Title: Luxury Vacations in Southeast Missouri 2025/2026 | Expedia.ca ![](https://images.trvl-media.com/place/553248635976196024/558eb86b-b1ac-4ef2-8a0c-6bebbb1e2aae.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Southeast Missouri Luxury Vacations ## Book a Hotel + Flight or Car together to unlock savings Stay added Flight added Car - Economy - Premium economy - Business class - First class Leaving from Going to Dates Travellers ## Room 1 Adults ChildrenAges 2 to 17 InfantsYounger than 2 I only need accommodation for part of my trip - ## Plan, book, travel with confidence ### Better together Save up to CA $1,096 when you book a flight and hotel together\* ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package ### Rest easy Plan, book, and manage your trip all in one place ## Plan the perfect luxury Southeast Missouri vacation with Expedia #### What are some benefits when booking luxury Southeast Missouri vacations? When you book a luxury Southeast Missouri vacation, you get to enjoy some of the best amenities and special features available. Luxury vacation options often feature spa facilities right in your accommodation, along with room service and an on-site restaurant. The quality of the bedding and even the water pressure tends to be better, so it's the perfect solution for travellers looking to put their feet up and relax. #### How can I find all-inclusive luxury vacations in Southeast Missouri? If you're looking for something luxurious in Southeast Missouri, all you have to do is take advantage of our search filters. You can implement a filter to only show 5-star accommodations as well as some amenities you may be interested in, like spa facilities and hot tubs. When you opt for an all-inclusive package, you can enjoy luxury alongside a potential discount for booking your accommodation and flight together. #### Can I book a cheap luxury vacation? While luxury vacations tend to be on the more costly end of the spectrum, ranging from , there are a few methods you can try to lower the price as much as possible. When booking a flight and accommodation together, you can enjoy savings of up to . After implementing filters for luxury features, you can also sort by price to list the cheapest luxury packages first. #### Are there luxury spa vacations? Yes, luxury spa vacations are available and quite popular in Southeast Missouri. When you book one of these experiences, it's easier than ever to relax, unwind and recharge in between excursions. Either way, you can easily find spa vacations by implementing the spa filter in your search. #### What should I look for in a luxury family vacation in Southeast Missouri? When booking something for the whole family, it's important to consider exactly what kind of experience your family will want.Luxury packages make it easy to keep everyone happy with creature comforts. Kids especially enjoy features like pools, a delicious breakfast and plenty of space. Suites tend to offer your family members a bit more privacy and comfort compared to simple rooms throughout Southeast Missouri. #### Can I book last-minute luxury vacations? Yes, last-minute bookings are often available in Southeast Missouri. All you have to do is enter your travel dates to see what's available. Sometimes, you'll even find additional discounts for booking last-minute, as accommodations are desperate to fill their last remaining spaces. #### What can help me find the best luxury vacation deals in Southeast Missouri? You can use a few strategies to find the best deals on luxury vacation packages. Consider travelling during the off-season to take advantage of the typically lower overall prices. Additionally, staying in the less popular parts of Southeast Missouri or travelling to more obscure destinations altogether can often lead to lower prices. #### Can