A group of men in red uniforms with gold accents, holding rifles and wearing kilts.

Photo by JG Morris

Southeast Missouri Luxury Vacations

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  • Discover the most popular places to visit in Southeast Missouri

    A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

    Photo by Pat Long

    Elephant Rocks State Park

    Rating: 9.6/10 (98 reviews)

    You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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    A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

    Southeast Missouri State University

    Rating: 8.8/10 (248 reviews)

    Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

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    A sunset over a lake with boats and ducks.

    Photo by JG Morris

    Lake Wappapello

    Rating: 8.8/10 (54 reviews)

    Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

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    Century Casino & Hotel Cape Girardeau

    Rating: 8.4/10 (176 reviews)

    Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.

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    Century Casino Caruthersville

    Rating: 7.0/10 (57 reviews)

    Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

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    What to do in Southeast Missouri

    Pythian Castle

    Night Ghost Tour of Pythian Castle in Springfield Missouri

    CA $28

    per adult

    96% of travellers recommend

    Ozark Craft Beverage - Brewery Tour

    Tour The Ozarks Private Springfield Brewery Tour

    CA $302

    per adult

    0% of travellers recommend

    See all activities in Southeast Missouri

    Top Luxury Southeast Missouri Hotels

    Hampton Inn & Suites By Hilton Festus

    A hotel room with a bed, bedside tables, a desk, a chair, a lamp, and a window.
    • Location: 109.2 km from Southeast Missouri
    • Guest rating: 9.4/10 (Exceptional, 29 reviews)
    • Price: CA $163, CA $186 total, includes taxes & fees, Dec 6 - Dec 7, for Top Luxury Southeast Missouri Hotels
    • Review: Good location, updated hotel!

    Drury Inn & Suites Poplar Bluff

    A spacious lobby with a reception desk, seating area, and large windows.
    • Address: 2220 N Westwood Blvd, Poplar Bluff, MO, 63901, US
    • Location: 49.3 km from Southeast Missouri
    • Star rating: 3/5
    • Guest rating: 9.4/10 (Exceptional, 1002 reviews)
    • Price: CA $134, CA $151 total, includes taxes & fees, Nov 20 - Nov 21, for Top Luxury Southeast Missouri Hotels
    • Review: I like how clean they were, and the food was excellent and the hot tub was great

    Holiday Inn Express & Suites Farmington by IHG

    A reception area with a modern design, featuring a decorative wall piece, a small table with a bowl, and a patterned partition.
    • Address: 820 Market St, Farmington, MO, 63640, US
    • Location: 63.2 km from Southeast Missouri
    • Star rating: 2.5/5
    • Guest rating: 8.6/10 (Excellent, 445 reviews)
    • Price: CA $158, CA $181 total, includes taxes & fees, Dec 13 - Dec 14, for Top Luxury Southeast Missouri Hotels
    • Review: We stayed one night and it was great! Breakfast was delicious.

    Hampton Inn Farmington

    An indoor swimming pool with clear water, surrounded by lounge chairs and a tiled floor.
    • Address: 850 Valley Creek Dr, Farmington, MO, 63640, US
    • Location: 63.4 km from Southeast Missouri
    • Star rating: 2.5/5
    • Guest rating: 8.8/10 (Excellent, 584 reviews)
    • Price: CA $148, CA $169 total, includes taxes & fees, Dec 13 - Dec 14, for Top Luxury Southeast Missouri Hotels

    Shepherd Mountain Inn

    A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.
    • Address: 1321 N Hwy 21, Ironton, MO, 63650, US
    • Location: 47.2 km from Southeast Missouri
    • Star rating: 2.5/5
    • Guest rating: 9.2/10 (Wonderful, 339 reviews)
    • Price: CA $176, CA $192 total, includes taxes & fees, Nov 16 - Nov 17, for Top Luxury Southeast Missouri Hotels

    The Riverview

    A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
    • Address: 777 Main St, Cape Girardeau, MO, 63701, US
    • Location: 81.1 km from Southeast Missouri
    • Star rating: 4/5
    • Guest rating: 9.4/10 (Exceptional, 704 reviews)
    • Price: CA $155, CA $175 total, includes taxes & fees, Nov 17 - Nov 18, for Top Luxury Southeast Missouri Hotels

