and a view of greenery through large windows.

A playground with multiple slides and climbing structures.

A conference room with a long table, chairs, and a carpeted floor.

A hotel room with two beds, a desk, a television, and an air conditioning unit.

8. Riande Aeropuerto Hotel & Casino

Tocumen Airport

Lucas

CA $130

CA $143 total

includes taxes & fees

Nov 8 - Nov 9

A building with a sign reading 'Lilia House' and a decorative wall with a sign stating 'Cada Familia tiene una.'

A dining area with a table set for two, chairs, a TV mounted on the wall, a decorative plant, and a window with decorative bars.

9. Swette Love 10 Minutes From the Airport Tocumen

Las Mañanitas

CA $80

CA $104 total

includes taxes & fees

Oct 18 - Oct 19

A buffet with various food items including fruits, juices, and cheeses.

A hotel reception area with a wooden reception desk, seating area with chairs and ottomans, and a large window providing natural light.

An aerial view of a rectangular swimming pool with two lounge chairs and a ladder.

A gym with treadmills, weight machines, and dumbbells.

10. Courtyard by Marriott Panama Metromall

San Antonio

Chaloma

CA $144

CA $159 total

includes taxes & fees

Oct 30 - Oct 31

A hotel entrance with a central water feature, seating areas, and potted plants.

A spacious lobby with a wooden ceiling, a central wooden table surrounded by potted plants, and a marble wall with a large window in the background.

An outdoor dining area with wicker chairs and tables, a bar with bottles, and a pool in the background.

A pool with a central water feature, surrounded by seating areas and potted plants.

11. The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Juan Diaz

Carmen

CA $395

CA $434 total

includes taxes & fees

Nov 1 - Nov 2

A rooftop pool with a city view, lounge chairs, and a clear sky.

A modern lounge area with a bar, seating, and a large window offering a city view.

A modern kitchen with a marble countertop, a refrigerator, and a dining area with a table set for two.

A modern lobby with a curved grey sofa, a round coffee table, and an orange armchair. There are potted plants and a reception desk in the background.

12. Corporate Stays Arcadia | Executive Furnished Apartments

Costa del Este

Rame

CA $119

CA $142 total

includes taxes & fees

Nov 10 - Nov 11

A lobby with seating arrangements, a marble wall, and potted plants.

A narrow street with multi-story buildings, balconies, and a central building with a red roof.

A rooftop pool with a city view, modern architecture, and outdoor seating.

A spacious lobby with a modern design, featuring a sofa, chairs, and large potted plants.

13. The Westin Panama

Costa del Este

Luke

CA $318

CA $349 total

includes taxes & fees

Nov 7 - Nov 8

A swimming pool with lounge chairs, surrounded by greenery and tall buildings in the background.

A gym with various exercise equipment, a brick wall, and a ceiling with wooden slats.

A modern apartment with a kitchen, dining area, and living room.

A modern building with the sign 'DOVILLE' and 'CIRCUNVENTENARIO' indicating a hotel or similar establishment.

14. Apex Executive Apartments - Dovle

Parque Lefevre

CA $139

CA $277 total

includes taxes & fees

Oct 14 - Oct 15

A modern outdoor swimming pool with a clear view of a tall building in the background.

A modern apartment with a living area, kitchen, and a staircase leading to an upper level.

A modern reception area with a brick wall, wooden paneling, and a neon sign.

A modern kitchen with a curved island, bar stools, pendant lighting, and wooden shelving with plants.

15. Dovle Residences by HMS-Preferred Member

San Francisco

David

CA $195

CA $218 total

includes taxes & fees

Oct 16 - Oct 17

A swimming pool with lounge chairs, surrounded by greenery and modern buildings.

A modern living room with a sofa, coffee table, and a staircase.

A modern apartment with a dining area, kitchen, and a large window with curtains.

A pathway lined with greenery, a small pavilion, and tall buildings in the background.

16. Cozy Urban Loft 1br Near Coast

San Francisco

CA $153

CA $217 total

includes taxes & fees

Oct 11 - Oct 12

A modern living room with a sofa, a coffee table with flowers, a TV, and a large window with a city view.

A dining area with a table set for four, large windows with a cityscape view, a small side table with a lamp, and a television on a stand.

