Southeast Missouri Luxury Vacations

Book a Hotel + Flight or Car together to unlock savings

Photo by JG Morris
  • Plan, book, travel with confidence

  • Better together

    Save up to CA $1,096 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Plan the perfect luxury Southeast Missouri vacation with Expedia

What are some benefits when booking luxury Southeast Missouri vacations?

When you book a luxury Southeast Missouri vacation, you get to enjoy some of the best amenities and special features available. Luxury vacation options often feature spa facilities right in your accommodation, along with room service and an on-site restaurant. The quality of the bedding and even the water pressure tends to be better, so it's the perfect solution for travellers looking to put their feet up and relax.


How can I find all-inclusive luxury vacations in Southeast Missouri?

If you're looking for something luxurious in Southeast Missouri, all you have to do is take advantage of our search filters. You can implement a filter to only show 5-star accommodations as well as some amenities you may be interested in, like spa facilities and hot tubs. When you opt for an all-inclusive package, you can enjoy luxury alongside a potential discount for booking your accommodation and flight together.

Can I book a cheap luxury vacation?

While luxury vacations tend to be on the more costly end of the spectrum, ranging from , there are a few methods you can try to lower the price as much as possible. When booking a flight and accommodation together, you can enjoy savings of up to . After implementing filters for luxury features, you can also sort by price to list the cheapest luxury packages first.

Are there luxury spa vacations?

Yes, luxury spa vacations are available and quite popular in Southeast Missouri. When you book one of these experiences, it's easier than ever to relax, unwind and recharge in between excursions. Either way, you can easily find spa vacations by implementing the spa filter in your search.

What should I look for in a luxury family vacation in Southeast Missouri?

When booking something for the whole family, it's important to consider exactly what kind of experience your family will want.Luxury packages make it easy to keep everyone happy with creature comforts. Kids especially enjoy features like pools, a delicious breakfast and plenty of space. Suites tend to offer your family members a bit more privacy and comfort compared to simple rooms throughout Southeast Missouri.

Can I book last-minute luxury vacations?

Yes, last-minute bookings are often available in Southeast Missouri. All you have to do is enter your travel dates to see what's available. Sometimes, you'll even find additional discounts for booking last-minute, as accommodations are desperate to fill their last remaining spaces.

What can help me find the best luxury vacation deals in Southeast Missouri?

You can use a few strategies to find the best deals on luxury vacation packages. Consider travelling during the off-season to take advantage of the typically lower overall prices. Additionally, staying in the less popular parts of Southeast Missouri or travelling to more obscure destinations altogether can often lead to lower prices.

Can I book a luxury vacation that is fully refundable?

Yes, fully refundable reservations are sometimes available on luxury vacation packages in Southeast Missouri. You can implement a filter for it specifically or check out the policy section on any one of your search results. It should clearly state what's necessary to qualify for a fully refundable booking.

Why should I book my luxury vacation with Expedia?

When you book with Expedia, you can enjoy a one-stop shop for all your travel planning needs. We offer accommodations as well as flights, and you may even be able to enjoy discounts by booking them together. Of course, Expedia Rewards members will find even more discounts and earn points that can be put toward discounts on future bookings.

Luxury Hotels in Southeast Missouri

Super 8 by Wyndham Pevely

Super 8 by Wyndham Pevely

2 out of 5
1711 Highway Z Pevely MO
  • 3 hours drive from Mark Twain National Forest
Book a stay at this business-friendly motel in Pevely. Enjoy free breakfast, free WiFi, and free parking. Popular attractions Pevely Park and Sun Valley Park ...
5.6/10 (831 reviews)
Awesome

Reviewed on Nov 11, 2025

Super 8 by Wyndham Pevely
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

2 out of 5
4101 Highway 67 N Poplar Bluff MO
  • 3 hours drive from Mark Twain National Forest
Stay at this motel in Poplar Bluff. Enjoy free WiFi, free parking, and a 24-hour front desk. Our guests praise the helpful staff and the clean rooms in our reviews. ...
7.8/10 Good! (1,000 reviews)
The stay this time was just wonderful. The staff was more than helpful when we needed extra things and especially when we got stuck for two extra days from the snow. Normally we just get a regular room but this time decided to do a kitchenette. Best decision ever. Made the hallway smell like bacon ...

Reviewed on Jan 28, 2026

Motel 6 Poplar Bluff, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
  • 4 hours drive from Mark Twain National Forest
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
7.2/10 Good! (1,000 reviews)
Clean comfy stay ! Thanks

Reviewed on Feb 2, 2026

Days Inn and Suites by Wyndham Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More vacations you might like

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.