I book a luxury vacation that is fully refundable? Yes, fully refundable reservations are sometimes available on luxury vacation packages in Southeast Missouri. You can implement a filter for it specifically or check out the policy section on any one of your search results. It should clearly state what's necessary to qualify for a fully refundable booking. #### Why should I book my luxury vacation with Expedia? When you book with Expedia, you can enjoy a one-stop shop for all your travel planning needs. We offer accommodations as well as flights, and you may even be able to enjoy discounts by booking them together. Of course, Expedia Rewards members will find even more discounts and earn points that can be put toward discounts on future bookings. ## Luxury Hotels in Southeast Missouri ![Super 8 by Wyndham Pevely](https://images.trvl-media.com/lodging/1000000/860000/856200/856190/5ceda82a_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Super 8 by Wyndham Pevely 1711 Highway Z, Pevely, MO - 3 hours drive from Mark Twain National Forest Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ... 5.6/10 (828 reviews) Adequate Hotel is in rough shape…but if you just need a place to sleep for the night it will fulfill that. Hotel needs a major revamping. Reviewed on May 17, 2025 [](https://expedia.ca/Farmington-Hotels-Super-8-By-Wyndham-Pevely.h856190.Hotel-Information) ![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Motel 6 Poplar Bluff, MO 4101 Highway 67 N, Poplar Bluff, MO - 3 hours drive from Mark Twain National Forest Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ... 7.8/10 Good! (1,000 reviews) Everything we needed Reviewed on Oct 19, 2025 [](https://expedia.ca/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) ![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Days Inn and Suites by Wyndham Sikeston 220 S Interstate Dr, Sikeston, MO - 4 hours drive from Mark Twain National Forest Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ... 7.2/10 Good! (1,000 reviews) The staff was very professional, kind and accommodating. Reviewed on Oct 12, 2025 [](https://expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) [See all 595 properties in Southeast Missouri](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Package®ionId=6058763) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## More vacations you might like ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.ca/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.ca/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Vacations [](https://expedia.ca/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Family_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.ca/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.ca/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.ca/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.ca/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ### Top Luxury Vacation Destinations > - [Luxury vacations in Portugal](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/147/Portugal) > - [Luxury vacations in India](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/80/India) > - [Luxury vacations in France](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/59/France) > - [Luxury vacations in Switzerland](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/174/Switzerland) > - [Luxury vacations in Canada](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/31/Canada) > - [Luxury vacations in Jamaica](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/88/Jamaica) > - [Luxury vacations in Italy](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/86/Italy) > - [Luxury vacations in New Zealand](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/133/New-Zealand) > - [Luxury vacations in the