A bedroom with a large bed, a view through a sliding door, and two framed pictures on the wall.

A modern living room with a sofa, a TV, and a dining area with a table and chairs.

17. Boutique Apartments Panamá Coco del Mar

San Francisco

purabi

CA $53

CA $259 total

includes taxes & fees

Oct 12 - Oct 13

A modern hotel with a prominent entrance, multiple floors, and a well-lit facade.

A modern rooftop pool with a view of high-rise buildings at night.

A modern lounge area with seating, a bar, and a staircase.

A modern interior with two escalators leading to upper floors, a prominent 'a loft Panama' sign, and a staircase with glass railings.

18. Aloft by Marriott Panama

San Francisco

ANDRELL

CA $170

CA $187 total

includes taxes & fees

Oct 16 - Oct 17

An elevator with a digital display showing the number 3, a sign above it reading 'PISO-3', and two safety signs on the wall.

A kitchen with a gas stove, a microwave, a trash bin, and a window.

A living room with a sectional sofa, a ceiling fan, a decorative wall piece, and a window with blinds.

A television mounted on a wall with a cityscape display, a small plant on a shelf, and a decorative light fixture.

19. Charming 3 Bedroom Apartment in San Miguelito, Panama City

José Domingo Espinar

caleb

CA $140

CA $182 total

includes taxes & fees

Oct 25 - Oct 26

A buffet with various food items and a decorative plant.

A gym with treadmills, weight machines, and a red carpet.

A spacious lobby with a high ceiling, a glass railing on the upper level, and a seating area with modern furniture.

A hotel with a swimming pool, outdoor seating, and a modern architectural design.

20. Sheraton Grand Panama

San Francisco

Nicole

CA $248

CA $273 total

includes taxes & fees

Oct 31 - Nov 1

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Top La Mesa Hotel Reviews

Corporate Stays Arcadia | Executive Furnished Apartments

10/10 Excellent

"Sin comentarios"

Riande Aeropuerto Hotel & Casino

8/10 Good

"Nice place for a 1 night stay. Nothing fancy. Rooms and hotel a little outdated but the breakfast was good. So a nice place for a 1 night stay during a layover."

Crowne Plaza Panama Airport by IHG

10/10 Excellent

"The best of this property is the customer services from the " Schedule Bus Driver ( they help me to advocate on my behalf with my rental car company) to the people that work in their restaurant.... so polite... so eager to help... it is AMAZING... the host (Odilia) help be to peel my boil egg... how does that... it is my favorite hotel to stay for years (15 years) whenever I leave Panama.."

Aloft by Marriott Panama

10/10 Excellent

"The room telephone was not operational. I asked the front desk for assistance twice, and it was never resolved. I was trying to order room service. So I had to walk downstairs each time I wanted service instead of having it delivered to my room. I wasn't happy about that."

ORHO Hotel Boutique 15 Minutes from PTY Airport

10/10 Excellent

"Staff was excellent. Best shuttle service. Good restaurants in the area. Room was small and walls thin. I was staying to catch morning flight. The two airport hotels had super high rates for this night. The airport was private versus the crowded shuttle at other airport hotels"

Sheraton Grand Panama

10/10 Excellent

"Clean rooms, comfy bed, helpful staff! Breakfast buffet was very complete with different options"

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

10/10 Excellent

"Beautful property, excellent service!"

Dovle Residences by HMS-Preferred Member

8/10 Good

"The room was a bit litter than I expected but it’s a good place to stay for little getaway, check in was super easy and staff was very friendly and clean room team have great service"

Modern Apartments PH Living 73 SF

10/10 Excellent

"Check in was relatively smooth, rooms was exactly as advertised. Conveniently located. Felt like home"

More cheap stays in La Mesa

Tocumen Comfort Stay

07168 24 de Diciembre Panama

CA $65

CA $71 total

Oct 14 - Oct 15

includes taxes & fees

B&B Lodgings

C. Tercera El Valle de Cerro Azul 24 de Diciembre Panamá Province

CA $70

CA $77 total

Nov 4 - Nov 5

includes taxes & fees

8/10 Very good! (97 reviews)

