Title: 5 Stars Hotels in Isla Santa Maria, Biobío - Find Cheap Isla Santa Maria Hotels With 5 Stars | Expedia.ca [Isla Santa Maria Travel Guide](https://expedia.ca/Isla-Santa-Maria.dx6101241)[Hotels in Isla Santa Maria](https://expedia.ca/Isla-Santa-Maria-Hotels.d6101241.Travel-Guide-Hotels)[Vacation Rentals in Isla Santa Maria](https://expedia.ca/Isla-Santa-Maria-Vacation-Rentals.d6101241.Travel-Guide-VacationRentals)[Flights to Isla Santa Maria](https://expedia.ca/Cheap-Flights-To-Isla-Santa-Maria.d6101241.Travel-Guide-Flights)[Isla Santa Maria Car Rentals](https://expedia.ca/Car-Rentals-In-Isla-Santa-Maria.d6101241.Car-Rental-Guide)[Isla Santa Maria Vacation Packages](https://expedia.ca/Isla-Santa-Maria.d6101241.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # 5 Stars Hotels in Isla Santa Maria, Biobío ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Isla Santa Maria 5 Star Hotels Tonight [Sep 24 - Sep 25](https://www.expedia.ca/Hotel-Search?regionId=6101241&startDate=2025-09-24&endDate=2025-09-25&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 25 - Sep 26](https://www.expedia.ca/Hotel-Search?regionId=6101241&startDate=2025-09-25&endDate=2025-09-26&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Sep 26 - Sep 28](https://www.expedia.ca/Hotel-Search?regionId=6101241&startDate=2025-09-26&endDate=2025-09-28&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=6101241&startDate=2025-10-03&endDate=2025-10-05&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Isla Santa Maria 5 Star Hotels ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Isla-Santa-Maria-Hotels.s50-0-d6101241.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Isla-Santa-Maria-Hotels.s50-0-d6101241.Travel-Guide-Filter-Hotels) ## Top Isla Santa Maria Hotel Reviews ## Find out more about Isla Santa Maria ## Five Star Hotels in Isla Santa Maria There's nothing wrong with enjoying the finer things in life. Indulge yourself on your next leisure time. After all, this is one of the Top 10 locations in Expedia's portfolio. You'll join the multitudes of vacationers who have made Isla Santa Maria so fashionable in the last year. We should also mention, the hotels in this area receive outstanding marks for guest services, so you know you'll be looked after during your getaway. You deserve the great vacation you're dreaming about. Book one of Expedia's luxurious 5-star hotels in Isla Santa Maria and get ready to be pampered like never before. #### Get a Great Deal on 5-Star Hotels in Isla Santa Maria Don't be afraid to live the high life while you're on vacation, along with pristine rooms. Excellent customer care, spacious rooms, and fabulous spa offerings are all on offer. We have a huge number of hotels in the region, and all of them offer outstanding amenities. Besides that, you'll find that these hotels are kept in fantastic condition and provide a fine place to kick back after your daily adventures. What kind of amenities will make your stay a wonderful one? A concierge to help you plan every detail of your day? A Swedish massage to help your cares fall away? Fluffy down pillows, piping hot coffees, and even space for your family pet in some cases...these hotels have it all. Want to see for yourself? Then explore the 31,943 reviews various guests have left on Expedia and get to know these places. Can't wait to get outside? We've got you covered. You'll find lots of attractions to see in a sprawling city like this one, like visiting art galleries and taking in live performances. Say hi to the locals—they're sure to have advice on what kind of excitement you can find in town. #### Make Your Escape to Isla Santa Maria The results are in, and Isla Santa Maria 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. This is a great time to find 5-star hotel deals in Isla Santa Maria! Don't put off your dream vacation any longer. 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