Maldives](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/109/Maldives) > - [Luxury vacations in Costa Rica](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/42/Costa-Rica) > - [Luxury vacations in Florida Keys](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/6023765/Florida-Keys) > - [Luxury vacations in Mexico](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/117/Mexico) > - [Luxury vacations in the Caribbean](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/6022969/Caribbean) > - [Luxury vacations in Zanzibar](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/4186/Zanzibar) > - [Luxury vacations in Cancun](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/179995/Cancun) > - [Luxury vacations in Kerala](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/602187/Kerala) > - [Luxury vacations in Australia](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/10/Australia) > - [Luxury vacations in Puglia](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/6048562/Puglia) > - [Luxury vacations in Cuba](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/44/Cuba) > - [Luxury vacations in Cyprus](https://www.expedia.ca/lp/theme-vacations/luxury-vacations/45/Cyprus) ## More Vacations Ideas [Flights to Southeast Missouri](https://expedia.ca/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Southeast Missouri Hotels](https://expedia.ca/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Southeast Missouri Vacation Rentals](https://expedia.ca/Southeast-Missouri-Vacation-Rentals.d6058763.Travel-Guide-VacationRentals)[Southeast Missouri Car Rentals](https://expedia.ca/Car-Rentals-In-Southeast-Missouri.d6058763.Car-Rental-Guide)[Southeast Missouri Vacations](https://expedia.ca/Southeast-Missouri.d6058763.Destination-Travel-Guides)[Things to do in Southeast Missouri](https://expedia.ca/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities) \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAyAAAAMgAQAAAADzCzvFAAAFZUlEQVR4Xu3bQXLbOBBGYbiy0DJH0FF4NPJoOoqOkKUXLmPcPxpAE+F4pmsqs7Df21iCGvi4o6k4pf4PlXXhTwSSCiQVSCqQVCCpQFKBpAJJBZIKJBVIKpBUIKlAUoGkAkkFkgokFUgqkFQgqUBSgaQCSQWSCiQVSCqQVAF5K0v3vvRS66PcPoY/ltQvW93qa/nY/rTXe1uK7fNkkAKyjoG09nkySAFZx0Ba+zz5qyL7fKcTp7u1xWfbHhHf+MsuZXQ+CwQEBMQCUSAKZOSz6jaQvX34sFUfPIrf9rX0tB+OaOm80QIBAbEfICAFBMT7HFG+/TamvM3e+msQkAIC4oEUEJDyn5HDj+nbvfeA/LAXIHdbPdqCpyULBAQE5NGnQHy7B3L+QIi7L/b+tT1P/zD350CsOBWXRiAgICAWyFwagYC8hXt5vFVr+6PcVnddWtrnySAXS0v7PBnkYmlpnyeDXCwt7fNkkIulpX2eDHKxtLTPk0Eulpb2eXJALlpOtHu8b3/3o8bUZ4GAXASyBAJyEcjS10X8Vv1xYin3dftYilOxrU2psBFkTsW2NqXCRpA5FdvalAobQeZUbGtTKmwEmVOxrU2psBFkTsW2NqXCRpA5FdvalAobz8j5u+tnm/alV7uha2mv8x5vrjbqL67H9+A+5YGAVBBtBNEsCAhIRN7GvnGPV3rEjo0TPW2cV2fvfoSPQUBAKggISAWJrcjP9tpv1ZrV87Tf4z1/xC7jhh43WiAgFQQEBKSCtI3WZ8hedUN/hHv80bdXW9J2W9INPV6Knrq39moseSAgICAgW3sFokAC4r3bUaVtV0LcFVKr3+Nv9tpP1NVVc+3qdMEjEAUCAgICAuKdkaPou+txohLi2wcyp+7t47jkUyMQkAqiQEBAKoj6HSnjSbnardrTkp9oUy/2Qq5u6GMqXsoIBKSCgHggIPYWJCA++3J5944n7n3p3Hw2XwMBAemBKJAZCIi2++zNFp5tU3zEHkjxG7pPra6f5YGAgICAjEBA6gmp9vCsv9wazSflh721E7WkE33Jk6urO2+0QEAqiAIBOW20QEC8jviJ5lY/sZR7m/ETfaqMG7pPgfj2e5sBGYGEKRDffm8zICOQMPVdEDvx3R+e7cT51L21gXGiLuW2blR+dSEQkAoyN4LsFWQGAvJmExPx1cO3nk70f4bWiZf51XkgICBXgYBUEBD/QN9dV0NKuYfZR0OendTURzbl6eq0VD69x4MoEBAQEK3MlyD+6vsifuJI21/thv607Uf7TWDkJ/ap89VZICAgICAgFkhvRXzWPpmz/UQfPNo7TVlv/rFnl1JAQECUpiwQ+wQEZGxXR3unKet7Ihdpu/6+67zk3exS1N4+HL8c+NV5ICAXgYCclkAuA/kOSNyu7rZ6FD1Pbxqe9QdxfzuezT1/6vZAQEAsEBAFYsMzkDebnZ2RYieOh2f/301xST3auvIlC0SBzEB6vmSBKJAZSM+XrK+LzO2GLK6dqLu3puK/Jo9+cy2QAgICAgIyByrIPyLepuGPJqLctd8E6rjHr1cH0gOxQNoiyKbhAjICAflb5N5GNeX3eLlH0Zfe1Zb6eTMQLYGAFBCQ3wLREsjMT7Tt8cTZFoaPvqQpbQyBaGl29CWQuD22heGjL4HE7bEtDB99CSRuj21h+OhLIHF7bAvDR18CidtjWxg++tK/QM7dbdUent/9xLBU7Xn6Zj+eNmq/HOgerynd9kMgFeQkFBAQkB5I/fbInwskFUgqkFQgqUBSgaQCSQWSCiQVSCqQVCCpQFKBpAJJBZIKJBVIKpBUIKlAUoGkAkkFkgokFUgqkFQgqb4O8hclvTeeuNO6zgAAAABJRU5ErkJggg==)