Orho Hotel Boutique 15 Minutes From PTY Airport

Calle Aeropuerto Tocumen Panamá Province

CA $153

CA $169 total

Nov 3 - Nov 4

includes taxes & fees

ORHO Hotel Boutique 15 Minutes from PTY Airport

Av. Domingo Díaz Tocumen Provincia de Panamá

CA $127

CA $170 total

Oct 18 - Oct 19

includes taxes & fees

9/10 Wonderful! (227 reviews)

Cozy Urban Loft 1br Near Coast

Panama City Panamá Province

CA $153

CA $217 total

Oct 11 - Oct 12

includes taxes & fees

Apex Executive Apartments - Dovle

Vía Cincuentenario 313 Panamá Panamá

CA $139

CA $277 total

Oct 14 - Oct 15

includes taxes & fees

Frequently asked questions

Where is the best place to stay in La Mesa?

Crowne Plaza Panama Airport by IHG, located 9.9 mi (15.9 km) from the heart of La Mesa, is a top choice for your stay based on our traveler data. Other good options for your stay in the area are Ramada Plaza by Wyndham Panama Punta Pacifica and Aloft by Marriott Panama. See all available top hotels, or vacation rentals in La Mesa.

What are some of the best vacation home rentals in La Mesa?

Cozy 3-bedroom townhome with WiFi, AC in fabulous Panamá: You might want to consider this vacation home rental near La Mesa, which is equipped with a selection of books, air-conditioning, and laundry facilities to help you feel comfortable during your stay. It has 3 bedrooms as well as a kitchen with a fridge, an oven, and a microwave, so you can cook with friends or family. See all vacation rentals in La Mesa.

If I need to cancel my hotel reservation in La Mesa, will I receive a refund?

Yes, the majority of room reservations are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in La Mesa.

What is staying in La Mesa like?

Visitors to La Mesa are sure to find plenty to explore and enjoy. There are 581 hotels and other accommodations in the surrounding area. Find out more about La Mesa.

What are the top places to visit in La Mesa?

Places to visit in the wider area include Metromall Panama, Los Pueblos Commercial Center, and Estadio Rommel Fernandez. You'll also find Chagres National Park and Chepo Youth Recreation Center in the area. Check out what more to see and do in Expedia's La Mesa guide.

What's the weather like in La Mesa?

The hottest months are usually April and March with an average temp of 80°F, while the coldest months are January and February with an average of 79°F. The rainiest months in La Mesa are July, August, October, and June, with each month seeing an average of 14 inches of rainfall.

Explore a world of travel with Expedia

Visit Pacora

Find hotels in La Mesa from CA $66

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in La Mesa

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for La Mesa hotels

1. Tocumen Comfort Stay

2. B&B Lodgings

3. PLEASANT HOSTAL PANAMA

4. Tiny Cabin

5. Express Inn Panama International Airport Hostel

6. Crowne Plaza Panama Airport by IHG

7. ORHO Hotel Boutique 15 Minutes from PTY Airport

8. Riande Aeropuerto Hotel & Casino

9. Swette Love 10 Minutes From the Airport Tocumen

10. Courtyard by Marriott Panama Metromall

11. The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

12. Corporate Stays Arcadia | Executive Furnished Apartments

13. The Westin Panama

14. Apex Executive Apartments - Dovle

15. Dovle Residences by HMS-Preferred Member

16. Cozy Urban Loft 1br Near Coast

17. Boutique Apartments Panamá Coco del Mar

18. Aloft by Marriott Panama

19. Charming 3 Bedroom Apartment in San Miguelito, Panama City

20. Sheraton Grand Panama

Top La Mesa Hotel Reviews

Corporate Stays Arcadia | Executive Furnished Apartments

Riande Aeropuerto Hotel & Casino

Crowne Plaza Panama Airport by IHG

Aloft by Marriott Panama

ORHO Hotel Boutique 15 Minutes from PTY Airport

Sheraton Grand Panama

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Dovle Residences by HMS-Preferred Member

Modern Apartments PH Living 73 SF

More cheap stays in La Mesa

Tocumen Comfort Stay

B&B Lodgings

Orho Hotel Boutique 15 Minutes From PTY Airport

ORHO Hotel Boutique 15 Minutes from PTY Airport

Cozy Urban Loft 1br Near Coast

Apex Executive Apartments - Dovle

Frequently asked questions

Explore a world of travel with Expedia

Go further with the Expedia app