    Fort Davidson Hotel

    A hotel room with two beds, a desk, a chair, a TV, and a lamp.
    • Address: 310 South McCune St, Ironton, MO, 63663, US
    • Location: 47.9 km from Southeast Missouri
    • Star rating: 2.5/5
    • Guest rating: 9.2/10 (Wonderful, 190 reviews)
    • Price: CA $178, CA $195 total, includes taxes & fees, Nov 18 - Nov 19, for Top Luxury Southeast Missouri Hotels

    Drury Plaza Hotel Cape Girardeau Conference Center

    A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
    • Address: 3351 Percy Drive, Cape Girardeau, MO, 63701, US
    • Location: 75.5 km from Southeast Missouri
    • Star rating: 3/5
    • Guest rating: 9.6/10 (Exceptional, 1005 reviews)
    • Price: CA $143, CA $161 total, includes taxes & fees, Nov 18 - Nov 19, for Top Luxury Southeast Missouri Hotels

    Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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    Plan the perfect luxury Southeast Missouri vacation with Expedia

    What are some benefits when booking luxury Southeast Missouri vacations?

    When you book a luxury Southeast Missouri vacation, you get to enjoy some of the best amenities and special features available. Luxury vacation options often feature spa facilities right in your accommodation, along with room service and an on-site restaurant. The quality of the bedding and even the water pressure tends to be better, so it's the perfect solution for travellers looking to put their feet up and relax.

    How can I find all-inclusive luxury vacations in Southeast Missouri?

    If you're looking for something luxurious in Southeast Missouri, all you have to do is take advantage of our search filters. You can implement a filter to only show 5-star accommodations as well as some amenities you may be interested in, like spa facilities and hot tubs. When you opt for an all-inclusive package, you can enjoy luxury alongside a potential discount for booking your accommodation and flight together.

    Can I book a cheap luxury vacation?

    While luxury vacations tend to be on the more costly end of the spectrum, ranging from , there are a few methods you can try to lower the price as much as possible. When booking a flight and accommodation together, you can enjoy savings of up to . After implementing filters for luxury features, you can also sort by price to list the cheapest luxury packages first.

    Are there luxury spa vacations?

    Yes, luxury spa vacations are available and quite popular in Southeast Missouri. When you book one of these experiences, it's easier than ever to relax, unwind and recharge in between excursions. Either way, you can easily find spa vacations by implementing the spa filter in your search.

    What should I look for in a luxury family vacation in Southeast Missouri?

    When booking something for the whole family, it's important to consider exactly what kind of experience your family will want.Luxury packages make it easy to keep everyone happy with creature comforts. Kids especially enjoy features like pools, a delicious breakfast and plenty of space. Suites tend to offer your family members a bit more privacy and comfort compared to simple rooms throughout Southeast Missouri.

    Can I book last-minute luxury vacations?

    Yes, last-minute bookings are often available in Southeast Missouri. All you have to do is enter your travel dates to see what's available. Sometimes, you'll even find additional discounts for booking last-minute, as accommodations are desperate to fill their last remaining spaces.

    What can help me find the best luxury vacation deals in Southeast Missouri?

    You can use a few strategies to find the best deals on luxury vacation packages. Consider travelling during the off-season to take advantage of the typically lower overall prices. Additionally, staying in the less popular parts of Southeast Missouri or travelling to more obscure destinations altogether can often lead to lower prices.

    Can I book a luxury vacation that is fully refundable?

    Yes, fully refundable reservations are sometimes available on luxury vacation packages in Southeast Missouri. You can implement a filter for it specifically or check out the policy section on any one of your search results. It should clearly state what's necessary to qualify for a fully refundable booking.

    Why should I book my luxury vacation with Expedia?

    When you book with Expedia, you can enjoy a one-stop shop for all your travel planning needs. We offer accommodations as well as flights, and you may even be able to enjoy discounts by booking them together. Of course, Expedia Rewards members will find even more discounts and earn points that can be put toward discounts on future bookings.

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