Byron Vacation Rentals

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
Sep 12 - Sep 14
In two months
Oct 24 - Oct 26
In three months
Nov 21 - Nov 23
In four months
Dec 19 - Dec 21

Browse Select Byron Vacation Homes

Clean, fun, comfy ranch home near parks, 2.5 mi to Mayo w Pingpong and Playroom
Fridge, microwave, oven, stovetop

Clean, fun, comfy ranch home near parks, 2.5 mi to Mayo w Pingpong and Playroom

10.0 out of 10, Exceptional, (55)
"We had a great stay. We usually stay at a hotel to visit our son in Rochester but this time decided to VRBO because we wanted to celebrate his birthday with family. The house was perfect. Well maintained, super clean, great location and the ping pong table was a surprise hit. We will definitely stay there again!"
Clean, fun, comfy ranch home near parks, 2.5 mi to Mayo w Pingpong and Playroom
Mayo Discount! Main Floor bed, bath, and laundry. 3 blocks from Mayo Clinic
Fridge, microwave, oven, stovetop

Mayo Discount! Main Floor bed, bath, and laundry. 3 blocks from Mayo Clinic

10.0 out of 10, Exceptional, (34)
"This home is Central to the Mayo clinic The home is very nice and clean with everything you could possibly need for your stay. We would be back in a few months and definitely be staying here"
Mayo Discount! Main Floor bed, bath, and laundry. 3 blocks from Mayo Clinic
Charming 3 bed 1 bath home. 1 block to St. Mary's. 10 min walk to Mayo downtown.
Fridge, microwave, oven, stovetop

Charming 3 bed 1 bath home. 1 block to St. Mary's. 10 min walk to Mayo downtown.

10.0 out of 10, Exceptional, (93)
"perfect location perfect house. "
Charming 3 bed 1 bath home. 1 block to St. Mary's. 10 min walk to Mayo downtown.
"Walden Pond" Adventure Amidst 44 Private Acres
Interior

"Walden Pond" Adventure Amidst 44 Private Acres

10.0 out of 10, Exceptional, (134)
"Beautiful accommodations, great communication, wonderful hiking, campfires and smores! Our third visit and we love it every time! "
"Walden Pond" Adventure Amidst 44 Private Acres
Red Juniper House // 4BR, 2.5 Bath, Large Yard, Pet Friendly, 3mi to Mayo Clinic
Private kitchen

Red Juniper House // 4BR, 2.5 Bath, Large Yard, Pet Friendly, 3mi to Mayo Clinic

10.0 out of 10, Exceptional, (8)
"Great option for a family! Loved our stay!"
Red Juniper House // 4BR, 2.5 Bath, Large Yard, Pet Friendly, 3mi to Mayo Clinic
Charming 4-bedroom house with 3 king/1 full beds, 2 full baths, AC, Wifi, Patio
Exterior detail

Charming 4-bedroom house with 3 king/1 full beds, 2 full baths, AC, Wifi, Patio

10.0 out of 10, Exceptional, (8)
"A lovely home that was so comfortable for us to stay in "
Charming 4-bedroom house with 3 king/1 full beds, 2 full baths, AC, Wifi, Patio
The Best of Southwest Rochester, MN
Living area

The Best of Southwest Rochester, MN

The Best of Southwest Rochester, MN
Riverside Retreat Near Town w Sauna, sleeps 8, Views & Abundant Activities!
Fridge, microwave, oven, stovetop

Riverside Retreat Near Town w Sauna, sleeps 8, Views & Abundant Activities!

9.8 out of 10, Exceptional, (7)
Riverside Retreat Near Town w Sauna, sleeps 8, Views & Abundant Activities!
New Listing! Bella Casa! Whole house downtown Rochester. (Near Mayo Clinic)
3 bedrooms, iron/ironing board, WiFi, bed sheets

New Listing! Bella Casa! Whole house downtown Rochester. (Near Mayo Clinic)

9.8 out of 10, Exceptional, (41)
"Communication was fantastic, lovely house! "
New Listing! Bella Casa! Whole house downtown Rochester. (Near Mayo Clinic)
SUNNY 3BD, 2BA…ONLY BLOCKS FROM MAYO
Interior

SUNNY 3BD, 2BA…ONLY BLOCKS FROM MAYO

SUNNY 3BD, 2BA…ONLY BLOCKS FROM MAYO
Magical Nest Hideaway
Exterior

Magical Nest Hideaway

10.0 out of 10, Exceptional, (122)
"Stayed a couple days. Nice location and friendly owners. "
Magical Nest Hideaway
☆Dee Dee's Den: A Dharma Dwellings Parent Company☆
Fridge, microwave, oven, stovetop

☆Dee Dee's Den: A Dharma Dwellings Parent Company☆

10.0 out of 10, Exceptional, (41)
"We stayed here a second time for the Mayo Clinic, Alex and Emily are the best hosts we’ve ever had at a VRBO"
☆Dee Dee's Den: A Dharma Dwellings Parent Company☆
Silver Lake Oasis
Property grounds

Silver Lake Oasis

9.6 out of 10, Exceptional, (38)
"A nice little place, well kept and just as advertised."
Silver Lake Oasis
Spacious and clean house near airport, theater and shopping center
Fridge, microwave, oven, stovetop

Spacious and clean house near airport, theater and shopping center

10.0 out of 10, Exceptional, (41)
"Great property, great fun, thank you!"
Spacious and clean house near airport, theater and shopping center
Discounted Oasis! 5 Star-3 Bedroom Showstopping Duplex 4 Minutes to Mayo Clinic!
Interior

Discounted Oasis! 5 Star-3 Bedroom Showstopping Duplex 4 Minutes to Mayo Clinic!

9.0 out of 10, Wonderful, (16)
"Overall a good stay. The property was clean and mostly updated, but the home was very old. The foundation was slanted so much that items would roll off the table quickly and you could feel the slant when walking through the house."
The price is CA $138
CA $379 total
includes taxes & fees
Aug 30 - Aug 31
Discounted Oasis! 5 Star-3 Bedroom Showstopping Duplex 4 Minutes to Mayo Clinic!
Lux 3BR Cozy Nook I Mins to Mayo & Dwtwn I Pets
Exterior

Lux 3BR Cozy Nook I Mins to Mayo & Dwtwn I Pets

9.6 out of 10, Exceptional, (4)
"Very cute and well maintained. We would definitely stay again. "
The price is CA $192
CA $555 total
includes taxes & fees
Aug 29 - Aug 30
Lux 3BR Cozy Nook I Mins to Mayo & Dwtwn I Pets
7 blks Mayo Gonda 8 blks St Marys 3 Bed Main Floor
Property grounds

7 blks Mayo Gonda 8 blks St Marys 3 Bed Main Floor

9.6 out of 10, Exceptional, (14)
" We were able to stay at the Harmony House a few blocks from the hospital. It worked well for us. Beds were very comfortable!"
The price is CA $142
CA $382 total
includes taxes & fees
Sep 3 - Sep 4
7 blks Mayo Gonda 8 blks St Marys 3 Bed Main Floor
Park-Side, Easy Access To Downtown, Mayo Clinic & Bike Trail, Family-Friendly
Fridge, microwave, oven, stovetop

Park-Side, Easy Access To Downtown, Mayo Clinic & Bike Trail, Family-Friendly

9.8 out of 10, Exceptional, (65)
"Everything about this Vrbo was excellent. My family raved about the lay-out, location and access to everything. It really felt like we were returning home everytime we pulled in. "
Park-Side, Easy Access To Downtown, Mayo Clinic & Bike Trail, Family-Friendly
Spacious Single Level House with Power Recliners
Fridge, microwave, oven, stovetop

Spacious Single Level House with Power Recliners

9.6 out of 10, Exceptional, (22)
"The home was prefect for us! It was close to a lot of venues. Loved the open rooms and the comfy furniture! "
Spacious Single Level House with Power Recliners
Discounted Charming 2-bedroom house in Rochester
Microwave, oven, stovetop, dishwasher

Discounted Charming 2-bedroom house in Rochester

8.8 out of 10, Excellent, (6)
"Needed a last minute place to stay with my elderly parents for Mayo appointments. The home was clean, cute, location great, easy to find--very homey."
Discounted Charming 2-bedroom house in Rochester
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Byron Hotel Reviews

Find out more about Byron

Find out more about Byron

Byron Vacation Homes information

Number of reviews
504
Accommodation
147 Vacation Homes
Lowest Price
CA $138
Highest Price
CA $192

Explore a world of travel with Expedia

Explore a world of travel with Expedia